ATE161842T1 - Indolin verbindungen und sie als aktivbestandteil enthaltende 5-ht3-antagonisten - Google Patents

Indolin verbindungen und sie als aktivbestandteil enthaltende 5-ht3-antagonisten

Info

Publication number
ATE161842T1
ATE161842T1 AT94927825T AT94927825T ATE161842T1 AT E161842 T1 ATE161842 T1 AT E161842T1 AT 94927825 T AT94927825 T AT 94927825T AT 94927825 T AT94927825 T AT 94927825T AT E161842 T1 ATE161842 T1 AT E161842T1
Authority
AT
Austria
Prior art keywords
group
indoline compounds
chem
receptor antagonists
active ingredients
Prior art date
Application number
AT94927825T
Other languages
English (en)
Inventor
Shinji Tsuchiya
Nobuyuki Yasuda
Atsushi Fukuzaki
Koichi Kazama
Original Assignee
Tokyo Tanabe Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tokyo Tanabe Co filed Critical Tokyo Tanabe Co
Application granted granted Critical
Publication of ATE161842T1 publication Critical patent/ATE161842T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
AT94927825T 1993-09-30 1994-09-30 Indolin verbindungen und sie als aktivbestandteil enthaltende 5-ht3-antagonisten ATE161842T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP24577893 1993-09-30
JP6272894 1994-03-31
PCT/JP1994/001622 WO1995009167A1 (fr) 1993-09-30 1994-09-29 Derive d'indoline et antagoniste du recepteur 5-ht3 contenant ce derive et utilise comme ingredient actif

Publications (1)

Publication Number Publication Date
ATE161842T1 true ATE161842T1 (de) 1998-01-15

Family

ID=26403780

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94927825T ATE161842T1 (de) 1993-09-30 1994-09-30 Indolin verbindungen und sie als aktivbestandteil enthaltende 5-ht3-antagonisten

Country Status (8)

Country Link
US (1) US5677326A (de)
EP (1) EP0721949B1 (de)
KR (1) KR960704881A (de)
AT (1) ATE161842T1 (de)
AU (2) AU7707994A (de)
CA (1) CA2173155A1 (de)
DE (1) DE69407807T2 (de)
WO (1) WO1995009167A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5521183A (en) * 1994-08-30 1996-05-28 Allergan Use of 5-HT ligands as anti-pruritic agents
CA2213249A1 (en) * 1995-02-17 1996-08-22 Mitsubishi-Tokyo Pharmaceuticals, Inc. Process for producing indoline compounds and intermediates for the production of the same
WO1996025396A1 (fr) * 1995-02-17 1996-08-22 Tokyo Tanabe Company Limited Procede de preparation de composes indoline et intermediaires de cette preparation
US6562629B1 (en) 1999-08-11 2003-05-13 Cedars-Sinai Medical Center Method of diagnosing irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth by detecting the presence of anti-saccharomyces cerivisiae antibodies (asca) in human serum
US6861053B1 (en) * 1999-08-11 2005-03-01 Cedars-Sinai Medical Center Methods of diagnosing or treating irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth
US7048906B2 (en) 1995-05-17 2006-05-23 Cedars-Sinai Medical Center Methods of diagnosing and treating small intestinal bacterial overgrowth (SIBO) and SIBO-related conditions
FR2744452B1 (fr) * 1996-02-06 1998-03-06 Cird Galderma Composes biaryles heterocycliques, compositions pharmaceutiques et cosmetiques les contenant et utilisations
AU2001244088A1 (en) * 2000-03-17 2001-09-24 Boehringer Ingelheim International G.M.B.H Condensed imidazoles as histamine h3 receptor ligands
US6437147B1 (en) 2000-03-17 2002-08-20 Novo Nordisk Imidazole compounds
EP1480631B1 (de) * 2002-12-20 2007-08-01 Dynogen Pharmaceuticals Inc. Behandlung nicht-schmerzhafter blasenstörungen mit modulatoren von alpha-2-delta- calciumkanaluntereinheiten
KR100742001B1 (ko) * 2003-03-21 2007-07-23 다이노젠 파마세우티컬스, 인코포레이티드 평활근 모듈레이터 및 알파2 델타 서브유닛 칼슘 채널모듈레이터를 이용한 하부 요로 질환의 치료 방법
PT2432467T (pt) 2009-05-20 2018-04-04 Inst Nat Sante Rech Med Antagonistas recetores de serotina 5-ht3 para utilização no tratamento de distúrbios vestibulares lesionais
ES2432618T3 (es) 2009-05-20 2013-12-04 Inserm (Institut National De La Santé Et De La Recherche Medicale) Antagonistas del receptor 5-HT3 de serotonina para usar en el tratamiento o prevención de una patología del oído interno con déficit vestibular

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3401173A (en) * 1966-04-05 1968-09-10 Smith Kline French Lab Heterocyclic acylaminobenzimidazoles
CH528514A (de) * 1969-05-22 1972-09-30 Bayer Ag Verfahren zur Herstellung von Acylimidazolen
US4080330A (en) * 1975-06-23 1978-03-21 Delmar Chemicals Limited Phenylindolines and process for their production
SU786266A1 (ru) * 1978-12-04 1982-05-07 Ростовский Ордена Трудового Красного Знамени Государственный Университет Способ получени 2-бензимидазолиларилкетонов
DE3708292A1 (de) * 1987-03-14 1988-09-29 Basf Ag Gegen einwirkung von licht stabilisierte polymere sowie neue imidazol-2-carbonsaeureanilide
AU626980B2 (en) * 1989-02-02 1992-08-13 Astellas Pharma Inc. Tetrahydrobenzimidazole derivatives
US5344927A (en) * 1989-02-02 1994-09-06 Yamanouchi Pharmaceutical Co., Ltd. Tetrahydrobenzimidazole derivatives and pharmaceutical compositions containing same

Also Published As

Publication number Publication date
CA2173155A1 (en) 1995-04-06
US5677326A (en) 1997-10-14
AU7708394A (en) 1995-04-18
AU7707994A (en) 1995-04-18
EP0721949A4 (de) 1996-08-28
WO1995009167A1 (fr) 1995-04-06
AU678057B2 (en) 1997-05-15
EP0721949B1 (de) 1998-01-07
DE69407807D1 (de) 1998-02-12
EP0721949A1 (de) 1996-07-17
KR960704881A (ko) 1996-10-09
DE69407807T2 (de) 1998-05-20

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties