KR940008586A - 전단 형태 매트릭스의 제조공정 - Google Patents

전단 형태 매트릭스의 제조공정 Download PDF

Info

Publication number
KR940008586A
KR940008586A KR1019930022262A KR930022262A KR940008586A KR 940008586 A KR940008586 A KR 940008586A KR 1019930022262 A KR1019930022262 A KR 1019930022262A KR 930022262 A KR930022262 A KR 930022262A KR 940008586 A KR940008586 A KR 940008586A
Authority
KR
South Korea
Prior art keywords
feedstock
temperature
fluid
nozzle
shearing
Prior art date
Application number
KR1019930022262A
Other languages
English (en)
Inventor
알리 보그 비.
씨. 푸이즈 리차드
지. 히스콕스 페터
Original Assignee
제랄드 이. 바티스트
푸이즈 테크노로지즈 리미티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 제랄드 이. 바티스트, 푸이즈 테크노로지즈 리미티드 filed Critical 제랄드 이. 바티스트
Publication of KR940008586A publication Critical patent/KR940008586A/ko

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
    • A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
    • A23G3/50—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by shape, structure or physical form, e.g. products with supported structure
    • A23G3/54—Composite products, e.g. layered, coated, filled
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
    • A23G3/02—Apparatus specially adapted for manufacture or treatment of sweetmeats or confectionery; Accessories therefor
    • A23G3/10—Candy-pulling machines ; Processes or apparatus for making cotton candy or candy floss
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor

Landscapes

  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Mechanical Engineering (AREA)
  • Confectionery (AREA)
  • Processing And Handling Of Plastics And Other Materials For Molding In General (AREA)
  • Glanulating (AREA)
  • Fats And Perfumes (AREA)
  • Formation And Processing Of Food Products (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Press-Shaping Or Shaping Using Conveyers (AREA)

Abstract

본 발명은 공급원료의 모양을 변형을 가져오는 전단형태 매트릭스라 불리는 새로운 매트릭스 물질을 제조하기 위한 독특한 공정 및 장치이다.
공정은 재부 유동을 겪는 점으로 비용해된 공급원료 담체의 온도를 증가시키고, 공급원료의 스트림을 방출하며, 이어서 공급원료를 변형된 모양을 갖는 분리된 부분 또는 덩어리로 분리하는 파괴적인 유체 전단힘을 받게 하는 것을 특징으로 한다. 전단형태 매트릭스는 유질 물질 및 활성물과 같은 다른 성분을 포함할 수 있을 것이다.

Description

전단 형태 미트릭스의 제조공정
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 제2도 및 제3도에 상술된 전단 영역을 가진 전체적인 공정 및 장치의 도해이고,
제2도는 제1도의 원이 쳐진 전단 영역(Ⅱ)의 상세한 도형이며; 제2a도는 연장된 가열없이 첨가제의 도입을 제공하는 바람직한 태양을 묘사하는 가상선을 갖는 제2도에 나타낸 것과 같은 도해이고,
제3도는 본 발명의 바람직한 태양에 대한 바람직한 방출 배열의 추가의 상세한 도해이다.

Claims (28)

  1. a)고체의 비용해된 담체 물질을 포함하는 공급원료의 온도를 유체 전단 힘의 적용을 갖는 내부 유동을 겪을 점까지 증가시키고, b)적어도 하나의 오리피스(orifice)로 부터 압력하에 단계(a)로 부터 생성된 상기 가열된 공급원료의 스트림을 방출하며, c)이어서, 상기 공급원료를, 공급원료의 유동을 다수의 부분으로 분리하고, 상기 공급원료의 모양을 변형시키는 파괴적인 유체 전단힘을 받게 함을 포함하는, 전단형태 매트릭스의 제조공정.
  2. 제1항에 있어서, 상기 유제 전단 힘에의 접촉 및 다수 부분으로의 상기 스트림의 분리후에 즉시 상기 다수의 부분이 상기 내부에 유동점 아래의 온도로 냉각되는 공정.
  3. 제1항에 있어서, 고체화될때가지 자유-유동을 허용하는 조건하에서 상기 다수의 부분이 고체 전단형태 매트릭스로서 재형성하도록 하기 위한 환경이 제공되는 공정.
  4. 제1항에 있어서, 상기 담체 물질이 당류-기재 물질, 열가소성 중합체, 생물분해성 중합제, 및 섬유소로 구성되는 그룹으로부터 선택되는 공정.
  5. 제4항에 있어서, 상기 공급원료가 추가로 결정화 조절제를 포함하는 공정.
  6. 제5항에 있어서, 상기 결정화 조절제가 항습윤제인 공정.
  7. 제5항에 있어서, 상기 공급원료가 식물성 오일, 콩기름, 카놀라유, 옥수수유, 해바라기유, 동물성 지방, 수지, 돼지기름, 어유, 갑각류유, 및 이것들의 혼합물로 구성되는 그룹으로부터 선택되는 유질 물질을 포함하는 공정.
  8. 제4항에 있어서, 상기 공급원료가 생물 영향제, 염료, 방향, 결정화 조절제, 감미료, 조리료, 및 이것들의 혼합물로 구성되는 그룹으로 부터 선택된 첨가제를 포함하는 공정.
  9. 제1항에 있어서, 상기 온도기 조절된 온도 증가 동안에 최소의 잔류시간을 가지고 상기 점을 넘에서 실질적인 가열이 없는 상태에서 상기 내부 유동점까지 상기 온도가 조절되어 증가 하는 공정.
  10. 제9항에 있어서, 상기 공급원료가 동시에 압력을 받는 공정.
  11. 제9항에 있어서, 상기 조절된 온도 증가가 다수의 온도-조절 영역을 갖는 공급장치 챔버를 통해 상기 공급원료를 보냄으로서 제공되는 공정.
  12. 제11항에 있어서, 상기 공급원료가 상기 내부 점위로 실질적으로 가열함으 방지하고 상기 챔버 내에서의 시간을 최소화하는 조건하에서 상기 다수의 영역을 통과하는 공정.
  13. 제4항에 있어서, 상기 유체 전단 힘이 상기 압출물의 스트림에 고속으로 유체를 향하게 함으로써 유발되는 공정.
  14. 제13항에 있어서, 상기 공급원료가 슈크로즈이고, 상기 유체가 약160℃ 내지 약200℃의 온도에서 유지되는 공기이며, 주변 대기는 30% RH 보다 적은 상대 습도를 갖는 공정.
  15. 제13항에 있어서, 상기 공급원료가 말토덱스트린이고, 상기 유체가 약85℃ 내지 약180℃의 온도 및 주변 기압으로 유지되는 공기인 공정.
  16. 제4항에 있어서, 상기 유체 전단 힘이 분리되고 불연속적인 덩어리를 제공하는 조건에서 유체 대기에 대해 고속으로 상기 노즐을 통해 상기 공급원료를 압출함으로써 유발되는 공정.
  17. 내부 유동을 겪고, 방출을 위해 공급원료를 동시에 전진시키는 점으로 비용해된 공급원료 물질상의 온도 및 적용된 압력을 증가시키기 위한 수단, 상기 전단형태 매트릭스를 제공하기 위해 상기 공급원료를 전단하기 위한 조건에서, 온도 및 압력을 증가시키기 위한 상기 수단과 유체적으로 연통하면서 상기 내부 유동조건 동안에 상기 공급원료 물질을 수용하기 위해 배열된, 상기 공급원료를 방출하기 위한 수단, 방출을 위한 상기 수단에 근접하여 고정되고, 상기 내부 유동 조건동안에 상기 공급원료의 전단을 하도록 배열됨으로써 상기 공급원료 물질이 상기 전단형태 매트릭스로 변형되는, 상기 공급원료를 전단하기 위한 수단을 포함하는 전단형태 매트릭스를 제조하기 위한 장치.
  18. 제17항에 있어서, 온도를 증가시키기 위한 상기 수단이 선택적으로 가열가능한 영역을 갖는 다수의 -영역챔버 및 상기 공급원료를 전진시키기 위해 연속적인 처리량 구조를 포함하는 장치.
  19. 제18항에 있어서, 상기 처리량 구조가 상기 공급원료를 압출하기 위한 적어도 하나의 스크류 구조를 포함하는 장치.
  20. 제19항에 있어서, 상기 수단이 적어도 네개의 영역을 갖는 트윈 스크류 압출기인 장치.
  21. 제20항에 있어서, 아홉개의 가열 영역이 있는 장치.
  22. 제17항에 있어서, 방출을 위한 상기 수단이 고압 노즐인 장치.
  23. 제22항에 있어서, 상기 노즐이 출구 오리피스에서 상기 공급원료의 실질적으로 점착성인 스트림을 제공하는 저속 노즐인 장치.
  24. 제22항에 있어서, 상기 노즐이 고속에서 공급원료를 방출하기 위한 적어도 하나의 개구를 갖는 고속 노즐인 장치.
  25. 제17항에 있어서, 상기 공급원료를 전단하기 위한 상기 수단이 공급원료가 방출을 위한 상기 수단을 빠져 나감에 따라 공급원료에 대해 고속으로 유체를 전달하기 위한 수단을 포함하는 장치.
  26. 제25항에 있어서, 유체를 전달하기 위한 상기 수단이 외부 분무 노즐을 포함하는 장치.
  27. 제24항에 있어서, 전단을 위한 상기 수단이 상기 환경에 대해 상기 고속 공급원료의 충돌시 전단을 유도하는 환경을 저속시키는 환경-지속 챔버를 포함하는 장치.
  28. 제17항에 있어서, 상기 장치가 근접한 상기 노즐점에서 상기 공급원료에 첨가제를 주입하기 위한 수단을 포함하는 장치.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019930022262A 1992-10-23 1993-10-23 전단 형태 매트릭스의 제조공정 KR940008586A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US965,804 1978-12-04
US07/965,804 US5380473A (en) 1992-10-23 1992-10-23 Process for making shearform matrix

Publications (1)

Publication Number Publication Date
KR940008586A true KR940008586A (ko) 1994-05-16

Family

ID=25510508

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019930022262A KR940008586A (ko) 1992-10-23 1993-10-23 전단 형태 매트릭스의 제조공정

Country Status (10)

Country Link
US (1) US5380473A (ko)
EP (1) EP0601965B1 (ko)
JP (1) JPH07308564A (ko)
KR (1) KR940008586A (ko)
AU (1) AU670625B2 (ko)
CA (1) CA2108832A1 (ko)
DE (1) DE69313418T2 (ko)
DK (1) DK0601965T3 (ko)
MX (1) MX9306622A (ko)
PL (1) PL178069B1 (ko)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20190007091A (ko) * 2010-10-22 2019-01-21 어퀘스티브 테라퓨틱스, 인크. 소형 필름 스트립의 제조

Families Citing this family (120)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6582728B1 (en) * 1992-07-08 2003-06-24 Inhale Therapeutic Systems, Inc. Spray drying of macromolecules to produce inhaleable dry powders
US6673335B1 (en) * 1992-07-08 2004-01-06 Nektar Therapeutics Compositions and methods for the pulmonary delivery of aerosolized medicaments
EP0679088B1 (en) * 1992-09-29 2002-07-10 Inhale Therapeutic Systems Pulmonary delivery of active fragments of parathyroid hormone
CA2128820A1 (en) * 1993-07-27 1995-01-28 Walter G. Gowan, Jr. Rapidly disintegrating pharmaceutical dosage form and process for preparation thereof
US5518551A (en) * 1993-09-10 1996-05-21 Fuisz Technologies Ltd. Spheroidal crystal sugar and method of making
US5965162A (en) * 1993-09-10 1999-10-12 Fuisz Technologies Ltd. Process for forming chewable quickly dispersing multi-vitamin preparation and product therefrom
US5597416A (en) * 1993-10-07 1997-01-28 Fuisz Technologies Ltd. Method of making crystalline sugar and products resulting therefrom
US5622719A (en) * 1993-09-10 1997-04-22 Fuisz Technologies Ltd. Process and apparatus for making rapidly dissolving dosage units and product therefrom
US5935600A (en) * 1993-09-10 1999-08-10 Fuisz Technologies Ltd. Process for forming chewable quickly dispersing comestible unit and product therefrom
US5895664A (en) * 1993-09-10 1999-04-20 Fuisz Technologies Ltd. Process for forming quickly dispersing comestible unit and product therefrom
US20030113273A1 (en) * 1996-06-17 2003-06-19 Patton John S. Methods and compositions for pulmonary delivery of insulin
AU689217B2 (en) * 1994-03-07 1998-03-26 Novartis Ag Methods and compositions for pulmonary delivery of insulin
DE69534318T2 (de) * 1994-05-18 2006-04-20 Nektar Therapeutics, San Carlos Methoden und zusammensetzungen für die trockenpuderarznei aus interferonen
US5567439A (en) * 1994-06-14 1996-10-22 Fuisz Technologies Ltd. Delivery of controlled-release systems(s)
US5582855A (en) 1994-07-01 1996-12-10 Fuisz Technologies Ltd. Flash flow formed solloid delivery systems
US6290991B1 (en) * 1994-12-02 2001-09-18 Quandrant Holdings Cambridge Limited Solid dose delivery vehicle and methods of making same
US6586006B2 (en) 1994-08-04 2003-07-01 Elan Drug Delivery Limited Solid delivery systems for controlled release of molecules incorporated therein and methods of making same
US6083430A (en) * 1994-10-28 2000-07-04 Fuisz Technologies Ltd. Method of preparing a dosage unit by direct tableting and product therefrom
US5683720A (en) * 1994-10-28 1997-11-04 Fuisz Technologies Ltd. Liquiflash particles and method of making same
US5587198A (en) * 1995-05-31 1996-12-24 Fuisz Technologies Ltd. Positive hydration method of preparing confectionery and product therefrom
US6964771B1 (en) 1995-06-07 2005-11-15 Elan Drug Delivery Limited Method for stably incorporating substances within dry, foamed glass matrices
US6391338B1 (en) 1995-09-07 2002-05-21 Biovail Technologies Ltd. System for rendering substantially non-dissoluble bio-affecting agents bio-available
US5637326A (en) 1995-12-04 1997-06-10 Fuisz Technologies Ltd. Apparatus for making chopped amorphous fibers with an air transport system
US6165518A (en) * 1996-04-11 2000-12-26 Loders Croklaan B.V. Free flowing fat compositions
US6468782B1 (en) 1996-12-05 2002-10-22 Quadrant Healthcare (Uk) Limited Methods of preserving prokaryotic cells and compositions obtained thereby
US6471992B1 (en) 1997-02-20 2002-10-29 Therics, Inc. Dosage form exhibiting rapid disperse properties, methods of use and process for the manufacture of same
AU7700198A (en) * 1997-06-24 1999-01-04 Fuisz Technologies Ltd. Positive hydration method of preparing confectionery and product therefrom
US20030035778A1 (en) * 1997-07-14 2003-02-20 Robert Platz Methods and compositions for the dry powder formulation of interferon
US5980941A (en) * 1997-08-20 1999-11-09 Fuisz Technologies Ltd. Self-binding shearform compositions
US20060165606A1 (en) * 1997-09-29 2006-07-27 Nektar Therapeutics Pulmonary delivery particles comprising water insoluble or crystalline active agents
US6565885B1 (en) * 1997-09-29 2003-05-20 Inhale Therapeutic Systems, Inc. Methods of spray drying pharmaceutical compositions
US6309623B1 (en) * 1997-09-29 2001-10-30 Inhale Therapeutic Systems, Inc. Stabilized preparations for use in metered dose inhalers
US6612826B1 (en) * 1997-10-15 2003-09-02 Iap Research, Inc. System for consolidating powders
CA2325941A1 (en) * 1998-03-23 1999-09-30 Fuisz Technologies Ltd. Calcium-based chewy nougat formulation with magnesium
IE980395A1 (en) 1998-05-22 1999-12-01 Fuisz Internat Ltd Fuisz House Method and appartus for forming and encapsulated product matrix
CA2362633A1 (en) * 1998-05-22 1999-12-02 Fuisz International Ltd. Method and apparatus for forming an encapsulated product matrix
US5976603A (en) * 1998-08-26 1999-11-02 Fuisz Technologies Ltd. Fiber and vitamin-fortified drink composition and beverage and method of making
WO2000013522A1 (en) * 1998-09-08 2000-03-16 Fuisz Technologies Ltd. Chewy nougat confectionery formulation with caffeine
US6171607B1 (en) 1998-09-28 2001-01-09 Fuisz Technologies Ltd. Process and apparatus for producing shearform matrix material
US8404217B2 (en) 2000-05-10 2013-03-26 Novartis Ag Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use
US7871598B1 (en) 2000-05-10 2011-01-18 Novartis Ag Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
DK1280520T4 (en) 2000-05-10 2018-06-25 Novartis Ag Phospholipid based powders for drug delivery
EP1301177A2 (en) * 2000-07-10 2003-04-16 Therics, Inc. Method and materials for controlling migration of binder liquid in a powder
US20020106368A1 (en) * 2000-07-28 2002-08-08 Adrian Bot Novel methods and compositions to upregulate, redirect or limit immune responses to peptides, proteins and other bioactive compounds and vectors expressing the same
EP1458360B1 (en) 2001-12-19 2011-05-11 Novartis AG Pulmonary delivery of aminoglycosides
US9079246B2 (en) 2009-12-08 2015-07-14 Baker Hughes Incorporated Method of making a nanomatrix powder metal compact
US8297364B2 (en) * 2009-12-08 2012-10-30 Baker Hughes Incorporated Telescopic unit with dissolvable barrier
US9101978B2 (en) 2002-12-08 2015-08-11 Baker Hughes Incorporated Nanomatrix powder metal compact
US9682425B2 (en) 2009-12-08 2017-06-20 Baker Hughes Incorporated Coated metallic powder and method of making the same
US8403037B2 (en) * 2009-12-08 2013-03-26 Baker Hughes Incorporated Dissolvable tool and method
US8327931B2 (en) 2009-12-08 2012-12-11 Baker Hughes Incorporated Multi-component disappearing tripping ball and method for making the same
US9109429B2 (en) 2002-12-08 2015-08-18 Baker Hughes Incorporated Engineered powder compact composite material
PT1691787E (pt) * 2003-12-04 2008-09-02 Pfizer Prod Inc Método de formação de multipartículas farmacêuticas
BRPI0416534A (pt) * 2003-12-04 2007-01-09 Pfizer Prod Inc composições multiparticuladas com estabilidade melhorada
WO2005053652A1 (en) 2003-12-04 2005-06-16 Pfizer Products Inc. Multiparticulate crystalline drug compositions containing a poloxamer and a glyceride
BRPI0417348A (pt) * 2003-12-04 2007-03-13 Pfizer Prod Inc processo de gelatinização por spray com utilização de uma extrusora para preparação de composições de droga cristalina multiparticulada contendo preferencialmente um poloxámero e um glicerìdeo
BRPI0417338A (pt) * 2003-12-04 2007-04-17 Pfizer Prod Inc formas de dosagem de azitromicina multiparticulada por processos a base de lìquido
US6984403B2 (en) * 2003-12-04 2006-01-10 Pfizer Inc. Azithromycin dosage forms with reduced side effects
WO2005053653A1 (en) * 2003-12-04 2005-06-16 Pfizer Products Inc. Spray-congeal process using an extruder for preparing multiparticulate azithromycin compositions containing preferably a poloxamer and a glyceride
WO2005053639A2 (en) * 2003-12-04 2005-06-16 Pfizer Products Inc. Controlled release multiparticulates formed with dissolution enhancers
US20050136112A1 (en) * 2003-12-19 2005-06-23 Pediamed Pharmaceuticals, Inc. Oral medicament delivery system
DK1804804T3 (da) 2004-09-21 2012-02-20 Hypnion Inc 3-[4-(dibenzo[b,f][1,4]oxazepin-11-yl)-piperazin-1-yl]-2,2-dimethylpropansyre til anvendelse ved behandlingen af søvnforstyrrelser
US20070031342A1 (en) * 2005-06-22 2007-02-08 Nektar Therapeutics Sustained release microparticles for pulmonary delivery
ES2500165T3 (es) 2006-06-29 2014-09-30 Kinex Pharmaceuticals, Llc Composiciones de biarilo y métodos para modular una cascada de quinasas
WO2009051848A1 (en) 2007-10-20 2009-04-23 Kinex Pharmaceuticals, Llc Pharmaceutical compositions for modulating a kinase cascade and methods of use thereof
US9848634B2 (en) 2009-06-30 2017-12-26 Philip Morris Products S.A. Smokeless tobacco product
US9227243B2 (en) 2009-12-08 2016-01-05 Baker Hughes Incorporated Method of making a powder metal compact
US10240419B2 (en) 2009-12-08 2019-03-26 Baker Hughes, A Ge Company, Llc Downhole flow inhibition tool and method of unplugging a seat
US8528633B2 (en) * 2009-12-08 2013-09-10 Baker Hughes Incorporated Dissolvable tool and method
US8425651B2 (en) 2010-07-30 2013-04-23 Baker Hughes Incorporated Nanomatrix metal composite
US8573295B2 (en) 2010-11-16 2013-11-05 Baker Hughes Incorporated Plug and method of unplugging a seat
US9127515B2 (en) 2010-10-27 2015-09-08 Baker Hughes Incorporated Nanomatrix carbon composite
US9243475B2 (en) 2009-12-08 2016-01-26 Baker Hughes Incorporated Extruded powder metal compact
US8776884B2 (en) 2010-08-09 2014-07-15 Baker Hughes Incorporated Formation treatment system and method
US9090955B2 (en) 2010-10-27 2015-07-28 Baker Hughes Incorporated Nanomatrix powder metal composite
EP2632920A1 (en) 2010-10-27 2013-09-04 Dynamix Pharmaceuticals Ltd. Sulfonamides for the modulation of pkm2
WO2012088438A1 (en) 2010-12-22 2012-06-28 Eutropics Pharmaceuticals, Inc. Compositions and methods useful for treating diseases
WO2012122370A2 (en) 2011-03-08 2012-09-13 Eutropics Pharmaceuticals, Inc. Compositions and methods useful for treating diseases
US9080098B2 (en) 2011-04-28 2015-07-14 Baker Hughes Incorporated Functionally gradient composite article
US8631876B2 (en) 2011-04-28 2014-01-21 Baker Hughes Incorporated Method of making and using a functionally gradient composite tool
WO2012160447A1 (en) 2011-05-25 2012-11-29 Dynamix Pharmaceuticals Ltd. 3, 5 -diphenyl- substituted pyrazolines for the treatment of cancer, proliferative, inflammatory or autoimmune diseases
PL2718290T3 (pl) 2011-06-07 2016-11-30 Kompozycje i sposoby modulowania kinazy
US9139928B2 (en) 2011-06-17 2015-09-22 Baker Hughes Incorporated Corrodible downhole article and method of removing the article from downhole environment
US9707739B2 (en) 2011-07-22 2017-07-18 Baker Hughes Incorporated Intermetallic metallic composite, method of manufacture thereof and articles comprising the same
US8783365B2 (en) 2011-07-28 2014-07-22 Baker Hughes Incorporated Selective hydraulic fracturing tool and method thereof
US9833838B2 (en) 2011-07-29 2017-12-05 Baker Hughes, A Ge Company, Llc Method of controlling the corrosion rate of alloy particles, alloy particle with controlled corrosion rate, and articles comprising the particle
US9643250B2 (en) 2011-07-29 2017-05-09 Baker Hughes Incorporated Method of controlling the corrosion rate of alloy particles, alloy particle with controlled corrosion rate, and articles comprising the particle
US9057242B2 (en) 2011-08-05 2015-06-16 Baker Hughes Incorporated Method of controlling corrosion rate in downhole article, and downhole article having controlled corrosion rate
US9033055B2 (en) 2011-08-17 2015-05-19 Baker Hughes Incorporated Selectively degradable passage restriction and method
US9856547B2 (en) 2011-08-30 2018-01-02 Bakers Hughes, A Ge Company, Llc Nanostructured powder metal compact
US9090956B2 (en) 2011-08-30 2015-07-28 Baker Hughes Incorporated Aluminum alloy powder metal compact
US9109269B2 (en) 2011-08-30 2015-08-18 Baker Hughes Incorporated Magnesium alloy powder metal compact
US9643144B2 (en) 2011-09-02 2017-05-09 Baker Hughes Incorporated Method to generate and disperse nanostructures in a composite material
US9347119B2 (en) 2011-09-03 2016-05-24 Baker Hughes Incorporated Degradable high shock impedance material
US9133695B2 (en) 2011-09-03 2015-09-15 Baker Hughes Incorporated Degradable shaped charge and perforating gun system
US9187990B2 (en) 2011-09-03 2015-11-17 Baker Hughes Incorporated Method of using a degradable shaped charge and perforating gun system
US9284812B2 (en) 2011-11-21 2016-03-15 Baker Hughes Incorporated System for increasing swelling efficiency
US9010416B2 (en) 2012-01-25 2015-04-21 Baker Hughes Incorporated Tubular anchoring system and a seat for use in the same
US9068428B2 (en) 2012-02-13 2015-06-30 Baker Hughes Incorporated Selectively corrodible downhole article and method of use
US9605508B2 (en) 2012-05-08 2017-03-28 Baker Hughes Incorporated Disintegrable and conformable metallic seal, and method of making the same
US20150150869A1 (en) 2012-06-20 2015-06-04 Eutropics Pharmaceuticals, Inc. Methods and compositions useful for treating diseases involving bcl-2 family proteins with quinoline derivatives
SI2890680T1 (en) 2012-08-30 2018-08-31 Athenex, Inc. Conventus Building N- (3-FLUOROBENZYL) -2- (5- (4-MORFOLINOPHENYL) PIRIDIN-2-IL) ACETAMIDE AS PROTEIN TIROZINE KINASE PROTECTORS
CN105188849B (zh) 2013-03-15 2019-01-15 阿普雷奇亚制药有限责任公司 包含左乙拉西坦的快速分散剂型
CN105050588B (zh) 2013-03-15 2019-01-15 阿普雷奇亚制药有限责任公司 托吡酯的快速分散剂型
US9339489B2 (en) 2013-03-15 2016-05-17 Aprecia Pharmaceuticals Company Rapid disperse dosage form containing levetiracetam
CA2906107C (en) 2013-03-15 2021-08-24 Aprecia Pharmaceuticals Company Rapidly dispersible dosage form of oxcarbazepine
US9816339B2 (en) 2013-09-03 2017-11-14 Baker Hughes, A Ge Company, Llc Plug reception assembly and method of reducing restriction in a borehole
US10150713B2 (en) 2014-02-21 2018-12-11 Terves, Inc. Fluid activated disintegrating metal system
US11167343B2 (en) 2014-02-21 2021-11-09 Terves, Llc Galvanically-active in situ formed particles for controlled rate dissolving tools
US9910026B2 (en) 2015-01-21 2018-03-06 Baker Hughes, A Ge Company, Llc High temperature tracers for downhole detection of produced water
US10378303B2 (en) 2015-03-05 2019-08-13 Baker Hughes, A Ge Company, Llc Downhole tool and method of forming the same
US10221637B2 (en) 2015-08-11 2019-03-05 Baker Hughes, A Ge Company, Llc Methods of manufacturing dissolvable tools via liquid-solid state molding
US10016810B2 (en) 2015-12-14 2018-07-10 Baker Hughes, A Ge Company, Llc Methods of manufacturing degradable tools using a galvanic carrier and tools manufactured thereof
CA3032586A1 (en) 2016-08-12 2018-02-15 Athenex, Inc. Biaryl compounds and use thereof for modulating a kinase cascade
CA3012511A1 (en) 2017-07-27 2019-01-27 Terves Inc. Degradable metal matrix composite
CN108454109B (zh) * 2018-02-05 2023-07-07 华北理工大学 3d打印机断料提示装置
WO2019240568A1 (es) 2018-06-14 2019-12-19 Centro De Investigación En Química Aplicada Método de obtención de partículas porosas mediante un proceso híbrido de pulverización por secado-enfriamiento
US20220016074A1 (en) 2018-11-21 2022-01-20 Rosemont Pharmaceuticals Limited Oral topiramate suspension formulations with extended shelf stability and enhanced bioavailability
WO2021263132A1 (en) 2020-06-26 2021-12-30 Aprecia Pharmaceuticals LLC Rapidly-orodispersible tablets having an interior cavity
CN112109231A (zh) * 2020-08-26 2020-12-22 常宇 一种聚丙烯的生产方法

Family Cites Families (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2508462A (en) * 1945-03-17 1950-05-23 Union Carbide & Carbon Corp Method and apparatus for the manufacture of synthetic staple fibers
US2826169A (en) * 1954-01-21 1958-03-11 Veen Harry H Le Reflective heat insulating coating for animals
US2918404A (en) * 1956-07-30 1959-12-22 Ortho Pharma Corp Solid compressed amino acid spermicidal vehicle
US3067743A (en) * 1958-11-12 1962-12-11 Alginate Ind Ltd Alginic compounds
US3131428A (en) * 1958-12-19 1964-05-05 Celanese Corp Spinneret and spinning method
US3036532A (en) * 1960-06-28 1962-05-29 Bowe John Cotton candy machine with product of alternating colors
US3019745A (en) * 1960-10-03 1962-02-06 Bois Albert Du Sugar spinning machine
US3070045A (en) * 1961-04-24 1962-12-25 Bowe John Machine for spinning sugar
NL279172A (ko) * 1961-06-02
US3073262A (en) * 1961-08-16 1963-01-15 Bowe John Spinner head for candy cotton machine
NL136087C (ko) * 1962-01-15
US3095258A (en) * 1962-06-22 1963-06-25 Du Pont Melt spinning process for producing hollow-core filament
US3308221A (en) * 1963-05-14 1967-03-07 Allied Chem Melt spinning of modified cross section yarn
US3595675A (en) * 1966-11-21 1971-07-27 Gen Mills Inc Gelatin composition
US3615671A (en) * 1968-04-19 1971-10-26 Gen Foods Corp Dry food products in spun filaments and method of making same
US3762846A (en) * 1968-05-17 1973-10-02 Gen Mills Inc Process and apparatus for making candy floss
US3723134A (en) * 1968-05-17 1973-03-27 Gen Mills Inc Process for making candy floss
US3557717A (en) * 1968-05-17 1971-01-26 Gen Mills Inc Process for making candy floss
US3625214A (en) * 1970-05-18 1971-12-07 Alza Corp Drug-delivery device
US3951821A (en) * 1972-07-14 1976-04-20 The Dow Chemical Company Disintegrating agent for tablets
US3875300A (en) * 1972-12-18 1975-04-01 Ortho Pharma Corp Composition for sustained release of a medicament and method of using same
US3930043A (en) * 1973-07-19 1975-12-30 Tec Pak Corp Method for making cotton candy
US3856443A (en) * 1973-08-06 1974-12-24 Gen Properties Anstalt Apparatus for producing candyfloss
US3925525A (en) * 1973-08-10 1975-12-09 Celanese Corp Spinning method
US4004039A (en) * 1973-12-03 1977-01-18 General Foods Corporation Sweetening composition and process therefor
GB1460614A (en) * 1974-04-16 1977-01-06 Tate & Lyle Ltd Production of crystalline sugar
US4136145A (en) * 1974-07-05 1979-01-23 Schering Aktiengesellschaft Medicament carriers in the form of film having active substance incorporated therein
US3967623A (en) * 1975-06-30 1976-07-06 Johnson & Johnson Disposable absorbent pad
US3992265A (en) * 1975-12-31 1976-11-16 American Cyanamid Company Antibiotic susceptibility testing
US4090920A (en) * 1976-02-19 1978-05-23 Fisher Scientific Company Disposable antibiotic susceptability test package
US4153512A (en) * 1976-04-07 1979-05-08 Fisher Scientific Company Storage stable antibiotic susceptibility test kit and method of testing
GB1548022A (en) * 1976-10-06 1979-07-04 Wyeth John & Brother Ltd Pharmaceutial dosage forms
US4293570A (en) * 1979-04-02 1981-10-06 Chimicasa Gmbh Process for the preparation of sweetener containing product
US4291015A (en) * 1979-08-14 1981-09-22 Key Pharmaceuticals, Inc. Polymeric diffusion matrix containing a vasodilator
US4303684A (en) * 1980-03-17 1981-12-01 General Foods Corporation Rapidly-soluble sweetener, process for its preparation and beverage mix employing it
US4500546A (en) * 1980-10-31 1985-02-19 International Telephone And Telegraph Corporation Suspensions containing microfibrillated cellulose
US4585797A (en) * 1981-04-13 1986-04-29 Seton Company Cosmetic and pharmaceutical sheet material containing polypeptides
US4376743A (en) * 1981-06-12 1983-03-15 Fiber Industries, Inc. Melt spinning process
JPS5966841A (ja) * 1982-10-05 1984-04-16 Meiji Seika Kaisha Ltd 複合繊維状チユ−インガムの製造方法
GB2137470B (en) * 1983-04-08 1986-11-26 Meiji Seika Kaisha Fleecy confectionery producing machine
JPS61501078A (ja) * 1984-01-31 1986-05-29 ダーキー　インダストリアル　フーヅ　コーポレーション カプセル化用基剤組成物及びこれを含むカプセル化物
IE56300B1 (en) * 1984-03-19 1991-06-05 Gen Foods Corp Method for fixing volatile flavorants in extruded vitreous substrates
DE3430809A1 (de) * 1984-08-22 1986-03-06 Merck Patent Gmbh, 6100 Darmstadt Sucralfat-suspension
US4619833A (en) * 1984-12-13 1986-10-28 General Foods Inc. Process for producing a rapidly water-soluble, free-flowing, sugar-free dry beverage mix
US4692371A (en) * 1985-07-30 1987-09-08 Kimberly-Clark Corporation High temperature method of making elastomeric materials and materials obtained thereby
US4793782A (en) * 1986-12-17 1988-12-27 Sells-Floto Inc. Cotton candy machine
US4855326A (en) * 1987-04-20 1989-08-08 Fuisz Pharmaceutical Ltd. Rapidly dissoluble medicinal dosage unit and method of manufacture
US5096492A (en) * 1987-04-20 1992-03-17 Fuisz Technologies Ltd. Dispersed systems and method of manufacture
US5028632A (en) * 1987-04-20 1991-07-02 Fuisz Pharmaceutical Ltd. Taste masked medicated pharmaceutical
US4873085A (en) * 1987-04-20 1989-10-10 Fuisz Pharmaceutical Ltd. Spun fibrous cosmetic and method of use
US5011532A (en) * 1988-03-18 1991-04-30 Fuisz Pharmaceutical Ltd. Dispersed systems and method of manufacture
RU2056835C1 (ru) * 1987-04-20 1996-03-27 Фьюиз Фармасьютикал Лтд. Способ получения растворимого лекарственного средства
US5387431A (en) * 1991-10-25 1995-02-07 Fuisz Technologies Ltd. Saccharide-based matrix
US4997856A (en) * 1987-04-20 1991-03-05 Fuisz Pharmaceutical Ltd. Method of producing compacted dispersable systems
US5034421A (en) * 1988-12-13 1991-07-23 Fuisz Pharmaceutical Ltd. Moderated spun fibrous system and method of manufacture
US4923646A (en) * 1988-11-08 1990-05-08 James River Corporation Method and apparatus for the manufacture of fibrids
US4978537A (en) * 1989-04-19 1990-12-18 Wm. Wrigley Jr. Company Gradual release structures for chewing gum
AU639645B2 (en) * 1989-10-10 1993-07-29 Wm. Wrigley Jr. Company Gradual release structures made from fiber spinning techniques
DE4011883A1 (de) * 1990-04-12 1991-10-17 Bayer Ag Verfahren zur herstellung von feinstfaservliesen aus thermoplastischen polymeren
JPH07501259A (ja) * 1990-06-01 1995-02-09 リサーチ　コーポレイション　テクノロジーズ，インコーポレイテッド 自己乳化型ガラス
ZA908406B (en) * 1990-10-19 1991-08-28 Fuisz Pharmaceutical Ltd Taste masked medicated floss
DE4040242A1 (de) * 1990-12-15 1992-06-17 Peter Roger Dipl Ing Nyssen Verfahren und vorrichtung zur herstellung von feinstfasern aus thermoplastischen polymeren
PL171695B1 (en) * 1991-11-04 1997-06-30 Fuisz Technologies Ltd Chewing gum
DE69231281T2 (de) * 1991-12-17 2001-03-01 Biovail Tech Ltd Zusammensetzung und verfahren zur ulcusprävention und -behandlung

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20190007091A (ko) * 2010-10-22 2019-01-21 어퀘스티브 테라퓨틱스, 인크. 소형 필름 스트립의 제조

Also Published As

Publication number Publication date
DE69313418T2 (de) 1998-03-26
AU4917093A (en) 1994-05-05
EP0601965A3 (ko) 1994-08-31
JPH07308564A (ja) 1995-11-28
DE69313418D1 (de) 1997-10-02
CA2108832A1 (en) 1994-04-24
EP0601965B1 (en) 1997-08-27
PL178069B1 (pl) 2000-02-29
EP0601965A2 (en) 1994-06-15
DK0601965T3 (da) 1997-09-29
MX9306622A (es) 1994-04-29
US5380473A (en) 1995-01-10
PL300831A1 (en) 1994-05-16
AU670625B2 (en) 1996-07-25

Similar Documents

Publication Publication Date Title
KR940008586A (ko) 전단 형태 매트릭스의 제조공정
US5595757A (en) Seamless capsules
US5888538A (en) Methods and apparatus for making seamless capsules
Wang et al. Tensile properties of extruded zein sheets and extrusion blown films
ATE217150T1 (de) Kontinuierlisches strangpressen von schokoladedenmassen
ES2094055T3 (es) Procedimiento para el secado y cristalizacion simultaneos de material sintetico termoplastico cristalizable.
US4838775A (en) Device for granulating strands of thermoplastic materials
ATE213592T1 (de) Extrusion von schokoladenmasse
Harrington et al. Extrusion-based microencapsulation for the food industry
AU589794B2 (en) Method and apparatus for extrusion, particularly for extruding masses of food products
US2469342A (en) Method and apparatus for molding plastics
US2994105A (en) Screw press and method of treating material
KR19990082101A (ko) 물질의 압축 방법 및 장치
US3103700A (en) Pelletizing apparatus with a tangential flow entry
EP1337217B1 (en) Methods and apparatus for making seamless capsules
US3079635A (en) Screwless extruder with multiple speed rotating disc
W Tackenberg et al. Encapsulation of liquids via extrusion-a review
US6224939B1 (en) Method and apparatus for forming an encapsulated product matrix
KR960703518A (ko) 식료품의 압출성형 및 코팅방법 및 이를 수행하기 위한 장치(process and device for extruding and coating foodsstuffs)
US6171607B1 (en) Process and apparatus for producing shearform matrix material
WO1999061145A1 (en) Method and apparatus for forming an encapsulated product matrix
WO1985005250A1 (en) Die for extruders
KR960003908A (ko) 건자재용 압출물의 압출공정 및 그 장치
IE36800L (en) Indicia-containing soap bars
CA2312917A1 (en) Extrusion device

Legal Events

Date Code Title Description
A201 Request for examination
E701 Decision to grant or registration of patent right
NORF Unpaid initial registration fee