KR940005649A - N-아르알킬-및 n-헤테로아르알킬-아미노알칸포스핀산 - Google Patents

N-아르알킬-및 n-헤테로아르알킬-아미노알칸포스핀산 Download PDF

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Publication number
KR940005649A
KR940005649A KR1019930007811A KR930007811A KR940005649A KR 940005649 A KR940005649 A KR 940005649A KR 1019930007811 A KR1019930007811 A KR 1019930007811A KR 930007811 A KR930007811 A KR 930007811A KR 940005649 A KR940005649 A KR 940005649A
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KR
South Korea
Prior art keywords
hydroxy
amino
alkyl
propyl
phosphinic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
KR1019930007811A
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English (en)
Korean (ko)
Inventor
죤 믹켈 스튜어트
프뢰스틀 볼프강
푸레 파스칼
Original Assignee
베르너 발데그
시바-가이기 에이지
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 베르너 발데그, 시바-가이기 에이지 filed Critical 베르너 발데그
Publication of KR940005649A publication Critical patent/KR940005649A/ko
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07F9/653—Five-membered rings
    • C07F9/65306—Five-membered rings containing two nitrogen atoms
    • C07F9/65318—Five-membered rings containing two nitrogen atoms having the two nitrogen atoms in positions 1 and 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/301—Acyclic saturated acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/58—Pyridine rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having three nitrogen atoms as the only ring hetero atoms
    • C07F9/6518—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6524—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having four or more nitrogen atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07F9/653—Five-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Confectionery (AREA)
  • Meat, Egg Or Seafood Products (AREA)
  • Alcoholic Beverages (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1019930007811A 1992-05-08 1993-05-07 N-아르알킬-및 n-헤테로아르알킬-아미노알칸포스핀산 Withdrawn KR940005649A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH01480/92-0 1992-05-08
CH148092 1992-05-08

Publications (1)

Publication Number Publication Date
KR940005649A true KR940005649A (ko) 1994-03-22

Family

ID=4211459

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019930007811A Withdrawn KR940005649A (ko) 1992-05-08 1993-05-07 N-아르알킬-및 n-헤테로아르알킬-아미노알칸포스핀산

Country Status (18)

Country Link
US (2) US5332729A (enExample)
EP (1) EP0569333B1 (enExample)
JP (1) JP3243056B2 (enExample)
KR (1) KR940005649A (enExample)
AT (1) ATE175415T1 (enExample)
AU (1) AU662404B2 (enExample)
CA (1) CA2095708C (enExample)
DE (1) DE59309265D1 (enExample)
ES (1) ES2128409T3 (enExample)
FI (1) FI932028L (enExample)
GR (1) GR3029899T3 (enExample)
HU (1) HUT64079A (enExample)
IL (1) IL105628A0 (enExample)
NO (1) NO931675L (enExample)
NZ (1) NZ247561A (enExample)
PH (1) PH30222A (enExample)
TW (1) TW224966B (enExample)
ZA (1) ZA933206B (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5457095A (en) * 1984-10-12 1995-10-10 Ciba-Geigy Corporation Substituted propane-phosponous acid compounds
IL114631A (en) * 1990-06-22 1998-12-06 Novartis Ag Anti-epileptic compositions containing gabab- antagonistic compounds
EP0543780A3 (en) * 1991-11-21 1993-09-01 Ciba-Geigy Ag Novel aminoalkanephosphinic acids and their salts
WO1997011953A1 (en) * 1995-09-28 1997-04-03 Novartis Ag Novel hydroxylated and alkoxylated n- and/or p-aralkylphosphinic acid derivatives
CA2254862A1 (en) * 1996-05-30 1997-12-11 Novartis Ag Metabotropic gaba[b] receptors, receptor-specific ligands and their uses
US7119189B2 (en) 1997-03-19 2006-10-10 Novartis Ag Metabotropic GABA [B] receptors, receptor-specific ligands and their uses
GB9906882D0 (en) * 1999-03-25 1999-05-19 Novartis Ag Organic compounds
US7319095B2 (en) * 1999-12-09 2008-01-15 Astrazeneca Ab Use of GABAB receptor agonists
SE9904508D0 (sv) * 1999-12-09 1999-12-09 Astra Ab New compounds
JP4709488B2 (ja) * 2002-01-18 2011-06-22 メルク・シャープ・エンド・ドーム・コーポレイション Ｅｄｇ受容体作動薬としてのＮ−（ベンジル）アミノアルキルカルボン酸化合物、ホスフィン酸化合物、ホスホン酸化合物およびテトラゾール類
AR045794A1 (es) * 2003-09-23 2005-11-16 Aventis Pharma Inc Procedimiento para preparar derivados de acido 3- amino-2- hidroxipropilfosfinico
GB0327186D0 (en) * 2003-11-21 2003-12-24 Novartis Ag Organic compounds
CA2566204A1 (en) * 2004-05-14 2005-12-01 The Johns Hopkins University Method for improving cognitive function by co-administration of a gabab receptor antagonist and an acetylcholinesterase inhibitor
US7566738B2 (en) * 2004-11-03 2009-07-28 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs of sulfinic acids, methods of synthesis, and use
US7494985B2 (en) * 2004-11-03 2009-02-24 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs, methods of synthesis, and use
US7585996B2 (en) * 2006-09-15 2009-09-08 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs, methods of synthesis and use

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3493639A (en) * 1965-10-27 1970-02-03 Shell Oil Co Process for producing pentavalent phosphorus derivatives
JPS4714129Y1 (enExample) * 1969-06-11 1972-05-22
DE2032712C3 (de) * 1970-07-02 1978-10-19 Bayer Ag, 5090 Leverkusen Verfahren zur Herstellung von w-Amino-alkanphosphonsäure bzw.- phosphinsäurederivaten
DE2440239A1 (de) * 1974-08-22 1976-03-04 Hoechst Ag Innere ammoniumsalze von phosphinsaeuren
JPS5463024A (en) * 1977-10-27 1979-05-21 Fujisawa Pharmaceut Co Ltd 3-(n-formyl-n-hydroxyamino)-2(r)-hydroxypropyl-phosphonic acid, its preparation, and its use
EP0093081B1 (de) * 1982-04-23 1986-03-19 Ciba-Geigy Ag Herbizide und pflanzenwuchsregulierende Mittel
US4536355A (en) * 1982-10-08 1985-08-20 Zoecon Corporation Phenoxyphenylaminoalkylphosphinates useful in weed control
GB8425872D0 (en) * 1984-10-12 1984-11-21 Ciba Geigy Ag Chemical compounds
FR2572078B1 (fr) * 1984-10-24 1988-07-15 Inst Francais Du Petrole Phosphobetaines neutres, leur preparation et leur application a la recuperation assistee du petrole
USD302521S (en) 1986-03-13 1989-08-01 Grinde James E Dual compartment container with measurement indicator
US5190933A (en) * 1987-12-04 1993-03-02 Ciba-Geigy Corporation Substituted propane-phosphinic acid compounds
GB8728483D0 (en) * 1987-12-04 1988-01-13 Ciba Geigy Ag Chemical compounds
GB8820266D0 (en) * 1988-08-26 1988-09-28 Smith Kline French Lab Compounds
US5212164A (en) * 1988-08-29 1993-05-18 E. R. Squibb & Sons, Inc. Phosphorus-containing squalene synthetase inhibitors
US5190934A (en) * 1989-06-03 1993-03-02 Ciba-Geigy Corporation P-subsituted propane-phosphinic acid compounds
IL114631A (en) * 1990-06-22 1998-12-06 Novartis Ag Anti-epileptic compositions containing gabab- antagonistic compounds
EP0543780A3 (en) * 1991-11-21 1993-09-01 Ciba-Geigy Ag Novel aminoalkanephosphinic acids and their salts
GB9125615D0 (en) * 1991-12-02 1992-01-29 Wyeth John & Brother Ltd Amines

Also Published As

Publication number Publication date
DE59309265D1 (de) 1999-02-18
EP0569333B1 (de) 1999-01-07
EP0569333A3 (enExample) 1994-04-06
AU662404B2 (en) 1995-08-31
FI932028A7 (fi) 1993-11-09
CA2095708A1 (en) 1993-11-09
PH30222A (en) 1997-02-05
JP3243056B2 (ja) 2002-01-07
ZA933206B (en) 1993-11-08
IL105628A0 (en) 1993-09-22
HU9301332D0 (en) 1993-09-28
GR3029899T3 (en) 1999-07-30
HUT64079A (en) 1993-11-29
ATE175415T1 (de) 1999-01-15
ES2128409T3 (es) 1999-05-16
FI932028A0 (fi) 1993-05-05
CA2095708C (en) 2005-12-06
TW224966B (enExample) 1994-06-11
AU3711293A (en) 1993-11-11
JPH0632793A (ja) 1994-02-08
US5332729A (en) 1994-07-26
US5424441A (en) 1995-06-13
NO931675D0 (no) 1993-05-07
FI932028L (fi) 1993-11-09
EP0569333A2 (de) 1993-11-10
NZ247561A (en) 1995-07-26
NO931675L (no) 1993-11-09

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Legal Events

Date Code Title Description
PA0109 Patent application

Patent event code: PA01091R01D

Comment text: Patent Application

Patent event date: 19930507

N231 Notification of change of applicant
PN2301 Change of applicant

Patent event date: 19970731

Comment text: Notification of Change of Applicant

Patent event code: PN23011R01D

PC1203 Withdrawal of no request for examination
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid