ES2128409T3 - Nuevos acidos n-aralquil- y n-heteroaralquilaminoalcano-fosfinicos. - Google Patents

Nuevos acidos n-aralquil- y n-heteroaralquilaminoalcano-fosfinicos.

Info

Publication number
ES2128409T3
ES2128409T3 ES93810316T ES93810316T ES2128409T3 ES 2128409 T3 ES2128409 T3 ES 2128409T3 ES 93810316 T ES93810316 T ES 93810316T ES 93810316 T ES93810316 T ES 93810316T ES 2128409 T3 ES2128409 T3 ES 2128409T3
Authority
ES
Spain
Prior art keywords
heteroaralquilaminoalcano
fosfinicos
aralquil
acides
new
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93810316T
Other languages
English (en)
Spanish (es)
Inventor
Stuart John Dr Mickel
Wolfgang Dr Frostl
Pascal Dr Furet
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG filed Critical Novartis AG
Application granted granted Critical
Publication of ES2128409T3 publication Critical patent/ES2128409T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07F9/653—Five-membered rings
    • C07F9/65306—Five-membered rings containing two nitrogen atoms
    • C07F9/65318—Five-membered rings containing two nitrogen atoms having the two nitrogen atoms in positions 1 and 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/301—Acyclic saturated acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/58—Pyridine rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having three nitrogen atoms as the only ring hetero atoms
    • C07F9/6518—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6524—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having four or more nitrogen atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07F9/653—Five-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Confectionery (AREA)
  • Meat, Egg Or Seafood Products (AREA)
  • Alcoholic Beverages (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ES93810316T 1992-05-08 1993-04-29 Nuevos acidos n-aralquil- y n-heteroaralquilaminoalcano-fosfinicos. Expired - Lifetime ES2128409T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH148092 1992-05-08

Publications (1)

Publication Number Publication Date
ES2128409T3 true ES2128409T3 (es) 1999-05-16

Family

ID=4211459

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93810316T Expired - Lifetime ES2128409T3 (es) 1992-05-08 1993-04-29 Nuevos acidos n-aralquil- y n-heteroaralquilaminoalcano-fosfinicos.

Country Status (18)

Country Link
US (2) US5332729A (enExample)
EP (1) EP0569333B1 (enExample)
JP (1) JP3243056B2 (enExample)
KR (1) KR940005649A (enExample)
AT (1) ATE175415T1 (enExample)
AU (1) AU662404B2 (enExample)
CA (1) CA2095708C (enExample)
DE (1) DE59309265D1 (enExample)
ES (1) ES2128409T3 (enExample)
FI (1) FI932028L (enExample)
GR (1) GR3029899T3 (enExample)
HU (1) HUT64079A (enExample)
IL (1) IL105628A0 (enExample)
NO (1) NO931675L (enExample)
NZ (1) NZ247561A (enExample)
PH (1) PH30222A (enExample)
TW (1) TW224966B (enExample)
ZA (1) ZA933206B (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5457095A (en) * 1984-10-12 1995-10-10 Ciba-Geigy Corporation Substituted propane-phosponous acid compounds
IL114631A (en) * 1990-06-22 1998-12-06 Novartis Ag Anti-epileptic compositions containing gabab- antagonistic compounds
EP0543780A3 (en) * 1991-11-21 1993-09-01 Ciba-Geigy Ag Novel aminoalkanephosphinic acids and their salts
WO1997011953A1 (en) * 1995-09-28 1997-04-03 Novartis Ag Novel hydroxylated and alkoxylated n- and/or p-aralkylphosphinic acid derivatives
CA2254862A1 (en) * 1996-05-30 1997-12-11 Novartis Ag Metabotropic gaba[b] receptors, receptor-specific ligands and their uses
US7119189B2 (en) 1997-03-19 2006-10-10 Novartis Ag Metabotropic GABA [B] receptors, receptor-specific ligands and their uses
GB9906882D0 (en) * 1999-03-25 1999-05-19 Novartis Ag Organic compounds
US7319095B2 (en) * 1999-12-09 2008-01-15 Astrazeneca Ab Use of GABAB receptor agonists
SE9904508D0 (sv) * 1999-12-09 1999-12-09 Astra Ab New compounds
JP4709488B2 (ja) * 2002-01-18 2011-06-22 メルク・シャープ・エンド・ドーム・コーポレイション Ｅｄｇ受容体作動薬としてのＮ−（ベンジル）アミノアルキルカルボン酸化合物、ホスフィン酸化合物、ホスホン酸化合物およびテトラゾール類
AR045794A1 (es) * 2003-09-23 2005-11-16 Aventis Pharma Inc Procedimiento para preparar derivados de acido 3- amino-2- hidroxipropilfosfinico
GB0327186D0 (en) * 2003-11-21 2003-12-24 Novartis Ag Organic compounds
CA2566204A1 (en) * 2004-05-14 2005-12-01 The Johns Hopkins University Method for improving cognitive function by co-administration of a gabab receptor antagonist and an acetylcholinesterase inhibitor
US7566738B2 (en) * 2004-11-03 2009-07-28 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs of sulfinic acids, methods of synthesis, and use
US7494985B2 (en) * 2004-11-03 2009-02-24 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs, methods of synthesis, and use
US7585996B2 (en) * 2006-09-15 2009-09-08 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs, methods of synthesis and use

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3493639A (en) * 1965-10-27 1970-02-03 Shell Oil Co Process for producing pentavalent phosphorus derivatives
JPS4714129Y1 (enExample) * 1969-06-11 1972-05-22
DE2032712C3 (de) * 1970-07-02 1978-10-19 Bayer Ag, 5090 Leverkusen Verfahren zur Herstellung von w-Amino-alkanphosphonsäure bzw.- phosphinsäurederivaten
DE2440239A1 (de) * 1974-08-22 1976-03-04 Hoechst Ag Innere ammoniumsalze von phosphinsaeuren
JPS5463024A (en) * 1977-10-27 1979-05-21 Fujisawa Pharmaceut Co Ltd 3-(n-formyl-n-hydroxyamino)-2(r)-hydroxypropyl-phosphonic acid, its preparation, and its use
EP0093081B1 (de) * 1982-04-23 1986-03-19 Ciba-Geigy Ag Herbizide und pflanzenwuchsregulierende Mittel
US4536355A (en) * 1982-10-08 1985-08-20 Zoecon Corporation Phenoxyphenylaminoalkylphosphinates useful in weed control
GB8425872D0 (en) * 1984-10-12 1984-11-21 Ciba Geigy Ag Chemical compounds
FR2572078B1 (fr) * 1984-10-24 1988-07-15 Inst Francais Du Petrole Phosphobetaines neutres, leur preparation et leur application a la recuperation assistee du petrole
USD302521S (en) 1986-03-13 1989-08-01 Grinde James E Dual compartment container with measurement indicator
US5190933A (en) * 1987-12-04 1993-03-02 Ciba-Geigy Corporation Substituted propane-phosphinic acid compounds
GB8728483D0 (en) * 1987-12-04 1988-01-13 Ciba Geigy Ag Chemical compounds
GB8820266D0 (en) * 1988-08-26 1988-09-28 Smith Kline French Lab Compounds
US5212164A (en) * 1988-08-29 1993-05-18 E. R. Squibb & Sons, Inc. Phosphorus-containing squalene synthetase inhibitors
US5190934A (en) * 1989-06-03 1993-03-02 Ciba-Geigy Corporation P-subsituted propane-phosphinic acid compounds
IL114631A (en) * 1990-06-22 1998-12-06 Novartis Ag Anti-epileptic compositions containing gabab- antagonistic compounds
EP0543780A3 (en) * 1991-11-21 1993-09-01 Ciba-Geigy Ag Novel aminoalkanephosphinic acids and their salts
GB9125615D0 (en) * 1991-12-02 1992-01-29 Wyeth John & Brother Ltd Amines

Also Published As

Publication number Publication date
DE59309265D1 (de) 1999-02-18
EP0569333B1 (de) 1999-01-07
EP0569333A3 (enExample) 1994-04-06
AU662404B2 (en) 1995-08-31
FI932028A7 (fi) 1993-11-09
CA2095708A1 (en) 1993-11-09
PH30222A (en) 1997-02-05
JP3243056B2 (ja) 2002-01-07
ZA933206B (en) 1993-11-08
IL105628A0 (en) 1993-09-22
HU9301332D0 (en) 1993-09-28
GR3029899T3 (en) 1999-07-30
HUT64079A (en) 1993-11-29
ATE175415T1 (de) 1999-01-15
FI932028A0 (fi) 1993-05-05
CA2095708C (en) 2005-12-06
TW224966B (enExample) 1994-06-11
AU3711293A (en) 1993-11-11
KR940005649A (ko) 1994-03-22
JPH0632793A (ja) 1994-02-08
US5332729A (en) 1994-07-26
US5424441A (en) 1995-06-13
NO931675D0 (no) 1993-05-07
FI932028L (fi) 1993-11-09
EP0569333A2 (de) 1993-11-10
NZ247561A (en) 1995-07-26
NO931675L (no) 1993-11-09

Similar Documents

Publication Publication Date Title
ES2128409T3 (es) Nuevos acidos n-aralquil- y n-heteroaralquilaminoalcano-fosfinicos.
ES2129679T3 (es) Derivados que contienen el grupo amidino, utiles como inhibidores de la sintasa de oxido nitrico.
AR247721A1 (es) Un procedimiento para la preparacion de compuestos de fenetanolamina y sus sales y solvatos farmaceuticamente aceptables
AR020691A1 (es) Derivados del acido 2,4-pentadienoico que tienen actividad selectiva para los receptores (rxr) del retinoide x
DE69522569D1 (de) Metalloproteinase hemmende verbindungen
ES2185338T3 (es) Derivados de fumagilol y procedimientos para su fabricacion.
ES8706165A1 (es) Un procedimiento para la preparacion de derivados de androstendiona 4-sustituida.
ATE184194T1 (de) Immunsuppressive und antiallergische verbindungen; z.b. n-(3-oxohexanoyl)- homoserinlacton
ES2076147T3 (es) Nuevos derivados de amina ciclicos, medicamento que contiene estos compuestos y procedimiento para su preparacion.
KR890003720A (ko) 벤조티아졸 및 그를 유효성분으로 함유하는 항류머티스제
ES2121888T3 (es) Derivados iminicos ciclicos, procedimientos para su preparacion y medicamentos que contienen a estos compuestos.
ES8604545A1 (es) Procedimiento para preparar nuevos derivados de acidos feni-laceticos
ES2177089T3 (es) Fosfolipidos con actividad antimicrobiana en presencia de antimicrobianos.
BR9806266A (pt) "método de preparação de ácidos de amino carboxìlicos"
MX164399B (es) Composiciones generadoras de gas que contienen sales de acido 5-nitrobarbiturico,sales de acido nitroorotico o 5-nitrouracilo
SE8204445D0 (sv) Pyrrolidinderivat
ATE10626T1 (de) N-substituierte omega-(2-oxo-imidazolin-1-yl)alkans[uren, deren salze und ester, verfahren zu deren herstellung und diese aktiven substanzen enthaltende pharmazeutische zubereitungen.
ES2070238T3 (es) Emulsion de lipidos que contiene un analogo de prostaglandina.
JPS57145850A (en) Novel carboxylic acid amide and medicine
DE3575715D1 (de) Adamantanamin-derivate, verfahren zur herstellung und diese enthaltende heilmittel.
ATE13308T1 (de) Neue saeuren des phosphors und deren derivate.
ES543786A0 (es) Procedimiento de preparacion de nuevos derivados a-etilben- zol con un grupo dietilaminoalcoxi sustituido y sus sales deadicion acidas y amonicas cuaternarias
ES2103440T3 (es) Nuevas amidas y sulfonamidas naftalenicas, procedimiento de preparacion y composiciones farmaceuticas que las contienen.
ES8304145A1 (es) "procedimiento para la preparacion de nuevas amidas de acidos carboxilicos".
ES2056808T3 (es) Derivados de antraciclina activos citostaticamente.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 569333

Country of ref document: ES