KR940003564A - 특정 질환의 예방 및 치료용 약제를 제조하기 위한 c1- 불활성제화제의 용도 - Google Patents

특정 질환의 예방 및 치료용 약제를 제조하기 위한 c1- 불활성제화제의 용도 Download PDF

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KR940003564A
KR940003564A KR1019930016325A KR930016325A KR940003564A KR 940003564 A KR940003564 A KR 940003564A KR 1019930016325 A KR1019930016325 A KR 1019930016325A KR 930016325 A KR930016325 A KR 930016325A KR 940003564 A KR940003564 A KR 940003564A
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prevention
treatment
surgery
ooou
capillary leakage
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KR1019930016325A
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KR100290753B1 (ko
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아이셀레 베른트
델보스 울리히
예셀 안드레아스
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스타인, 하아스
베링베르케 아크티엔게젤샤프트
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0029—Parenteral nutrition; Parenteral nutrition compositions as drug carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/829—Blood
    • Y10S530/83—Plasma; serum

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Abstract

본 발명은 심한 화상(burns 또는 Scalds), 다외상, 칙외 순환의 상태에서의 수술, 시토킨, 내인성 조정기, 조정기 하이브리드 및 유전 공학에 의해 제조된 성장 인자를 사용할 경우 모세혈관 누출 증상(전신적 일헐(extravasation)) 및 순환쇼크(고질적 저혈압) 및 치료적 또는 예방적 징후를 나타내는 골수 이식 수술시간의 정맥-폐쇄 질환의 예방 및 치료용 약제를 제조하기 위한 Cl-불활성화제의 용도에 관한 것이다.

Description

특정 질환의 예방 및 치료용 약제를 제초하기 위한 Cl -불활성화제의 용도
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (5)

  1. 심한 화상(burns또는Scalds), 다외상, 체회순환의 상태에서의 수술, 시토킨, 내인성 조정기, 조정기 하이브리드 및 유전 공학에 의해 제조된 성장 인자를 사용할 경우 모세혈관 눅출증상(전신적 일헐(extravasation)및 순환 쇼크(고질적 저혈압) 및 치료적 또는 예방적 징후를 나타내는 골수 이식 수술시 모세혈관 누출 증상 및 간의 정맥-궤쇄 질환의 예방 및 치료용 약제를 제조하기 위한 Cl-불즐성화제의 용도.
  2. 제1항에 있어서, Cl-불존성화제를 1일 체중 1kg당 1내지 5, OOOU, 바람직하게는 5내지 1,070u를 함유하는 조성물을 제조하는 용도.
  3. 제1항에 있어서, Cl-불활성화제를 1일 체중 Ik9당 1내지 300,OOOU, 바람직하게는 50내지 60,000를 함유하는 고체 조성물을 제조하는 용도.
  4. 제1항에 있어서, 정맥내, 근육내 및 피하용 조성물을 바람직하게는 약제학적 보조제와함께 제조하는 용도.
  5. 제4항에 있어서, 경구 또는 직장용 조성물을 제조하는 용도.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019930016325A 1992-08-24 1993-08-23 C1-불활성화제를포함하는약제학적조성물 KR100290753B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP4227762.0 1992-08-24
DE4227762A DE4227762A1 (de) 1992-08-24 1992-08-24 Verwendung eines Kallikrein-Inhibitors zur Herstellung eines Arzneimittels zur Prophylaxe und Therapie bestimmter Krankheiten

Publications (2)

Publication Number Publication Date
KR940003564A true KR940003564A (ko) 1994-03-12
KR100290753B1 KR100290753B1 (ko) 2001-09-17

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KR1019930016325A KR100290753B1 (ko) 1992-08-24 1993-08-23 C1-불활성화제를포함하는약제학적조성물

Country Status (9)

Country Link
US (1) US5939389A (ko)
EP (1) EP0586909A3 (ko)
JP (1) JPH06157343A (ko)
KR (1) KR100290753B1 (ko)
AU (1) AU671287B2 (ko)
CA (1) CA2104636C (ko)
DE (2) DE4227762A1 (ko)
IL (1) IL106776A0 (ko)
NO (1) NO933000L (ko)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
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DE4227762A1 (de) * 1992-08-24 1994-03-03 Behringwerke Ag Verwendung eines Kallikrein-Inhibitors zur Herstellung eines Arzneimittels zur Prophylaxe und Therapie bestimmter Krankheiten
JP2000507204A (ja) * 1995-12-18 2000-06-13 ステイヒテイング・サンキン・ブロードボールジーニング Ｃ１―インヒビターの補体及び血液凝固阻害特性の強化
US20040152635A1 (en) * 1998-06-22 2004-08-05 Albrecht Groner Modified C1 esterase inhibitor for blocking the infectiousness of HIV
DE19827750C1 (de) 1998-06-22 1999-07-29 Centeon Pharma Gmbh Verfahren zum Abtrennen von HIV aus einer Flüssigkeit
AU2006203549B2 (en) * 2000-01-31 2008-10-09 Pharming Intellectual Property B.V. C1 inhibitor produced in the milk of transgenic mammals
DE122011000002I1 (de) * 2000-01-31 2011-05-05 Pharming Intellectual Pty Bv Humaner c1 inhibitor hergestellt in der milch transgener säugetiere
US7067713B2 (en) 2000-01-31 2006-06-27 Pharming Intellectual Property B.V. C1 Inhibitor produced in the milk of transgenic non-human mammals
ES2830499T3 (es) 2003-05-16 2021-06-03 Pharming Intellectual Property B V Inhibidor de C1 con una semivida corta para un tratamiento transitorio
US8703136B2 (en) 2006-10-10 2014-04-22 Regenesance B.V. Complement inhibition for improved nerve regeneration
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CA2858984C (en) 2011-12-22 2021-01-05 Csl Behring Gmbh Use of c1-inhibitor for the treatment of secondary edema of the central nervous system
ES2609070T3 (es) * 2013-02-28 2017-04-18 Csl Behring Gmbh Agente terapéutico para el embolismo de líquido amniótico
KR102403299B1 (ko) 2013-03-08 2022-06-03 체에스엘 베링 게엠베하 원격 허혈-재관류 손상의 치료 및 예방
KR20160026905A (ko) 2013-06-28 2016-03-09 체에스엘 베링 게엠베하 인자 ｘｉｉ 억제제 및 ｃ1-억제제를 이용한 병용 치료요법
US10532087B2 (en) 2015-06-03 2020-01-14 Children's Hospital Medical Center Compositions and methods for treating neonatal biliary atresia
EP3493832A1 (en) 2016-08-05 2019-06-12 CSL Behring GmbH Pharmaceutical formulations of c1 esterase inhibitor
WO2018037046A1 (en) 2016-08-23 2018-03-01 Csl Behring Gmbh Method of preventing acute attacks of hereditary angioedema associated with c1 esterase inhibitor deficiency
US20200276283A1 (en) 2017-09-15 2020-09-03 Cedars-Sinai Medical Center Methods for improving organ function in organ transplant patients
KR20230110563A (ko) 2020-11-20 2023-07-24 체에스엘 베링 게엠베하 항체 매개 거부 반응의 치료 방법

Family Cites Families (7)

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Publication number Priority date Publication date Assignee Title
DE3228502A1 (de) * 1982-07-30 1984-02-02 Behringwerke Ag, 3550 Marburg Verfahren zur herstellung des c1-inaktivators und seine verwendung
US5271931A (en) * 1988-09-14 1993-12-21 The Scripps Research Institute Methods for increasing C1 inhibitor concentrations using interferon-gamma and/or interleukin-6
US5030578A (en) * 1989-07-10 1991-07-09 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Process for the purification of C1-inhibitor
EP0512090B2 (en) * 1990-10-16 2006-11-22 Sonoran Desert Chemicals LLC Treatment of inflammation
WO1992022320A1 (en) * 1991-06-14 1992-12-23 Genentech, Inc. C1 inhibitor variants and treating inflammatory response with c1 inhibitor
DE4227735C2 (de) * 1992-08-21 1995-10-12 Leybold Ag Anordnung zum berührungslosen Messen der Dicke von Schichten
DE4227762A1 (de) * 1992-08-24 1994-03-03 Behringwerke Ag Verwendung eines Kallikrein-Inhibitors zur Herstellung eines Arzneimittels zur Prophylaxe und Therapie bestimmter Krankheiten

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EP0586909A2 (de) 1994-03-16
EP0586909A3 (de) 1995-04-05
AU4477893A (en) 1994-03-03
AU671287B2 (en) 1996-08-22
DE4244735A1 (de) 1994-03-31
NO933000D0 (no) 1993-08-23
JPH06157343A (ja) 1994-06-03
DE4227762A1 (de) 1994-03-03
CA2104636A1 (en) 1994-02-25
CA2104636C (en) 2003-11-11
KR100290753B1 (ko) 2001-09-17
NO933000L (no) 1994-02-25
IL106776A0 (en) 1993-12-08
US5939389A (en) 1999-08-17

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