KR940003564A - 특정 질환의 예방 및 치료용 약제를 제조하기 위한 c1- 불활성제화제의 용도 - Google Patents
특정 질환의 예방 및 치료용 약제를 제조하기 위한 c1- 불활성제화제의 용도 Download PDFInfo
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- KR940003564A KR940003564A KR1019930016325A KR930016325A KR940003564A KR 940003564 A KR940003564 A KR 940003564A KR 1019930016325 A KR1019930016325 A KR 1019930016325A KR 930016325 A KR930016325 A KR 930016325A KR 940003564 A KR940003564 A KR 940003564A
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- Prior art keywords
- prevention
- treatment
- surgery
- ooou
- capillary leakage
- Prior art date
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/57—Protease inhibitors from animals; from humans
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0029—Parenteral nutrition; Parenteral nutrition compositions as drug carriers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/829—Blood
- Y10S530/83—Plasma; serum
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- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Physiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
본 발명은 심한 화상(burns 또는 Scalds), 다외상, 칙외 순환의 상태에서의 수술, 시토킨, 내인성 조정기, 조정기 하이브리드 및 유전 공학에 의해 제조된 성장 인자를 사용할 경우 모세혈관 누출 증상(전신적 일헐(extravasation)) 및 순환쇼크(고질적 저혈압) 및 치료적 또는 예방적 징후를 나타내는 골수 이식 수술시간의 정맥-폐쇄 질환의 예방 및 치료용 약제를 제조하기 위한 Cl-불활성화제의 용도에 관한 것이다.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (5)
- 심한 화상(burns또는Scalds), 다외상, 체회순환의 상태에서의 수술, 시토킨, 내인성 조정기, 조정기 하이브리드 및 유전 공학에 의해 제조된 성장 인자를 사용할 경우 모세혈관 눅출증상(전신적 일헐(extravasation)및 순환 쇼크(고질적 저혈압) 및 치료적 또는 예방적 징후를 나타내는 골수 이식 수술시 모세혈관 누출 증상 및 간의 정맥-궤쇄 질환의 예방 및 치료용 약제를 제조하기 위한 Cl-불즐성화제의 용도.
- 제1항에 있어서, Cl-불존성화제를 1일 체중 1kg당 1내지 5, OOOU, 바람직하게는 5내지 1,070u를 함유하는 조성물을 제조하는 용도.
- 제1항에 있어서, Cl-불활성화제를 1일 체중 Ik9당 1내지 300,OOOU, 바람직하게는 50내지 60,000를 함유하는 고체 조성물을 제조하는 용도.
- 제1항에 있어서, 정맥내, 근육내 및 피하용 조성물을 바람직하게는 약제학적 보조제와함께 제조하는 용도.
- 제4항에 있어서, 경구 또는 직장용 조성물을 제조하는 용도.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4227762A DE4227762A1 (de) | 1992-08-24 | 1992-08-24 | Verwendung eines Kallikrein-Inhibitors zur Herstellung eines Arzneimittels zur Prophylaxe und Therapie bestimmter Krankheiten |
DEP4227762.0 | 1992-08-24 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR940003564A true KR940003564A (ko) | 1994-03-12 |
KR100290753B1 KR100290753B1 (ko) | 2001-09-17 |
Family
ID=6466096
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019930016325A KR100290753B1 (ko) | 1992-08-24 | 1993-08-23 | C1-불활성화제를포함하는약제학적조성물 |
Country Status (9)
Country | Link |
---|---|
US (1) | US5939389A (ko) |
EP (1) | EP0586909A3 (ko) |
JP (1) | JPH06157343A (ko) |
KR (1) | KR100290753B1 (ko) |
AU (1) | AU671287B2 (ko) |
CA (1) | CA2104636C (ko) |
DE (2) | DE4227762A1 (ko) |
IL (1) | IL106776A0 (ko) |
NO (1) | NO933000L (ko) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4227762A1 (de) * | 1992-08-24 | 1994-03-03 | Behringwerke Ag | Verwendung eines Kallikrein-Inhibitors zur Herstellung eines Arzneimittels zur Prophylaxe und Therapie bestimmter Krankheiten |
WO1997022347A1 (en) * | 1995-12-18 | 1997-06-26 | Stichting Sanquin Bloedvoorziening | Potentiation of complement and coagulation inhibitory properties of c1-inhibitor. |
US20040152635A1 (en) * | 1998-06-22 | 2004-08-05 | Albrecht Groner | Modified C1 esterase inhibitor for blocking the infectiousness of HIV |
DE19827750C1 (de) | 1998-06-22 | 1999-07-29 | Centeon Pharma Gmbh | Verfahren zum Abtrennen von HIV aus einer Flüssigkeit |
ATE382635T1 (de) * | 2000-01-31 | 2008-01-15 | Pharming Intellectual Pty Bv | Humaner c1 inhibitor hergestellt in der milch transgener säugetiere |
AU2006203549B2 (en) * | 2000-01-31 | 2008-10-09 | Pharming Intellectual Property B.V. | C1 inhibitor produced in the milk of transgenic mammals |
US7067713B2 (en) | 2000-01-31 | 2006-06-27 | Pharming Intellectual Property B.V. | C1 Inhibitor produced in the milk of transgenic non-human mammals |
ES2830499T3 (es) | 2003-05-16 | 2021-06-03 | Pharming Intellectual Property B V | Inhibidor de C1 con una semivida corta para un tratamiento transitorio |
EP3028716B1 (en) | 2006-10-10 | 2020-09-16 | Regenesance B.V. | Complement inhibition for improved nerve regeneration |
ES2714999T3 (es) | 2011-09-24 | 2019-05-31 | Csl Behring Gmbh | Terapia de combinación que usa inmunoglobulina e inhibidor de C1 |
JP6127063B2 (ja) | 2011-12-22 | 2017-05-10 | ツェー・エス・エル・ベーリング・ゲー・エム・ベー・ハー | 中枢神経系の続発性浮腫の治療のためのc1インヒビターの使用 |
JP6289511B2 (ja) * | 2013-02-28 | 2018-03-07 | ツェー・エス・エル・ベーリング・ゲー・エム・ベー・ハー | 羊水塞栓の治療剤 |
EP2964255B1 (en) | 2013-03-08 | 2020-11-04 | CSL Behring GmbH | Treatment and prevention of remote ischemia-reperfusion injury |
CN105339010A (zh) | 2013-06-28 | 2016-02-17 | 德国杰特贝林生物制品有限公司 | 使用因子xii抑制剂和c1-抑制剂的联合疗法 |
CA2986957A1 (en) | 2015-06-03 | 2016-12-08 | Children's Hospital Medical Center | Compositions and methods for treating neonatal biliary atresia |
AU2017305856A1 (en) | 2016-08-05 | 2019-03-21 | Csl Behring Gmbh | Pharmaceutical formulations of C1 esterase inhibitor |
JP2019534240A (ja) | 2016-08-23 | 2019-11-28 | ツェー・エス・エル・ベーリング・ゲー・エム・ベー・ハー | C1エステラーゼ阻害剤欠乏に関連する遺伝性血管浮腫の急性発作を予防する方法 |
CA3075686A1 (en) | 2017-09-15 | 2019-03-21 | Cedars-Sinai Medical Center | Methods for improving organ function in organ transplant patients |
EP4247416A1 (en) | 2020-11-20 | 2023-09-27 | CSL Behring GmbH | Method for treating antibody-mediated rejection |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3228502A1 (de) * | 1982-07-30 | 1984-02-02 | Behringwerke Ag, 3550 Marburg | Verfahren zur herstellung des c1-inaktivators und seine verwendung |
US5271931A (en) * | 1988-09-14 | 1993-12-21 | The Scripps Research Institute | Methods for increasing C1 inhibitor concentrations using interferon-gamma and/or interleukin-6 |
US5030578A (en) * | 1989-07-10 | 1991-07-09 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Process for the purification of C1-inhibitor |
ES2096665T3 (es) * | 1990-10-16 | 1997-03-16 | John Lezdey | Tratamiento de la inflamacion. |
WO1992022320A1 (en) * | 1991-06-14 | 1992-12-23 | Genentech, Inc. | C1 inhibitor variants and treating inflammatory response with c1 inhibitor |
DE4227735C2 (de) * | 1992-08-21 | 1995-10-12 | Leybold Ag | Anordnung zum berührungslosen Messen der Dicke von Schichten |
DE4227762A1 (de) * | 1992-08-24 | 1994-03-03 | Behringwerke Ag | Verwendung eines Kallikrein-Inhibitors zur Herstellung eines Arzneimittels zur Prophylaxe und Therapie bestimmter Krankheiten |
-
1992
- 1992-08-24 DE DE4227762A patent/DE4227762A1/de not_active Withdrawn
- 1992-08-24 DE DE4244735A patent/DE4244735A1/de not_active Withdrawn
-
1993
- 1993-08-11 EP EP93112844A patent/EP0586909A3/de not_active Ceased
- 1993-08-23 KR KR1019930016325A patent/KR100290753B1/ko not_active IP Right Cessation
- 1993-08-23 AU AU44778/93A patent/AU671287B2/en not_active Ceased
- 1993-08-23 NO NO933000A patent/NO933000L/no not_active Application Discontinuation
- 1993-08-23 JP JP5207334A patent/JPH06157343A/ja active Pending
- 1993-08-23 IL IL106776A patent/IL106776A0/xx unknown
- 1993-08-23 CA CA002104636A patent/CA2104636C/en not_active Expired - Lifetime
-
1997
- 1997-05-12 US US08/854,365 patent/US5939389A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
KR100290753B1 (ko) | 2001-09-17 |
EP0586909A2 (de) | 1994-03-16 |
AU671287B2 (en) | 1996-08-22 |
DE4227762A1 (de) | 1994-03-03 |
CA2104636C (en) | 2003-11-11 |
US5939389A (en) | 1999-08-17 |
IL106776A0 (en) | 1993-12-08 |
EP0586909A3 (de) | 1995-04-05 |
NO933000D0 (no) | 1993-08-23 |
JPH06157343A (ja) | 1994-06-03 |
AU4477893A (en) | 1994-03-03 |
NO933000L (no) | 1994-02-25 |
CA2104636A1 (en) | 1994-02-25 |
DE4244735A1 (de) | 1994-03-31 |
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