KR940002254A - 피리돈이소옥사졸 세펨화합물 및 이의 제조방법 - Google Patents

피리돈이소옥사졸 세펨화합물 및 이의 제조방법 Download PDF

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Publication number
KR940002254A
KR940002254A KR1019920012641A KR920012641A KR940002254A KR 940002254 A KR940002254 A KR 940002254A KR 1019920012641 A KR1019920012641 A KR 1019920012641A KR 920012641 A KR920012641 A KR 920012641A KR 940002254 A KR940002254 A KR 940002254A
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KR
South Korea
Prior art keywords
compound
formula
same
isoxoxazole
pyridone
Prior art date
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KR1019920012641A
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English (en)
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KR950008318B1 (ko
Inventor
장문호
강한영
고훈영
차주환
심상철
Original Assignee
서정욱
한국과학기술연구원
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Publication date
Application filed by 서정욱, 한국과학기술연구원 filed Critical 서정욱
Priority to KR1019920012641A priority Critical patent/KR950008318B1/ko
Priority to JP5175253A priority patent/JP2549494B2/ja
Publication of KR940002254A publication Critical patent/KR940002254A/ko
Application granted granted Critical
Publication of KR950008318B1 publication Critical patent/KR950008318B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

본 발명은 일반(I)의 광범위한 항균력을 지닌 세파로스포린 화합물 및 그의 약제학적으로 허용되는 염 및 그 제조방법에 관한 것이다.
본 발명에서 합성된 화합물들은 그람양성균이나, 그람음성균에서 뛰어난 항균력을 나타내므로 세파로스포린 화합물 계열 의약품에 유용하게 사용할 수 있다.

Description

피리돈이소옥사졸 세펨화합물 및 이의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (3)

  1. 다음 일반식(I)으로 표시되는 세파로스포린 화합물 및 약제학적으로 허용되는 그의 염.
    상기 일반식(I)에 있어서, R1은 H, 또는 트리틸, 3급 부톡시 카르보닐, 포르밀기이고, R2는 수소, 파라-메톡시벤질, 디페닐메틸이거나 Na나 K와 같은 염을 만드는 원자이고, R3,R4는 같거나 서로 다르며,1H 또는 파라-메톡시벤질, 디페닐메틸기이고, Q는 수소, 클로로, 비닐, 아세톡시메틸, 할로메틸, N-에틸피리디니움일티오메틸, N-카르복시메틸피리디니움일티오메틸, N-메틸-테트라졸릴티오메틸이다.
  2. 일반식(II)의 화합물과 일반식(III)의 화합물을 아실화 반응시키는 것이 특징인 제1항의 일반식(I)의 화합물의 제조방법.
    상기식에서, R1,R2,R3,R4및 Q는 각각 제1항에서 정의한 것과 동일하다.
  3. 일반식(VII)의 화합물과 일반식(VIII)의 화합물을 반응시키는 것이 특징인 일반식(II)의 화합물의 제조방법.
    상기식에서, R1,R2,R3,R4및 Q는 각각 제1항에서 정의한 것과 동일하다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019920012641A 1992-07-15 1992-07-15 피리돈이소옥사졸 세펨화합물 및 이의 제조방법 KR950008318B1 (ko)

Priority Applications (2)

Application Number Priority Date Filing Date Title
KR1019920012641A KR950008318B1 (ko) 1992-07-15 1992-07-15 피리돈이소옥사졸 세펨화합물 및 이의 제조방법
JP5175253A JP2549494B2 (ja) 1992-07-15 1993-07-15 ピリドンイソオキサゾールセフェム化合物及びその製造方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019920012641A KR950008318B1 (ko) 1992-07-15 1992-07-15 피리돈이소옥사졸 세펨화합물 및 이의 제조방법

Publications (2)

Publication Number Publication Date
KR940002254A true KR940002254A (ko) 1994-02-17
KR950008318B1 KR950008318B1 (ko) 1995-07-27

Family

ID=19336399

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019920012641A KR950008318B1 (ko) 1992-07-15 1992-07-15 피리돈이소옥사졸 세펨화합물 및 이의 제조방법

Country Status (2)

Country Link
JP (1) JP2549494B2 (ko)
KR (1) KR950008318B1 (ko)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100462005B1 (ko) * 2002-08-29 2004-12-17 박형갑 마늘 파종판

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20080050029A (ko) * 2006-12-01 2008-06-05 기아자동차주식회사 컨넥팅 로드의 소단부 가공구조
WO2015099107A1 (ja) 2013-12-26 2015-07-02 塩野義製薬株式会社 含窒素６員環誘導体およびそれらを含有する医薬組成物

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100462005B1 (ko) * 2002-08-29 2004-12-17 박형갑 마늘 파종판

Also Published As

Publication number Publication date
JP2549494B2 (ja) 1996-10-30
KR950008318B1 (ko) 1995-07-27
JPH06179683A (ja) 1994-06-28

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