KR930021143A - 안정한 포르피머 나트륨 조성물 및 그의 제조방법 - Google Patents
안정한 포르피머 나트륨 조성물 및 그의 제조방법 Download PDFInfo
- Publication number
- KR930021143A KR930021143A KR1019930007074A KR930007074A KR930021143A KR 930021143 A KR930021143 A KR 930021143A KR 1019930007074 A KR1019930007074 A KR 1019930007074A KR 930007074 A KR930007074 A KR 930007074A KR 930021143 A KR930021143 A KR 930021143A
- Authority
- KR
- South Korea
- Prior art keywords
- composition
- porphyrin
- less
- sodium hydroxide
- sodium
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
- A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Abstract
암 또는 다른 조건의 광역학적 치료에 유용한 저장안정성 포르피머 나트륨(폴리 헤마토포르피린 에테르/에스테르)조성물이 제공되어 있다. 조성물은 에스테르 결합 포르피린 올리고머의 백분율이 조성물의 10%이하인 것을 특징으로 한다.
그러한 조성물의 개선된 제조방법이 또한 제공되어 있으며, 거기에서 아세틸화 해마토 포르피린은 에스테르결합에 의해 연결된 포르피린 올리고머의 양을 조성물의 10%이하로 감소시키는 온도에서 충분한 시간동안 알칼리로 처리된다.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
내용없음
Claims (8)
- 에테르 및 에스테르 공유 결합을 지는 포르피린 올리고머와 약학적으로 허용된 담체로 이루어진 포르피머 나트륨 약한 조성물에 있어서, 포르피머 올리고머10%이하가 에스테르 결합에 의해 연결되어 있는 것을 특징으로 하는 조성물.
- 형광을 띠고 감광작용을 하며 정상조직에 비해 종양조직에 집중되어 존재하고 포르피린 올리고머의 혼합물, 및 그의 약학적으로 허용된 염으로 이루어진 생물학적 활성 조성물에 있어서, 상기 올리고머는 에테르 및 에스테르결합에 의해 공유결합된 2~8개의 포르피린 분자로 이루어지고, 적어도 1개의 포르피린 분자는 식;을 지니며, 상기식에서 R은 히드록시에틸 또는 비닐이고 나타낸 결합은 상기 공유결합을 형성하고, 상기 조성물중 에스테르 결합의 백분율은 조성물10%이하인 것을 특징으로 하는 조성물.
- 에테르 및 에스테르 결합을 지니는 포르피린 올리고머로 이루어진 포리피머 나트륨 약학 조성물의 제조방법에 있어서, 에스테르 결합에 의해 연결된 포리피린 올리고머의 양을 조성물의 10%이하로 감소시키기에 충분한 온도에서 아세틸화 헤마토포르피린을 충분한 시간동안 알칼리로 처리하는것을 포함하는 것을 특징으로 하는방법.
- 제3항에 있어서, 알칼리는 수산화 나트륨인 것을 특징으로 하는 방법.
- 아세틸화 헤마토포르피린과 수산화 나트륨의 반응을 이용한 포르피머 나트륨 조성물의 제조방법에 있어서, 아세틸화 헤마토포르피린을 적어도 1시간동안 0. 1N 수산화 나트륨과 접촉시키는것, 용액을 4℃에서 14내지 21시간동안 저장하는것, 및 투석여과로 정제하는 것이 개선점인 것을 특징으로 하는 방법.
- 아세틸화 헤마토포르피린과 수산화 나트륨의 반응을 이용한 포르피머 나트륨 조성물의 제조방법에 있어서, 아세틸화 헤마토포르피린을 적어도 0.1N 수산화 나트륨과 45℃이하의 온도에서 16내지 24시간동안 접촉시키는것, 및 45℃이하의 온도에서 투석여과를 통해 정제하는 것이 개선점인 것을 특징으로 하는 방법.
- 아세틸화 헤마토포르피린과 수산화 나트륨의 반응을 이용한 포르피머 나트륨 조성물의 제조방법에 있어서, 아세틸화 헤마토포르피린을 0.1N 수산화 나트륨과 적어도 1시간동안 접촉시키는 것, 농도를 적어도 0.2N 내지 1N미만으로 2내지 24시간동안 증가시키는것. 및 실온에서 투석여과로 정제하는 것이 개선점인 것을 특징으로 하는 방법.
- 제3항, 제4항, 제5항, 제6항 또는 제7항의 방법으로 제도된 약학 조성물.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/873,860 US5244914A (en) | 1992-04-27 | 1992-04-27 | Stable porfimer sodium compositions and methods for their manufacture |
US7/873,860 | 1992-04-27 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR930021143A true KR930021143A (ko) | 1993-11-22 |
KR100221206B1 KR100221206B1 (ko) | 1999-10-01 |
Family
ID=25362473
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019930007074A KR100221206B1 (ko) | 1992-04-27 | 1993-04-27 | 안정한 포르피머 나트륨 조성물 및 그의 제조방법 |
Country Status (10)
Country | Link |
---|---|
US (2) | US5244914A (ko) |
EP (1) | EP0568323B1 (ko) |
JP (1) | JP2928047B2 (ko) |
KR (1) | KR100221206B1 (ko) |
AT (1) | ATE150968T1 (ko) |
CA (1) | CA2094974C (ko) |
DE (1) | DE69309340T2 (ko) |
DK (1) | DK0568323T3 (ko) |
ES (1) | ES2104056T3 (ko) |
GR (1) | GR3023978T3 (ko) |
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-
1992
- 1992-04-27 US US07/873,860 patent/US5244914A/en not_active Expired - Lifetime
-
1993
- 1993-04-27 DK DK93303290.6T patent/DK0568323T3/da active
- 1993-04-27 DE DE69309340T patent/DE69309340T2/de not_active Expired - Lifetime
- 1993-04-27 EP EP93303290A patent/EP0568323B1/en not_active Expired - Lifetime
- 1993-04-27 AT AT93303290T patent/ATE150968T1/de active
- 1993-04-27 CA CA002094974A patent/CA2094974C/en not_active Expired - Lifetime
- 1993-04-27 KR KR1019930007074A patent/KR100221206B1/ko not_active IP Right Cessation
- 1993-04-27 JP JP5101601A patent/JP2928047B2/ja not_active Expired - Lifetime
- 1993-04-27 ES ES93303290T patent/ES2104056T3/es not_active Expired - Lifetime
- 1993-06-10 US US08/075,227 patent/US5438071A/en not_active Expired - Lifetime
-
1997
- 1997-07-02 GR GR970401631T patent/GR3023978T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
DE69309340T2 (de) | 1997-07-17 |
DE69309340D1 (de) | 1997-05-07 |
DK0568323T3 (da) | 1997-07-07 |
EP0568323B1 (en) | 1997-04-02 |
CA2094974A1 (en) | 1993-10-28 |
JPH06220062A (ja) | 1994-08-09 |
EP0568323A1 (en) | 1993-11-03 |
ES2104056T3 (es) | 1997-10-01 |
US5438071A (en) | 1995-08-01 |
JP2928047B2 (ja) | 1999-07-28 |
KR100221206B1 (ko) | 1999-10-01 |
GR3023978T3 (en) | 1997-10-31 |
US5244914A (en) | 1993-09-14 |
CA2094974C (en) | 1996-10-22 |
ATE150968T1 (de) | 1997-04-15 |
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