KR930004269A - 헥사하이드로벤조[에프] 퀴놀리논 - Google Patents
헥사하이드로벤조[에프] 퀴놀리논 Download PDFInfo
- Publication number
- KR930004269A KR930004269A KR1019920014993A KR920014993A KR930004269A KR 930004269 A KR930004269 A KR 930004269A KR 1019920014993 A KR1019920014993 A KR 1019920014993A KR 920014993 A KR920014993 A KR 920014993A KR 930004269 A KR930004269 A KR 930004269A
- Authority
- KR
- South Korea
- Prior art keywords
- alkyl
- hydrogen
- methyl
- pharmaceutically acceptable
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- OWLQOJATYCZTSV-UHFFFAOYSA-N 3,4,4a,5,6,10b-hexahydro-2h-benzo[f]quinolin-1-one Chemical compound C1=CC=C2C3C(=O)CCNC3CCC2=C1 OWLQOJATYCZTSV-UHFFFAOYSA-N 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 12
- 239000001257 hydrogen Substances 0.000 claims 12
- 150000001875 compounds Chemical class 0.000 claims 8
- 150000002431 hydrogen Chemical group 0.000 claims 8
- 125000003368 amide group Chemical group 0.000 claims 6
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 5
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims 4
- 201000004384 Alopecia Diseases 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 4
- 229910052736 halogen Inorganic materials 0.000 claims 4
- 150000002367 halogens Chemical group 0.000 claims 4
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 4
- IHNINSVQYKIZIC-UHFFFAOYSA-N 2h-quinolin-3-one Chemical compound C1=CC=CC2=CC(=O)CN=C21 IHNINSVQYKIZIC-UHFFFAOYSA-N 0.000 claims 3
- 239000003085 diluting agent Substances 0.000 claims 3
- 239000003937 drug carrier Substances 0.000 claims 3
- 239000000546 pharmaceutical excipient Substances 0.000 claims 3
- 125000004760 (C1-C4) alkylsulfonylamino group Chemical group 0.000 claims 2
- 125000004738 (C1-C6) alkyl sulfinyl group Chemical group 0.000 claims 2
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims 2
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 claims 2
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 claims 2
- 206010020112 Hirsutism Diseases 0.000 claims 2
- 229910004013 NO 2 Inorganic materials 0.000 claims 2
- YNPNZTXNASCQKK-UHFFFAOYSA-N Phenanthrene Natural products C1=CC=C2C3=CC=CC=C3C=CC2=C1 YNPNZTXNASCQKK-UHFFFAOYSA-N 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 2
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims 2
- 206010068168 androgenetic alopecia Diseases 0.000 claims 2
- 201000002996 androgenic alopecia Diseases 0.000 claims 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 230000003676 hair loss Effects 0.000 claims 2
- 125000001475 halogen functional group Chemical group 0.000 claims 2
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 2
- PXQLVRUNWNTZOS-UHFFFAOYSA-N sulfanyl Chemical class [SH] PXQLVRUNWNTZOS-UHFFFAOYSA-N 0.000 claims 2
- 229940113178 5 Alpha reductase inhibitor Drugs 0.000 claims 1
- 239000002677 5-alpha reductase inhibitor Substances 0.000 claims 1
- 241000538562 Banjos Species 0.000 claims 1
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 claims 1
- -1 C 1 -C 4 alkyl Chemical group 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000004403 Prostatic Hyperplasia Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 206010039793 Seborrhoeic dermatitis Diseases 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 208000008742 seborrheic dermatitis Diseases 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/04—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
- C07D215/06—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms having only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/10—Aza-phenanthrenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Photoreceptors In Electrophotography (AREA)
- Fats And Perfumes (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74813491A | 1991-08-21 | 1991-08-21 | |
| US748,134 | 1991-08-21 | ||
| US07/780,166 US5250539A (en) | 1991-08-21 | 1991-10-21 | Hexahydrobenzo[f]quinolinones |
| US780,166 | 1991-10-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR930004269A true KR930004269A (ko) | 1993-03-22 |
Family
ID=27114886
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019920014993A Withdrawn KR930004269A (ko) | 1991-08-21 | 1992-08-20 | 헥사하이드로벤조[에프] 퀴놀리논 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US5250539A (https=) |
| EP (1) | EP0531026B1 (https=) |
| JP (1) | JPH05213889A (https=) |
| KR (1) | KR930004269A (https=) |
| CN (1) | CN1069488A (https=) |
| AT (1) | ATE173467T1 (https=) |
| AU (1) | AU2118292A (https=) |
| BR (1) | BR9203266A (https=) |
| CA (1) | CA2076509A1 (https=) |
| CZ (1) | CZ256792A3 (https=) |
| DE (1) | DE69227612T2 (https=) |
| FI (1) | FI923751L (https=) |
| HU (1) | HUT68064A (https=) |
| IL (1) | IL102880A0 (https=) |
| MX (1) | MX9204815A (https=) |
| NO (1) | NO923266L (https=) |
| TW (1) | TW218011B (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5239075A (en) * | 1991-08-21 | 1993-08-24 | Eli Lilly And Company | Process for the preparation of benzo (f) quinolinones |
| AU654573B2 (en) * | 1991-08-21 | 1994-11-10 | Eli Lilly And Company | Benzo(f)quinolinones |
| GB9317314D0 (en) * | 1993-08-20 | 1993-10-06 | Smithkline Beecham Corp | Compounds |
| US5578724A (en) * | 1994-09-20 | 1996-11-26 | Eli Lilly And Company | Process for preparation of benzo[f]quinolinones |
| FR2737721B1 (fr) | 1995-08-08 | 1997-09-05 | Roussel Uclaf | Nouveaux composes biphenyles, leur procede de preparation et les intermediaires de ce procede, leur application a titre de medicament et les compositions pharmaceutiques les contenant |
| EP0926148A1 (en) * | 1997-12-23 | 1999-06-30 | Applied Research Systems Ars Holding N.V. | Benzo (C)quinolizine derivatives, their preparation and use as 5-alphareductases inhibitors |
| GB0222516D0 (en) * | 2002-09-27 | 2002-11-06 | Karobio Ab | Novel compounds |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0102046A1 (en) * | 1982-08-26 | 1984-03-07 | Schering Corporation | Tricyclic lactams, method for making them, pharmaceutical compositions containing them |
| US4511569A (en) * | 1982-08-26 | 1985-04-16 | Schering Corporation | Tricyclic lactams and derivatives useful in increasing cardiac contractility |
| US4859681A (en) * | 1984-02-27 | 1989-08-22 | Merck & Co., Inc. | 17 α-Acyl-4-aza-5a-androst-1-en-3-ones as 5 alpha-reductase inhibitors |
| US5120742A (en) * | 1984-02-27 | 1992-06-09 | Merck & Co., Inc. | 17 β-acyl-4-aza-5 α-androst-1-ene-3-ones as 5 α-reductase inhibitors |
| MW187A1 (en) * | 1986-01-23 | 1987-10-14 | Hoffmann La Roche | Benzazecine derivatives |
| US4888336A (en) * | 1987-01-28 | 1989-12-19 | Smithkline Beckman Corporation | Steroid 5-alpha-reductase inhibitors |
| US4980372A (en) * | 1987-05-11 | 1990-12-25 | Ono Pharmaceutical Co., Ltd. | Benzoylaminophenoxybutanoic acid derivatives |
| IN167395B (https=) * | 1987-07-21 | 1990-10-20 | Hoffmann La Roche | |
| US5120840A (en) * | 1990-08-01 | 1992-06-09 | Merrell Dow Pharmaceuticals Inc. | 4-amino-4-ene-steroids and their use as 5α-reductase inhibitors |
-
1991
- 1991-10-21 US US07/780,166 patent/US5250539A/en not_active Expired - Fee Related
-
1992
- 1992-08-19 HU HU9202710A patent/HUT68064A/hu unknown
- 1992-08-20 JP JP4221358A patent/JPH05213889A/ja active Pending
- 1992-08-20 CA CA002076509A patent/CA2076509A1/en not_active Abandoned
- 1992-08-20 AU AU21182/92A patent/AU2118292A/en not_active Abandoned
- 1992-08-20 IL IL102880A patent/IL102880A0/xx unknown
- 1992-08-20 NO NO92923266A patent/NO923266L/no unknown
- 1992-08-20 CN CN92109570A patent/CN1069488A/zh active Pending
- 1992-08-20 MX MX9204815A patent/MX9204815A/es unknown
- 1992-08-20 AT AT92307636T patent/ATE173467T1/de not_active IP Right Cessation
- 1992-08-20 FI FI923751A patent/FI923751L/fi not_active Application Discontinuation
- 1992-08-20 KR KR1019920014993A patent/KR930004269A/ko not_active Withdrawn
- 1992-08-20 EP EP92307636A patent/EP0531026B1/en not_active Expired - Lifetime
- 1992-08-20 CZ CS922567A patent/CZ256792A3/cs unknown
- 1992-08-20 DE DE69227612T patent/DE69227612T2/de not_active Expired - Fee Related
- 1992-08-21 BR BR929203266A patent/BR9203266A/pt not_active Application Discontinuation
- 1992-09-25 TW TW081107628A patent/TW218011B/zh active
Also Published As
| Publication number | Publication date |
|---|---|
| NO923266L (no) | 1993-02-22 |
| JPH05213889A (ja) | 1993-08-24 |
| EP0531026B1 (en) | 1998-11-18 |
| CZ256792A3 (en) | 1993-04-14 |
| HUT68064A (en) | 1995-05-29 |
| DE69227612T2 (de) | 1999-05-06 |
| ATE173467T1 (de) | 1998-12-15 |
| NO923266D0 (no) | 1992-08-20 |
| BR9203266A (pt) | 1993-04-06 |
| AU2118292A (en) | 1993-02-25 |
| DE69227612D1 (de) | 1998-12-24 |
| FI923751A0 (fi) | 1992-08-20 |
| FI923751A7 (fi) | 1993-02-22 |
| IL102880A0 (en) | 1993-01-31 |
| US5250539A (en) | 1993-10-05 |
| FI923751L (fi) | 1993-02-22 |
| CN1069488A (zh) | 1993-03-03 |
| TW218011B (https=) | 1993-12-21 |
| EP0531026A1 (en) | 1993-03-10 |
| CA2076509A1 (en) | 1993-02-22 |
| MX9204815A (es) | 1993-12-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0109 | Patent application |
Patent event code: PA01091R01D Comment text: Patent Application Patent event date: 19920820 |
|
| PG1501 | Laying open of application | ||
| PC1203 | Withdrawal of no request for examination | ||
| WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |