DE69519728D1 - 17 beta-aryl-4-aza-steroidderivate - Google Patents

17 beta-aryl-4-aza-steroidderivate

Info

Publication number
DE69519728D1
DE69519728D1 DE69519728T DE69519728T DE69519728D1 DE 69519728 D1 DE69519728 D1 DE 69519728D1 DE 69519728 T DE69519728 T DE 69519728T DE 69519728 T DE69519728 T DE 69519728T DE 69519728 D1 DE69519728 D1 DE 69519728D1
Authority
DE
Germany
Prior art keywords
steroid derivatives
aza steroid
beta
aryl
beta aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69519728T
Other languages
English (en)
Inventor
Alan D Adams
Gary H Rasmusson
Nathan G Steinberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of DE69519728D1 publication Critical patent/DE69519728D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
DE69519728T 1994-04-20 1995-04-17 17 beta-aryl-4-aza-steroidderivate Expired - Lifetime DE69519728D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/230,277 US5525608A (en) 1994-04-20 1994-04-20 17b-aryl-4-aza-steroid derivatives useful as 5-alpha-reductase inhibitors
PCT/US1995/004743 WO1995028928A1 (en) 1994-04-20 1995-04-17 17β-ARYL-4-AZA-STEROID DERIVATIVES

Publications (1)

Publication Number Publication Date
DE69519728D1 true DE69519728D1 (de) 2001-02-01

Family

ID=22864586

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69519728T Expired - Lifetime DE69519728D1 (de) 1994-04-20 1995-04-17 17 beta-aryl-4-aza-steroidderivate

Country Status (8)

Country Link
US (1) US5525608A (de)
EP (1) EP0756481B1 (de)
JP (1) JPH09512535A (de)
AT (1) ATE198274T1 (de)
AU (1) AU684634B2 (de)
CA (1) CA2188034A1 (de)
DE (1) DE69519728D1 (de)
WO (1) WO1995028928A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5547957A (en) * 1993-10-15 1996-08-20 Merck & Co., Inc. Method of treating androgenic alopecia with 5-α reductase inhibitors
TW382595B (en) * 1993-10-15 2000-02-21 Merck & Co Inc Pharmaceutical composition for use in arresting and reversing androgenic alopecia
CA2173863C (en) * 1993-10-21 2003-05-13 Philippe L. Durette 16-substituted-4-aza-androstane 5-alpha-reductase isozyme 1 inhibitors
US5470976A (en) * 1994-09-07 1995-11-28 Merck & Co., Inc. Process for the stereoselective reduction of steroid enelactams
US5872126A (en) * 1996-09-06 1999-02-16 Merck & Co., Inc. Methods and compositions for treating preterm labor
US5935968A (en) * 1997-03-17 1999-08-10 Merck & Co., Inc. Methods for treating polycystic ovary syndrome
CA2283098A1 (en) * 1997-03-17 1998-09-24 Merck & Co., Inc. Methods and compositions for treating polycystic ovary syndrome
AU2004272004B2 (en) * 2003-09-10 2009-01-22 Merck Sharp & Dohme Corp. 17-heterocyclic-4-azasteroid derivatives as androgen receptor modulators
EP1663228A4 (de) * 2003-09-10 2010-10-06 Merck Sharp & Dohme 17-heterocyclische 4-azasteroid-derivate als androgen-rezeptormodulatoren
CN1871005B (zh) * 2003-10-31 2010-10-27 默沙东公司 雄激素受体调节剂21-杂环-4-氮杂甾体衍生物
AU2009320250A1 (en) * 2008-10-28 2010-06-03 Biomarin Pharmaceutical Inc. Decahydro-1H-indenoquinolinone and decahydro-3H-cyclopentaphenanthridinone CYP17 inhibitors
WO2023070071A2 (en) * 2021-10-21 2023-04-27 The Board Of Trustees Of The University Of Illinois Small molecule activators of the immune system

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4377584A (en) * 1978-04-13 1983-03-22 Merck & Co., Inc. 4-Aza-17β-substituted-5α-androstan-3-one-reductase inhibitors
US5049562A (en) * 1984-02-27 1991-09-17 Merck & Co., Inc. 17β-acyl-4-aza-5α-androst-1-ene-3-ones as 5α-reductase inhibitors
US4760071A (en) * 1984-02-27 1988-07-26 Merck & Co., Inc. 17β-N-monosubstituted carbamoyl-4-aza-5α-androst-1-en-3-ones which are active as testosterone 5α-reductase inhibitors
US4882319A (en) * 1988-12-23 1989-11-21 Smithkline Beckman Corporation Phosphonic acid substituted aromatic steroids as inhibitors of steroid 5-α-reductase
US5162332A (en) * 1990-06-20 1992-11-10 Merck & Co., Inc. Selected 17 β-polyaroyl-4-aza-5 α-androst-1-en-3-ones as steroidal reductase inhibitors
US5151430A (en) * 1990-06-20 1992-09-29 Merck & Co., Inc. Specific 17β-thiobenzoyl-4-aza-5α-androst-1-en-3-ones as antiandrogen agents
US5098908A (en) * 1990-06-20 1992-03-24 Merck & Co., Inc. 17β-hydroxybenzoyl-4-aza-5α-androst-1-en-3-ones as testosterone reductase inhibitors
US5061802A (en) * 1990-06-20 1991-10-29 Merck & Co. Inc. 17β-aminobenzoyl-4-aza-5α-androst-1-en-3-ones as benign prostatic hypertrophy agents
IL101245A0 (en) * 1991-03-20 1992-11-15 Merck & Co Inc Pharmaceutical compositions for the treatment of prostatic cancer
IL101243A (en) * 1991-03-20 1999-12-22 Merck & Co Inc Pharmaceutical preparations for the treatment of benign prostatic hyperplasia containing steroid history
US5175155A (en) * 1991-10-07 1992-12-29 Sterling Winthrop Inc. Win 49596-finasteride method of use and compositions
US5710275A (en) * 1992-05-20 1998-01-20 Merck & Co., Inc. 7β-substituted-4-aza-5α-androstan-3-ones as 5α-reductase inhibitors
AU4251993A (en) * 1992-05-20 1993-12-13 Merck & Co., Inc. Substituted 4-aza-5A-androstan-ones as 5A-reductase inhibitors
US5359071A (en) * 1993-03-12 1994-10-25 Merck & Co., Inc. 15-substituted 4-azasteroids

Also Published As

Publication number Publication date
AU2294195A (en) 1995-11-16
JPH09512535A (ja) 1997-12-16
WO1995028928A1 (en) 1995-11-02
AU684634B2 (en) 1997-12-18
EP0756481B1 (de) 2000-12-27
ATE198274T1 (de) 2001-01-15
CA2188034A1 (en) 1995-11-02
EP0756481A1 (de) 1997-02-05
US5525608A (en) 1996-06-11
EP0756481A4 (de) 1998-11-18

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Legal Events

Date Code Title Description
8332 No legal effect for de