LV12721A - 17-beta-carboxanilides of 4-aza-5-alpha-androstan-3-ones as 5-alpha-reductase inhibitors - Google Patents

17-beta-carboxanilides of 4-aza-5-alpha-androstan-3-ones as 5-alpha-reductase inhibitors

Info

Publication number
LV12721A
LV12721A LV010088A LV010088A LV12721A LV 12721 A LV12721 A LV 12721A LV 010088 A LV010088 A LV 010088A LV 010088 A LV010088 A LV 010088A LV 12721 A LV12721 A LV 12721A
Authority
LV
Latvia
Prior art keywords
alpha
androstan
aza
beta
ones
Prior art date
Application number
LV010088A
Other languages
English (en)
Other versions
LV12721B (lv
Inventor
Gary H Rasmusson
Raman K Bakshi
Gool F Patel
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of LV12721A publication Critical patent/LV12721A/lv
Publication of LV12721B publication Critical patent/LV12721B/lv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/0065—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by an OH group free esterified or etherified
    • C07J7/007—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by an OH group free esterified or etherified not substituted in position 17 alfa
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
LVP-01-88A 1992-10-06 2001-06-01 4-aza-5-alfa-androstān-3-on-17-beta-karboksamīds kā 5-alfa reduktāzes inhibitors LV12721B (lv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US95723192A 1992-10-06 1992-10-06

Publications (2)

Publication Number Publication Date
LV12721A true LV12721A (lv) 2001-09-20
LV12721B LV12721B (lv) 2001-12-20

Family

ID=25499272

Family Applications (1)

Application Number Title Priority Date Filing Date
LVP-01-88A LV12721B (lv) 1992-10-06 2001-06-01 4-aza-5-alfa-androstān-3-on-17-beta-karboksamīds kā 5-alfa reduktāzes inhibitors

Country Status (6)

Country Link
US (1) US5693810A (lv)
EP (1) EP0663924B1 (lv)
AU (1) AU5323694A (lv)
DE (1) DE69329933T2 (lv)
LV (1) LV12721B (lv)
WO (1) WO1994007861A1 (lv)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU220064B (hu) * 1992-12-18 2001-10-28 Merck And Co. Inc. Eljárás 17béta-(N-monoszubsztituált-karbamoil)-4-aza-5alfa-androszt-1-én-3-ont tartalmazó krónikus prosztatitisz kezelésére alkalmas gyógyászati készítmény előállítására
TW408127B (en) * 1993-09-17 2000-10-11 Glaxo Inc Androstenones
TW369521B (en) * 1993-09-17 1999-09-11 Smithkline Beecham Corp Androstenone derivative
US5470976A (en) * 1994-09-07 1995-11-28 Merck & Co., Inc. Process for the stereoselective reduction of steroid enelactams
US5817818A (en) * 1994-09-16 1998-10-06 Glaxo Wellcome Inc. Androstenones
US5541322A (en) * 1994-10-14 1996-07-30 Glaxo Wellcome Inc. Synthesis of 6-azaandrostenones
US5656613A (en) * 1995-01-04 1997-08-12 Merck & Co., Inc. Treatment of hyperandrogenic conditions
JPH11512434A (ja) * 1995-09-15 1999-10-26 メルク エンド カンパニー インコーポレーテッド アンドロゲン過剰状態治療用の４−アザステロイド
US6001844A (en) * 1995-09-15 1999-12-14 Merck & Co., Inc. 4-Azasteroids for treatment of hyperandrogenic conditions
US5872126A (en) * 1996-09-06 1999-02-16 Merck & Co., Inc. Methods and compositions for treating preterm labor
US5998427A (en) * 1998-05-14 1999-12-07 Glaxo Wellcome Inc. Androstenones
US6645974B2 (en) 2001-07-31 2003-11-11 Merck & Co., Inc. Androgen receptor modulators and methods for use thereof
CA2524409C (en) * 2003-05-07 2011-12-20 Merck & Co., Inc. Androgen receptor modulators and methods of use thereof
CN103554213A (zh) * 2012-01-05 2014-02-05 中国药科大学 4-氧杂-雄甾-3-酮-17β-酰胺类衍生物、其制备方法及其医药用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4377584A (en) * 1978-04-13 1983-03-22 Merck & Co., Inc. 4-Aza-17β-substituted-5α-androstan-3-one-reductase inhibitors
US4760071A (en) * 1984-02-27 1988-07-26 Merck & Co., Inc. 17β-N-monosubstituted carbamoyl-4-aza-5α-androst-1-en-3-ones which are active as testosterone 5α-reductase inhibitors
US5116983A (en) * 1988-04-18 1992-05-26 Merck & Co., Inc. Dehydrogenation process intermediates
IE76452B1 (en) * 1990-10-29 1997-10-22 Sankyo Co Azasteroid compounds for the treatment of prostatic hypertrophy their preparation and use
US5304562A (en) * 1991-10-09 1994-04-19 Ciba-Geigy Corporation 17β-substituted Aza-androstane derivatives
US5710275A (en) * 1992-05-20 1998-01-20 Merck & Co., Inc. 7β-substituted-4-aza-5α-androstan-3-ones as 5α-reductase inhibitors
TW369521B (en) * 1993-09-17 1999-09-11 Smithkline Beecham Corp Androstenone derivative
ATE178795T1 (de) * 1993-11-04 1999-04-15 Merck & Co Inc 7-substituierte-4-aza-steroid-derivate als 5- alpha-reductase-hemmer

Also Published As

Publication number Publication date
US5693810A (en) 1997-12-02
EP0663924A1 (en) 1995-07-26
AU5323694A (en) 1994-04-26
EP0663924B1 (en) 2001-02-14
LV12721B (lv) 2001-12-20
WO1994007861A1 (en) 1994-04-14
DE69329933D1 (de) 2001-03-22
DE69329933T2 (de) 2001-07-19
EP0663924A4 (en) 1995-10-04

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