KR920703640A - 비a비b형 간염 바이러스 항원 단백질 - Google Patents
비a비b형 간염 바이러스 항원 단백질Info
- Publication number
- KR920703640A KR920703640A KR1019920701818A KR920701818A KR920703640A KR 920703640 A KR920703640 A KR 920703640A KR 1019920701818 A KR1019920701818 A KR 1019920701818A KR 920701818 A KR920701818 A KR 920701818A KR 920703640 A KR920703640 A KR 920703640A
- Authority
- KR
- South Korea
- Prior art keywords
- virus antigen
- amino acid
- protein
- hepatitis
- antigen protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 102000036639 antigens Human genes 0.000 title claims description 26
- 108091007433 antigens Proteins 0.000 title claims description 26
- 241000700721 Hepatitis B virus Species 0.000 title claims 3
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 19
- 241000724832 Non-A, non-B hepatitis virus Species 0.000 claims 20
- 102000004169 proteins and genes Human genes 0.000 claims 15
- 108090000623 proteins and genes Proteins 0.000 claims 15
- 230000000890 antigenic effect Effects 0.000 claims 13
- 206010019786 Hepatitis non-A non-B Diseases 0.000 claims 8
- 239000000556 agonist Substances 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 5
- 229940079593 drug Drugs 0.000 claims 5
- 108020004414 DNA Proteins 0.000 claims 4
- 239000013604 expression vector Substances 0.000 claims 4
- 239000002299 complementary DNA Substances 0.000 claims 3
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 241000588724 Escherichia coli Species 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 102000037865 fusion proteins Human genes 0.000 claims 1
- 208000006454 hepatitis Diseases 0.000 claims 1
- 231100000283 hepatitis Toxicity 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 208000002672 hepatitis B Diseases 0.000 description 3
- 238000002965 ELISA Methods 0.000 description 2
- 208000005176 Hepatitis C Diseases 0.000 description 2
- 239000000427 antigen Substances 0.000 description 2
- 208000008439 Biliary Liver Cirrhosis Diseases 0.000 description 1
- 208000033222 Biliary cirrhosis primary Diseases 0.000 description 1
- 206010016654 Fibrosis Diseases 0.000 description 1
- 208000012654 Primary biliary cholangitis Diseases 0.000 description 1
- 230000007882 cirrhosis Effects 0.000 description 1
- 208000019425 cirrhosis of liver Diseases 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
- C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Virology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP325435/90 | 1990-11-29 | ||
| JP32543490 | 1990-11-29 | ||
| JP325434/90 | 1990-11-29 | ||
| JP32543590 | 1990-11-29 | ||
| JP7023191 | 1991-01-16 | ||
| JP70231/91 | 1991-01-16 | ||
| JP17907491 | 1991-04-19 | ||
| JP179074/91 | 1991-04-19 | ||
| JP23259091 | 1991-06-07 | ||
| JP232590/91 | 1991-06-07 | ||
| PCT/JP1991/001662 WO1992009634A1 (fr) | 1990-11-29 | 1991-11-29 | Proteine anti-genique du virus de l'hepatite non a et non b |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR920703640A true KR920703640A (ko) | 1992-12-18 |
Family
ID=27524245
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019920701818A Ceased KR920703640A (ko) | 1990-11-29 | 1991-11-29 | 비a비b형 간염 바이러스 항원 단백질 |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP0516859A1 (enExample) |
| KR (1) | KR920703640A (enExample) |
| WO (1) | WO1992009634A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE185350T1 (de) * | 1990-12-14 | 1999-10-15 | Innogenetics Nv | Synthetische antigene zum nachweis von antikörpern gegen hepatitis c virus |
| KR0185426B1 (ko) | 1991-06-24 | 1999-04-01 | 로버트 피. 블랙버언 | 씨형 간염 바이러스 폴리펩티드 |
| EP0532167A3 (en) * | 1991-08-09 | 1993-03-31 | Immuno Japan Inc. | Non-a, non-b hepatitis virus genome, polynucleotides, polypeptides, antigen, antibody and detection systems |
| US5428145A (en) * | 1991-08-09 | 1995-06-27 | Immuno Japan, Inc. | Non-A, non-B, hepatitis virus genome, polynucleotides, polypeptides, antigen, antibody and detection systems |
| US6667387B1 (en) | 1996-09-30 | 2003-12-23 | N.V. Innogenetics S.A. | HCV core peptides |
| US6709828B1 (en) | 1992-03-06 | 2004-03-23 | N.V. Innogenetics S.A. | Process for the determination of peptides corresponding to immunologically important epitopes and their use in a process for determination of antibodies or biotinylated peptides corresponding to immunologically important epitopes, a process for preparing them and compositions containing them |
| JPH10503364A (ja) * | 1994-05-10 | 1998-03-31 | ザ ジェネラル ホスピタル コーポレーション | Ｃ型肝炎ウイルスのアンチセンス阻害 |
| WO1996034013A1 (en) * | 1995-04-28 | 1996-10-31 | Srl, Inc. | Antigen peptide compound and immunoassay method |
| JP2002125688A (ja) * | 2000-10-30 | 2002-05-08 | Tosoh Corp | Ｃ型肝炎ウイルスの高感度検出のためのオリゴヌクレオチドおよび検出法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1989004669A1 (en) * | 1987-11-18 | 1989-06-01 | Chiron Corporation | Nanbv diagnostics and vaccines |
| HUT54896A (en) * | 1989-03-17 | 1991-04-29 | Chiron Corp | Process for producing aquous diagnosticum and vaccine of nanbv |
| WO1990014436A1 (en) * | 1989-05-18 | 1990-11-29 | Chiron Corporation | Nanbv diagnostics: polynucleotides useful for screening for hepatitis c virus |
| EP0416725A3 (en) * | 1989-07-14 | 1991-03-20 | Chugai Seiyaku Kabushiki Kaisha | Blood-borne non-a, non-b hepatitis specific protein, dna encoding it, and process for its production |
| WO1991004262A1 (en) * | 1989-09-15 | 1991-04-04 | National Institute Of Health Of Japan | New hcv isolates |
| DE4040339C2 (de) * | 1989-12-18 | 1999-07-08 | Wellcome Found | Virales Agens |
| AU638304B2 (en) * | 1989-12-22 | 1993-06-24 | Abbott Laboratories | Hepatitis c assay |
| KR940000755B1 (ko) * | 1990-02-16 | 1994-01-29 | 유나이티드 바이오메디칼 인코오포레이티드 | Hcv에 대한 항체 검출, hcv 감염의 진단 및 백신으로서의 그 예방에 특히 적합한 합성 펩티드 |
| AU660925B2 (en) * | 1990-04-06 | 1995-07-13 | Genelabs Technologies, Inc. | Hepatitis C virus epitopes |
| CA2047792C (en) * | 1990-07-26 | 2002-07-02 | Chang Y. Wang | Synthetic peptides specific for the detection of antibodies to hcv, diagnosis of hcv infection and prevention thereof as vaccines |
-
1991
- 1991-11-29 EP EP91920779A patent/EP0516859A1/en not_active Withdrawn
- 1991-11-29 WO PCT/JP1991/001662 patent/WO1992009634A1/ja not_active Ceased
- 1991-11-29 KR KR1019920701818A patent/KR920703640A/ko not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO1992009634A1 (fr) | 1992-06-11 |
| EP0516859A1 (en) | 1992-12-09 |
| EP0516859A4 (enExample) | 1995-03-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Sottrup-Jensen et al. | Domain structure of human α2‐macroglobulin: Characterization of a receptor‐binding domain obtained by digestion with papain | |
| Koketsu et al. | Immunochemistry of sperm-whale myoglobin—XVI: Accurate delineation of the single region in sequence 1–55 by immunochemical studies of synthetic peptides. Some conclusions concerining antigenic structures of proteins | |
| ABEL et al. | Synthesis and characterization of indolicidin, a tryptophan‐rich antimicrobial peptide from bovine neutrophils | |
| KR870700100A (ko) | 최소한 일부분이 알려진 뉴클레오티드 암호서열 또는 아미노산 서열을 갖는 프로테인 또는 펩티드에 상보적인 폴리펩티드와 이것의 디자인 방법 | |
| ATE195953T1 (de) | Peptide zur induktion von immunantwort durch zytotoxischen t lymphocyten gegen das virus von hepatitis c | |
| NO178789B (no) | Fremgangsmåte for fremstilling av gamma-interferonpolypeptid med forbedret stabilitet, ekspresjonsvektor samt DNA-sekvens kodende for polypeptidene | |
| KR870009025A (ko) | 재조합 숙주로부터 제조한 아프로티닌 동족체, 그의 방법, 표현 벡타 및 재조합 숙주 및 그의 재약상 용도 | |
| KR960704038A (ko) | 세포 표면 수용체 Hek와 결합하는 사이토킨(Cytokines That Bind the Cell Surface Receptor Hek) | |
| RU2003106809A (ru) | Гены гомологичных иммунодоминантных белков ehrlichia canis в 28-килодальтон и их применение | |
| KR940703860A (ko) | 신규한 사람 쿠니즈형 프로테아제 저해제 및 그의 변이체(a novel human kunitz-type protease inhibitor and variants thereof) | |
| AU750606B2 (en) | Amino-terminally truncated MCP-2 as chemokine antagonists | |
| KR880000589A (ko) | 플라비 비루스 항원 | |
| KR910016769A (ko) | 펩티드 및 그의 용도 | |
| Browning et al. | Disulfide scrambling of interleukin-2: HPLC resolution of the three possible isomers | |
| Milstein et al. | Studies on the variability of immunoglobulin sequence | |
| JP2003527073A5 (enExample) | ||
| RU2001127439A (ru) | Пептиды из последовательности Т-вируса и моноспецифические антитела, связывающиеся с ТТ-вирусом | |
| EP0516859A1 (en) | Non-a non-b hepatitis virus antigen protein | |
| Sakaguchi et al. | Human interferon‐γ lacking 23 COOH‐terminal amino acids is biologically active | |
| Takkinen et al. | Nucleotide sequence of the rubella virus capsid protein gene reveals an unusually high G/C content | |
| KR930000684A (ko) | 클로닝된 글루탐산 탈탄산효소 | |
| Winkler et al. | Exclusive use of high-performance liquid chromatographic techniques for the isolation, 4-dimethylaminoazobenzene-4′-sulphonyl chloride amino acid analysis and 4-N, N-dimethylaminoazobenzene-4′-isothiocyanate-phenyl isothiocyanate sequencing of a viral membrane protein | |
| KR950032620A (ko) | 인터페론 α/β 결합 단백질과 이의 제조 및 용도 | |
| AU5315790A (en) | Molecules containing at least one peptide sequence carrying one or several epitopes characteristic of a protein produced by p. falciparum at the sporozoite stage and in the hepatocytes | |
| Yoshioka et al. | Deficiency of antibody response to hypervariable region of hepatitis C virus in patients with chronic hepatitis C |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0109 | Patent application |
Patent event code: PA01091R01D Comment text: Patent Application Patent event date: 19920729 |
|
| PG1501 | Laying open of application | ||
| A201 | Request for examination | ||
| PA0201 | Request for examination |
Patent event code: PA02012R01D Patent event date: 19930331 Comment text: Request for Examination of Application Patent event code: PA02011R01I Patent event date: 19920729 Comment text: Patent Application |
|
| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
Comment text: Notification of reason for refusal Patent event date: 19961226 Patent event code: PE09021S01D |
|
| E601 | Decision to refuse application | ||
| PE0601 | Decision on rejection of patent |
Patent event date: 19970520 Comment text: Decision to Refuse Application Patent event code: PE06012S01D Patent event date: 19961226 Comment text: Notification of reason for refusal Patent event code: PE06011S01I |