ATE195953T1 - Peptide zur induktion von immunantwort durch zytotoxischen t lymphocyten gegen das virus von hepatitis c - Google Patents
Peptide zur induktion von immunantwort durch zytotoxischen t lymphocyten gegen das virus von hepatitis cInfo
- Publication number
- ATE195953T1 ATE195953T1 AT95914048T AT95914048T ATE195953T1 AT E195953 T1 ATE195953 T1 AT E195953T1 AT 95914048 T AT95914048 T AT 95914048T AT 95914048 T AT95914048 T AT 95914048T AT E195953 T1 ATE195953 T1 AT E195953T1
- Authority
- AT
- Austria
- Prior art keywords
- sub
- seq
- cytotoxic
- peptides
- virus
- Prior art date
Links
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
- 241000711549 Hepacivirus C Species 0.000 title 1
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 title 1
- 230000028993 immune response Effects 0.000 title 1
- 230000001939 inductive effect Effects 0.000 title 1
- 230000001154 acute effect Effects 0.000 abstract 1
- 230000001684 chronic effect Effects 0.000 abstract 1
- 208000006454 hepatitis Diseases 0.000 abstract 1
- 231100000283 hepatitis Toxicity 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
- C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/214,650 US5709995A (en) | 1994-03-17 | 1994-03-17 | Hepatitis C virus-derived peptides capable of inducing cytotoxic T lymphocyte responses |
| PCT/US1995/003224 WO1995025122A1 (en) | 1994-03-17 | 1995-03-16 | Peptides for inducing cytotoxic t lymphocyte responses to hepatitis c virus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE195953T1 true ATE195953T1 (de) | 2000-09-15 |
Family
ID=22799919
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95914048T ATE195953T1 (de) | 1994-03-17 | 1995-03-16 | Peptide zur induktion von immunantwort durch zytotoxischen t lymphocyten gegen das virus von hepatitis c |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US5709995A (de) |
| EP (1) | EP0759937B2 (de) |
| JP (3) | JP3844494B2 (de) |
| AT (1) | ATE195953T1 (de) |
| CA (1) | CA2184890C (de) |
| DE (1) | DE69518642T3 (de) |
| WO (1) | WO1995025122A1 (de) |
Families Citing this family (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5804381A (en) * | 1996-10-03 | 1998-09-08 | Cornell Research Foundation | Isolated nucleic acid molecule encoding an esophageal cancer associated antigen, the antigen itself, and uses thereof |
| JPH08510240A (ja) | 1993-05-12 | 1996-10-29 | カイロン コーポレイション | C型肝炎ウイルスe2/ns1領域の保存モチーフ |
| CA2175692A1 (en) * | 1993-11-04 | 1995-05-11 | Geert Leroux-Roels | Immunodominant human t-cell epitopes of hepatitis c virus |
| US6057294A (en) * | 1995-01-16 | 2000-05-02 | Northern Sydney Area Health Service Of Pacific Highway | Peptide |
| US7019112B1 (en) | 1996-03-19 | 2006-03-28 | University Of Virginia Patent Foundation | Peptides recognized by melanoma-specific A1-, A2- and A3-restricted cytoxic lymphocytes, and uses therefor |
| EP0921805A4 (de) * | 1996-03-19 | 2002-06-26 | Univ Virginia | Peptide, die von melanomspezifischen a1-, a2- und a3-beschränkten zytotoxischen lymphozyten erkannt werden, sowie deren verwendungen |
| EP1767542B1 (de) * | 1996-03-21 | 2016-05-11 | Epimmune Inc. | HLA-A2.1 bindende Peptide und deren Verwendung |
| BR9708220A (pt) * | 1996-03-21 | 2000-01-04 | Epimmune Inc | Peptìdios de ligação hla-a2.1 e seus usos |
| US6265215B1 (en) * | 1996-09-13 | 2001-07-24 | Ludwig Institute For Cancer Research | Isolated peptides which complex with HLA-Cw16 and uses thereof |
| US6413517B1 (en) * | 1997-01-23 | 2002-07-02 | Epimmune, Inc. | Identification of broadly reactive DR restricted epitopes |
| US6685944B1 (en) * | 1998-08-21 | 2004-02-03 | The United States Of America As Represented By The Department Of Health And Human Services | Modified HCV peptide vaccines |
| US7091324B2 (en) | 1998-11-05 | 2006-08-15 | Board Of Trustees Of Leland Stanford Junior University | Prevention and treatment of HCV infection employing antibodies directed against conformational epitopes |
| CA2377525A1 (en) * | 1999-07-19 | 2001-03-29 | Epimmune Inc. | Inducing cellular immune responses to hepatitis c virus using peptide and nucleic acid compositions |
| US20090130135A1 (en) * | 1999-10-01 | 2009-05-21 | Michael Buschle | Hcv vaccines |
| US6534064B1 (en) * | 1999-10-13 | 2003-03-18 | Chiron Corporation | Stabilized protein particles for inducing cellular immune responses |
| EP1233982B1 (de) * | 1999-11-24 | 2007-10-24 | Novartis Vaccines and Diagnostics, Inc. | Neues nichtstrukturelles hcv polypeptid |
| US6986892B1 (en) | 1999-11-24 | 2006-01-17 | Chiron Corporation | Immunogenic Hepatitis C virus non-structural polypeptides |
| KR100879810B1 (ko) * | 2000-02-21 | 2009-01-22 | 하. 룬드벡 아크티에셀스카브 | 아밀로이드의 하향-조절을 위한 신규한 방법 |
| EE200200444A (et) * | 2000-02-21 | 2003-12-15 | Pharmexa A/S | Meetod autoloogse beeta-amüloidvaigu in vivo mahasurumiseks, amüloidogeense polüpeptiidi analoog, seda kodeeriv nukleiinhappefragment ning kasutamineimmunogeense kompositsiooni valmistamiseks |
| IL142802A (en) * | 2000-04-27 | 2015-01-29 | Enzo Therapeutics Inc | Use of one or more HBV antigens for the preparation of oral pharmaceutical preparations for the treatment of a person with active HBV infection or hepatocellular carcinoma |
| CA2409287A1 (en) * | 2000-06-02 | 2001-12-13 | Merck & Co., Inc. | Hepatitis c virus conjugates |
| US9974847B2 (en) * | 2000-08-24 | 2018-05-22 | Immunitor USA, Inc. | Treatment and prevention of tuberculosis |
| US20030092145A1 (en) * | 2000-08-24 | 2003-05-15 | Vic Jira | Viral vaccine composition, process, and methods of use |
| AU2000275748A1 (en) * | 2000-09-01 | 2002-03-22 | Epimmune, Inc. | Hla-a2.1 binding peptides and their uses |
| EP1195381A1 (de) * | 2000-09-28 | 2002-04-10 | Immusystems GmbH | CD4+ T-Lymphozyten spezifische Hepatitis C Virus-Epitope |
| BR0207297A (pt) | 2001-02-15 | 2005-04-19 | King Pharmaceuticals Inc | Composição farmacêutica em forma sólida e método de preparar uma forma de dosagem sólida de um ingrediente farmaceuticamente ativo |
| US7097837B2 (en) * | 2001-02-19 | 2006-08-29 | Pharmexa A/S | Synthetic vaccine agents |
| US7326536B2 (en) | 2001-05-03 | 2008-02-05 | Eli Lilly And Company | Agents for treatment of HCV and methods of use |
| US20030224011A1 (en) * | 2001-05-29 | 2003-12-04 | Conley Anthony J | Hepatitis c virus conjugates |
| US7101569B2 (en) | 2001-08-14 | 2006-09-05 | Franz G Andrew | Methods of administering levothyroxine pharmaceutical compositions |
| MY144532A (en) * | 2001-08-20 | 2011-09-30 | Lundbeck & Co As H | Novel method for down-regulation of amyloid |
| AU2003301865A1 (en) * | 2002-05-16 | 2004-06-07 | The General Hospital Corporation | Epitopes of hepatitis c virus |
| FR2839722A1 (fr) * | 2002-05-17 | 2003-11-21 | Bio Merieux | Nouvelles compositions peptidiques et leur utilisation notamment dans la preparation de compositions pharmaceutiques actives contre le virus de l'hepatite c |
| WO2004011650A2 (en) | 2002-07-24 | 2004-02-05 | Intercell Ag | Antigens encoded by alternative reading frame from pathogenic viruses |
| WO2004024182A2 (en) | 2002-09-13 | 2004-03-25 | Intercell Ag | Method for isolating hepatitis c virus peptides |
| EP2557164A1 (de) | 2003-02-18 | 2013-02-13 | Kevin M. Slawin | Induzierte Aktivierung ein dendritischen Zellen |
| US7704514B2 (en) | 2003-03-24 | 2010-04-27 | Intercell Ag | Vaccines |
| ATE489967T1 (de) * | 2003-07-11 | 2010-12-15 | Intercell Ag | Hcv-vakzin |
| FR2862648B1 (fr) * | 2003-11-21 | 2006-02-03 | Biomerieux Sa | Nouveau peptide immunogene et nouveaux epitopes et utilisations notamment dans la preparation de compositions pharmaceutiques actives contre le virus de l 'hepatite c |
| AU2005250170A1 (en) * | 2004-06-01 | 2005-12-15 | Genimmune N.V. | Peptides for inducing a CTL and/or HTL response to hepatitis C virus |
| WO2006124412A2 (en) * | 2005-05-11 | 2006-11-23 | The Trustees Of The University Of Pennsylvania | Methods for the rapid expansion of antigen specific t-cells |
| US7951384B2 (en) * | 2005-08-05 | 2011-05-31 | University Of Massachusetts | Virus-like particles as vaccines for paramyxovirus |
| US9216212B2 (en) | 2005-08-05 | 2015-12-22 | University Of Massachusetts | Virus-like particles as vaccines for paramyxovirus |
| KR20080079243A (ko) * | 2005-11-10 | 2008-08-29 | 유니버시티 오브 시카고 | Hcv-반응성 t 세포 수용체 |
| CN101336110B (zh) | 2006-06-01 | 2011-06-01 | 程云 | 预防或治疗肝损伤的肽及其衍生物及其应用 |
| AU2007310946B2 (en) | 2006-10-19 | 2014-06-05 | Baylor College Of Medicine | Generating an immune response by inducing CD40 and pattern recognition receptors |
| DK2331680T3 (en) | 2008-09-22 | 2017-08-21 | Baylor College Medicine | Methods and Compositions for Generating an Immune Response by Induction of CD-40 as well as Pattern Recognition Receptor Adapters |
| US8580270B2 (en) * | 2008-09-30 | 2013-11-12 | University Of Massachusetts | Respiratory synctial virus (RSV) sequences for protein expression and vaccines |
| EP2462451B1 (de) * | 2009-08-05 | 2016-02-17 | Nexigen GmbH | Mit hcv interagierende humane proteine und methoden für deren verwendung |
| US9089520B2 (en) | 2010-05-21 | 2015-07-28 | Baylor College Of Medicine | Methods for inducing selective apoptosis |
| US20130183376A1 (en) | 2010-09-08 | 2013-07-18 | Saitama Medical University | Hepatitis c virus liposome vaccine |
| JP6069212B2 (ja) | 2010-12-02 | 2017-02-01 | ビオノール イミュノ エーエスBionor Immuno As | ペプチド骨格設計 |
| JP6294076B2 (ja) | 2011-01-06 | 2018-03-14 | ビオノール イミュノ エーエスBionor Immuno As | 多量体ペプチド |
| WO2012145509A2 (en) | 2011-04-19 | 2012-10-26 | The Research Foundation Of State University Of New York | Adeno-associated-virus rep sequences, vectors, and viruses |
| EP2760892A1 (de) | 2011-09-29 | 2014-08-06 | Apo-T B.V. | Multispezifische bindungsmoleküle zur anzielung aberranter zellen |
| SG11201404007WA (en) | 2012-01-13 | 2014-08-28 | Apo T B V | Aberrant cell-restricted immunoglobulins provided with a toxic moiety |
| KR20150018870A (ko) | 2012-06-06 | 2015-02-24 | 바이오노르 이뮤노 에이에스 | 면역원 및 투여 반응제로서 사용하기 위한 바이러스 단백질로부터 유래하는 펩타이드 |
| EP3456735A1 (de) * | 2012-06-26 | 2019-03-20 | Apo-T B.V. | Auf krankheitserreger abzielende bindungsmoleküle |
| US9434935B2 (en) | 2013-03-10 | 2016-09-06 | Bellicum Pharmaceuticals, Inc. | Modified caspase polypeptides and uses thereof |
| AU2014236726A1 (en) | 2013-03-14 | 2015-09-17 | Bellicum Pharmaceuticals, Inc. | Methods for controlling T cell proliferation |
| JP6467406B2 (ja) | 2013-06-05 | 2019-02-13 | ベリカム ファーマシューティカルズ, インコーポレイテッド | カスパーゼポリペプチドを使用して部分的なアポトーシスを誘導するための方法 |
| JP6772063B2 (ja) | 2014-02-14 | 2020-10-21 | ベリカム ファーマシューティカルズ, インコーポレイテッド | 誘導可能なキメラポリペプチドを使用して細胞を活性化するための方法 |
| WO2016036746A1 (en) | 2014-09-02 | 2016-03-10 | Bellicum Pharmaceuticals, Inc. | Costimulation of chimeric antigen receptors by myd88 and cd40 polypeptides |
| US10189880B2 (en) | 2014-11-03 | 2019-01-29 | Leiden University Medical Center | T cell receptors directed against Bob1 and uses thereof |
| EP3268014B1 (de) | 2015-03-10 | 2022-09-21 | Academisch Ziekenhuis Leiden H.O.D.N. Leids Universitair Medisch Centrum | Gegen das bevorzugt exprimierte antigen von melanomen gerichtete t-zell-rezeptoren und verwendungen davon |
| WO2017180420A1 (en) * | 2016-04-11 | 2017-10-19 | Board Of Regents, The University Of Texas System | Methods and compositions for detecting single t cell receptor affinity and sequence |
| CN109963587A (zh) | 2016-09-21 | 2019-07-02 | 艾伯塔大学理事会 | 丙型肝炎病毒免疫原性组合物及其使用方法 |
| EP3621988A1 (de) | 2017-05-09 | 2020-03-18 | Bellicum Pharmaceuticals, Inc. | Verfahren zur verstärkung oder änderung der signaltransduktion |
| EP3720479A2 (de) | 2017-12-08 | 2020-10-14 | Bellicum Pharmaceuticals, Inc. | Verfahren zur steigerung und erhaltung der wirksamkeit von car-t-zellen |
| AU2021397278A1 (en) * | 2020-12-09 | 2023-07-06 | Tevogen Bio Inc. | Virus specific t-cells and methods of treating and preventing viral infections |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5017558A (en) * | 1980-01-14 | 1991-05-21 | The Regents Of The University Of California | Synthetic vaccine peptide epitomes of hepatitis B surface antigen |
| ZW18282A1 (en) * | 1981-08-31 | 1983-03-23 | Genentech Inc | Preparation of polypeptides in vertebrate cell culture |
| US4803164A (en) * | 1981-08-31 | 1989-02-07 | Genentech, Inc. | Preparation of hepatitis b surface antigen in yeast |
| US4977092A (en) * | 1985-06-26 | 1990-12-11 | Amgen | Expression of exogenous polypeptides and polypeptide products including hepatitis B surface antigen in yeast cells |
| DK154394C (da) * | 1982-10-21 | 1989-04-24 | Apv Pasilac As | Fremgangsmaade til at foroege kapaciteten af anlaeg for membranfiltrering af maelk eller maelkeprodukter til foderstoffer eller vaekstmedier. |
| JPS59101426A (ja) * | 1982-11-29 | 1984-06-12 | Green Cross Corp:The | B型肝炎感染予防用ワクチンの製造方法 |
| US4625918A (en) * | 1983-07-29 | 1986-12-02 | Diesel Kiki Co., Ltd. | Fuel injection valve |
| US4847080A (en) * | 1984-03-07 | 1989-07-11 | New York Blood Center, Inc. | Pre-S gene coded peptide hepatitis B immunogens, vaccines, diagnostics, and synthetic lipide vesicle carriers |
| US4599230A (en) * | 1984-03-09 | 1986-07-08 | Scripps Clinic And Research Foundation | Synthetic hepatitis B virus vaccine including both T cell and B cell determinants |
| US4599231A (en) * | 1984-03-09 | 1986-07-08 | Scripps Clinic And Research Foundation | Synthetic hepatitis B virus vaccine including both T cell and B cell determinants |
| US4624918A (en) | 1984-07-09 | 1986-11-25 | Genentech, Inc. | Purification process for hepatitis surface antigen and product thereof |
| JPS6137738A (ja) * | 1984-07-31 | 1986-02-22 | Tetsuo Nakamura | B型肝炎ワクチン |
| US4690915A (en) * | 1985-08-08 | 1987-09-01 | The United States Of America As Represented By The Department Of Health And Human Services | Adoptive immunotherapy as a treatment modality in humans |
| US4882145A (en) * | 1986-12-09 | 1989-11-21 | Scripps Clinic And Research Foundation | T cell epitopes of the hepatitis B virus nucleocapsid protein |
| US5350671A (en) * | 1987-11-18 | 1994-09-27 | Chiron Corporation | HCV immunoassays employing C domain antigens |
| KR0185373B1 (ko) * | 1989-03-17 | 1999-05-01 | 로버트 피. 블랙버언 | Hcv 폴리단백질에서 유래되는 hcv 아미노산 서열 부분을 포함하는 폴리펩티드 및 그 사용 |
| US5372928A (en) * | 1989-09-15 | 1994-12-13 | Chiron Corporation | Hepatitis C virus isolates |
| IT1237764B (it) * | 1989-11-10 | 1993-06-17 | Eniricerche Spa | Peptidi sintetici utili come carriers universali per la preparazione di coniugati immunogenici e loro impiego per lo sviluppo di vaccini sintetici. |
| US5106726A (en) * | 1990-02-16 | 1992-04-21 | United Biomedical, Inc. | Synthetic peptides specific for the detection of antibodies to HCV |
| JPH0454197A (ja) * | 1990-06-19 | 1992-02-21 | Chemo Sero Therapeut Res Inst | C型肝炎ウイルス抗体検出用合成ペプチド抗原、その組成物およびその使用方法 |
| NZ238681A (en) * | 1990-06-25 | 1992-03-26 | Univ Osaka Res Found | Non-a, non-b hepatitis virus particles and their production |
| HU227547B1 (en) * | 1991-06-24 | 2011-08-29 | Novartis Vaccines & Diagnostic | Hepatitis c virus (hcv) polypeptides |
| US6419931B1 (en) | 1991-08-26 | 2002-07-16 | Epimmune Inc. | Compositions and methods for eliciting CTL immunity |
| ES2287969T3 (es) | 1992-03-06 | 2007-12-16 | Innogenetics N.V. | Peptidos de vih. |
| US5980899A (en) | 1992-06-10 | 1999-11-09 | The United States Of America As Represented By The Department Of Health And Human Services | Identification of peptides that stimulate hepatitis C virus specific cytotoxic T cells |
| JP3908271B2 (ja) * | 1993-03-05 | 2007-04-25 | エピミューン,インコーポレイティド | Hla−a2.1結合ペプチドおよびそれらの使用 |
| CA2175692A1 (en) * | 1993-11-04 | 1995-05-11 | Geert Leroux-Roels | Immunodominant human t-cell epitopes of hepatitis c virus |
| EP0754193B1 (de) * | 1994-04-08 | 2000-06-14 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, represented by THE DEPARTMENT OF HEALTH & HUMAN SERVICES | Peptid aus dem inneren des hepatitis-c-virus brauchbar für die stimulation cytotoxischer t-lymphocyten und die diagnose des hcv-kontaktes |
-
1994
- 1994-03-17 US US08/214,650 patent/US5709995A/en not_active Expired - Lifetime
-
1995
- 1995-03-16 CA CA2184890A patent/CA2184890C/en not_active Expired - Lifetime
- 1995-03-16 EP EP95914048A patent/EP0759937B2/de not_active Expired - Lifetime
- 1995-03-16 WO PCT/US1995/003224 patent/WO1995025122A1/en not_active Ceased
- 1995-03-16 JP JP52415195A patent/JP3844494B2/ja not_active Expired - Lifetime
- 1995-03-16 AT AT95914048T patent/ATE195953T1/de not_active IP Right Cessation
- 1995-03-16 DE DE69518642T patent/DE69518642T3/de not_active Expired - Lifetime
-
1997
- 1997-05-12 US US08/854,825 patent/US7220420B2/en not_active Expired - Fee Related
-
2005
- 2005-03-07 JP JP2005061923A patent/JP4394019B2/ja not_active Expired - Lifetime
-
2006
- 2006-06-07 JP JP2006158108A patent/JP4463786B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20020115061A1 (en) | 2002-08-22 |
| JP4394019B2 (ja) | 2010-01-06 |
| JP3844494B2 (ja) | 2006-11-15 |
| DE69518642D1 (de) | 2000-10-05 |
| DE69518642T2 (de) | 2001-05-03 |
| CA2184890C (en) | 2011-05-24 |
| JPH09510455A (ja) | 1997-10-21 |
| JP2006265264A (ja) | 2006-10-05 |
| WO1995025122A1 (en) | 1995-09-21 |
| JP4463786B2 (ja) | 2010-05-19 |
| EP0759937A1 (de) | 1997-03-05 |
| US7220420B2 (en) | 2007-05-22 |
| EP0759937B1 (de) | 2000-08-30 |
| US5709995A (en) | 1998-01-20 |
| EP0759937B2 (de) | 2008-12-31 |
| DE69518642T3 (de) | 2009-05-14 |
| CA2184890A1 (en) | 1995-09-21 |
| JP2005247852A (ja) | 2005-09-15 |
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