DE69518642D1 - Peptide zur induktion von immunantwort durch zytotoxischen t lymphocyten gegen das virus von hepatitis c - Google Patents
Peptide zur induktion von immunantwort durch zytotoxischen t lymphocyten gegen das virus von hepatitis cInfo
- Publication number
- DE69518642D1 DE69518642D1 DE69518642T DE69518642T DE69518642D1 DE 69518642 D1 DE69518642 D1 DE 69518642D1 DE 69518642 T DE69518642 T DE 69518642T DE 69518642 T DE69518642 T DE 69518642T DE 69518642 D1 DE69518642 D1 DE 69518642D1
- Authority
- DE
- Germany
- Prior art keywords
- sub
- seq
- hepatitis
- cytotoxic
- peptides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 208000006454 hepatitis Diseases 0.000 title abstract 2
- 231100000283 hepatitis Toxicity 0.000 title abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
- 241000700605 Viruses Species 0.000 title 1
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 title 1
- 230000028993 immune response Effects 0.000 title 1
- 230000006698 induction Effects 0.000 title 1
- 230000001154 acute effect Effects 0.000 abstract 1
- 230000001684 chronic effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
- C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/214,650 US5709995A (en) | 1994-03-17 | 1994-03-17 | Hepatitis C virus-derived peptides capable of inducing cytotoxic T lymphocyte responses |
US214650 | 1994-03-17 | ||
PCT/US1995/003224 WO1995025122A1 (en) | 1994-03-17 | 1995-03-16 | Peptides for inducing cytotoxic t lymphocyte responses to hepatitis c virus |
Publications (3)
Publication Number | Publication Date |
---|---|
DE69518642D1 true DE69518642D1 (de) | 2000-10-05 |
DE69518642T2 DE69518642T2 (de) | 2001-05-03 |
DE69518642T3 DE69518642T3 (de) | 2009-05-14 |
Family
ID=22799919
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69518642T Expired - Lifetime DE69518642T3 (de) | 1994-03-17 | 1995-03-16 | Peptide zur induktion von immunantwort durch zytotoxischen t lymphocyten gegen das virus von hepatitis c |
Country Status (7)
Country | Link |
---|---|
US (2) | US5709995A (de) |
EP (1) | EP0759937B2 (de) |
JP (3) | JP3844494B2 (de) |
AT (1) | ATE195953T1 (de) |
CA (1) | CA2184890C (de) |
DE (1) | DE69518642T3 (de) |
WO (1) | WO1995025122A1 (de) |
Families Citing this family (68)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5804381A (en) * | 1996-10-03 | 1998-09-08 | Cornell Research Foundation | Isolated nucleic acid molecule encoding an esophageal cancer associated antigen, the antigen itself, and uses thereof |
CA2162557C (en) | 1993-05-12 | 2004-09-28 | Amy J. Weiner | Conserved motif of hepatitis c virus e2/ns1 region |
US6555114B1 (en) * | 1993-11-04 | 2003-04-29 | Innogenetics N.V. | Immunodominant human T-cell epitopes of hepatitis C virus |
EP0804469B1 (de) * | 1995-01-16 | 2001-11-28 | Northern Sydney Area Health Service | T-Zellen beeinflussende Peptide |
EP0921805A4 (de) * | 1996-03-19 | 2002-06-26 | Univ Virginia | Peptide, die von melanomspezifischen a1-, a2- und a3-beschränkten zytotoxischen lymphozyten erkannt werden, sowie deren verwendungen |
US7019112B1 (en) | 1996-03-19 | 2006-03-28 | University Of Virginia Patent Foundation | Peptides recognized by melanoma-specific A1-, A2- and A3-restricted cytoxic lymphocytes, and uses therefor |
AU2658897A (en) * | 1996-03-21 | 1997-10-10 | Epimmune, Inc. | Hla-a2.1 binding peptides and their uses |
EP1767542B1 (de) * | 1996-03-21 | 2016-05-11 | Epimmune Inc. | HLA-A2.1 bindende Peptide und deren Verwendung |
US6265215B1 (en) * | 1996-09-13 | 2001-07-24 | Ludwig Institute For Cancer Research | Isolated peptides which complex with HLA-Cw16 and uses thereof |
US6413517B1 (en) * | 1997-01-23 | 2002-07-02 | Epimmune, Inc. | Identification of broadly reactive DR restricted epitopes |
ATE357526T1 (de) * | 1998-08-21 | 2007-04-15 | Us Gov Health & Human Serv | Modifizierte hcv peptid-impfstoffe |
US7091324B2 (en) | 1998-11-05 | 2006-08-15 | Board Of Trustees Of Leland Stanford Junior University | Prevention and treatment of HCV infection employing antibodies directed against conformational epitopes |
WO2001021189A1 (en) * | 1999-07-19 | 2001-03-29 | Epimmune Inc. | Inducing cellular immune responses to hepatitis c virus using peptide and nucleic acid compositions |
US20090130135A1 (en) * | 1999-10-01 | 2009-05-21 | Michael Buschle | Hcv vaccines |
JP2003511420A (ja) * | 1999-10-13 | 2003-03-25 | カイロン コーポレイション | タンパク質から細胞性免疫応答を得る方法 |
CN101684146A (zh) * | 1999-11-24 | 2010-03-31 | 诺华疫苗和诊断公司 | 新颖的hcv非结构多肽 |
US6986892B1 (en) | 1999-11-24 | 2006-01-17 | Chiron Corporation | Immunogenic Hepatitis C virus non-structural polypeptides |
KR100879810B1 (ko) * | 2000-02-21 | 2009-01-22 | 하. 룬드벡 아크티에셀스카브 | 아밀로이드의 하향-조절을 위한 신규한 방법 |
WO2001062284A2 (en) * | 2000-02-21 | 2001-08-30 | Pharmexa A/S | Novel method for down-regulation of amyloid |
IL142802A (en) * | 2000-04-27 | 2015-01-29 | Enzo Therapeutics Inc | Use of one or more HBV antigens for the preparation of oral pharmaceutical preparations for the treatment of a person with active HBV infection or hepatocellular carcinoma |
WO2001093804A2 (en) * | 2000-06-02 | 2001-12-13 | Merck & Co., Inc. | Hepatitis c virus conjugates |
US20030092145A1 (en) * | 2000-08-24 | 2003-05-15 | Vic Jira | Viral vaccine composition, process, and methods of use |
US9974847B2 (en) * | 2000-08-24 | 2018-05-22 | Immunitor USA, Inc. | Treatment and prevention of tuberculosis |
WO2002020616A1 (en) * | 2000-09-01 | 2002-03-14 | Epimmune Inc. | Hla-a2.1 binding peptides and their uses |
EP1195381A1 (de) * | 2000-09-28 | 2002-04-10 | Immusystems GmbH | CD4+ T-Lymphozyten spezifische Hepatitis C Virus-Epitope |
US7097837B2 (en) * | 2001-02-19 | 2006-08-29 | Pharmexa A/S | Synthetic vaccine agents |
AU2002259130A1 (en) | 2001-05-03 | 2002-11-18 | Eli Lilly And Company | Agents for treatment of hcv and methods of use |
US20030224011A1 (en) * | 2001-05-29 | 2003-12-04 | Conley Anthony J | Hepatitis c virus conjugates |
MY144532A (en) * | 2001-08-20 | 2011-09-30 | Lundbeck & Co As H | Novel method for down-regulation of amyloid |
AU2003301865A1 (en) * | 2002-05-16 | 2004-06-07 | The General Hospital Corporation | Epitopes of hepatitis c virus |
FR2839722A1 (fr) * | 2002-05-17 | 2003-11-21 | Bio Merieux | Nouvelles compositions peptidiques et leur utilisation notamment dans la preparation de compositions pharmaceutiques actives contre le virus de l'hepatite c |
AU2003254585A1 (en) | 2002-07-24 | 2004-02-16 | Intercell Ag | Antigens encoded by alternative reading frame from pathogenic viruses |
AU2003258672B2 (en) | 2002-09-13 | 2008-10-30 | Intercell Ag | Method for isolating hepatitis C virus peptides |
ES2543084T3 (es) | 2003-02-18 | 2015-08-14 | Baylor College Of Medicine | Activación inducida en células dendríticas |
AU2004224746B2 (en) | 2003-03-24 | 2009-04-23 | Valneva Austria Gmbh | Improved vaccines |
CN1822856B (zh) | 2003-07-11 | 2010-04-28 | 英特塞尔股份公司 | Hcv疫苗 |
FR2862648B1 (fr) * | 2003-11-21 | 2006-02-03 | Biomerieux Sa | Nouveau peptide immunogene et nouveaux epitopes et utilisations notamment dans la preparation de compositions pharmaceutiques actives contre le virus de l 'hepatite c |
CA2566506A1 (en) * | 2004-06-01 | 2005-12-15 | Innogenetics N.V. | Peptides for inducing a ctl and/or htl response to hepatitis c virus |
CA2608193A1 (en) * | 2005-05-11 | 2006-11-23 | The Trustees Of The University Of Pennsylvania | Methods for the rapid expansion of antigen specific t-cells |
US9216212B2 (en) | 2005-08-05 | 2015-12-22 | University Of Massachusetts | Virus-like particles as vaccines for paramyxovirus |
US7951384B2 (en) * | 2005-08-05 | 2011-05-31 | University Of Massachusetts | Virus-like particles as vaccines for paramyxovirus |
EP1976981A2 (de) * | 2005-11-10 | 2008-10-08 | The University Of Chicago | Hcv-reaktive t-zellrezeptoren |
CN101336110B (zh) | 2006-06-01 | 2011-06-01 | 程云 | 预防或治疗肝损伤的肽及其衍生物及其应用 |
CA2666667C (en) * | 2006-10-19 | 2023-06-20 | Baylor College Of Medicine | Generating an immune response by inducing cd40 and pattern recognition receptors |
EP2331680B1 (de) | 2008-09-22 | 2017-05-03 | Baylor College Of Medicine | Verfahren und zusammensetzungen zur erzeugung einer immunreaktion mittels cd40-induktion sowie strukturerkennungsrezeptoradaptern |
WO2010039224A2 (en) * | 2008-09-30 | 2010-04-08 | University Of Massachusetts Medical School | Respiratory syncytial virus (rsv) sequences for protein expression and vaccines |
AU2010280981B2 (en) * | 2009-08-05 | 2016-01-28 | Nexigen Gmbh | Human HCV-interacting proteins and methods of use |
US9089520B2 (en) | 2010-05-21 | 2015-07-28 | Baylor College Of Medicine | Methods for inducing selective apoptosis |
JP5930967B2 (ja) | 2010-09-08 | 2016-06-08 | 学校法人 埼玉医科大学 | C型肝炎ウイルスリポソームワクチン |
WO2012072088A1 (en) | 2010-12-02 | 2012-06-07 | Bionor Immuno As | Peptide scaffold design |
CA2821995C (en) | 2011-01-06 | 2019-02-12 | Bionor Immuno As | Monomeric and multimeric peptides immunogenic against hiv |
US20140155469A1 (en) | 2011-04-19 | 2014-06-05 | The Research Foundation Of State University Of New York | Adeno-associated-virus rep sequences, vectors and viruses |
JP2014530009A (ja) | 2011-09-29 | 2014-11-17 | エーピーオー‐ティー ビー.ヴイ. | 異常細胞を標的とする多重特異性結合分子 |
CA2860914A1 (en) | 2012-01-13 | 2013-07-18 | Apo-T B.V. | Aberrant cell-restricted immunoglobulins provided with a toxic moiety |
CA2874923C (en) | 2012-06-06 | 2021-08-31 | Bionor Immuno As | Peptides derived from viral proteins for use as immunogens and dosage reactants |
EP2864354A1 (de) * | 2012-06-26 | 2015-04-29 | Apo-T B.V. | Gegen pathogene gerichtete bindungsmoleküle |
US9434935B2 (en) | 2013-03-10 | 2016-09-06 | Bellicum Pharmaceuticals, Inc. | Modified caspase polypeptides and uses thereof |
JP6541639B2 (ja) | 2013-03-14 | 2019-07-10 | ベリカム ファーマシューティカルズ, インコーポレイテッド | T細胞増殖をコントロールするための方法 |
ES2791598T3 (es) | 2013-06-05 | 2020-11-05 | Bellicum Pharmaceuticals Inc | Métodos para inducir apoptosis parcial utilizando polipéptidos de caspasa |
CA2937750A1 (en) | 2014-02-14 | 2015-08-20 | Bellicum Pharmaceuticals, Inc. | Methods for activating t cells using an inducible chimeric polypeptide |
EP3189148A4 (de) | 2014-09-02 | 2018-05-02 | Bellicum Pharmaceuticals, Inc. | Co-stimulierung von chimären antigenrezeptoren durch myd88- und cd40-polypeptide |
EP3215522B1 (de) | 2014-11-03 | 2021-12-01 | Academisch Ziekenhuis Leiden H.O.D.N. Leids Universitair Medisch Centrum | Gegen bob1 gerichtete t-zell-rezeptoren und verwendungen davon |
CA2978171A1 (en) | 2015-03-10 | 2016-09-15 | J.H. Frederik Falkenburg | T-cell receptors directed against the preferentially expressed antigen of melanoma and uses thereof |
WO2017180420A1 (en) * | 2016-04-11 | 2017-10-19 | Board Of Regents, The University Of Texas System | Methods and compositions for detecting single t cell receptor affinity and sequence |
WO2018055535A2 (en) | 2016-09-21 | 2018-03-29 | The Governors Of The University Of Alberta | Hepatitis c virus immunogenic compositions and methods of use thereof |
EP3621988A1 (de) | 2017-05-09 | 2020-03-18 | Bellicum Pharmaceuticals, Inc. | Verfahren zur verstärkung oder änderung der signaltransduktion |
US20200347148A1 (en) | 2017-12-08 | 2020-11-05 | Bellicum Pharmaceuticals, Inc. | Methods for enhancing and maintaining car-t cell efficacy |
EP4259163A2 (de) * | 2020-12-09 | 2023-10-18 | Tevogen Bio Inc. | Virusspezifische t-zellen und verfahren zur behandlung und prävention von virusinfektionen |
Family Cites Families (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5017558A (en) * | 1980-01-14 | 1991-05-21 | The Regents Of The University Of California | Synthetic vaccine peptide epitomes of hepatitis B surface antigen |
ZW18282A1 (en) * | 1981-08-31 | 1983-03-23 | Genentech Inc | Preparation of polypeptides in vertebrate cell culture |
US4803164A (en) * | 1981-08-31 | 1989-02-07 | Genentech, Inc. | Preparation of hepatitis b surface antigen in yeast |
US4977092A (en) * | 1985-06-26 | 1990-12-11 | Amgen | Expression of exogenous polypeptides and polypeptide products including hepatitis B surface antigen in yeast cells |
DK154394C (da) * | 1982-10-21 | 1989-04-24 | Apv Pasilac As | Fremgangsmaade til at foroege kapaciteten af anlaeg for membranfiltrering af maelk eller maelkeprodukter til foderstoffer eller vaekstmedier. |
JPS59101426A (ja) * | 1982-11-29 | 1984-06-12 | Green Cross Corp:The | B型肝炎感染予防用ワクチンの製造方法 |
US4625918A (en) * | 1983-07-29 | 1986-12-02 | Diesel Kiki Co., Ltd. | Fuel injection valve |
US4847080A (en) * | 1984-03-07 | 1989-07-11 | New York Blood Center, Inc. | Pre-S gene coded peptide hepatitis B immunogens, vaccines, diagnostics, and synthetic lipide vesicle carriers |
US4599231A (en) * | 1984-03-09 | 1986-07-08 | Scripps Clinic And Research Foundation | Synthetic hepatitis B virus vaccine including both T cell and B cell determinants |
US4599230A (en) * | 1984-03-09 | 1986-07-08 | Scripps Clinic And Research Foundation | Synthetic hepatitis B virus vaccine including both T cell and B cell determinants |
US4624918A (en) | 1984-07-09 | 1986-11-25 | Genentech, Inc. | Purification process for hepatitis surface antigen and product thereof |
JPS6137738A (ja) * | 1984-07-31 | 1986-02-22 | Tetsuo Nakamura | B型肝炎ワクチン |
US4690915A (en) * | 1985-08-08 | 1987-09-01 | The United States Of America As Represented By The Department Of Health And Human Services | Adoptive immunotherapy as a treatment modality in humans |
US4882145A (en) * | 1986-12-09 | 1989-11-21 | Scripps Clinic And Research Foundation | T cell epitopes of the hepatitis B virus nucleocapsid protein |
US5350671A (en) * | 1987-11-18 | 1994-09-27 | Chiron Corporation | HCV immunoassays employing C domain antigens |
KR0185373B1 (ko) * | 1989-03-17 | 1999-05-01 | 로버트 피. 블랙버언 | Hcv 폴리단백질에서 유래되는 hcv 아미노산 서열 부분을 포함하는 폴리펩티드 및 그 사용 |
US5372928A (en) * | 1989-09-15 | 1994-12-13 | Chiron Corporation | Hepatitis C virus isolates |
IT1237764B (it) * | 1989-11-10 | 1993-06-17 | Eniricerche Spa | Peptidi sintetici utili come carriers universali per la preparazione di coniugati immunogenici e loro impiego per lo sviluppo di vaccini sintetici. |
US5106726A (en) * | 1990-02-16 | 1992-04-21 | United Biomedical, Inc. | Synthetic peptides specific for the detection of antibodies to HCV |
JPH0454197A (ja) * | 1990-06-19 | 1992-02-21 | Chemo Sero Therapeut Res Inst | C型肝炎ウイルス抗体検出用合成ペプチド抗原、その組成物およびその使用方法 |
AU652941B2 (en) * | 1990-06-25 | 1994-09-15 | Research Foundation For Microbial Diseases Of Osaka University, The | Non-A, Non-B hepatitis virus particles |
RO117329B1 (ro) * | 1991-06-24 | 2002-01-30 | Chiron Corp Emeryville | Polipeptide care contin o secventa a virusului hepatitei c |
US6419931B1 (en) | 1991-08-26 | 2002-07-16 | Epimmune Inc. | Compositions and methods for eliciting CTL immunity |
ATE179716T1 (de) | 1992-03-06 | 1999-05-15 | Innogenetics Nv | Verfahren zur bestimmung von peptiden, die immunologisch wichtigen epitopen von hcv zugehörig sind |
US5980899A (en) | 1992-06-10 | 1999-11-09 | The United States Of America As Represented By The Department Of Health And Human Services | Identification of peptides that stimulate hepatitis C virus specific cytotoxic T cells |
KR960700739A (ko) * | 1993-03-05 | 1996-02-24 | 카린 이스텀 | Hla-a2. 1 결합 펩티드 및 그의 용도(hla-a2. 1 binding peptides and their uses) |
US6555114B1 (en) * | 1993-11-04 | 2003-04-29 | Innogenetics N.V. | Immunodominant human T-cell epitopes of hepatitis C virus |
AU697171B2 (en) * | 1994-04-08 | 1998-10-01 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Hepatitis C virus core peptide for stimulation of cytotoxic T lymphocytes and diagnosis of HCV exposure |
-
1994
- 1994-03-17 US US08/214,650 patent/US5709995A/en not_active Expired - Lifetime
-
1995
- 1995-03-16 JP JP52415195A patent/JP3844494B2/ja not_active Expired - Lifetime
- 1995-03-16 WO PCT/US1995/003224 patent/WO1995025122A1/en active IP Right Grant
- 1995-03-16 EP EP95914048A patent/EP0759937B2/de not_active Expired - Lifetime
- 1995-03-16 CA CA2184890A patent/CA2184890C/en not_active Expired - Lifetime
- 1995-03-16 DE DE69518642T patent/DE69518642T3/de not_active Expired - Lifetime
- 1995-03-16 AT AT95914048T patent/ATE195953T1/de not_active IP Right Cessation
-
1997
- 1997-05-12 US US08/854,825 patent/US7220420B2/en not_active Expired - Fee Related
-
2005
- 2005-03-07 JP JP2005061923A patent/JP4394019B2/ja not_active Expired - Lifetime
-
2006
- 2006-06-07 JP JP2006158108A patent/JP4463786B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DE69518642T2 (de) | 2001-05-03 |
JP3844494B2 (ja) | 2006-11-15 |
JP4394019B2 (ja) | 2010-01-06 |
ATE195953T1 (de) | 2000-09-15 |
CA2184890A1 (en) | 1995-09-21 |
JP2005247852A (ja) | 2005-09-15 |
US7220420B2 (en) | 2007-05-22 |
JPH09510455A (ja) | 1997-10-21 |
EP0759937A1 (de) | 1997-03-05 |
DE69518642T3 (de) | 2009-05-14 |
JP2006265264A (ja) | 2006-10-05 |
JP4463786B2 (ja) | 2010-05-19 |
EP0759937B1 (de) | 2000-08-30 |
WO1995025122A1 (en) | 1995-09-21 |
CA2184890C (en) | 2011-05-24 |
US5709995A (en) | 1998-01-20 |
EP0759937B2 (de) | 2008-12-31 |
US20020115061A1 (en) | 2002-08-22 |
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