KR920700631A - 광화학 요법에 의한 악성 및 비악성 병소의 검사 및 치료방법 - Google Patents

광화학 요법에 의한 악성 및 비악성 병소의 검사 및 치료방법

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Publication number
KR920700631A
KR920700631A KR1019910700294A KR910700294A KR920700631A KR 920700631 A KR920700631 A KR 920700631A KR 1019910700294 A KR1019910700294 A KR 1019910700294A KR 910700294 A KR910700294 A KR 910700294A KR 920700631 A KR920700631 A KR 920700631A
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South Korea
Prior art keywords
endometrium
malignant
lesions
protoporphyrin
skin
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KR1019910700294A
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English (en)
Other versions
KR0178277B1 (ko
Inventor
제임스 씨. 케네디
로이 에이치. 포티르
로버트 엘. 라이드
Original Assignee
윌리암 맥래치·마가렛 후이
퀸즈 유니버시티 엣 킹스턴
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Application filed by 윌리암 맥래치·마가렛 후이, 퀸즈 유니버시티 엣 킹스턴 filed Critical 윌리암 맥래치·마가렛 후이
Publication of KR920700631A publication Critical patent/KR920700631A/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0061—5-aminolevulinic acid-based PDT: 5-ALA-PDT involving porphyrins or precursors of protoporphyrins generated in vivo from 5-ALA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Radiation-Therapy Devices (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

내용 없음

Description

광화학 요법에 의한 악성 및 비악성 병소의 검사 및 치료방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (11)

  1. 환자의 피부 : 결막; 호흡기, 소화기 및 질 점막; 자궁내막; 및 요로상피의 병소에서 프로토포르피린 Ⅸ의 합성을 유발시키도록 5-아미노레블린산의 유효량을 그 병소에 투여하고, 프로토포르피린 Ⅸ의 광할성 작용 스펙트럼 이내의 광선에 병소를 노출시키는 것으로 이루어진 환자의 피부; 결막; 호흡기, 소화기 및 질 점막; 자궁내막; 및 요로 상피의 악성 및 비악성 조직이상과 병소의 치료방법.
  2. 제1항에 있어서, 상기 악성 병소가 기저암, 염기-편평암 및 편평암 중에서 선택도는 것을 특징으로 하는 치료방법.
  3. 제1항에 있어서, 상기 비악성 병소가 건선 및 생식기 혹중에서 선택되는 것을 특징으로 하는 치료방법.
  4. 제1항에 있어서, 상기 광활성 광선이 350-635nm인 것을 특징으로하는 치료방법.
  5. 5-아미노레블린산을 자궁내막에 국부투여하고 프로토포프린 Ⅸ의 광활성 작용 스펙트럼 이내의 파장을 가진 광선에 그 자궁내막을 노출시키는 것으로 이루어진 월경과다의 치료방법.
  6. 제1항에 있어서, 상기 5-아미노레블린산을 비경구투여하는 것을 특징으로 하는 치료방법.
  7. 제1항에 있어서, 상기 5-아미노레블린산을 국부투여하는 것을 특징으로 하는 치료방법.
  8. 제1항에 있어서, 상기 5-아미노레블린산을 경구투여하는 것을 특징으로 하는 치료방법.
  9. 환자의 피부, 점막, 자궁내막 및 요로상피의 병소에서 헴이 프로토포르피린 Ⅸ의 합성을 유발시키도록 생합성 경로로 프로토포르피린 Ⅸ의 전구체 유효량을 환자에게 투여하고, 프로토포르프린 Ⅸ의 광할성 작용 스펙트럼 이내의 광선에 그 병소를 노출시키는 것으로 이루어진 환자의 피부, 점막, 자궁내막 및 요로상피의 악성 및 비악성 광중식 병소의 치료방법.
  10. 제9항에 있어서, 상기 전구체가 5-아미노레블린산인 것을 특징으로 하는 치료방법.
  11. 환자의 피부, 점막, 자궁내막 및 요로상피의 악성 및 비악성 조직이상 및 병소에서 헴이 우선적으로 프로토포르피린 Ⅸ의 합성을 유발시키도록 생합성 경로로 프로토포르피린 Ⅸ의 전구체 유효량을 환자에게 투여하고, 프로토포르프린 Ⅸ의 스펙트럼 이내의 파장을 가진 광선에 환자를 노출시켜 상기 이상 변소에 형광을 유발시킨 다음, 그 형광을 검출하는 것으로 이루어진 환자의 피부, 점막, 자궁내막 및 요로상피의 악성 및 비악성 광중식 병소의 검사방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개되는 것임.
KR1019910700294A 1989-07-28 1990-07-25 광화학 요법에 의한 악성 및 비악성 병소의 검사 및 치료용 제약 조성물 KR0178277B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US07/386,414 US5079262A (en) 1989-07-28 1989-07-28 Method of detection and treatment of malignant and non-malignant lesions utilizing 5-aminolevulinic acid
US386414 1989-07-28
US386,414 1989-07-28
PCT/CA1990/000233 WO1991001727A2 (en) 1989-07-28 1990-07-25 Method of detection and treatment of malignant and non-malignant lesions by photochemotherapy

Publications (2)

Publication Number Publication Date
KR920700631A true KR920700631A (ko) 1992-08-10
KR0178277B1 KR0178277B1 (ko) 1999-03-20

Family

ID=23525469

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019910700294A KR0178277B1 (ko) 1989-07-28 1990-07-25 광화학 요법에 의한 악성 및 비악성 병소의 검사 및 치료용 제약 조성물

Country Status (6)

Country Link
US (2) US5079262A (ko)
JP (1) JP2731032B2 (ko)
KR (1) KR0178277B1 (ko)
AU (1) AU624985B2 (ko)
NL (1) NL194694C (ko)
WO (1) WO1991001727A2 (ko)

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JP2731032B2 (ja) 1998-03-25
AU6034390A (en) 1991-03-11
US5211938B1 (en) 1997-07-08
NL194694B (ko) 2002-08-01
US5211938A (en) 1993-05-18
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US5079262A (en) 1992-01-07
NL9021172A (nl) 1991-07-01

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