KR920021519A - 고순도 1-(3-클로로페닐)-4-메틸-7,8-디메톡시-5h-2,3-벤조디아제핀의 제조방법 - Google Patents

고순도 1-(3-클로로페닐)-4-메틸-7,8-디메톡시-5h-2,3-벤조디아제핀의 제조방법 Download PDF

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Publication number
KR920021519A
KR920021519A KR1019920007570A KR920007570A KR920021519A KR 920021519 A KR920021519 A KR 920021519A KR 1019920007570 A KR1019920007570 A KR 1019920007570A KR 920007570 A KR920007570 A KR 920007570A KR 920021519 A KR920021519 A KR 920021519A
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South Korea
Prior art keywords
benzodiazepine
methyl
structural formula
following structural
solvent
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KR1019920007570A
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English (en)
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소모기 기요기
보트카 페터
하모리 타마스
코로시 제노
키스 칠라
발로프 티보르
비들로 니 이글로이 마리아
호바츠 기율라
시메이 알탄
기엔게 로짜
모라프시크 임레
오르반 에르노
우스케르트 니 디발드 에밀리아
Original Assignee
원본미기재
에기스 기오기스제르갸르 알티.
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Publication of KR920021519A publication Critical patent/KR920021519A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/12—1,5-Benzodiazepines; Hydrogenated 1,5-benzodiazepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/02—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

내용 없음

Description

고순도 1-(3-클로로페닐)-4-메틸-7,8-디메톡시-5H-2,3-벤조디아제핀의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (6)

  1. 다음 구조식(Ⅱ)로 표시되는 2-아세토닐-3'-클로로-4,5-메톡시벤조페논 1몰 및 히드라진 수화물 3 내지 7몰을 유기용매 또는 유기용매의 혼합물중에서 15 내지 85℃의 온도로 반응시킨후, 얻어진 조생성물을 탄소원자 1 내지 5개의 지방족 알콜로 재결정시켜서 1-(3-클로로페닐)-4-메틸-7,8-디메톡시-5H-2,3-벤조디아제핀을 제조하는데 있어서, 상기 2-아세토닐-3'-클로로-4,5-디메톡시벤조페논과 히드라진 수화물과의 반응을 공기산소 부재하에, 필요에 따라서 물의 존재하에서 실시하는 것임을 특징으로 하는 고순도 및 제약학적 용도로 사용되기에 적당한 특성을 갖는 다음 구조식(Ⅰ)로 표시되는 1-(3-클로로페닐)-4-메틸-7,8-디메톡시-5H-2,3-벤조디아제핀의 제조방법.
  2. 제1항에 있어서, 상기 용매는 탄소원자 1 내지 5개의 일가 또는 다가 지방족 알콜, 디메틸포름아미드, 디메틸술폭시드, 염소화 탄화수소, 과산화물-유리 디옥산, 테트라히드로퓨란, 이들의 혼합물 또는 가능하면 상기 용매와 물과의 혼합물인 것임을 특징으로 하는 방법.
  3. 제1항 또는 제2항에 있어서, 상기 반응은 질소 또는 영족기체의 분위기하에서 실시하는 것임을 특징으로 하는 방법.
  4. 다음 구조식(Ⅴ)로 표시되는 화합물 및/또는 특히 다음 구조식(Ⅲ)으로 표시되는 화합물을 불순물로 함유하는 다음 구조식(Ⅰ)로 표시되는 1-(3-클로로페닐)-4-메틸-7,8-디메톡시-5H-2,3-벤조디아제핀을 정제시키는데 있어서, 다음 구조식(Ⅰ)로 표시되는 오염된 화합물을 비양자성 용매중에 용해시킨 후, 이것을 알칼리 수산화물, 알칼리탄산염 또는 알칼리 알콜산염으로 처리한 다음, 다음 구조식(Ⅰ)로 표시되는 화합물을 상기 용액으로부터 결정화시키고, 필요에 따라서 탄소원자수가 1 내지 5개인 지방족 알콜로 재결정시켜서 되는 것임을 특징으로 하는 다음 구조식(Ⅰ)로 표시되는 1-(3-클로로페닐)-4-메틸-7,8-디메톡시-5H-2,3-벤조디아제핀의 정제방법.
  5. 제4항에 있어서, 상기 용매는 탄소원자 1 내지 5개의 일가 또는 다가 지방족 알콜 또는 그들의 혼합물인 것임을 특징으로 하는 방법.
  6. 제4항에 또는 제5항에 있어서, 상기 알칼리 수산화물, 알칼리 탄산염 또는 알칼리 알콜산염으로 처리하는 공정은 용매의 비등점에서 실시하는 것을 특징으로 하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개되는 것임
KR1019920007570A 1991-05-03 1992-05-04 고순도 1-(3-클로로페닐)-4-메틸-7,8-디메톡시-5h-2,3-벤조디아제핀의 제조방법 KR920021519A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU1482/91 1991-05-03
HU911482A HU208429B (en) 1991-05-03 1991-05-03 Process for producing 1-/3-chloro-phenyl/-4-methyl-7,8-dimethoxy-5h-2,3-benzodiazepine of high purity

Publications (1)

Publication Number Publication Date
KR920021519A true KR920021519A (ko) 1992-12-18

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ID=10954672

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KR1019920007570A KR920021519A (ko) 1991-05-03 1992-05-04 고순도 1-(3-클로로페닐)-4-메틸-7,8-디메톡시-5h-2,3-벤조디아제핀의 제조방법

Country Status (11)

Country Link
US (1) US5288863A (ko)
EP (1) EP0512419B1 (ko)
JP (1) JPH0656800A (ko)
KR (1) KR920021519A (ko)
CN (1) CN1067652A (ko)
AT (1) ATE115571T1 (ko)
DE (1) DE69200889T2 (ko)
GB (1) GB2255338B (ko)
HU (1) HU208429B (ko)
RU (1) RU2065852C1 (ko)
YU (1) YU44992A (ko)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19604920A1 (de) 1996-02-01 1997-08-07 Schering Ag Neue 2,3-Benzodiazepinderivate, deren Herstellung und Verwendung als Arzneimittel
ZA972746B (en) * 1996-04-04 1998-10-09 Egyt Gyogyszervegyeszeti Gyar Novel 2,3-benzodiazepine derivatives
HU9600871D0 (en) * 1996-04-04 1996-05-28 Gyogyszerkutato Intezet New 2,3-benzodiazepine derivatives
EP1567161A4 (en) * 2002-12-03 2008-09-03 Vela Acquisition Corp PHARMACEUTICAL COMPOSITION OF 1- (3,4-DIMETHOXYPHENYL) -4-METHYL-5-ETHYL-7-METHOXY-8-HYDROXY-5H-2,3-BENZODIAZEPINE AND ITS USE
US6864251B2 (en) * 2002-12-03 2005-03-08 Vela Pharmaceuticals, Inc. Treatment of LTB4-mediated inflammatory disorders with optically-pure (R)-2,3-benzodiazepines
US7022700B2 (en) * 2002-12-03 2006-04-04 Vela Pharmaceuticals, Inc. Method of increasing neutrophil production using optically-pure (R)-2,3-benzodiazepines
US6638928B1 (en) 2002-12-03 2003-10-28 Vela Pharmaceuticals, Inc. Treatment of irritable bowel syndrome and nonulcer dyspepsia with substituted 2,3-benzodiazepines
MXPA05005893A (es) * 2002-12-03 2006-02-08 Vela Pharmaceuticals Inc Composicion farmaceutica de 1-(3-hidroxi -4-metoxifenil) -4-metil-5 -etil-7, 8-dimetoxi- 5h-2, 3-benzodiazepina y usos de la misma.
US20040162284A1 (en) * 2003-02-19 2004-08-19 Harris Herbert W. Method of lowering body temperature with (S) tofisopam
US20040224943A1 (en) * 2003-02-19 2004-11-11 Leventer Steven M. Method of lowering body temperature with (R) - 2,3-benzodiazepines
PE20070530A1 (es) * 2005-10-26 2007-05-31 Smithkline Beecham Corp Compuestos derivados de tiazoles sustituidos como agentes de apertura de canales de potasio activados por calcio de alta conductancia
EA201590356A1 (ru) 2012-08-16 2015-07-30 Байер Фарма Акциенгезельшафт 2,3-бензодиазепины
EP2958909A1 (de) 2013-02-19 2015-12-30 Bayer Pharma Aktiengesellschaft Bicyclo- und spirocyclisch substituierte 2,3-benzodiazepine
CN110128270B (zh) * 2018-11-09 2022-05-24 郑州手性药物研究院有限公司 2,2-二苯基环丙基类化合物及其合成方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU179018B (en) * 1978-10-19 1982-08-28 Gyogyszerkutato Intezet Process for producing new 5h-2,3-benzodiazepine derivatives
HU191702B (en) * 1984-06-27 1987-03-30 Gyogyszerkutato Intezet New process for preparing 1-aryl-5 h-2,3-benzodiazepines

Also Published As

Publication number Publication date
RU2065852C1 (ru) 1996-08-27
CN1067652A (zh) 1993-01-06
ATE115571T1 (de) 1994-12-15
JPH0656800A (ja) 1994-03-01
DE69200889T2 (de) 1995-05-18
EP0512419B1 (en) 1994-12-14
HUT61005A (en) 1992-11-30
GB2255338A (en) 1992-11-04
HU208429B (en) 1993-10-28
GB9209433D0 (en) 1992-06-17
HU911482D0 (en) 1991-11-28
YU44992A (sh) 1994-11-15
EP0512419A1 (en) 1992-11-11
GB2255338B (en) 1995-01-18
DE69200889D1 (de) 1995-01-26
US5288863A (en) 1994-02-22

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