YU44992A - Postupak za dobijanje 1-(3-hlorofenil)-4-metil-7,8-dimetoksi-5h-2,3-benzodiazepina velike čistoće - Google Patents

Postupak za dobijanje 1-(3-hlorofenil)-4-metil-7,8-dimetoksi-5h-2,3-benzodiazepina velike čistoće

Info

Publication number
YU44992A
YU44992A YU44992A YU44992A YU44992A YU 44992 A YU44992 A YU 44992A YU 44992 A YU44992 A YU 44992A YU 44992 A YU44992 A YU 44992A YU 44992 A YU44992 A YU 44992A
Authority
YU
Yugoslavia
Prior art keywords
formula
benzodiazepine
methyl
chloro
methoxy
Prior art date
Application number
YU44992A
Other languages
English (en)
Inventor
G. Somogyi
P. Botka
T. Hamori
J. Korosi
C. Kiss
T. Bologh
M. Bidlo
G. Horvath
A. Simay
R. Gyenge
I. Moravcsik
E. Orban
E. Uskert
Original Assignee
Egys Gyogyszergyar Rt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egys Gyogyszergyar Rt. filed Critical Egys Gyogyszergyar Rt.
Publication of YU44992A publication Critical patent/YU44992A/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/12—1,5-Benzodiazepines; Hydrogenated 1,5-benzodiazepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/02—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

POSTUPAK ZA DOBIJANJE 1-(3-HLOROFENIL)-4-METIL-7,8-DIMETOKSI-5H-2,3-BENZODIAZEPINA VELIKE ČISTOĆE, pronalazak se odnosi na postupak za dobijanje 1-(3-hlorofenil)-4-mestil-7,8-dimetoksi-5-h-2,3-benzodiazepina formule (I) velike čistoće i kvaliteta podesnih za farmaceutske potrebe. Prema pronalasku reakcija 1 mola 2-acetonil-3'-hloro-4,5-dimetoksi-fenona formule (II) sa 3-7 mola hidrazin hidrata u organskom rastvaraču ili u smeši organskih rastvarača na temperaturi izmedju 15В°C i 85В°C vrši se u odsustvu kiseonika iz vazduha, opcionalno u prisustvu vode. Sirovi proizvod se zatim rekristališe iz alifatičnog alkohola koji sadrži 1 do 5 atoma ugljenika. Pronalazak se takodje odnosi na postupak za prečišćavanje 1-(3-hlorofenil)-4-metil-7,8-dimetoksi-5H-2,3-ben-zodiazepina formule (I).
YU44992A 1991-05-03 1992-04-24 Postupak za dobijanje 1-(3-hlorofenil)-4-metil-7,8-dimetoksi-5h-2,3-benzodiazepina velike čistoće YU44992A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU911482A HU208429B (en) 1991-05-03 1991-05-03 Process for producing 1-/3-chloro-phenyl/-4-methyl-7,8-dimethoxy-5h-2,3-benzodiazepine of high purity

Publications (1)

Publication Number Publication Date
YU44992A true YU44992A (sh) 1994-11-15

Family

ID=10954672

Family Applications (1)

Application Number Title Priority Date Filing Date
YU44992A YU44992A (sh) 1991-05-03 1992-04-24 Postupak za dobijanje 1-(3-hlorofenil)-4-metil-7,8-dimetoksi-5h-2,3-benzodiazepina velike čistoće

Country Status (11)

Country Link
US (1) US5288863A (sh)
EP (1) EP0512419B1 (sh)
JP (1) JPH0656800A (sh)
KR (1) KR920021519A (sh)
CN (1) CN1067652A (sh)
AT (1) ATE115571T1 (sh)
DE (1) DE69200889T2 (sh)
GB (1) GB2255338B (sh)
HU (1) HU208429B (sh)
RU (1) RU2065852C1 (sh)
YU (1) YU44992A (sh)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19604920A1 (de) * 1996-02-01 1997-08-07 Schering Ag Neue 2,3-Benzodiazepinderivate, deren Herstellung und Verwendung als Arzneimittel
HU9600871D0 (en) * 1996-04-04 1996-05-28 Gyogyszerkutato Intezet New 2,3-benzodiazepine derivatives
ZA972746B (en) * 1996-04-04 1998-10-09 Egyt Gyogyszervegyeszeti Gyar Novel 2,3-benzodiazepine derivatives
MXPA05005895A (es) * 2002-12-03 2006-02-08 Vela Pharmaceuticals Inc Composicion farmaceutica de 1-(3, 4-dimetoxifenil)-4 -metil-5-etil -7-metoxi-8 -hidroxi- 5h-2, 3-benzodiacepina y usos de la misma.
US7022700B2 (en) * 2002-12-03 2006-04-04 Vela Pharmaceuticals, Inc. Method of increasing neutrophil production using optically-pure (R)-2,3-benzodiazepines
US6864251B2 (en) * 2002-12-03 2005-03-08 Vela Pharmaceuticals, Inc. Treatment of LTB4-mediated inflammatory disorders with optically-pure (R)-2,3-benzodiazepines
WO2004069155A2 (en) * 2002-12-03 2004-08-19 Vela Pharmaceuticals, Inc. Pharmaceutical composition of 1-(3-hydroxy-4-methoxyphenyl)-4-methyl-5-ethyl-7,8-dimethoxy-5h-2,3-benzodiazepine and uses therof
US6638928B1 (en) 2002-12-03 2003-10-28 Vela Pharmaceuticals, Inc. Treatment of irritable bowel syndrome and nonulcer dyspepsia with substituted 2,3-benzodiazepines
US20040162284A1 (en) * 2003-02-19 2004-08-19 Harris Herbert W. Method of lowering body temperature with (S) tofisopam
US20040224943A1 (en) * 2003-02-19 2004-11-11 Leventer Steven M. Method of lowering body temperature with (R) - 2,3-benzodiazepines
AR056720A1 (es) * 2005-10-26 2007-10-17 Smithkline Beecham Corp Compuesto de tiazol substtuido composicion farmaceuticamente que lo comprende y su uso para preparar un medicamento
US9890147B2 (en) 2012-08-16 2018-02-13 Bayer Pharma Aktiengesellshaft 2,3-benzodiazepines
MA38346B1 (fr) 2013-02-19 2019-05-31 Bayer Pharma AG 2,3-benzodiazépines bicyclo- et spirocyclosubstituées
CN110128270B (zh) * 2018-11-09 2022-05-24 郑州手性药物研究院有限公司 2,2-二苯基环丙基类化合物及其合成方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU179018B (en) * 1978-10-19 1982-08-28 Gyogyszerkutato Intezet Process for producing new 5h-2,3-benzodiazepine derivatives
HU191702B (en) * 1984-06-27 1987-03-30 Gyogyszerkutato Intezet New process for preparing 1-aryl-5 h-2,3-benzodiazepines

Also Published As

Publication number Publication date
GB9209433D0 (en) 1992-06-17
DE69200889T2 (de) 1995-05-18
HU911482D0 (en) 1991-11-28
ATE115571T1 (de) 1994-12-15
EP0512419A1 (en) 1992-11-11
HU208429B (en) 1993-10-28
EP0512419B1 (en) 1994-12-14
JPH0656800A (ja) 1994-03-01
US5288863A (en) 1994-02-22
GB2255338A (en) 1992-11-04
KR920021519A (ko) 1992-12-18
DE69200889D1 (de) 1995-01-26
RU2065852C1 (ru) 1996-08-27
HUT61005A (en) 1992-11-30
GB2255338B (en) 1995-01-18
CN1067652A (zh) 1993-01-06

Similar Documents

Publication Publication Date Title
YU44992A (sh) Postupak za dobijanje 1-(3-hlorofenil)-4-metil-7,8-dimetoksi-5h-2,3-benzodiazepina velike čistoće
HU204506B (en) Process for producing phenyl-hydrazine derivatives
EP2192117B1 (en) Organic amine salt of 6-fluoro-3-hydroxy-2-pyrazinecarbonitrile and method for producing the same
EP1982983B1 (en) Improved process for producing moxonidine
LU83609A1 (fr) Procede de preparation de derives d'acides quinoleine-carboxyliques
KR920014787A (ko) 2-(2',4'-디하이드록시페닐)-4,6-디아릴-s-트리아진의 제조방법
EP1873152B1 (en) Novel purification process of moxonidine
KR20020062362A (ko) 피라졸로피리다진 유도체의 제조 방법
SE464707B (sv) Nya 2-(difenylmetylpiperazinyl)-1-fenyletanol-derivat, foerfarande foer deras framstaellning samt farmaceutiskt preparat
Loev et al. 2-Sulfobenzoic acid esters. I. 2-Sulfamyl derivatives
EP0729947A1 (en) Process for the methylation of 2,2,6,6-tetramethylpiperidin-4-one
JP2889838B2 (ja) ハロゲン化エーテルの製造方法
Ulrich et al. Cycloaddition reactions of isocyanates. Addition of sulfonyl isocyanates to carbodiimides
FI102748B (fi) Menetelmä N-(2,6-dialkyylifenyyli)-2-(2-okso-1-pyrrolidinyyli)asetamid ijohdannaisen valmistamiseksi
US6160160A (en) Process for preparing benzyl carbazates
EP0133322A1 (en) Fluorinated benzodiazepins
JPH02149550A (ja) Ｎ―（２―カルボキシ―３’，４’―ジメトキシ―シンナモイル）―アンスラニル酸及びその製造方法
HU203540B (en) Process for producing 1-propargyl-2,4-dioxo-imidazolidine
US4010160A (en) Process for the manufacture of 1,3-bis-(β-ethylhexyl)-5-amino-5-methyl-hexahydropyrimidine
AU680989B2 (en) Method of preparing 6-aryloxymethyl-1-hydroxy-4-methyl-2-pyridones
JP2000119260A (ja) 新規な酸化防止機能を有する反応型紫外線吸収剤化合物
CA1137482A (en) Process for the production of 5-aminoisoxazoles
US5159086A (en) Process for the preparation of pyrazolecarboxylic acid derivatives
CA1289558C (en) Purification of 1-(alkylamino)-alkyl-2-keto-1,4- diazacycloalkanes
Satsumabayashi et al. Stereochemistry of organic compounds (2): Conformation of oxazolidinone derivatives