KR920011491A - 헥사히드로-8-히드록시-2, 6-메타노-2h-퀴놀리진-3(4h)-온 및 관련 화합물의 특정 에스테르를 함유하는 인식 장애 치료용 제약 조성물 - Google Patents

헥사히드로-8-히드록시-2, 6-메타노-2h-퀴놀리진-3(4h)-온 및 관련 화합물의 특정 에스테르를 함유하는 인식 장애 치료용 제약 조성물 Download PDF

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KR920011491A
KR920011491A KR1019910023701A KR910023701A KR920011491A KR 920011491 A KR920011491 A KR 920011491A KR 1019910023701 A KR1019910023701 A KR 1019910023701A KR 910023701 A KR910023701 A KR 910023701A KR 920011491 A KR920011491 A KR 920011491A
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South Korea
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alkyl
quinolizine
methano
pharmaceutical composition
hexahydro
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KR1019910023701A
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KR100220878B1 (ko
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워드 기토스 모리스
위베르 마르셀
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스티븐 에리. 네스비트
메렐 다우 파마슈티칼스 인크.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

내용 없음

Description

헥사히드로-8-히드록시-2, 6-메타노-2H-퀴놀리진-3(4H)-온 및 관련 화합물의 특정 에스테르를 함유하는 인식 장애 치료용 제약 조성물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (4)

  1. 치료 유효량의 하기 일반식(1)의 화합물 또는 그의 제약학상 허용되는 산 부가염 또는 4급 암모늄염으로 이루어진 인식 장애 치료용 제약 조성물.
    상기 식 중, A는 =H2, =O, =(H)(OH) 또는 =N-OH이고, B는 =H2, =(H)(CH3), =(H)(CH2NR3R4) 또는 =CH2이고, R3및 R4는 각각 C2-4알킬이거나 또는 함께 테트라메틸렌, 펜타메틸렌 또는 -CH2CH2-O-CH2CH2-이고,
    R1은
    Z는 NR9, O 또는 S이고, R5, R6및 R8은 각각 수소, 할로겐, C1-3알킬 또는 C1-3알콕시이고, R7은 수소, 아미노, (C1-4알킬)아미노, (C1-4알킬)2아미노, C1-3알콕시 또는 니트로이고, R9는 수소, C1-4알킬 또는 페닐(C1-2알킬)이고, R10은 수소, 할로겐, C1-4알킬, C1-4알콕시, 히드록시, 시아노 또는 -CONH2이고, R11은 수소, 할로겐, C1-4알킬 또는 페닐이고, 물결 모양의 선은 고리 상의 산소 치환체의 배위가 엔도 또는 엑소일 수 있다는 것을 나타낸다.
  2. 제1항에 있어서, 상기 화합물이 트랜스-헥사히드로-8-(3-인돌릴 카르보닐옥시(2, 6-메타노-2H-퀴놀리진-3(4H)-온 또는 트랜스-헥사히드로-8-(3-인돌릴카르보닐옥시)-2, 6-메타노-2H-퀴놀리진-3(4H)-올인 제약 조성물.
  3. 제1항에 있어서, 상기 인식 장애가 알쯔하이머병인 제약 조성물.
  4. 제3항에 있어서, 상기 화합물이 트랜스-헥사히드로-8-(3-인돌릴카르보닐옥시)-2, 6-메타노-2H-퀴놀리진-3(4H)-온 또는 트랜스-헥사히드로-8-(3-인돌릴카르보닐옥시)-2, 6-메타노-2H-퀴놀리진-3(4H)-올인 제약 조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019910023701A 1990-12-21 1991-12-20 헥사히드로-8-히드록시-2,6-메타노-2h-퀴놀리진-3(4h)-온 및 관련 화합물의 특정 에스테르를 함유하는 인식 장애 치료용 제약 조성물 KR100220878B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP90403748A EP0492020A1 (en) 1990-12-21 1990-12-21 Use of certain esters of hexahydro-8-hydroxy-2,6-methano-2H-quinolizin-3(4H)-one and related compounds for treating cognitive disorders
EP90403748.8 1990-12-21

Publications (2)

Publication Number Publication Date
KR920011491A true KR920011491A (ko) 1992-07-24
KR100220878B1 KR100220878B1 (ko) 1999-09-15

Family

ID=8205789

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019910023701A KR100220878B1 (ko) 1990-12-21 1991-12-20 헥사히드로-8-히드록시-2,6-메타노-2h-퀴놀리진-3(4h)-온 및 관련 화합물의 특정 에스테르를 함유하는 인식 장애 치료용 제약 조성물

Country Status (6)

Country Link
US (1) US5910501A (ko)
EP (2) EP0492020A1 (ko)
JP (1) JPH04334381A (ko)
KR (1) KR100220878B1 (ko)
AU (1) AU652009B2 (ko)
IE (1) IE914517A1 (ko)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5607938A (en) * 1993-03-08 1997-03-04 Fujisawa Pharmaceutical Co., Ltd. Medicament for treating or preventing cerebrovascular infarction
EP2033632A1 (en) * 2007-09-10 2009-03-11 Novasearch AG 5-HT3 receptor antagonists for the teatment of myocardial infarction, stroke, thrombosis and atherosclerosis

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4605652A (en) * 1985-02-04 1986-08-12 A. H. Robins Company, Inc. Method of enhancing memory or correcting memory deficiency with arylamido (and arylthioamido)-azabicycloalkanes
HU895334D0 (en) * 1986-07-30 1990-01-28 Sandoz Ag Process for the preparation of nasal pharmaceutical compositions
US4906755A (en) * 1986-11-03 1990-03-06 Merrell Dow Pharmaceuticals Inc. Esters of hexahydro-8-hydroxy-2,6-methano-2H-quinolizin-3-(4H)-one and related compounds
ZA878096B (en) * 1986-11-03 1988-04-26 Merrell Dow Pharmaceuticals Inc. Esters of hexahydro-8-hydroxy-2,6-methano-2h-quinolizin-3(4h)-one and related compounds
ATE152623T1 (de) * 1986-12-17 1997-05-15 Glaxo Group Ltd Verwendung von heterozyklischen derivaten zur herstellung von arzneimitteln
JP2608078B2 (ja) * 1986-12-17 1997-05-07 グラクソ、グループ、リミテッド 医 薬
EP0329932B1 (en) * 1988-02-23 1995-10-18 Merrell Pharmaceuticals Inc. Use of quinolizine and quinolizinone derivatives in the manufacture of medicaments
EP0330788A1 (en) * 1988-03-01 1989-09-06 Merrell Dow Pharmaceuticals Inc. Use of quinolizine and quinolizinone derivatives in the manufacture of medicaments for the treatment of cardiac arrhythmia
EP0342558B1 (en) * 1988-05-16 1994-02-02 G.D. Searle & Co. 2-amino-4,5-methyleneadipic acid compounds for treatment of CNS disorders
GB8820651D0 (en) * 1988-09-01 1988-10-05 Glaxo Group Ltd Medicaments
YU150489A (sh) * 1989-08-10 1992-12-21 W.L. Gore & Co. Gmbh. Uređaj za ispitivanje odevnih predmeta na nepromočivost
DE69029737T2 (de) * 1989-10-16 1997-06-19 Hem Pharma Corp Diagnose und behandlung von neuro-cognitiven störungen assoziiert mit systemisch-immunologischer fehlfunktion
ATE108448T1 (de) * 1990-05-11 1994-07-15 Sankyo Co Piperdinyloxy- und chinindidinyloxy- isoxazol- derivate, ihre herstellung und ihre therapeutische verwendung.

Also Published As

Publication number Publication date
JPH04334381A (ja) 1992-11-20
EP0494002A2 (en) 1992-07-08
EP0494002A3 (en) 1992-10-14
KR100220878B1 (ko) 1999-09-15
EP0492020A1 (en) 1992-07-01
AU652009B2 (en) 1994-08-11
US5910501A (en) 1999-06-08
AU8981891A (en) 1992-06-25
IE914517A1 (en) 1992-07-01

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