KR920002656A - 세그먼트된 흡수성 공중합체, 이의 제조방법 및 이로 구성된 제품 - Google Patents

세그먼트된 흡수성 공중합체, 이의 제조방법 및 이로 구성된 제품 Download PDF

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KR920002656A
KR920002656A KR1019910011407A KR910011407A KR920002656A KR 920002656 A KR920002656 A KR 920002656A KR 1019910011407 A KR1019910011407 A KR 1019910011407A KR 910011407 A KR910011407 A KR 910011407A KR 920002656 A KR920002656 A KR 920002656A
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cyclic ester
ester monomer
copolymer
bonds
melt
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KR1019910011407A
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켄드릭 재릿트 피이터
로사티 루이스
제임즈 케이시 도널드
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알퐁스 아아르 노에
아메리칸 사이아나밋드 캄파니
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Publication of KR920002656A publication Critical patent/KR920002656A/ko

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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
    • A61L17/06—At least partially resorbable materials
    • A61L17/10—At least partially resorbable materials containing macromolecular materials
    • A61L17/12—Homopolymers or copolymers of glycolic acid or lactic acid
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
    • C08G63/08—Lactones or lactides
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/64—Polyesters containing both carboxylic ester groups and carbonate groups

Abstract

내용 없음

Description

세그먼트된 흡수성 공중합체, 이의 제조방법 및 이로 구성된 제품
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 중합 시간(단계 Ⅲ 첨가후)의 함수로서 실시예 8B-8I 의 공중합체에 대한 다양한 세그먼트 길이를 그래프 형태로 보여준다 ;
제2도는 단계 Ⅲ 첨가후, 중합 시간의 함수로서, 실시예 8D-8I의 공중합체에 대한 융점을 그래프 형태로 보여준다 ;
제3도는 실시예 8D-8I의 공중합체에 대한 융점과 Lg간의 상관관계를 그래프형태로 보여준다.

Claims (15)

  1. 적어도 두개의 서로 다른 에스테르 결합을 갖는 생 흡수성, 세그먼트된 분자 구조로 구성된 공중합체로서, 상기 세그먼트된 분자 구조가 1.3이상의 세그먼트 길이 분포를 갖는 다수의 빠르게 에스테르 교환하는 결합. 및 다수의 느리게 에스테르교환하는 결합으로 구성되고, 단 근본적으로 글리콜레이트 결합으로 구성된 상기 빠르게 에스테로교환하는 겨랍 및 트리메릴렌 카르보네이트 및 카프로에이트 결합으로 구성된 군으로부터 선택되는 상기 느리게 에스테르교환하는 결합의 경우, 상기 빠르게 에스테르교환하는 결합의 세그먼트 길이 분포가 2.0이하이고 상기 느리게 에스테르교환하는 결합의 수평균 세그머트 길이가 세그먼트당 2.5결합 이상인 공중합체.
  2. 제1항에 있어서, 상기 빠르게 에스테르교환하는 결합이 락테이트 및/또는 글리콜레이트 결합으로 구성되는 공중합체.
  3. 제2항에 있어서, 락테이트 결합이 시차 주사 열량계를 근거로 약40%이하의 결정도 및 약 170℃이하의 융점을 갖고/갖거나 글리콜레이트 결합이 시차 주사 열량계를 근거로 약30%이하의 결정도 및 약 215℃이하의 융점을 갖는 공중합체.
  4. 다수의 느리게 에스테르교환하는 결합이 트리메틸렌 카르보네이트, 카프로에이트 및 디옥사논 결합으로 구성된 군으로부터 선택되는 제2항의 공중합체로 구성된 제품.
  5. 느리게 에스테르교환하는 결합이 트리메틸렌 카르보네이트 및 카프로에이트 결합으로 구성된 군으로부터 선택되는 제1항 내지 제3항의 중합체 또는 제4항의 제품.
  6. 제4항에 있어서, 성형 수지, 필름, 외과용 기소(element), 조절된 방출 장치, 및 압출 펠릿으로 구성된 군으로부터 선택되는 제품.
  7. 제4항에 있어서, 약 100,000~700,000psi의 Young의 모듈러스를 갖는, 적어도 하나의 필라멘트를 갖는 외과용 기소로 구성되는 제품.
  8. 제7항에 있어서, 봉합사 또는 결찰사로 구성되는 제품.
  9. 제7항 또는 제8항에 있어서, 모노필라멘트로 구성되는 제품.
  10. 제9항에 있어서, 모노필라멘트 봉합사 또는 결착사가 약 0.02-0.70mm의 직경; 약500,000psi 이하의 Young의 모듈러스; 약50,000-150,000psi의 인장강도; 및 약 50%이하의 파단점 신장율을 갖는 제품.
  11. 연속첨가가 Ⅰ. 첫번째 단계에서 적어도 첫번째 시클릭 에스테르 단량체를 촉매의 존재하에 약 160-220℃의 온도에서 첫번째 중합시켜 중합체 용융물을 얻고; Ⅱ. 첫번째 중합체 용융뮬에 적어도 두번째 시클릭에스테르 단량체를 첨가하고; 및 Ⅲ. 두번째 또는 그이상의 단계에서 상기 첫번째 중합체 용융물을 적어도 상기 두번째 시클릭 에스테르 단량체와 두번째 또는 그이상 공중합시켜 두번재 또는 그 이상의 공중합체 용융물을 얻는 것으로 구성되고, 첫번째 시클릭에스테르 단량체가 카르보네이트 및 락톤, 및 이들의 혼합물로 구성된 군으로부터 선택되고, 두번째 시클릭 에스테르 단량체가 락티드 및 이들의 혼합물로 구성된 군으로부터 선택되는, 적어도 2단계로 적어도 두개의 서로다른 시클릭에스테르 단량체의 연속 첨가를 사용하고; 및 약5시간 이하동안 약 180℃ 이상의 온도에서 두번째 또는 그이상의 공중합체 용융물을 에스테르 교환시키는 것으로 구성된, 제1항의 공중합체를 제조하기 위한 방법.
  12. 제11항에 있어서, 연속 첨가가 Ⅰ. 첫번째 단계에서 적어도 상기 첫번째 시클릭 에스테르 단량체를 첫번째 중합시키고; Ⅱ. 첫번째 중합체 용융뮬에 적어도 상기 두번째 시클릭에스테르 단량체를 첫번째 첨가하고; Ⅲ. 두번째 단계에서 상기 첫번째 중합체 용융물을 적어도 상기 두번째 시클릭 에스테르 단량체와 두번째 공중합시켜 두번째 공중합체 용융물을 얻고; Ⅳ. 적어도 상기 두번째 시클릭 에스테르 단량체를 두번째 공증합체 용융물에두번째 참가하고; 및 Ⅴ. 세번째 단계에서 상기 두번째 공중합체 용융물을 적어도 상기 두번째 시클릭 에스테르 단량체와 세번째 공중합시켜 세번째 공중합체 용융물을 얻는 것으로 구성되고; 약5시간 이하동안 약 180℃이상의 온도에서 세번째 공중합체 용융물을 에스테르교환시키는 것으로 구성되는 방법.
  13. 제11항 또는 제12항에 있어서, 부단계 Ⅰ이 첫번째 단계에서 상기 첫번째 시클릭 에스테르 단량체의 약 90몰%이하를 첫번째 중합시키는 것으로 구성되고, 존재한다면, 나머지 몰 백분율이 상기 두번째 시클릭 에스테르 단량체로 구성되며 부단계 Ⅱ 및/또는 Ⅳ가 상기 두번째 시클릭 에스테르 단량체의 약80몰%이상을 첨가하는 것으로 구성되고, 존재한다면, 나머지 몰 백분율이 상기 첫번째 시클릭 에스테르 단량체로 구성되는 방법.
  14. 제11항 또는 제12항에 있어서, 사용되는 단계에 금속 배위 촉매 및 /또는 개시제의존재하에 중합시키는 것이 포함되는 방법.
  15. 제14항에 있어서, 개시제가 일관능 및 다관능 알코올로 구성된 군으로부터 선택되는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019910011407A 1990-07-06 1991-07-05 세그먼트된 흡수성 공중합체, 이의 제조방법 및 이로 구성된 제품 KR920002656A (ko)

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US07/548,801 1990-07-06
US07/548,801 US5252701A (en) 1990-07-06 1990-07-06 Segmented absorbable copolymer

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KR920002656A true KR920002656A (ko) 1992-02-28

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US (1) US5252701A (ko)
EP (1) EP0460428A3 (ko)
JP (1) JP3218055B2 (ko)
KR (1) KR920002656A (ko)
AU (1) AU648088B2 (ko)
BR (1) BR9102854A (ko)
CA (1) CA2046225C (ko)
FI (1) FI913283A (ko)
PT (1) PT98203A (ko)
ZA (1) ZA915238B (ko)

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US5252701A (en) 1993-10-12
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CA2046225C (en) 2002-09-10
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