KR920002266B1 - N-비사이클로헵틸- 및 n-비사이클로헵테닐-이미다졸의 제조방법 - Google Patents

N-비사이클로헵틸- 및 n-비사이클로헵테닐-이미다졸의 제조방법 Download PDF

Info

Publication number
KR920002266B1
KR920002266B1 KR1019850001854A KR850001854A KR920002266B1 KR 920002266 B1 KR920002266 B1 KR 920002266B1 KR 1019850001854 A KR1019850001854 A KR 1019850001854A KR 850001854 A KR850001854 A KR 850001854A KR 920002266 B1 KR920002266 B1 KR 920002266B1
Authority
KR
South Korea
Prior art keywords
formula
alkyl
phenyl
exo
different
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
KR1019850001854A
Other languages
English (en)
Korean (ko)
Other versions
KR850006186A (ko
Inventor
지겔 헤르베르트
그란쩨르 에르놀트
Original Assignee
훽스트 아크티엔게젤샤프트
하인리히 벡커·베른하르트 벡크
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 훽스트 아크티엔게젤샤프트, 하인리히 벡커·베른하르트 벡크 filed Critical 훽스트 아크티엔게젤샤프트
Publication of KR850006186A publication Critical patent/KR850006186A/ko
Application granted granted Critical
Publication of KR920002266B1 publication Critical patent/KR920002266B1/ko
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/61—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms not forming part of a nitro radical, attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/05—Alcohols containing rings other than six-membered aromatic rings
    • C07C33/12—Alcohols containing rings other than six-membered aromatic rings containing five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/38—Alcohols containing six-membered aromatic rings and other rings and having unsaturation outside the aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C35/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C35/22—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system
    • C07C35/23—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings
    • C07C35/28—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings the condensed ring system containing seven carbon atoms
    • C07C35/29—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings the condensed ring system containing seven carbon atoms being a (2.2.1) system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Epoxy Resins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
KR1019850001854A 1984-03-22 1985-03-21 N-비사이클로헵틸- 및 n-비사이클로헵테닐-이미다졸의 제조방법 Expired KR920002266B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP3410498.4 1984-03-22
DE19843410498 DE3410498A1 (de) 1984-03-22 1984-03-22 N-bicycloheptyl- und n-bicycloheptenyl-imidazole, verfahren zu ihrer herstellung, ihre verwendung sowie pharmazeutische praeparate

Publications (2)

Publication Number Publication Date
KR850006186A KR850006186A (ko) 1985-10-02
KR920002266B1 true KR920002266B1 (ko) 1992-03-20

Family

ID=6231259

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019850001854A Expired KR920002266B1 (ko) 1984-03-22 1985-03-21 N-비사이클로헵틸- 및 n-비사이클로헵테닐-이미다졸의 제조방법

Country Status (17)

Country Link
US (1) US4647575A (enExample)
EP (1) EP0158144B1 (enExample)
JP (1) JPS60209569A (enExample)
KR (1) KR920002266B1 (enExample)
AT (1) ATE33642T1 (enExample)
AU (1) AU568728B2 (enExample)
CA (1) CA1242206A (enExample)
DE (2) DE3410498A1 (enExample)
DK (1) DK163506C (enExample)
ES (1) ES541401A0 (enExample)
FI (1) FI84820C (enExample)
GR (1) GR850699B (enExample)
HU (1) HU193312B (enExample)
IL (1) IL74678A (enExample)
NO (1) NO163283C (enExample)
PT (1) PT80144B (enExample)
ZA (1) ZA852115B (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3731913A1 (de) * 1987-09-23 1989-04-06 Hoechst Ag Pharmazeutische praeparate enthaltend ein 7-diphenylmethylenbicycloheptan- oder 7-diphenylmethylenbicyclohepten-derivat, die verwendung dieser verbindungen als arzneimittel sowie neue 7-diphenylmethylenbicycloheptane und 7-diphenylmethylenbicloheptene und verfahren zu ihrer herstellung
JO2409B1 (en) * 2000-11-21 2007-06-17 شركة جانسين فارماسوتيكا ان. في Second-phenyl carboxy amides are useful as lipid-lowering agents

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3682951A (en) * 1970-11-02 1972-08-08 Searle & Co 1-{8 {62 -(1-adamantyloxy)halophenethyl{9 {0 imidazoles and congeners
DE2944663A1 (de) * 1979-11-06 1981-05-14 Bayer Ag, 5090 Leverkusen Imidazolderivate, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
US4522948A (en) * 1981-04-24 1985-06-11 Syntex (U.S.A.) Inc. Spermicidal substituted 1-(cycloalkyl)alkylimidazoles
DE3224129A1 (de) * 1982-06-29 1983-12-29 Bayer Ag, 5090 Leverkusen Substituierte azolyl-ketone und -alkohole

Also Published As

Publication number Publication date
FI851102L (fi) 1985-09-23
HUT37924A (en) 1986-03-28
JPS60209569A (ja) 1985-10-22
FI84820B (fi) 1991-10-15
AU4020985A (en) 1985-09-26
ATE33642T1 (de) 1988-05-15
DK163506B (da) 1992-03-09
KR850006186A (ko) 1985-10-02
EP0158144A1 (de) 1985-10-16
NO851145L (no) 1985-09-23
EP0158144B1 (de) 1988-04-20
IL74678A (en) 1989-02-28
DK128985A (da) 1985-09-23
DK128985D0 (da) 1985-03-21
GR850699B (enExample) 1985-07-16
HU193312B (en) 1987-09-28
IL74678A0 (en) 1985-06-30
PT80144B (de) 1987-01-16
ZA852115B (en) 1985-11-27
FI84820C (fi) 1992-01-27
US4647575A (en) 1987-03-03
ES8603429A1 (es) 1985-12-16
DK163506C (da) 1992-07-27
FI851102A0 (fi) 1985-03-20
NO163283B (no) 1990-01-22
NO163283C (no) 1990-05-02
AU568728B2 (en) 1988-01-07
PT80144A (de) 1985-04-01
DE3410498A1 (de) 1985-10-03
CA1242206A (en) 1988-09-20
ES541401A0 (es) 1985-12-16
DE3562243D1 (en) 1988-05-26

Similar Documents

Publication Publication Date Title
CA2185192C (fr) Nouveaux acides et esters 2,2- dimethyl-w-phenoxy alcanoiques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US4759880A (en) Alkanoarachidonic acids
KR850000627B1 (ko) 시클로헥센 유도체의 제조방법
EP0239461A1 (fr) Dérivés de N-¬¬(hydroxy-2 phényl) (phényl) méthylène amino-2 éthyl acétamide, leur préparation et leur application en thérapeutique
US4020177A (en) Substituted phenoxy-tridecanoic acids
US4061643A (en) Certain 16-aryloxy-11,12-seco-prostaglandins
US3860636A (en) Substituted indenyl phosphonic acids having anti-inflammatory activity
EP0096890B1 (en) Oxazoleacetic acid derivatives, process for their production and compositions containing said derivatives
US4092356A (en) 11,12-Secoprostaglandins
KR920002266B1 (ko) N-비사이클로헵틸- 및 n-비사이클로헵테닐-이미다졸의 제조방법
US4097504A (en) 11,12-Secoprostaglandins
FR2542743A1 (fr) Analogues de prostaglandines a substituant 7-oxabicycloheptane, a proprietes therapeutiques
EP0074873B1 (fr) Dérivés de phénoxy-3 propanol-2, leur préparation et leur application en thérapeutique
EP0301936A1 (fr) Dérivés de pipéridine, leur préparation et leur application en thérapeutique
US4059601A (en) 8-Halo-11,12-secoprostaglandins
US4059602A (en) 8-Methyl-, phenyl-, or substituted phenyl-11,12-secoprostaglandins
FR2563522A1 (fr) Analogues de 7 oxabicycloheptane prostaglandines, a action anti-inflammatoire, analgesique et cardiovasculaire
FR2534577A1 (fr) Naphtalenecarboxamides, leur procede de preparation et leur utilisation
MC1387A1 (fr) Nouveaux derives de phenoxyaminopropanol et leur preparation
EP0002401B1 (fr) Dérivés de naphtalène, leur préparation et leur application en thérapeutique
US4209529A (en) Farnesyl carboxylic acid α-bisabolol ester, a mucosal stabilizing composition and method of manufacturing the same
EP0198762A1 (fr) Dérivés d'acide dibenzo[be]oxépinne-acétique, leur préparation, et des médicaments les contenant
US4970077A (en) 6-substituted-4-hydroxytetrahydropyran-2-one derivatives and pharmaceutical compositions containing them
MC1439A1 (fr) Derives de cycloheptene
US4172949A (en) 2,4-Disubstituted-5-oxo-5H-dibenzo[a,d]cycloheptenes

Legal Events

Date Code Title Description
PA0109 Patent application

St.27 status event code: A-0-1-A10-A12-nap-PA0109

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

A201 Request for examination
PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

G160 Decision to publish patent application
PG1605 Publication of application before grant of patent

St.27 status event code: A-2-2-Q10-Q13-nap-PG1605

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U11-oth-PR1002

Fee payment year number: 1

LAPS Lapse due to unpaid annual fee
PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 19950321

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 19950321

PN2301 Change of applicant

St.27 status event code: A-5-5-R10-R13-asn-PN2301

St.27 status event code: A-5-5-R10-R11-asn-PN2301

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000

PN2301 Change of applicant

St.27 status event code: A-5-5-R10-R13-asn-PN2301

St.27 status event code: A-5-5-R10-R11-asn-PN2301

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000