KR910018407A - 부갑상샘 호르몬 길항물질 - Google Patents

부갑상샘 호르몬 길항물질 Download PDF

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Publication number
KR910018407A
KR910018407A KR1019910005858A KR910005858A KR910018407A KR 910018407 A KR910018407 A KR 910018407A KR 1019910005858 A KR1019910005858 A KR 1019910005858A KR 910005858 A KR910005858 A KR 910005858A KR 910018407 A KR910018407 A KR 910018407A
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Prior art keywords
leu
lys
jjj
hhh
fff
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KR1019910005858A
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KR0173478B1 (ko
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다쓰히꼬 간메라
아끼히사 모리
요시히데 나까오
도시히꼬 미네기시
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에또오 다께도시
미쓰비시 가세이 가부시기 가이샤
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Endocrinology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

내용 없음

Description

부갑상샘 호르몬 길항물질
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (3)

  1. 하기 일반식 구조식(Ⅰ)의 펩티드 유도체 및 이들의 염.
    위의 식에서 AAA 는 결실(deletion) 또는 Ser이고, BBB는 결실 또는 Glu 이며, CCC는 ε위치에 C6-C18알킬카르보닐 그룹이 치환된 Lys, D-alle,시클로헥실알라닌, Leu, Phe, 또는 Ile이거나 결실이고,DDD는 Gly또는, Gln이며, EEE는 Leu,Nle 또는 Phe이고, FFF는 Met, Leu 또는 Nle이며, GGG는 Ala, Ser, Leu, Asn, Asp 또는 Gln이고, HHH는 Leu, Glu 또는 Lys이고, III는 His, Lys또는 Arg이고, JJJ는 His, Lys또는 Arg이며,Xaa는 카르복시 말단에서 아미노 그룹으로 변경된 Ala 인데, 단 CCC와 DDD는 각각 아미노 말단에서 C2-C18알킬카르보닐 그룹에의해 변질될 수도 있고, FFF가 Met이고 GGG가 Asn이며 HHH가 Leu이고 III및 JJJ가 His인 경우에는 EEE는 Leu가 아니다.
  2. 제2항에 있어서, AAA와 BBB는 결실이고 CCC는 Ile이며 DDD 는 Gln이고 EEE 는 Leu이며 FFF는 Met이고 GGG는 Asp 이고 HHH는 Lys이며 III와 JJJ는 His 인 펩티드 유도체.
  3. 제1항에 있어서, AAA와 BBB는 결실이고, CCC는 아미노 말단에서 C6-C18알킬카르보닐 그룹에 의해 변경된 Ile이거나 ε위치에 C6-C18알킬카르보닐 그룹으로 치환된 Lys이고, DDD는 Gln이며, EEE는 Leu이고 FFF는 Met 이며 GGG는 Asp이며 HHH는 Lys이고, Ⅲ는 His이며 JJJ는 His또는 Lys인 펩티드 유도체.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019910005858A 1990-04-12 1991-04-12 부갑상선 호르몬 길항물질 KR0173478B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP02-96952 1990-04-12
JP9695290 1990-04-12

Publications (2)

Publication Number Publication Date
KR910018407A true KR910018407A (ko) 1991-11-30
KR0173478B1 KR0173478B1 (ko) 1999-02-01

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ID=14178624

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019910005858A KR0173478B1 (ko) 1990-04-12 1991-04-12 부갑상선 호르몬 길항물질

Country Status (5)

Country Link
US (2) US5229489A (ko)
EP (1) EP0451867B1 (ko)
KR (1) KR0173478B1 (ko)
CA (1) CA2040264A1 (ko)
DE (1) DE69117788T2 (ko)

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Publication number Priority date Publication date Assignee Title
CA2040264A1 (en) * 1990-04-12 1991-10-13 Tatsuhiko Kanmera Parathyroid hormone antagonists
JPH05271279A (ja) * 1991-08-07 1993-10-19 Takeda Chem Ind Ltd ヒト副甲状腺ホルモンムテインおよびその製造法
EP0528271B1 (en) * 1991-08-07 1997-04-23 Takeda Chemical Industries, Ltd. Human parathyroid hormone muteins and production thereof
US5977070A (en) * 1992-07-14 1999-11-02 Piazza; Christin Teresa Pharmaceutical compositions for the nasal delivery of compounds useful for the treatment of osteoporosis
US5821225A (en) * 1992-07-14 1998-10-13 Syntex (U.S.A.) Inc. Method for the treatment of corticosteroid induced osteopenia comprising administration of modified PTH or PTHrp
US5589452A (en) * 1992-07-14 1996-12-31 Syntex (U.S.A.) Inc. Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis
AU672790B2 (en) * 1992-07-15 1996-10-17 Novartis Ag Variants of parathyroid hormone and its fragments
US5786327A (en) 1993-03-12 1998-07-28 Gensci Regeneration Sciences Inc. Bone stimulating factor, methods of isolating same, and methods of increasing bone growth comprising administering same
CN1070500C (zh) * 1993-07-13 2001-09-05 森德克斯(美国)股份有限公司 甲状旁腺激素类似物和甲状旁腺激素相关肽：合成和治疗骨质疏松症的用途
CO4410206A1 (es) * 1994-07-28 1997-01-09 Sandoz Ag DERIVADOS DE PTH o PTHrP, SU PREPARACION Y COMPOSICIONES FARMACEUTICAS QUE LAS COMPRENDEN
CA2213261C (en) * 1995-02-20 2009-04-14 Yukio Kato Therapeutics of osteoarthritis and inflammatory joint disease
US5849708A (en) * 1995-06-06 1998-12-15 Joslin Diabetes Center, Inc. Promotion of eating behavior
US6352973B1 (en) 1995-06-07 2002-03-05 Osteopharm Inc. Bone stimulating factor
US7410948B2 (en) 1995-07-13 2008-08-12 Societe De Conseils De Recherches Et D'applications Scientifiques, Sas Analogs of parathyroid hormone
US5955574A (en) * 1995-07-13 1999-09-21 Societe De Conseils De Recherches Et D'applications Scientifiques, S.A. Analogs of parathyroid hormone
US5969095A (en) * 1995-07-13 1999-10-19 Biomeasure, Inc. Analogs of parathyroid hormone
US6544949B1 (en) * 1995-07-13 2003-04-08 Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. Analogs of parathyroid hormone
US5723577A (en) * 1995-07-13 1998-03-03 Biomeasure Inc. Analogs of parathyroid hormone
US6693081B2 (en) 1995-09-26 2004-02-17 Osteopharm Inc. Bone stimulating factor
BR9808786A (pt) 1997-05-14 2000-07-11 Rhone Poulenc Rorer Pharma Composto peptìdio cìclico ou um seu sal ou pró-medicamento farmaceuticamente aceitáveis, composição farmacêutica, e, processos para tratar doenças associadas com a regulagem do cálcio em um paciente e para tratar a osteopenia ou a osteoporose em um mamìfero hospedeiro
EP1075491B1 (en) 1998-05-05 2008-04-16 Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. Pth2 receptor selective compounds
WO2004028444A2 (en) * 1999-06-02 2004-04-08 Scantibodies Laboratory, Inc. Parathyroid hormone antagonists and uses thereof
US6923968B2 (en) * 2000-08-10 2005-08-02 Scantibodies Laboratory, Inc. Cyclase inhibiting parathyroid hormone antagonists or modulators and osteoporosis
US20080108086A1 (en) * 1999-06-02 2008-05-08 Cantor Thomas L Parathyroid hormone antagonists and uses thereof
US6815421B1 (en) * 2001-03-22 2004-11-09 Osteopharm Inc. Polypeptides for use in ameliorating effects of aging in mammals
DE10116552A1 (de) 2001-04-03 2002-10-10 Abc Armbruster Biochemicals Verfahren zur Bestimmung der wirksamen Parathormon-Aktivität in einer Probe
JP2005525312A (ja) * 2002-01-10 2005-08-25 オステオトロフィン エルエルシー 骨同化物質を用いた骨疾患の治療方法
US7906480B2 (en) * 2002-05-23 2011-03-15 Michael Holick Use of a parathyroid hormone peptide analogs for the treatment of vaginal atrophy
WO2004103410A1 (en) 2002-06-06 2004-12-02 Yissum Research Development Company Of The Hebrew University Of Jerusalem Methods compositions and articles of manufacture for modulating bone growth
US7407753B2 (en) 2004-05-24 2008-08-05 Yissum Research Development Company Of The Hebrewuniversityofjerusalem Methods, kits and pharmaceutical compositions for diagnosing, delaying onset of, preventing and/or treating osteoporosis
EP2631247A1 (en) 2012-02-22 2013-08-28 Immundiagnostik AG Means and methods of measuring parathyroid hormone in patients suffering from oxidative stress
EP2775306B1 (en) 2013-03-08 2018-06-27 Immundiagnostik AG Non-oxidized, biological active parathyroid hormone determines mortality in hemodialysis patients
EP3740762A1 (en) 2018-01-17 2020-11-25 Immundiagnostik AG Biomarker predicting coronary artery disease

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US3886132A (en) * 1972-12-21 1975-05-27 Us Health Human parathyroid hormone
US4423037A (en) * 1982-05-13 1983-12-27 The General Hospital Corporation Inhibitors of peptide hormone action
FR2550204B1 (fr) * 1983-08-05 1987-11-13 Toyo Jozo Kk Derives peptidiques de (nle8,nle1b, tyr34)-h-pth
EP0293158A3 (en) * 1987-05-26 1990-05-09 Merck & Co. Inc. Parathyroid hormone antagonists
EP0293160A3 (en) * 1987-05-26 1990-05-09 Merck & Co. Inc. Parathyroid hormone antagonists with enhanced metabolic properties
EP0341962B1 (en) * 1988-05-09 1995-03-15 Merck & Co. Inc. Humoral hypercalcemic factor antagonists
EP0341963A3 (en) * 1988-05-09 1991-07-24 Merck & Co. Inc. Parathyroid hormone antagonists
CA2040264A1 (en) * 1990-04-12 1991-10-13 Tatsuhiko Kanmera Parathyroid hormone antagonists

Also Published As

Publication number Publication date
KR0173478B1 (ko) 1999-02-01
DE69117788T2 (de) 1996-08-08
US5229489A (en) 1993-07-20
CA2040264A1 (en) 1991-10-13
EP0451867B1 (en) 1996-03-13
DE69117788D1 (de) 1996-04-18
US5446130A (en) 1995-08-29
EP0451867A1 (en) 1991-10-16

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