KR910018390A - 신규 노지리마이신 유도체 - Google Patents
신규 노지리마이신 유도체 Download PDFInfo
- Publication number
- KR910018390A KR910018390A KR1019910006722A KR910006722A KR910018390A KR 910018390 A KR910018390 A KR 910018390A KR 1019910006722 A KR1019910006722 A KR 1019910006722A KR 910006722 A KR910006722 A KR 910006722A KR 910018390 A KR910018390 A KR 910018390A
- Authority
- KR
- South Korea
- Prior art keywords
- compound
- alkyl
- alkoxy
- mch
- alkylene
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 claims 25
- 125000000217 alkyl group Chemical group 0.000 claims 14
- 238000000034 method Methods 0.000 claims 12
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 8
- 125000003545 alkoxy group Chemical group 0.000 claims 5
- 239000000377 silicon dioxide Substances 0.000 claims 4
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical group [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims 3
- 125000002947 alkylene group Chemical group 0.000 claims 3
- 125000004122 cyclic group Chemical group 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 claims 3
- 125000004429 atom Chemical group 0.000 claims 2
- 125000002619 bicyclic group Chemical group 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 125000006239 protecting group Chemical group 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 208000030507 AIDS Diseases 0.000 claims 1
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 1
- 150000001450 anions Chemical class 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 238000009833 condensation Methods 0.000 claims 1
- 230000005494 condensation Effects 0.000 claims 1
- 230000037213 diet Effects 0.000 claims 1
- 235000005911 diet Nutrition 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000008030 elimination Effects 0.000 claims 1
- 238000003379 elimination reaction Methods 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 201000001421 hyperglycemia Diseases 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 230000003472 neutralizing effect Effects 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 239000000376 reactant Substances 0.000 claims 1
- 229910052710 silicon Inorganic materials 0.000 claims 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Virology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (29)
- 하기 일반식(Ⅰ)의 화합물, 이들의 이성질체 형태 및 제약학상 허용되는 이들이 염.상기식중, Q는 C1-7알킬렌, (CH2)mCH=CH(CH2)n, (CH2)mC≡C(CH2)n, (CH2)mCH=C=(CH2)n, (CH2)p페닐렌, (CH2)m시클로펜테닐렌, (CH2)pT(여기에서, T는 이것이 결합된 규소원자와 함께 5내지 6개의 원자로 된 환식 실리칸을 형성하고, 이환식 실리칸은 임의로 이중 결합을 가지며, m은 1,2이고 또는 3이고, n은 0,1또는 2이며, p는 0,1,2,3 도는 4임)이고, R1은 C1-7알킬, C1-7알콕시, 모노-또는 폴리히드록시 C1-6알킬, 클로로C1-6알킬이며,R2및 R3은 C1-10(CH2) p-X,Y-치환된 페닐(여기에서, X 및 Y는 각각 H, OH, 할로겐, C1-6알킬, 모노-또는 폴리알콕시 C1-C6알킬, C1-6알콕시,CF3, CN, NO2, SH 또는 -S-C1-6알킬임)이되, 단, Q가 (CH2)pT일 경우, R1, R2또는 R3중 하나는 존재하지 않는다.
- 제1항에 있어서, Q가 C1-7알킬렌인 화합물.
- 제2항에 있어서, R1,R2및 R3이 C1-7알킬인 화합물.
- 제2항에 있어서, C1-7알킬이 메틸인 화합물.
- 제2항에 있어서, R1이 히드톡실화 C1-7알킬인 화합물.
- 제1항에 있어서, Q가 (CH2)mHC=CH(CH2)n인 화합물.
- 제6항에 있어서, R1,R2및 R3이 C1-7저급 알킬인 화합물.
- 제1항에 있어서, Q가 (CH2)nT 인 화합물.
- 제8항에 있어서, R1및 R2가 C1-7알킬이고, R3이 존재하지 않는 화합물.
- 제9항에 있어서, (CH2)pT의 환식 실리칸이 불포화된 화합물.
- 제1항에 있어서,Q가 -CH2-페닐렌이고, R1R2및 R3이 각각 C1-7인 화합물.
- 제1항에 있어서,-Q-Si-R1R2R3이 -CH2-Si(CH3)3인 화합물.
- 제1항에 있어서,-Q-Si-R1R2R3이 -(CH2)3-Si(CH3)3인 화합물.
- 제1항에 있어서,-Q-Si-R1R2R3이 -(CH2)4-Si(CH3)3인 화합물.
- 제1항에 있어서,-Q-Si-R1R2R3이 -CH2Si(CH3)2C6H5인 화합물.
- 제1항에 있어서,-Q-Si-R1R2R3이 -CH2Si(CH3)2C2H5인 화합물.
- 제1항에 있어서,-Q-Si-R1R2R3이 -CH2Si(CH3)2C3H7인 화합물.
- 제1항에 있어서,-Q-Si-R1R2R3이 트랜스 -CH2-CH-CH=Si(CH3)3인 화합물.
- 제1항에 있어서,-Q-Si-R1R2R3이 -CH2-C6H4-메타-Si(CH|3)3인 화합물.
- 제1항에 있어서,-Q-Si-R1R2R3이 -(CH2)3-Si(CH3)2CH2OH인 화합물.
- 제1항에 있어서,-Q-Si-R1R2R3이 -(CH2)3-Si(CH3)2CH2CH2CHOHCH2-OH인 화합물.
- 제1항에 있어서,-Q-Si-R1R2R3이 인 화합물.
- 제1항에 있어서, -Q-Si-R1R2R3이 인 화합물.
- 제1항에 있어서, -Q-Si-R1R2R3이 인 화합물.
- 제1항에 따른 화합물과 제약학상 허용되는 담체로 이루어진 제약 조성물.
- 제1항 기재의 화합물을 치료학적 유효량으로 투여하는 것으로 이루어지는 과혈당증의 치료방법.
- 제1항 기재의 하합물을 치료학적 유효량으로 투여하는 것으로 이루어진는 부적절한 식사로 인한 비만중의 치료 방법.
- 제1항 기재의 화합물을 치료학적 유효량으로 투여하는 것으로 이루어지는 AIDS의 치료 방법.
- 임의로 히드록시보호된 하기 일반식의 화합물을(상기식 중, R은 H 또는 임의의 보호기임)반응물 X′-Q-SiR1R2R3(여기에서, Z′은 할로게노, 메실레이트 또는 토실레이트임)과 축합시킨 후, 이어서 임의의 히드록시-보호기를 제거하고, 필요에 따라, 보호기를 제거하는 과정 동안 형성된 음이온을 중화시키는 것으로 이루어진 하기 일반식(Ⅰ)의 화합물, 이들의 이성질체 형태 및 제약학상 허용되는 이들의 염의 제조 방법.상기식중, Q는 C1-7알킬렌, (CH2)mCH=CH(CH2)n, (CH2)mC≡C(CH2)n, (CH2)mCH=(CH2)n, (CH2)p페닐렌, (CH2)m시클로펜테닐렌, (CH2)m시클로헥세닐렌, (CH2)pT(여기에서, T는 이것이 결합된 규소원자와 함께 5내지 6개의 원자로 된 환식 실리칸을 형성하고, 이환식 실리칸은 임의로 이중 결합을 가지며, m은 1,2이고 또는 3이고,n은 0,1,또는2이며, p는 0,1,2,3 도는 4임)이고, R1은 C1-7알킬, C1-7알콕시,모노-또는 폴리히드록시 C1-6알킬, 모노-또는 폴리알콕시C1-6클로로C1-6알킬이며, R2및 R3은 (CH2)p-X, Y-치환된 페닐(여기에서, X 및 Y는 각각 H, OH, 할로겐, C1-6알킬, C1-6알콕시, CF3, CN, NO2SH 또는 -S-C1-6알킬임)이되, 단, Q가 (CH2)pT일 경우, R1,R2또는 R3중 하나는 존재하지 않는다.※ 참고사항 : 최초출원 내용에 의하여 공개되는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP90401169A EP0453692A1 (en) | 1990-04-27 | 1990-04-27 | Novel nojirimycin derivatives |
EP90401169.9 | 1990-04-27 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR910018390A true KR910018390A (ko) | 1991-11-30 |
KR100191051B1 KR100191051B1 (ko) | 1999-06-15 |
Family
ID=8205706
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019910006722A KR100191051B1 (ko) | 1990-04-27 | 1991-04-26 | 신규노지리마이신유도체 |
Country Status (20)
Country | Link |
---|---|
EP (2) | EP0453692A1 (ko) |
JP (1) | JP2968088B2 (ko) |
KR (1) | KR100191051B1 (ko) |
CN (1) | CN1028368C (ko) |
AR (1) | AR248026A1 (ko) |
AT (1) | ATE132153T1 (ko) |
AU (1) | AU632926B2 (ko) |
CA (1) | CA2041331C (ko) |
DE (1) | DE69115750T2 (ko) |
DK (1) | DK0454580T3 (ko) |
ES (1) | ES2084126T3 (ko) |
FI (1) | FI97885C (ko) |
GR (1) | GR3018797T3 (ko) |
HU (1) | HU212496B (ko) |
IE (1) | IE72477B1 (ko) |
IL (1) | IL97975A (ko) |
NO (1) | NO179913C (ko) |
PT (1) | PT97485B (ko) |
TW (1) | TW201302B (ko) |
ZA (1) | ZA912994B (ko) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5986230A (en) * | 1996-09-13 | 1999-11-16 | Uncle Ben's, Inc. | Method and apparatus for sorting product |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1555654A (en) * | 1977-06-25 | 1979-11-14 | Exxon Research Engineering Co | Agricultural burner apparatus |
GB8705654D0 (en) * | 1987-03-10 | 1987-04-15 | Safe Haul Ltd | Pneumatic valve |
EP0282618A1 (en) * | 1987-03-18 | 1988-09-21 | Vereniging Het Nederlands Kanker Instituut | 1-Deoxynojirimycin as an anti-HIV therapeutic |
EP0350012A3 (en) * | 1988-07-08 | 1990-09-05 | Meiji Seika Kaisha Ltd. | Antiviral composition |
US5043273A (en) * | 1989-08-17 | 1991-08-27 | Monsanto Company | Phosphorylated glycosidase inhibitor prodrugs |
-
1990
- 1990-04-27 EP EP90401169A patent/EP0453692A1/en not_active Withdrawn
-
1991
- 1991-04-22 ZA ZA912994A patent/ZA912994B/xx unknown
- 1991-04-23 TW TW080103185A patent/TW201302B/zh active
- 1991-04-24 AU AU75351/91A patent/AU632926B2/en not_active Ceased
- 1991-04-24 AR AR91319515A patent/AR248026A1/es active
- 1991-04-25 DE DE69115750T patent/DE69115750T2/de not_active Expired - Fee Related
- 1991-04-25 DK DK91401096.2T patent/DK0454580T3/da active
- 1991-04-25 ES ES91401096T patent/ES2084126T3/es not_active Expired - Lifetime
- 1991-04-25 EP EP91401096A patent/EP0454580B1/en not_active Expired - Lifetime
- 1991-04-25 AT AT91401096T patent/ATE132153T1/de not_active IP Right Cessation
- 1991-04-26 NO NO911665A patent/NO179913C/no unknown
- 1991-04-26 IE IE141791A patent/IE72477B1/en not_active IP Right Cessation
- 1991-04-26 PT PT97485A patent/PT97485B/pt not_active IP Right Cessation
- 1991-04-26 IL IL9797591A patent/IL97975A/en not_active IP Right Cessation
- 1991-04-26 CA CA002041331A patent/CA2041331C/en not_active Expired - Fee Related
- 1991-04-26 JP JP3122818A patent/JP2968088B2/ja not_active Expired - Fee Related
- 1991-04-26 FI FI912033A patent/FI97885C/fi not_active IP Right Cessation
- 1991-04-26 HU HU911430A patent/HU212496B/hu not_active IP Right Cessation
- 1991-04-26 CN CN91102641A patent/CN1028368C/zh not_active Expired - Fee Related
- 1991-04-26 KR KR1019910006722A patent/KR100191051B1/ko not_active IP Right Cessation
-
1996
- 1996-01-25 GR GR960400185T patent/GR3018797T3/el unknown
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