KR910016342A - 항원 용액을 위한 보조제로서의 아연, 칼슘 하이드록 사이드, 렉시틴 및 pao의 용도, 및 이러한 유형의 보조제로 처리된 항원 용액 - Google Patents

항원 용액을 위한 보조제로서의 아연, 칼슘 하이드록 사이드, 렉시틴 및 pao의 용도, 및 이러한 유형의 보조제로 처리된 항원 용액 Download PDF

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Publication number
KR910016342A
KR910016342A KR1019910003576A KR910003576A KR910016342A KR 910016342 A KR910016342 A KR 910016342A KR 1019910003576 A KR1019910003576 A KR 1019910003576A KR 910003576 A KR910003576 A KR 910003576A KR 910016342 A KR910016342 A KR 910016342A
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KR
South Korea
Prior art keywords
antigen solution
adjuvant
lecithin
calcium hydroxide
pao
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KR1019910003576A
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English (en)
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KR100195571B1 (ko
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베른하르트 디터
힐펜하우스 요아힘
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스타인, 버그
베링베르케 아크티엔게젤샤프트
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Publication of KR910016342A publication Critical patent/KR910016342A/ko
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Publication of KR100195571B1 publication Critical patent/KR100195571B1/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55516—Proteins; Peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Compositions Of Macromolecular Compounds (AREA)

Abstract

내용 없음

Description

항원 용액을 위한 보조제로서의 아연, 칼슘 하이드록 사이드, 렉시틴 및 PAO의 용도, 및 이러한 유형의 보조제로 처리된 항원 용액
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (9)

  1. 항원 용액을 보조제로 처리하는 공정에서 아연 하이드록사이드/칼슘 하이드록사이드 겔의 용도.
  2. 제1항에 있어서, 렉시틴을 추가로 사용하는 용도.
  3. 제1항에 있어서, 폴리 알파올레핀을 추가로 사용하는 용도.
  4. 항원 용액에 아연 하이드록사이드/칼슘 하이드록 사이드 겔이 첨가된, 제1항에 청구된 바와 같이 보조제로 처리된 항원 용액.
  5. 제4항에 있어서, 항원 용액에 1 내지 10%, 바람직하게는 5%의 20% 렉시틴 현탄액이 추가로 첨가된 항원 용액.
  6. 제4항에 있어서, 항원 용액에 1 내지 40%, 바람직하게는 10%의 폴리 알파올레핀이 추가로 첨가된 항원 용액.
  7. 아연 하이드록사이드/칼슘 하이드록사이드 겔을 항원 용액에 첨가시킴을 특징으로 하여, 보조제로 처리된 항원 용액을 제조하는 방법.
  8. 제7항에 있어서, 렉시틴이 항원 용액에 추가로 첨가되는 방법.
  9. 제7항에 있어서, 폴리 알파올레핀이 항원 용액에 추가로 첨가되는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019910003576A 1990-03-08 1991-03-06 수산화아연/수산화칼슘 겔, 레시틴 및 폴리알파올레핀으로 처리된 항원용액 및 이의 제조방법 KR100195571B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4007315A DE4007315A1 (de) 1990-03-08 1990-03-08 Verwendung von zink-calciumhydroxid, lecithin und pao zur adjuvierung von antigenloesungen und auf diese weise adjuvierte antigenloesungen
DE40073157 1990-03-08

Publications (2)

Publication Number Publication Date
KR910016342A true KR910016342A (ko) 1991-11-05
KR100195571B1 KR100195571B1 (ko) 1999-06-15

Family

ID=6401694

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019910003576A KR100195571B1 (ko) 1990-03-08 1991-03-06 수산화아연/수산화칼슘 겔, 레시틴 및 폴리알파올레핀으로 처리된 항원용액 및 이의 제조방법

Country Status (12)

Country Link
US (1) US5232690A (ko)
EP (1) EP0445710B1 (ko)
JP (1) JP3018256B2 (ko)
KR (1) KR100195571B1 (ko)
AT (1) ATE101045T1 (ko)
AU (1) AU653331B2 (ko)
CA (1) CA2037709C (ko)
DE (2) DE4007315A1 (ko)
DK (1) DK0445710T3 (ko)
ES (1) ES2049999T3 (ko)
IE (1) IE65211B1 (ko)
PT (1) PT96959B (ko)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4333376C2 (de) * 1993-09-30 1995-09-07 Gerbu Biotechnik Gmbh Mittel zur Steigerung der Ausbeute von Antikörpern in der Immunologie
US6764682B1 (en) * 1994-06-16 2004-07-20 Aventis Pasteur Limited Adjuvant compositions containing more than one adjuvant
ATE223235T1 (de) * 1994-09-23 2002-09-15 Zonagen Inc Chitosan induzierte verstärkung
US6290971B1 (en) 1995-06-15 2001-09-18 Aventis Pasteur Limited Adjuvant compositions comprising a mineral salt and another immunostimulating compound
FR2754182B1 (fr) * 1996-10-07 1998-11-06 Seppic Sa Nouvelles compositions vaccinales comportant comme adjuvant un compose sympathomimetique
GB9924351D0 (en) 1999-10-14 1999-12-15 Brennan Frank Immunomodulation methods and compositions
US20020051794A1 (en) 2000-08-09 2002-05-02 Alk-Abello A/S Novel parenteral vaccine formulations and uses thereof
JP2004515468A (ja) * 2000-08-09 2004-05-27 アルカベロ アクチェセルスカプ 非経口ワクチン製剤およびその使用
US20040131643A1 (en) * 2001-03-05 2004-07-08 Harleen Grewal Immune response potentiation

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1502774A (en) * 1974-06-25 1978-03-01 Nat Res Dev Immunological preparations
FR2466991A1 (fr) * 1979-10-08 1981-04-17 Pasteur Institut Perfectionnement a la preparation d'allergene
DE3241113A1 (de) * 1982-11-06 1984-05-10 Bayer Ag, 5090 Leverkusen Vakzinen mit zuschlagstoffen
US4803070A (en) * 1986-04-15 1989-02-07 Ribi Immunochem Research Inc. Immunological emulsion adjuvants for polysaccharide vaccines
US4806352A (en) * 1986-04-15 1989-02-21 Ribi Immunochem Research Inc. Immunological lipid emulsion adjuvant
DE3817531A1 (de) * 1988-05-24 1989-12-07 Behringwerke Ag Antigenloesung enthaltend ein polyalphaolefin (pao), verfahren ihrer herstellung und die verwendung von pao als adjuvans
DE3834729A1 (de) * 1988-10-12 1990-04-19 Behringwerke Ag Verwendung von zink-oder eisenhydroxid zur adjuvierung von antigenloesungen und auf diese weise adjuvierte antigenloesungen

Also Published As

Publication number Publication date
DE4007315A1 (de) 1991-09-12
DK0445710T3 (da) 1994-06-06
ATE101045T1 (de) 1994-02-15
CA2037709A1 (en) 1991-09-09
US5232690A (en) 1993-08-03
KR100195571B1 (ko) 1999-06-15
PT96959A (pt) 1991-12-31
JPH04217631A (ja) 1992-08-07
AU653331B2 (en) 1994-09-29
AU7271291A (en) 1991-09-12
ES2049999T3 (es) 1994-05-01
PT96959B (pt) 1998-07-31
DE59100964D1 (de) 1994-03-17
EP0445710A1 (de) 1991-09-11
JP3018256B2 (ja) 2000-03-13
CA2037709C (en) 2002-02-26
IE65211B1 (en) 1995-10-04
EP0445710B1 (de) 1994-02-02
IE910757A1 (en) 1991-09-11

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