KR910014702A - 과산화 활성 물질 검정을 위한 조성물. 장치 및 방법 - Google Patents

과산화 활성 물질 검정을 위한 조성물. 장치 및 방법 Download PDF

Info

Publication number
KR910014702A
KR910014702A KR1019910001366A KR910001366A KR910014702A KR 910014702 A KR910014702 A KR 910014702A KR 1019910001366 A KR1019910001366 A KR 1019910001366A KR 910001366 A KR910001366 A KR 910001366A KR 910014702 A KR910014702 A KR 910014702A
Authority
KR
South Korea
Prior art keywords
composition
hydroperoxide
indicator
concentration
suitable carrier
Prior art date
Application number
KR1019910001366A
Other languages
English (en)
Other versions
KR0163792B1 (ko
Inventor
피. 알바렐라 제임스
제이. 퍼기아 마이클
Original Assignee
스티븐 비. 페이지
마일즈 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 스티븐 비. 페이지, 마일즈 인코포레이티드 filed Critical 스티븐 비. 페이지
Publication of KR910014702A publication Critical patent/KR910014702A/ko
Application granted granted Critical
Publication of KR0163792B1 publication Critical patent/KR0163792B1/ko

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C12Q1/28—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving peroxidase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
    • G01N33/721—Haemoglobin
    • G01N33/725—Haemoglobin using peroxidative activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2326/00—Chromogens for determinations of oxidoreductase enzymes
    • C12Q2326/10—Benzidines
    • C12Q2326/12—3,3',5,5'-Tetramethylbenzidine, i.e. TMB
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/805—Test papers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/904—Oxidation - reduction indicators
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25125—Digestion or removing interfering materials

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)

Abstract

내용 없음

Description

과산화 활성 물질 검정을 위한 조성물, 장치 및 방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

  1. (a) 지시제 염료; (b) 하이드로퍼옥사이드; (c) 완충액; (d) 일반식
    (여기서, R1, R2및 R3은 독립적으로 메틸그룹 또는 에틸그룹이고, m, n 및 p는 1 내지 약 3범위의 수이다)의 아민 보레이트 화합물 및 (e) 적합한 담체 비히클을 함유함을 특징으로 하는, 시험 샘플과 접촉시 충분한 색변화를 나타내어 시험 샘플중의 과산화 활성물질의 존재 유무 또는 농도를 측정할 수 있는 조성물.
  2. 제1항에 있어서, 지시제 염료가 조성물 1당 약 5mmole 내지 약 60mmole 범위의 양으로 존재하는 조성물.
  3. 제1항에 있어서, 지시제 염료가 산화 환원 지시제인 조성물.
  4. 제3항에 있어서, 산화 환원 지시제가 벤지딘; 0-톨리딘;3, 3', 4, 5'-테트라알킬벤지딘(여기서 알킬 그룹은 1 내지 약 6개 탄소원자를 함유한다); 0-디아니시딘; 2, 7-디아미노플루오렌; 비스-(N-에틸퀴놀-2-온)-아진; (N-메틸벤즈트리아졸-2-온)-(1-에틸-3-페닐-5-메틸트리아졸-2-온)-아진 및 이의 배합물로 이루어진 그룹중에서 선택되는 조성물.
  5. 제1항에 있어서, 지시제 염료가 3, 3', 5, 5'-테트라메틸벤지딘인 조성물.
  6. 제1항에 있어서, 하이드로피옥사이드가 큐멘 하이드로퍼옥사이드, t-부틸 하이드로퍼옥사이드, 디이소프로필벤젠 하이드로퍼옥사이드, 1-하이드록시 사이클로헥산-1-하이드로퍼옥사이드, 2, 5-디메틸헥산-2, 5-디하이드로퍼옥사이드, 파라멘탄 하이드로퍼옥사이드, 1, 4-디이소프로필벤젠 모노하이드로퍼옥사이드, P-t-부틸-이소프로필벤젠 하이드로퍼옥사이드, 2-(α-하이드로퍼옥시이소프로필)-6-이소프로필나프탈렌, 테트랄린 하이드로퍼옥사이드 및 이의 배합물로 이루어진 그룹중에서 선택되는 조성물.
  7. (a) 지시제염료, 하이드로퍼옥사이드, 완충액, 일반식
    (여기서, R1, R2및 R3은 독립적으로 메틸그룹 또는 에틸그룹이고, m, n 및 p는 1 내지 약 3범위의 수이다)의 아민 보레이트 화합물 및 적합한 담체 비히클을 함유하는 조성물과 시험샘플을 접촉시키고, (b) 조성물의 색변화의 강도 또는 정도에 의해 시험 샘플중의 과산화 활성물질의 존재유무 또는 농도를 측정함을 특징으로 하여, 시험 샘플 중의 과산화 활성 물질의 존재 유무 또는 농도를 측정하는 방법.
  8. (a) 지시제염료, 하이드로퍼옥사이드, 완충액, 일반식
    (여기서, R1, R2및 R3은 독립적으로 메틸그룹 또는 에틸그룹이고, m, n 및 p는 1 내지 약 3범위의 수이다)의 아민 보레이트 화합물 및 적합한 담체 비히클을 함유하는 조성물과 시험샘플을 접촉시키고, (b) 조성물의 색변화의 강도 또는 정도에 의해 생물학적 체액중 잠혈(occuit blood)의 존재유무 또는 농도를 측정함을 특징으로하여, 생물학적 체액내 잠혈의 존재 유무 또는 농도를 측정하는 방법.
  9. (a) 지시제염료, 하이드로퍼옥사이드, 완충액, 일반식
    (여기서, R1, R2및 R3은 독립적으로 메틸그룹 또는 에틸그룹이고, m, n 및 p는 1 내지 약 3범위의 수이다)의 아민 보레이트 화합물 및 적합한 담체 비히클을 함유하는 조성물을 갖는 시약 시험패드(pad)를 함유하는 분석물 검출 장치와 액체 샘플을 접촉시키고, (b) 분석물 검출장치를 검사하여 액체 샘플중에 존재하는 과산화 활성물질에 반응하여 나타나는 색변화를 측정함을 특징으로 하여 액체 샘플 중의 과산화 활성 화합물의 존재 유무 또는 농도를 측정하는 방법.
  10. 지용 스트립; 시약시험패드; 및 시약 시험 패드내에 혼입되는, (a) 지시제 염료, (b) 하이드로퍼옥사이드, (c) 완충액, (d) 일반식
    (여기서, R1, R2및 R3은 독립적으로 메틸그룹 또는 에틸그룹이고, m, n 및 p는 1 내지 약 3범위의 수이다)의 아민 보레이트 화합물 및 (e) 적합한 담체 비히클을 함유하는 조성물을 함유함을 특징으로 하는, 액체 시험 샘플중의 과산화 활성물질의 존재 또는 농도를 측정하기 위한 분석물 검출장치.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019910001366A 1990-01-30 1991-01-28 과산화 활성 물질의 검정을 위한 조성물, 장치 및 방법 KR0163792B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/472,282 US5089420A (en) 1990-01-30 1990-01-30 Composition, device and method of assaying for a peroxidatively active substance utilizing amine borate compounds
US472,282 1990-01-30
US472282 1990-01-30

Publications (2)

Publication Number Publication Date
KR910014702A true KR910014702A (ko) 1991-08-31
KR0163792B1 KR0163792B1 (ko) 1999-03-30

Family

ID=23874869

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019910001366A KR0163792B1 (ko) 1990-01-30 1991-01-28 과산화 활성 물질의 검정을 위한 조성물, 장치 및 방법

Country Status (10)

Country Link
US (1) US5089420A (ko)
EP (1) EP0444273B1 (ko)
JP (1) JP2928649B2 (ko)
KR (1) KR0163792B1 (ko)
AT (1) ATE113664T1 (ko)
AU (1) AU621510B2 (ko)
CA (1) CA2025802A1 (ko)
DE (1) DE69013882T2 (ko)
DK (1) DK0444273T3 (ko)
ES (1) ES2066093T3 (ko)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4024544A1 (de) * 1990-08-02 1992-02-06 Boehringer Mannheim Gmbh Analyseelement und verfahren zu seiner herstellung
GB9027131D0 (en) * 1990-12-14 1991-02-06 Rice Evans Catherine Diagnostic test
US5182213A (en) * 1991-03-18 1993-01-26 Miles Inc. Method for detecting the presence of peroxidatively active substance in basic media
JP2704679B2 (ja) * 1991-04-11 1998-01-26 栄研化学株式会社 液体試料のイオン強度又は比重測定用組成物及び該組成物を用いた試験片
WO1993008684A1 (en) * 1991-10-28 1993-05-13 Steinman Gary D Process and device for measuring magnesium in biological fluids and method of preparing the device
DE4202850A1 (de) * 1992-01-31 1993-08-05 Boehringer Mannheim Gmbh Analysenelement fuer immunoassays
US5302531A (en) * 1992-10-22 1994-04-12 Miles Inc. Composition for the semiquantitative determination of specific gravity of a test sample
US5320969A (en) * 1992-10-22 1994-06-14 Miles Inc. Method, composition and device for the semiquantitative determination of specific gravity of a test sample
US5733785A (en) * 1993-05-28 1998-03-31 Chinera Research Chemical, Inc. Automated urinalysis method for detecting blood in urine
US5447868A (en) 1993-09-14 1995-09-05 Propper Manufacturing Co. Inc. Method, reagent and kit for the detection of fecal occult blood
US5516645A (en) * 1994-04-25 1996-05-14 Johnson & Johnson Clinical Diagnostics, Inc. Immunoassay analytical elements containing vanadium IV(V+4)ions
US5910423A (en) * 1995-04-28 1999-06-08 Ricoh Kyosan, Inc. Water soluble powered formulation of reagent mixture containing water-insoluble reagents, and process for their production
US5702955A (en) * 1995-05-22 1997-12-30 Bayer Corporation Ascorbate resistant detection of hydrogen peroxide
US6140368A (en) * 1997-05-05 2000-10-31 The Regents Of The University Of California Naphthols useful in antiviral methods
CA2249778A1 (en) * 1997-12-15 1999-06-15 Bayer Corporation Competitive apo-peroxidase assay
IL125880A (en) * 1998-08-21 2000-11-21 Fish Falk Method for the determination of analyte concentration in blood
JP4618932B2 (ja) * 2001-05-28 2011-01-26 株式会社同仁化学研究所 塩素濃度の測定用組成物
US7459127B2 (en) * 2002-02-26 2008-12-02 Siemens Healthcare Diagnostics Inc. Method and apparatus for precise transfer and manipulation of fluids by centrifugal and/or capillary forces
US7094354B2 (en) * 2002-12-19 2006-08-22 Bayer Healthcare Llc Method and apparatus for separation of particles in a microfluidic device
US7125711B2 (en) * 2002-12-19 2006-10-24 Bayer Healthcare Llc Method and apparatus for splitting of specimens into multiple channels of a microfluidic device
US7435381B2 (en) * 2003-05-29 2008-10-14 Siemens Healthcare Diagnostics Inc. Packaging of microfluidic devices
US20040265172A1 (en) * 2003-06-27 2004-12-30 Pugia Michael J. Method and apparatus for entry and storage of specimens into a microfluidic device
US20080257754A1 (en) * 2003-06-27 2008-10-23 Pugia Michael J Method and apparatus for entry of specimens into a microfluidic device
US20040265171A1 (en) * 2003-06-27 2004-12-30 Pugia Michael J. Method for uniform application of fluid into a reactive reagent area
US7347617B2 (en) * 2003-08-19 2008-03-25 Siemens Healthcare Diagnostics Inc. Mixing in microfluidic devices
CN101948906B (zh) * 2004-08-05 2013-02-27 旭化成制药株式会社 含有蛋白酶反应促进剂和/或色素稳定剂的试剂
JP4697809B2 (ja) * 2007-02-22 2011-06-08 旭化成ファーマ株式会社 ロイコ色素の安定化方法
TWI368029B (en) * 2007-10-19 2012-07-11 Gen Life Biotechnology Co Ltd Electrochemical method for detecting hemoglobin and test strip thereof
US7915047B2 (en) 2007-11-19 2011-03-29 Los Alamos National Security, Llc Coating for leak detection and method
JP2010189662A (ja) * 2010-05-13 2010-09-02 Asahi Kasei Pharma Kk ロイコ色素の安定化方法
JP5274590B2 (ja) * 2011-01-27 2013-08-28 旭化成ファーマ株式会社 ロイコ色素の安定化方法
RU2458992C1 (ru) * 2011-05-04 2012-08-20 Белорусский Государственный Университет (Бгу) Способ определения пероксидазной активности гемоглобина в плазме крови
WO2016077996A1 (en) * 2014-11-18 2016-05-26 Colgate-Palmolive Company Detecting blood
WO2020139767A1 (en) * 2018-12-28 2020-07-02 Beckman Coulter, Inc. Methods for enhanced detection of hemoglobin
CN112710595B (zh) * 2020-12-22 2022-10-28 西南石油大学 一种气藏储层水锁伤害实验评价方法
WO2023132551A1 (ko) * 2022-01-10 2023-07-13 주식회사 퓨쳐바이오웍스 동물의 소변 상태 진단용 모래, 이의 제조방법 및 이를 이용한 소변 상태 진단 방법

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2235127C2 (de) * 1972-07-18 1974-08-08 Boehringer Mannheim Gmbh, 6800 Mannheim Diagnostisches Mittel zum Nachweis von Blut und anderen peroxidatisch wirksamen Substanzen in Körperflüssigkeiten
US4071321A (en) * 1977-03-14 1978-01-31 Miles Laboratories, Inc. Test composition and device for determining peroxidatively active substances
US4071318A (en) * 1977-03-14 1978-01-31 Miles Laboratories, Inc. Test composition and device for determining peroxidatively active substances
US4251223A (en) * 1979-12-17 1981-02-17 Miles Laboratories, Inc. Sensitizers for peroxidative activity tests
US4755472A (en) * 1986-01-16 1988-07-05 Miles Inc. Stable composition for the determination of peroxidatively active substances
AU2382988A (en) * 1988-08-16 1990-03-23 Cetus Corporation Stable indicator solutions for detection of peroxidatic activity

Also Published As

Publication number Publication date
JPH04213064A (ja) 1992-08-04
KR0163792B1 (ko) 1999-03-30
JP2928649B2 (ja) 1999-08-03
DE69013882D1 (de) 1994-12-08
AU621510B2 (en) 1992-03-12
US5089420A (en) 1992-02-18
ATE113664T1 (de) 1994-11-15
EP0444273A1 (en) 1991-09-04
ES2066093T3 (es) 1995-03-01
DK0444273T3 (da) 1995-04-24
DE69013882T2 (de) 1995-03-09
EP0444273B1 (en) 1994-11-02
CA2025802A1 (en) 1991-07-31
AU6365990A (en) 1991-08-01

Similar Documents

Publication Publication Date Title
KR910014702A (ko) 과산화 활성 물질 검정을 위한 조성물. 장치 및 방법
KR910014703A (ko) 과산화 활성물질용 조성물, 분석장치 및 방법
JP3118029B2 (ja) ケトン体の検定のための組成物及び方法
JPS5838842A (ja) ルミネセンス検出装置
KR960018584A (ko) 특이성 결합검정용 시약
ES2158900T3 (es) Biosensor potenciometrico y metodo de utilizacion del mismo.
DK249085D0 (da) Testmateriale til bestemmelse af naervaerelsen af ethanol i en vandig proeve, dets fremstilling og anvendelse
CA2024206A1 (en) Test device and method of assaying for fructoasmines
ES2074051T3 (es) Ensayo de proteccion homogeneo.
RU2003100531A (ru) Композиции, содержащие краситель на основе производного мочевины, для выявления аналита, и способы их использования
ES524637A0 (es) Procedimiento y dispositivo para detectar la presencia yno determinar la concentracion de glucosa en una muestra de analisis.
KR937000679A (ko) 아스파르테이트 아미노트랜스퍼라제에 대한 1단계 시험
KR950032639A (ko) 생물학적 샘플중의 단백질을 측정하기 위한 검정법
CA1272125A (en) Chemiluminescent methods and kit
FI875210A0 (fi) Foerfarande och testanordning foer paovisning av ett aemne i ett prov.
ACRIDINONE ENZYMATIC ETHANOL TEST
ES2087892T3 (es) Utilizacion de la superoxido dismutasa en ensayos que implican una oxidasa.

Legal Events

Date Code Title Description
A201 Request for examination
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
G170 Re-publication after modification of scope of protection [patent]
LAPS Lapse due to unpaid annual fee