KR910008132A - 자기 가공 활성을 갖는 다기능 rna, 이의 제조방법 및 용도 - Google Patents

자기 가공 활성을 갖는 다기능 rna, 이의 제조방법 및 용도 Download PDF

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KR910008132A
KR910008132A KR1019900015779A KR900015779A KR910008132A KR 910008132 A KR910008132 A KR 910008132A KR 1019900015779 A KR1019900015779 A KR 1019900015779A KR 900015779 A KR900015779 A KR 900015779A KR 910008132 A KR910008132 A KR 910008132A
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rna
gene
ribozyme
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plants
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뮐르너 휴베르트
울만 오이겐
엑케스 피터
슈나이더 루돌프
윗트바알 베르나두스
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오일러, 라피체
훽스트 아크티엔게젤샤프트
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Publication of KR910008132A publication Critical patent/KR910008132A/ko

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Abstract

내용 없음

Description

자기 가공 활성을 갖는 다기능 RNA, 이의 제조방법 및 용도
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (11)

  1. 스페이서에 의해 안티쎈스 RNA 서열에 커플링된 리보자임 RNA 서열을 암호화하는 유전자.
  2. 제1항에 있어서, 하기 패턴을 갖는 유전자:5'－리보자임 RNA－스페이서－안티쎈스 RNA－(안티쎈스 RNA－스페이서－안티쎈스RNA)n－스페이서－리보자임 RNA－3' (상기에서, n은 0 내지 10의 수이고 각 경우에 리보자임 절단 부위를 함유하는 20개 내지 25개의 뉴클레오티드 쇄가 스페이서로서 삽입된다.)
  3. 제1항 또는 제2항에 있어서, 상기 암호화된 안티쎈스 RNA가 바이러스성 RNA에 상보적인 유전자.
  4. 제1항 내지 제3항중 어느 한 항에 있어서, 상기 암호화된 리보자임 mRNA가 바이러스성 RNA에 상보적인 유전자.
  5. 제1항 내지 제4항중 어느 한 항에 있어서, 표1에 열거된 DNA 서열을 포함하는 유전자.
  6. 제1항 내지 제5항중 어느 한 항에 청구된 유전자에 의해 암호화된 다기능 RNA.
  7. 제1항 내지 제5항중 어느 한 항에 청구된 유전자를 함유하는 숙주 세포.
  8. 제6항에 청구된 RNA를 함유하는 숙주세포.
  9. 제1항 내지 제5항중 어느 한 항에 청구된 유전자를 함유하는 식물. 식물세포 및 식물의 일부 또는 종자.
  10. 제6항에 청구된 RNA를 함유하는 식물, 식물세포 및 식물의 일부 또는 종자.
  11. 식물에서 항바이러스재료의 제3항 및 제4항의 유전자에 의해 암호화된 RNA의 용도.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019900015779A 1989-10-06 1990-10-05 자기 가공 활성을 갖는 다기능 rna, 이의 제조방법 및 용도 KR910008132A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3933384A DE3933384A1 (de) 1989-10-06 1989-10-06 Multifunktionelle rna mit selbstprozessierungsaktivitaet, ihre herstellung und ihre verwendung
DE39333841 1989-10-06

Publications (1)

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KR910008132A true KR910008132A (ko) 1991-05-30

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KR1019900015779A KR910008132A (ko) 1989-10-06 1990-10-05 자기 가공 활성을 갖는 다기능 rna, 이의 제조방법 및 용도

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US (2) US5707840A (ko)
EP (1) EP0421376B1 (ko)
JP (1) JPH03210180A (ko)
KR (1) KR910008132A (ko)
AT (1) ATE121452T1 (ko)
AU (1) AU634289B2 (ko)
DE (2) DE3933384A1 (ko)
DK (1) DK0421376T3 (ko)
ES (1) ES2073491T3 (ko)
HU (1) HUT62038A (ko)
IE (1) IE67652B1 (ko)
NZ (1) NZ235562A (ko)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4002885A1 (de) * 1990-02-01 1991-08-08 Hoechst Ag Expression einer multigen rna mit self-splicing aktivitaet
US5596132A (en) 1990-03-12 1997-01-21 Cornell Research Foundation, Inc. Induction of resistance to virus diseases by transformation of plants with a portion of a plant virus genome involving a read-through replicase gene
US5633449A (en) * 1990-03-12 1997-05-27 Cornell Research Foundation, Inc. Induction of resistance to viral diseases in plants
JPH05508535A (ja) * 1990-03-12 1993-12-02 コーネル・リサーチ・ファウンデーション・インコーポレイテッド 非構造植物ウイルス遺伝子配列による植物の形質転換
GB9018646D0 (en) * 1990-08-24 1990-10-10 Imperial College Replication of a eukaryotic virus rna
DK0625194T3 (da) * 1992-02-04 1996-05-28 Worcester Found Ex Biology Forøgelse af ribozym-katalytisk aktivitet med et tilstødende facilitator oligonukleotid
KR950700408A (ko) * 1992-02-04 1995-01-16 토루페터슨 인접한 촉진제 올리고누클레오티드에 의한 리보자임 촉매활성의 증강(enhancement of ribozyme catalytic activity by a neighboring facilitator oligonucleotide)
US6087484A (en) * 1992-02-04 2000-07-11 University Of Massachusetts Worcester Enhancement of ribozyme catalytic activity by A 2'-O-substituted facilitator oligonucleotide
DE4203441C1 (de) * 1992-02-06 1993-10-14 Max Planck Gesellschaft RNA- und DNA-Moleküle zur Erzeugung von Virusresistenzen
DE69331216T2 (de) * 1992-04-17 2002-07-25 Kirin Brewery Planze resistent gegen mindestens zwei viren und dessen preparation
ES2255703T3 (es) * 1992-06-29 2006-07-01 Gene Shears Pty Limited Acidos nucleicos y procedimientos para la utilizacion de los mismos para el control de patogenos viricos.
WO1994013793A1 (en) * 1992-12-04 1994-06-23 Apollon, Inc. Compounds and methods for the treatment of leukemias
FR2701960B1 (fr) * 1993-02-26 2002-09-13 Gene Shears Pty Ltd Polyribozyme apte à conférer, aux plantes, une résistance aux virus et plantes résistantes produisant ce polyribozyme.
EP0728199A1 (en) * 1993-07-22 1996-08-28 Gene Shears Pty Limited Dna virus ribozymes
GB9320548D0 (en) * 1993-10-06 1993-11-24 Sandoz Ltd Improvements in or relating to organic compounds
US5908779A (en) * 1993-12-01 1999-06-01 University Of Connecticut Targeted RNA degradation using nuclear antisense RNA
DE4420298A1 (de) * 1994-06-10 1995-12-14 Hoechst Schering Agrevo Gmbh Modifizierte Satelliten-RNAs und Satelliten-Viren als Träger adaptierter Ribozyme
US5824519A (en) * 1995-11-08 1998-10-20 Medical University Of South Carolina Tissue-specific and target RNA-specific ribozymes
IT1283631B1 (it) * 1996-05-09 1998-04-23 Metapontum Agrobios Srl Metodo per la preparazione di piante transgeniche resistenti ad in- fezioni virali e piante cosi' ottenute
DE10212892A1 (de) * 2002-03-20 2003-10-09 Basf Plant Science Gmbh Konstrukte und Verfahren zur Regulation der Genexpression

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4987071A (en) * 1986-12-03 1991-01-22 University Patents, Inc. RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods
MC2115A1 (fr) * 1987-12-15 1991-07-05 Gene Shears Pty Ltd Ribozynes
DK0625194T3 (da) * 1992-02-04 1996-05-28 Worcester Found Ex Biology Forøgelse af ribozym-katalytisk aktivitet med et tilstødende facilitator oligonukleotid

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Publication number Publication date
IE903579A1 (en) 1991-04-10
HUT62038A (en) 1993-03-29
EP0421376A1 (de) 1991-04-10
ATE121452T1 (de) 1995-05-15
HU906339D0 (en) 1991-04-29
AU6382790A (en) 1991-04-11
NZ235562A (en) 1992-12-23
DE59008928D1 (de) 1995-05-24
EP0421376B1 (de) 1995-04-19
US5834265A (en) 1998-11-10
ES2073491T3 (es) 1995-08-16
US5707840A (en) 1998-01-13
AU634289B2 (en) 1993-02-18
IE67652B1 (en) 1996-04-17
DK0421376T3 (da) 1995-09-04
DE3933384A1 (de) 1991-04-18
JPH03210180A (ja) 1991-09-13

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