KR910001563A - 아닐리노푸마르산염의 제조방법 - Google Patents

아닐리노푸마르산염의 제조방법 Download PDF

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Publication number
KR910001563A
KR910001563A KR1019900000384A KR900000384A KR910001563A KR 910001563 A KR910001563 A KR 910001563A KR 1019900000384 A KR1019900000384 A KR 1019900000384A KR 900000384 A KR900000384 A KR 900000384A KR 910001563 A KR910001563 A KR 910001563A
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KR
South Korea
Prior art keywords
alkyl
chloromaleate
general formula
phase transfer
transfer catalyst
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Application number
KR1019900000384A
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English (en)
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KR100207247B1 (ko
Inventor
앤소니 세바스코 앨버트
로이 몰딩 도놀드
Original Assignee
알퐁스 아아르 노에
아메리칸 사이아나밋드 캄파니
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Application filed by 알퐁스 아아르 노에, 아메리칸 사이아나밋드 캄파니 filed Critical 알퐁스 아아르 노에
Publication of KR910001563A publication Critical patent/KR910001563A/ko
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Publication of KR100207247B1 publication Critical patent/KR100207247B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/04—Formation of amino groups in compounds containing carboxyl groups
    • C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
    • C07C227/08—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid by reaction of ammonia or amines with acids containing functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/30—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and unsaturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Color Printing (AREA)

Abstract

내용 없음

Description

아닐리노푸마르산염의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (8)

  1. 상전이 촉매를 함유하는 약 1.0 내지 1.8몰당량의 수성염기의 존재하에서 약1.0내지 1.5몰당량이 아닐린과 일반식(II) ;
    (여기서, R은 C1-C4알킬임)의 클로로말레산염 또는 일반식(III) ;
    (여기서, R은 C1-C4알킬임)의 클로로푸마르산염 또는 이들의 혼합물을 반응시켜아닐리 노푸마르산염을 형성하는 것으로 구성된, 일반식(I) ;
    (여기서, R은 C1-C4알킬임)의 아닐지노푸마르산염의 제조방법.
  2. 제 1항에 있어서, 수성 염기가 알칼리 금속 수산화물, 중탄산염 또는 탄산염의 15% 내지 50% 수용액인 방법.
  3. 제 2항에 있어서, 염기가 약 20% 내지 30%수용액으로 존재하는 탄산 나트륨인 방법.
  4. 제 1항에 있어서, 상 전이 촉매가 테트라알킬화된 암모늄염인 방법.
  5. 제 1항에 있어서, 상 전이 촉매가 브롬화 테트라 -n-부틸 암모늄인 방법.
  6. 제 1항에 있어서, 방법이 약 70℃ 내지 110℃에서 수행되는 방법.
  7. 제 6항에 있어서, 온도가 약 90℃ 내지 95℃인 방법.
  8. 제 1항에 있어서, 일반식(II)의 클로로말레산염이 디에틸 클로로말레산염인 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019900000384A 1989-06-15 1990-01-13 아닐리노푸 마르산염의 제조 방법 KR100207247B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/366,554 1989-06-15
US07/366,554 US4904816A (en) 1989-06-15 1989-06-15 Process for the manufacture of anilinofumarate via chloromaleate or chlorofumarate or mixtures thereof
US7/366,554 1989-06-15

Publications (2)

Publication Number Publication Date
KR910001563A true KR910001563A (ko) 1991-01-31
KR100207247B1 KR100207247B1 (ko) 1999-07-15

Family

ID=23443514

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019900000384A KR100207247B1 (ko) 1989-06-15 1990-01-13 아닐리노푸 마르산염의 제조 방법

Country Status (16)

Country Link
US (1) US4904816A (ko)
EP (1) EP0402561B1 (ko)
JP (1) JP2812761B2 (ko)
KR (1) KR100207247B1 (ko)
AR (1) AR245437A1 (ko)
AT (1) ATE112548T1 (ko)
AU (1) AU617576B2 (ko)
BR (1) BR9000119A (ko)
CA (1) CA2007653C (ko)
DE (1) DE69013062T2 (ko)
DK (1) DK0402561T3 (ko)
ES (1) ES2060819T3 (ko)
HU (1) HU204771B (ko)
IE (1) IE64431B1 (ko)
IL (1) IL92786A (ko)
ZA (1) ZA90100B (ko)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5276157A (en) * 1991-12-20 1994-01-04 American Cyanamid Company Process for the purification of 2,3-pyridine and quinolinedicarboxylic acid diester compounds
CN109187521A (zh) * 2018-08-30 2019-01-11 湖南博隽生物医药有限公司 一种检测唾液中酒精含量的聚合物膜及其制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD71545A (ko) *
US4656283A (en) * 1982-05-25 1987-04-07 American Cyanamid Company Alkyl esters of substituted 2-methyl-3-quinolinecarboxylic acid and quinoline-2,3-dicarboxylic acid
US4843162A (en) * 1982-05-25 1989-06-27 American Cyanamid Company Alkyl esters of substituted 2-methyl-3-quinolinecarboxylic acid and quinoline-2,3-dicarboxylic acid
ATE57912T1 (de) * 1986-08-29 1990-11-15 American Cyanamid Co Verfahren zur herstellung von anilinofumarat und 2,3-chinolindicarbonsaeure.
US4675432A (en) * 1986-08-29 1987-06-23 American Cyanamid Company Method for the preparation of anilinofumarate
US4814486A (en) * 1987-10-01 1989-03-21 American Cyanamid Company Method for the preparation of anilinofumarate

Also Published As

Publication number Publication date
HUT54101A (en) 1991-01-28
US4904816A (en) 1990-02-27
CA2007653C (en) 1999-04-06
BR9000119A (pt) 1991-10-08
JPH0324045A (ja) 1991-02-01
AU4792990A (en) 1990-12-20
CA2007653A1 (en) 1990-12-15
KR100207247B1 (ko) 1999-07-15
HU204771B (en) 1992-02-28
DE69013062D1 (de) 1994-11-10
EP0402561B1 (en) 1994-10-05
ATE112548T1 (de) 1994-10-15
AR245437A1 (es) 1994-01-31
DK0402561T3 (da) 1994-10-31
IE900133A1 (en) 1991-01-02
IL92786A0 (en) 1990-09-17
IE64431B1 (en) 1995-08-09
ZA90100B (en) 1990-10-31
JP2812761B2 (ja) 1998-10-22
AU617576B2 (en) 1991-11-28
IL92786A (en) 1994-05-30
EP0402561A2 (en) 1990-12-19
ES2060819T3 (es) 1994-12-01
HU900120D0 (en) 1990-03-28
IE900133L (en) 1990-12-15
EP0402561A3 (en) 1991-05-29
DE69013062T2 (de) 1995-05-11

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