KR900700083A - 뮤우신에 대하여 친화력을 갖는 리포소옴 - Google Patents

뮤우신에 대하여 친화력을 갖는 리포소옴

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Publication number
KR900700083A
KR900700083A KR1019890702003A KR890702003A KR900700083A KR 900700083 A KR900700083 A KR 900700083A KR 1019890702003 A KR1019890702003 A KR 1019890702003A KR 890702003 A KR890702003 A KR 890702003A KR 900700083 A KR900700083 A KR 900700083A
Authority
KR
South Korea
Prior art keywords
charge
lipid
group
molecule
liposome
Prior art date
Application number
KR1019890702003A
Other languages
English (en)
Other versions
KR970005004B1 (ko
Inventor
더블유.블레어 게호
죤 알. 라우.
Original Assignee
죠셉 자콥
테크 놀로지 운리미티드, 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22584939&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR900700083(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 죠셉 자콥, 테크 놀로지 운리미티드, 인코포레이티드 filed Critical 죠셉 자콥
Publication of KR900700083A publication Critical patent/KR900700083A/ko
Application granted granted Critical
Publication of KR970005004B1 publication Critical patent/KR970005004B1/ko

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2989—Microcapsule with solid core [includes liposome]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

내용 없음

Description

뮤우신에 대하여 친화력을 갖는 리포소옴
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 약극성 지방질들로 이루어진 리포소옴 구조를 설명하기 위하여 통상적으로 사용된 수단이다. 제2-5도는 본 발명을 연구하고 시험하기 위하여 사용된 리포소옴막 구조중 두개의 지방질 성분들간의 공간배열관계에 관한 설명이다.

Claims (4)

  1. 제1 및 제2 구조형태의 양극성 지방질분자에 있어서, 제1형태의 분자는 직렬로 친수성 머리기를 가지며 그 직렬식배열은 중간위치에(-)전하부분을 가지며 맨끝위치에(+)전하부분을 가지고, 이러한 직렬식 전하 배열에 의해 실제적으로 중화효과전하가 야기되며: 그리고 제2형태의 분자는 직렬식(+)전하의 확장위치미만으로 확장하는 (+)전하의 친수성 머리부분을 가지며 그것에 의해서 중간부분에 위치한 (-)전하는 제2형태 분자에의해 효과적으로 중화되며 맨 끝부분은 주위에 대하여(+)전하를 안출함을 특징으로하는 적어도 제1구조형태 및 제2구조형태의 양극성 지방질 분자로 이루어진 리포소옴.
  2. 제2성분에 캡슐화되거나 또는 제2성에 혼입되는 약물 또는 진단제인 제1성분: 소포 또는 리포소옴형태의 지방질막구조를 구성하는 제2성분: 극성지방질들로 이루어진 막구조, 제1구조형태의 극성 지방질은 (+) 전하를 띠는 맨끝 작용기와 맨끝에 위치한 기를 다른 지방질 말단기에 상호 연결하는 작용기에 의해 성취된 실제적으로 중화결과 및 전하를 가지며, 그 상호 연결기는 (-)전하를 가지며, 그리고 제2구조형태의 극성기는 단지 다른 말단기에 상호연결된 (+)전하를 띤 머리작용기만을 가지며: 그같은 결과에 의해 제2형태의 (+)머리기 및 제1형태의 상호 연결기는 서로 중화되어 제1형태의 맨끝 작용기만이 우세하게 남게됨으로 이루어지는 물질조성물.
  3. 제1항에 있어서, 제1형태의 분자는 디스테아로일 레시틴이며 제2형태의 분자는 스테아릴아민인 리포소옴.
  4. 아실부분과 콜린부분 그리고 상호 연결기인 포스파티딜부분을 갖는 제1지방질과(+)전하를 띠는 친수성 머리부분을 갖는 제2지방질의 혼합물 그리고 적어도 약간의 콜레스테롤을 함유하는 혼합물의 나머지에 에너지를 주입하고, 약물 또는 진단물질을 가진 그 리포소옴을 상기 혼합물에 혼입함으로 이루어지는, 혼혈숙주의 뮤우신막에 대하여 친화력을 갖는 닫힌 지방질막으로 특징지워진 리포소옴 구성방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890702003A 1988-02-29 1989-02-24 뮤우신에 대하여 친화력을 갖는 리포조옴 KR970005004B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/162,275 US4921644A (en) 1988-02-29 1988-02-29 Mucin directed lipsome
US162,275 1988-02-29
PCT/US1989/000692 WO1989007937A1 (en) 1988-02-29 1989-02-24 Mucin directed liposome

Publications (2)

Publication Number Publication Date
KR900700083A true KR900700083A (ko) 1990-08-11
KR970005004B1 KR970005004B1 (ko) 1997-04-11

Family

ID=22584939

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019890702003A KR970005004B1 (ko) 1988-02-29 1989-02-24 뮤우신에 대하여 친화력을 갖는 리포조옴

Country Status (9)

Country Link
US (1) US4921644A (ko)
EP (1) EP0402386B1 (ko)
JP (1) JP2832472B2 (ko)
KR (1) KR970005004B1 (ko)
AT (1) ATE144702T1 (ko)
AU (1) AU611348B2 (ko)
DE (1) DE68927406T2 (ko)
DK (1) DK205490D0 (ko)
WO (1) WO1989007937A1 (ko)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07122055B2 (ja) * 1989-11-17 1995-12-25 富士写真フイルム株式会社 ポリペプチド薄膜
US5603872A (en) * 1991-02-14 1997-02-18 Baxter International Inc. Method of binding recognizing substances to liposomes
US5997899A (en) * 1996-10-01 1999-12-07 Skyepharma Inc. Method for producing liposomes with increased percent of compound encapsulated
US5827533A (en) * 1997-02-06 1998-10-27 Duke University Liposomes containing active agents aggregated with lipid surfactants
NZ503513A (en) 1997-09-18 2004-12-24 Skyepharma Inc Sustained-release liposomal anesthetic compositions
US7169410B1 (en) * 1998-05-19 2007-01-30 Sdg, Inc. Targeted liposomal drug delivery system
US6200598B1 (en) * 1998-06-18 2001-03-13 Duke University Temperature-sensitive liposomal formulation
US6726925B1 (en) * 1998-06-18 2004-04-27 Duke University Temperature-sensitive liposomal formulation
MXPA02004700A (es) 1999-11-09 2004-09-10 Alcon Inc Compuestos relacionados con acido 15-hidroxieicosatetraenoico y metodos de uso.
WO2001034550A2 (en) 1999-11-09 2001-05-17 Alcon Universal Ltd. 15-hydroxyeicosatetraenoic acid analogs with enhanced metabolic stability and methods of their use in treating dry eye disorders
US6803385B2 (en) 1999-11-09 2004-10-12 Alcon, Inc. Hydroxyeicosatetraenoic acid analogs and methods of their use in treating dry eye disorders
WO2001034548A2 (en) 1999-11-09 2001-05-17 Alcon Universal Ltd. 3-heteroatom substituted and two carbon homologs of 15-hete and methods of use
TR200201249T2 (tr) 1999-11-09 2002-09-23 Alcon, Inc. 15-hidroksieikosatetraenoik asitin heteroatomun araya girdiği analogları ve bunların kullanım yöntemleri.
US6552084B2 (en) 1999-11-09 2003-04-22 Alcon Universal Ltd. Hydroxyeicosatetraenoic acid analogs and methods of their use in treating dry eye disorders
KR20020050239A (ko) 1999-11-09 2002-06-26 구이도 콜러, 스테판 바슬러 하이드록시에이코사테트라엔산 유도체를 함유하는 조성물및 안구 건조증 치료에서의 사용 방법
BR0015402A (pt) 1999-11-09 2002-06-25 Alcon Inc Derivados de ácido 15-hidroxieicosatetraenóico de cadeia Èmega modificada e métodos de seu uso para o tratamento de olho seco
US6353032B1 (en) 1999-11-09 2002-03-05 Alcon Universal Ltd. Phospholipids of hydroxyeicosatetraenoic acid-like derivatives and methods of use
DE60020591T2 (de) 1999-11-09 2005-11-10 Alcon Inc. Benzenoidderivate von 15-hydroxyeicosatetraesäure und verfahren zur verwendung zur behandlung des trockenen auges
BR0015436A (pt) 1999-11-09 2002-07-16 Alcon Inc Sais de hidroxieicosatetraenoato, composições e métodos de uso no tratamento de distúrbios dos olhos secos
US6458854B2 (en) 1999-11-09 2002-10-01 Alcon Universal Ltd. Phospholipids of hydroxyeicosatetraenoic acid-like derivatives and methods of use
WO2001034553A2 (en) 1999-11-09 2001-05-17 Alcon Universal Ltd. 2,2-difluoro 15-hydroxyeicosatetraenoic acid analogs and methods of use
US6312736B1 (en) 1999-12-09 2001-11-06 Biotech Corporation Herbal composition to relieve pain
IL158819A0 (en) * 2001-05-31 2004-05-12 Skyepharma Inc Encapsulation of nanosuspensions in liposomes and microspheres
AU2003203034A1 (en) * 2002-01-14 2003-07-30 Vertex Pharmaceuticals Incorporated Mucin immobilized chromatography
FR2870741B1 (fr) * 2004-05-25 2008-03-14 Coletica Sa Phase lamellaires hydratees ou liposomes, contenant une monoamine grasse ou un polymere cationique favorisant la penetration intercellulaire, et composition cosmetique ou pharmaceutique la contenant.
US20100272859A1 (en) * 2007-08-28 2010-10-28 Pepsico, Inc. Delivery and controlled release of encapsulated water-insoluble flavorants
US9186640B2 (en) * 2007-08-28 2015-11-17 Pepsico, Inc. Delivery and controlled release of encapsulated lipophilic nutrients
US11278494B1 (en) 2021-01-22 2022-03-22 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US11357727B1 (en) 2021-01-22 2022-06-14 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US11033495B1 (en) 2021-01-22 2021-06-15 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4086257A (en) * 1976-10-12 1978-04-25 Sears Barry D Phosphatidyl quaternary ammonium compounds
US4501728A (en) * 1983-01-06 1985-02-26 Technology Unlimited, Inc. Masking of liposomes from RES recognition
US4614796A (en) * 1983-03-25 1986-09-30 Nippon Shinyaku Co., Ltd. Liposome and method of manufacture therefor
JPS6176414A (ja) * 1984-09-21 1986-04-18 Shionogi & Co Ltd リポソーム製剤の製法
US4762915A (en) * 1985-01-18 1988-08-09 Liposome Technology, Inc. Protein-liposome conjugates
US4751219A (en) * 1985-02-05 1988-06-14 Nederlandse Centrale Organisatie Voor Toegepast-Natuur-Wetenschappelijk Onderzoek Synthetic glycolipides, a process for the preparation thereof and several uses for these synthetic glycolipides
FR2586587B1 (fr) * 1985-08-30 1987-10-23 Adir Nouveaux surfactants artificiels, leur preparation et les compositions pharmaceutiques qui les contiennent.
EP0316345A1 (en) * 1986-07-28 1989-05-24 Liposome Technology, Inc. Liposomes with enhanced retention on mucosal tissue
US4938965A (en) * 1987-07-22 1990-07-03 Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of National Defence Of Her Majesty's Canadian Government Ocular delivery of prophylactic agents

Also Published As

Publication number Publication date
EP0402386A1 (en) 1990-12-19
DK205490A (da) 1990-08-28
AU3194889A (en) 1989-09-22
JPH03503408A (ja) 1991-08-01
EP0402386B1 (en) 1996-10-30
US4921644A (en) 1990-05-01
ATE144702T1 (de) 1996-11-15
DE68927406T2 (de) 1997-06-12
WO1989007937A1 (en) 1989-09-08
DE68927406D1 (de) 1996-12-05
DK205490D0 (da) 1990-08-28
KR970005004B1 (ko) 1997-04-11
JP2832472B2 (ja) 1998-12-09
EP0402386A4 (en) 1991-10-30
AU611348B2 (en) 1991-06-06

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