KR900700083A - 뮤우신에 대하여 친화력을 갖는 리포소옴 - Google Patents
뮤우신에 대하여 친화력을 갖는 리포소옴Info
- Publication number
- KR900700083A KR900700083A KR1019890702003A KR890702003A KR900700083A KR 900700083 A KR900700083 A KR 900700083A KR 1019890702003 A KR1019890702003 A KR 1019890702003A KR 890702003 A KR890702003 A KR 890702003A KR 900700083 A KR900700083 A KR 900700083A
- Authority
- KR
- South Korea
- Prior art keywords
- charge
- lipid
- group
- molecule
- liposome
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2984—Microcapsule with fluid core [includes liposome]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2989—Microcapsule with solid core [includes liposome]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Preparation (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 약극성 지방질들로 이루어진 리포소옴 구조를 설명하기 위하여 통상적으로 사용된 수단이다. 제2-5도는 본 발명을 연구하고 시험하기 위하여 사용된 리포소옴막 구조중 두개의 지방질 성분들간의 공간배열관계에 관한 설명이다.
Claims (4)
- 제1 및 제2 구조형태의 양극성 지방질분자에 있어서, 제1형태의 분자는 직렬로 친수성 머리기를 가지며 그 직렬식배열은 중간위치에(-)전하부분을 가지며 맨끝위치에(+)전하부분을 가지고, 이러한 직렬식 전하 배열에 의해 실제적으로 중화효과전하가 야기되며: 그리고 제2형태의 분자는 직렬식(+)전하의 확장위치미만으로 확장하는 (+)전하의 친수성 머리부분을 가지며 그것에 의해서 중간부분에 위치한 (-)전하는 제2형태 분자에의해 효과적으로 중화되며 맨 끝부분은 주위에 대하여(+)전하를 안출함을 특징으로하는 적어도 제1구조형태 및 제2구조형태의 양극성 지방질 분자로 이루어진 리포소옴.
- 제2성분에 캡슐화되거나 또는 제2성에 혼입되는 약물 또는 진단제인 제1성분: 소포 또는 리포소옴형태의 지방질막구조를 구성하는 제2성분: 극성지방질들로 이루어진 막구조, 제1구조형태의 극성 지방질은 (+) 전하를 띠는 맨끝 작용기와 맨끝에 위치한 기를 다른 지방질 말단기에 상호 연결하는 작용기에 의해 성취된 실제적으로 중화결과 및 전하를 가지며, 그 상호 연결기는 (-)전하를 가지며, 그리고 제2구조형태의 극성기는 단지 다른 말단기에 상호연결된 (+)전하를 띤 머리작용기만을 가지며: 그같은 결과에 의해 제2형태의 (+)머리기 및 제1형태의 상호 연결기는 서로 중화되어 제1형태의 맨끝 작용기만이 우세하게 남게됨으로 이루어지는 물질조성물.
- 제1항에 있어서, 제1형태의 분자는 디스테아로일 레시틴이며 제2형태의 분자는 스테아릴아민인 리포소옴.
- 아실부분과 콜린부분 그리고 상호 연결기인 포스파티딜부분을 갖는 제1지방질과(+)전하를 띠는 친수성 머리부분을 갖는 제2지방질의 혼합물 그리고 적어도 약간의 콜레스테롤을 함유하는 혼합물의 나머지에 에너지를 주입하고, 약물 또는 진단물질을 가진 그 리포소옴을 상기 혼합물에 혼입함으로 이루어지는, 혼혈숙주의 뮤우신막에 대하여 친화력을 갖는 닫힌 지방질막으로 특징지워진 리포소옴 구성방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/162,275 US4921644A (en) | 1988-02-29 | 1988-02-29 | Mucin directed lipsome |
US162,275 | 1988-02-29 | ||
PCT/US1989/000692 WO1989007937A1 (en) | 1988-02-29 | 1989-02-24 | Mucin directed liposome |
Publications (2)
Publication Number | Publication Date |
---|---|
KR900700083A true KR900700083A (ko) | 1990-08-11 |
KR970005004B1 KR970005004B1 (ko) | 1997-04-11 |
Family
ID=22584939
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019890702003A KR970005004B1 (ko) | 1988-02-29 | 1989-02-24 | 뮤우신에 대하여 친화력을 갖는 리포조옴 |
Country Status (9)
Country | Link |
---|---|
US (1) | US4921644A (ko) |
EP (1) | EP0402386B1 (ko) |
JP (1) | JP2832472B2 (ko) |
KR (1) | KR970005004B1 (ko) |
AT (1) | ATE144702T1 (ko) |
AU (1) | AU611348B2 (ko) |
DE (1) | DE68927406T2 (ko) |
DK (1) | DK205490D0 (ko) |
WO (1) | WO1989007937A1 (ko) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH07122055B2 (ja) * | 1989-11-17 | 1995-12-25 | 富士写真フイルム株式会社 | ポリペプチド薄膜 |
US5603872A (en) * | 1991-02-14 | 1997-02-18 | Baxter International Inc. | Method of binding recognizing substances to liposomes |
US5997899A (en) * | 1996-10-01 | 1999-12-07 | Skyepharma Inc. | Method for producing liposomes with increased percent of compound encapsulated |
US5827533A (en) * | 1997-02-06 | 1998-10-27 | Duke University | Liposomes containing active agents aggregated with lipid surfactants |
NZ503513A (en) | 1997-09-18 | 2004-12-24 | Skyepharma Inc | Sustained-release liposomal anesthetic compositions |
US7169410B1 (en) * | 1998-05-19 | 2007-01-30 | Sdg, Inc. | Targeted liposomal drug delivery system |
US6200598B1 (en) * | 1998-06-18 | 2001-03-13 | Duke University | Temperature-sensitive liposomal formulation |
US6726925B1 (en) * | 1998-06-18 | 2004-04-27 | Duke University | Temperature-sensitive liposomal formulation |
MXPA02004700A (es) | 1999-11-09 | 2004-09-10 | Alcon Inc | Compuestos relacionados con acido 15-hidroxieicosatetraenoico y metodos de uso. |
WO2001034550A2 (en) | 1999-11-09 | 2001-05-17 | Alcon Universal Ltd. | 15-hydroxyeicosatetraenoic acid analogs with enhanced metabolic stability and methods of their use in treating dry eye disorders |
US6803385B2 (en) | 1999-11-09 | 2004-10-12 | Alcon, Inc. | Hydroxyeicosatetraenoic acid analogs and methods of their use in treating dry eye disorders |
WO2001034548A2 (en) | 1999-11-09 | 2001-05-17 | Alcon Universal Ltd. | 3-heteroatom substituted and two carbon homologs of 15-hete and methods of use |
TR200201249T2 (tr) | 1999-11-09 | 2002-09-23 | Alcon, Inc. | 15-hidroksieikosatetraenoik asitin heteroatomun araya girdiği analogları ve bunların kullanım yöntemleri. |
US6552084B2 (en) | 1999-11-09 | 2003-04-22 | Alcon Universal Ltd. | Hydroxyeicosatetraenoic acid analogs and methods of their use in treating dry eye disorders |
KR20020050239A (ko) | 1999-11-09 | 2002-06-26 | 구이도 콜러, 스테판 바슬러 | 하이드록시에이코사테트라엔산 유도체를 함유하는 조성물및 안구 건조증 치료에서의 사용 방법 |
BR0015402A (pt) | 1999-11-09 | 2002-06-25 | Alcon Inc | Derivados de ácido 15-hidroxieicosatetraenóico de cadeia Èmega modificada e métodos de seu uso para o tratamento de olho seco |
US6353032B1 (en) | 1999-11-09 | 2002-03-05 | Alcon Universal Ltd. | Phospholipids of hydroxyeicosatetraenoic acid-like derivatives and methods of use |
DE60020591T2 (de) | 1999-11-09 | 2005-11-10 | Alcon Inc. | Benzenoidderivate von 15-hydroxyeicosatetraesäure und verfahren zur verwendung zur behandlung des trockenen auges |
BR0015436A (pt) | 1999-11-09 | 2002-07-16 | Alcon Inc | Sais de hidroxieicosatetraenoato, composições e métodos de uso no tratamento de distúrbios dos olhos secos |
US6458854B2 (en) | 1999-11-09 | 2002-10-01 | Alcon Universal Ltd. | Phospholipids of hydroxyeicosatetraenoic acid-like derivatives and methods of use |
WO2001034553A2 (en) | 1999-11-09 | 2001-05-17 | Alcon Universal Ltd. | 2,2-difluoro 15-hydroxyeicosatetraenoic acid analogs and methods of use |
US6312736B1 (en) | 1999-12-09 | 2001-11-06 | Biotech Corporation | Herbal composition to relieve pain |
IL158819A0 (en) * | 2001-05-31 | 2004-05-12 | Skyepharma Inc | Encapsulation of nanosuspensions in liposomes and microspheres |
AU2003203034A1 (en) * | 2002-01-14 | 2003-07-30 | Vertex Pharmaceuticals Incorporated | Mucin immobilized chromatography |
FR2870741B1 (fr) * | 2004-05-25 | 2008-03-14 | Coletica Sa | Phase lamellaires hydratees ou liposomes, contenant une monoamine grasse ou un polymere cationique favorisant la penetration intercellulaire, et composition cosmetique ou pharmaceutique la contenant. |
US20100272859A1 (en) * | 2007-08-28 | 2010-10-28 | Pepsico, Inc. | Delivery and controlled release of encapsulated water-insoluble flavorants |
US9186640B2 (en) * | 2007-08-28 | 2015-11-17 | Pepsico, Inc. | Delivery and controlled release of encapsulated lipophilic nutrients |
US11278494B1 (en) | 2021-01-22 | 2022-03-22 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
US11357727B1 (en) | 2021-01-22 | 2022-06-14 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
US11033495B1 (en) | 2021-01-22 | 2021-06-15 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4086257A (en) * | 1976-10-12 | 1978-04-25 | Sears Barry D | Phosphatidyl quaternary ammonium compounds |
US4501728A (en) * | 1983-01-06 | 1985-02-26 | Technology Unlimited, Inc. | Masking of liposomes from RES recognition |
US4614796A (en) * | 1983-03-25 | 1986-09-30 | Nippon Shinyaku Co., Ltd. | Liposome and method of manufacture therefor |
JPS6176414A (ja) * | 1984-09-21 | 1986-04-18 | Shionogi & Co Ltd | リポソーム製剤の製法 |
US4762915A (en) * | 1985-01-18 | 1988-08-09 | Liposome Technology, Inc. | Protein-liposome conjugates |
US4751219A (en) * | 1985-02-05 | 1988-06-14 | Nederlandse Centrale Organisatie Voor Toegepast-Natuur-Wetenschappelijk Onderzoek | Synthetic glycolipides, a process for the preparation thereof and several uses for these synthetic glycolipides |
FR2586587B1 (fr) * | 1985-08-30 | 1987-10-23 | Adir | Nouveaux surfactants artificiels, leur preparation et les compositions pharmaceutiques qui les contiennent. |
EP0316345A1 (en) * | 1986-07-28 | 1989-05-24 | Liposome Technology, Inc. | Liposomes with enhanced retention on mucosal tissue |
US4938965A (en) * | 1987-07-22 | 1990-07-03 | Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of National Defence Of Her Majesty's Canadian Government | Ocular delivery of prophylactic agents |
-
1988
- 1988-02-29 US US07/162,275 patent/US4921644A/en not_active Expired - Lifetime
-
1989
- 1989-02-24 AU AU31948/89A patent/AU611348B2/en not_active Ceased
- 1989-02-24 WO PCT/US1989/000692 patent/WO1989007937A1/en active IP Right Grant
- 1989-02-24 JP JP1502708A patent/JP2832472B2/ja not_active Expired - Lifetime
- 1989-02-24 EP EP89902916A patent/EP0402386B1/en not_active Expired - Lifetime
- 1989-02-24 DE DE68927406T patent/DE68927406T2/de not_active Expired - Fee Related
- 1989-02-24 KR KR1019890702003A patent/KR970005004B1/ko not_active IP Right Cessation
- 1989-02-24 AT AT89902916T patent/ATE144702T1/de not_active IP Right Cessation
-
1990
- 1990-08-28 DK DK205490A patent/DK205490D0/da not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EP0402386A1 (en) | 1990-12-19 |
DK205490A (da) | 1990-08-28 |
AU3194889A (en) | 1989-09-22 |
JPH03503408A (ja) | 1991-08-01 |
EP0402386B1 (en) | 1996-10-30 |
US4921644A (en) | 1990-05-01 |
ATE144702T1 (de) | 1996-11-15 |
DE68927406T2 (de) | 1997-06-12 |
WO1989007937A1 (en) | 1989-09-08 |
DE68927406D1 (de) | 1996-12-05 |
DK205490D0 (da) | 1990-08-28 |
KR970005004B1 (ko) | 1997-04-11 |
JP2832472B2 (ja) | 1998-12-09 |
EP0402386A4 (en) | 1991-10-30 |
AU611348B2 (en) | 1991-06-06 |
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