KR900011896A - 사람 항트롬빈3의 돌연변이체 및 이의 제조방법 - Google Patents

사람 항트롬빈3의 돌연변이체 및 이의 제조방법

Info

Publication number
KR900011896A
KR900011896A KR1019900000748A KR900000748A KR900011896A KR 900011896 A KR900011896 A KR 900011896A KR 1019900000748 A KR1019900000748 A KR 1019900000748A KR 900000748 A KR900000748 A KR 900000748A KR 900011896 A KR900011896 A KR 900011896A
Authority
KR
South Korea
Prior art keywords
mutant
preparation
human antithrombin
antithrombin
human
Prior art date
Application number
KR1019900000748A
Other languages
English (en)
Other versions
KR0171197B1 (ko
Inventor
제틀마이슬 게르트
에릭 카르게스 헤르만
벡커 아침
Original Assignee
센테온 파르마 게엠베하
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 센테온 파르마 게엠베하 filed Critical 센테온 파르마 게엠베하
Publication of KR900011896A publication Critical patent/KR900011896A/ko
Application granted granted Critical
Publication of KR0171197B1 publication Critical patent/KR0171197B1/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • C07K14/8128—Antithrombin III
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
KR1019900000748A 1989-01-24 1990-01-23 사람 항트롬빈3의 돌연변이체 및 이의 제조방법 KR0171197B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP3901917.9 1989-01-24
DE3901917A DE3901917A1 (de) 1989-01-24 1989-01-24 Mutanten von humanem antithrombin iii

Publications (2)

Publication Number Publication Date
KR900011896A true KR900011896A (ko) 1990-08-02
KR0171197B1 KR0171197B1 (ko) 1999-02-01

Family

ID=6372631

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019900000748A KR0171197B1 (ko) 1989-01-24 1990-01-23 사람 항트롬빈3의 돌연변이체 및 이의 제조방법

Country Status (13)

Country Link
US (2) US5618713A (ko)
EP (1) EP0384122B1 (ko)
JP (1) JP3226215B2 (ko)
KR (1) KR0171197B1 (ko)
AT (1) ATE184913T1 (ko)
AU (1) AU625667B2 (ko)
CA (1) CA2008390C (ko)
DE (2) DE3901917A1 (ko)
DK (1) DK0384122T3 (ko)
ES (1) ES2137918T3 (ko)
GR (1) GR3031991T3 (ko)
IE (1) IE900251L (ko)
PT (1) PT92928B (ko)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3479539B2 (ja) * 1992-04-10 2003-12-15 エーザイ株式会社 ヒトアンチトロンビンｉｉｉ変異体
EP1079791A4 (en) * 1998-05-12 2003-09-03 Susan C Bock HUMAN ANTITHROMBINS III AND RELATED METHODS
DE19839337A1 (de) * 1998-08-28 2000-03-02 Centeon Pharma Gmbh Antithrombin III-beta enthaltende Arzneimittelzubereitung
JP2002526418A (ja) 1998-10-08 2002-08-20 チルドレンズ ホスピタル 血管形成を阻害するための組成物と方法
AUPP971299A0 (en) * 1999-04-12 1999-05-06 South Eastern Sydney Area Health Service Procoagulant assay
ES2299425T3 (es) * 1999-05-13 2008-06-01 Gtc Biotherapeutics, Inc. Antitrombina iii producida geneticamente y formas mutantes de la misma.
JP4339962B2 (ja) * 1999-06-23 2009-10-07 武比古 小出 ヒトアンチトロンビン変異体
DE19932782A1 (de) * 1999-07-14 2001-01-18 Biotest Pharma Gmbh Verfahren zur chromatographischen Fraktionierung von Plasma oder Serum, so erhaltene Präparate und deren Verwendung
AU2003243381A1 (en) * 2002-05-31 2003-12-19 University Of Utah Research Foundation Variants of antithrombin iii
EP1725868A4 (en) * 2004-01-09 2008-02-06 Univ Utah Res Found METHODS OF USING ATIII VARIANTS WITH HIGH AFFINITY
WO2009013251A1 (en) * 2007-07-20 2009-01-29 Universite Paris-Sud Xi Use of mutated antithrombins for treating or preventing coagulation disorders
WO2010081878A1 (en) * 2009-01-16 2010-07-22 Universite Paris-Sud Xi Mutated antithrombins, a process for preparing the same and their use as drugs
JP2013510158A (ja) 2009-11-03 2013-03-21 グリフオルス・セラピユーテイクス・インコーポレーテツド α‐１プロテイナーゼインヒビターのための組成物、方法およびキット
WO2011066291A2 (en) 2009-11-24 2011-06-03 Talecris Biotherapeutics, Inc. Lyophilization methods, compositions, and kits

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2116183B (en) * 1982-03-03 1985-06-05 Genentech Inc Human antithrombin iii dna sequences therefore expression vehicles and cloning vectors containing such sequences and cell cultures transformed thereby a process for expressing human antithrombin iii and pharmaceutical compositions comprising it
US4746306A (en) * 1982-03-26 1988-05-24 General Motors Corporation Electrical connector lock with gauge pin
US4632981A (en) * 1982-07-30 1986-12-30 Genentech, Inc. Human antithrombin III
US4711848A (en) * 1984-03-14 1987-12-08 Zymogenetics, Inc. Site specific mutagenesis in alpha-1-antitrypsin
DE3624453A1 (de) * 1986-07-19 1988-01-28 Behringwerke Ag Verfahren zur herstellung von humanem antithrombin iii (atiii), dafuer geeignete vektoren und wirtszellen, so erhaltenes, biologisch aktives atiii und dieses enthaltende arzneimittel
GB8621118D0 (en) * 1986-09-01 1986-10-08 Whitbread & Co Plc Stabilised polypeptides
IE902276A1 (en) * 1989-06-26 1991-01-16 Akzo Nv Serpin variants

Also Published As

Publication number Publication date
JP3226215B2 (ja) 2001-11-05
EP0384122A3 (de) 1991-07-03
ATE184913T1 (de) 1999-10-15
KR0171197B1 (ko) 1999-02-01
DK0384122T3 (da) 2000-03-27
AU4863990A (en) 1990-09-13
GR3031991T3 (en) 2000-03-31
JPH02262598A (ja) 1990-10-25
DE3901917A1 (de) 1990-07-26
EP0384122A2 (de) 1990-08-29
US5700663A (en) 1997-12-23
EP0384122B1 (de) 1999-09-22
IE900251L (en) 1990-07-24
ES2137918T3 (es) 2000-01-01
PT92928B (pt) 1995-12-29
CA2008390C (en) 2002-03-19
US5618713A (en) 1997-04-08
AU625667B2 (en) 1992-07-16
PT92928A (pt) 1990-07-31
CA2008390A1 (en) 1990-07-24
DE59010884D1 (de) 1999-10-28

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