KR900001717A - 호모노지리마이신 유도체의 제조방법 - Google Patents

호모노지리마이신 유도체의 제조방법 Download PDF

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Publication number
KR900001717A
KR900001717A KR1019890009150A KR890009150A KR900001717A KR 900001717 A KR900001717 A KR 900001717A KR 1019890009150 A KR1019890009150 A KR 1019890009150A KR 890009150 A KR890009150 A KR 890009150A KR 900001717 A KR900001717 A KR 900001717A
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South Korea
Prior art keywords
glycero
acid
benzoyl
tetra
heptitol
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KR1019890009150A
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English (en)
Inventor
비.안제베노 피터
케이.다니엘 존
제이.크리머 로라
에스.리우 폴
Original Assignee
게리 디.스트리트
메렐 다우 파미슈티칼즈 인코포레이티드
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Application filed by 게리 디.스트리트, 메렐 다우 파미슈티칼즈 인코포레이티드 filed Critical 게리 디.스트리트
Publication of KR900001717A publication Critical patent/KR900001717A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/04—Carbocyclic radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

내용 없음

Description

호모노리지마이신 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (4)

  1. 카보니트릴을 임의로 촉매량의 수은 이온의 존재하에 트리플루오로아세트산으로 처리한 다음, 사산화 이질소 산화성 가수분해시키는 공정을 포함함을 특징으로 하여 전자 결핍 카보니트릴을 카복실산으로 전환시키는 방법.
  2. 제 1 항에 있어서, 카보니트릴이 3,4,5,7-테트라-0-벤조일-2,6-[(트리플루오로아세틸)아미노]-D-글리세로-D-이도-헵토노니트릴이고,카복실산이 3,4,5,7테트라-0-벤조일-2,6-[(트리플루오로아세틸)아미노]-D-글리세로-D-이도-헵토산인 방법.
  3. 헵토노니트릴을 트리플르오로아세트산 무수물과 반응시켜 상응하는 2,6-트리플르오로아세틸아미노 화합물을 수득하고; 이 화합물을 임의로 촉매량의 수은 이온의 존재하에 트리플르오로아세트산과 반응시킨 다음, 사산화이질소와 반응시켜 상응하는 헵톤산을 수득하고; 이어서 보란, 수소화붕소나트륨 및 삼불화붕소로 처리하여 목적하는 헵티톨을 수득하고; 임의로 강산과 반응시켜 헵티톨의 상응하는 염을 수득하는 공정을 포함함을 특징으로 하여 3,4,5,7-테트라-0-(A)-2.6-이미노]-D-글리세로-D-이도-헵토노니트릴(여기서,A는 탄소수 1 내지 4의 알카노일이거나 벤조일이다)을 1,3,4,5-테트라-0-(A)-2,6-디데옥시-2,6-아미노-D-글리세로-L-굴로-헵티톨 염산염으로 전환시키는 방법.
  4. 제 3 항에 있어서, 헵토노니트릴을 트리플루오로아세트산 무수물과 반응시켜 상응하는 2,6-트리플루오로아세틸아미노 화합물을 수득하고; 이 화합물을 촉배량의 수은 이온의 존재하에 트리플루오로아세트산과 반응시킨 다음, 사산화이질소와 반응시켜 상응하는 헵톤산을 수득하며; 이어서 보란, 수소화붕소나트륨 및 삼불화붕소로 처리하여 목적하는 헵티톨을 수득하고; 임의로 강산과 반응시켜 헵티톨의 상응하는 염을 수득하는 공정을 포함함을 특징으로 하여 3,4,5,7-테트라-0-벤조일-2,6-디데옥시-2,6-이미노-D-글리세로-D-이도-헵토노니트릴을 1,3,4,5-테트라-0-벤조일-2,6-디데옥시-2,6-아미노-D-글리세로-L-굴로-헵티톨 염산염으로 전환시키는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890009150A 1988-07-01 1989-06-30 호모노지리마이신 유도체의 제조방법 KR900001717A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/214,229 US4880917A (en) 1988-07-01 1988-07-01 Process for hydrolyzing 2,6-dideoxy-2,6-iminoheptononitrile derivatives using trifluoroacetic acid and dinitrogen tetroxide
US214229 1988-07-01

Publications (1)

Publication Number Publication Date
KR900001717A true KR900001717A (ko) 1990-02-27

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ID=22798282

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019890009150A KR900001717A (ko) 1988-07-01 1989-06-30 호모노지리마이신 유도체의 제조방법

Country Status (9)

Country Link
US (1) US4880917A (ko)
EP (1) EP0348987A3 (ko)
JP (1) JPH0248595A (ko)
KR (1) KR900001717A (ko)
CA (1) CA1314894C (ko)
DK (1) DK326789A (ko)
HU (1) HU201951B (ko)
IL (1) IL90774A0 (ko)
ZA (1) ZA894833B (ko)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5227479A (en) * 1989-12-20 1993-07-13 Merrell Dow Pharmaceuticals Inc. Process for the preparation of nojirimycin and related compounds
EP3782655A1 (en) 2005-05-17 2021-02-24 Amicus Therapeutics, Inc. A method for the treatment of pompe disease using 1-deoxynojirimycin and derivatives

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO154918C (no) * 1977-08-27 1987-01-14 Bayer Ag Analogifremgangsmaate til fremstilling av terapeutisk aktive derivater av 3,4,5-trihydroksypiperidin.
US4634765A (en) * 1984-12-18 1987-01-06 Merrell Dow Pharmaceuticals Inc. Homodisaccharide hypoglycemic agents

Also Published As

Publication number Publication date
JPH0248595A (ja) 1990-02-19
HUT50192A (en) 1989-12-28
IL90774A0 (en) 1990-01-18
CA1314894C (en) 1993-03-23
DK326789D0 (da) 1989-06-30
DK326789A (da) 1990-01-02
US4880917A (en) 1989-11-14
EP0348987A3 (en) 1991-07-17
EP0348987A2 (en) 1990-01-03
HU201951B (en) 1991-01-28
ZA894833B (en) 1990-03-28

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