HUT57195A - New process for producing an isoxazole derivative
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New process for producing an isoxazole derivative
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Publication number
HUT57195A
HUT57195AHU633489AHU633489AHUT57195AHU T57195 AHUT57195 AHU T57195AHU 633489 AHU633489 AHU 633489AHU 633489 AHU633489 AHU 633489AHU T57195 AHUT57195 AHU T57195A
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Application filed by Egyt Gyogyszervegyeszeti GyarfiledCriticalEgyt Gyogyszervegyeszeti Gyar
Priority to HU633489ApriorityCriticalpatent/HU205749B/en
Publication of HU896334D0publicationCriticalpatent/HU896334D0/en
Publication of HUT57195ApublicationCriticalpatent/HUT57195A/en
Publication of HU205749BpublicationCriticalpatent/HU205749B/en
5-methyl-3-carbamoyl-iso-oxazole of formula (I) is prepd. as follows: Methyl-ester of acetyl-pyruvic-acid of formula (III) is obtd. by base catalysed condensn. of oxalic-acid-di:tert-butyl-ester or oxalic-acid-di:iso-butyl-ester and acetone. (III) reacts with hydroxyl-amine-sulphate or hydroxylamine-hydrochloride to yield 5-methyl-iso-oxazole-3-carboxylic-acid-methyl-ester of formula (IV), (IV) reacts with ammonia by known means without being isolated or purified.
HU633489A1989-12-011989-12-01New process for producing an isoxazole derivative
HU205749B
(en)