KR890701601A - 테그네튬-99m의 양이온 착물 - Google Patents

테그네튬-99m의 양이온 착물

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Publication number
KR890701601A
KR890701601A KR1019890701012A KR890701012A KR890701601A KR 890701601 A KR890701601 A KR 890701601A KR 1019890701012 A KR1019890701012 A KR 1019890701012A KR 890701012 A KR890701012 A KR 890701012A KR 890701601 A KR890701601 A KR 890701601A
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South Korea
Prior art keywords
ligand
formula
ether
coc
ccc
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KR1019890701012A
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English (en)
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KR970011165B1 (ko
Inventor
쿽 와이 치우
제임스 던칸 켈리
이안 앤드류 래탐
데이비드 보우간 그리피쓰
피터 제랄드 에드워드
Original Assignee
오스티스 안토니 에반스
에머샴 인터내쇼날 피엘씨
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Application filed by 오스티스 안토니 에반스, 에머샴 인터내쇼날 피엘씨 filed Critical 오스티스 안토니 에반스
Publication of KR890701601A publication Critical patent/KR890701601A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/50—Organo-phosphines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/6552—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic System
    • C07F13/005—Compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/50—Organo-phosphines
    • C07F9/5027—Polyphosphines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/66—Arsenic compounds
    • C07F9/70—Organo-arsenic compounds
    • C07F9/72—Aliphatic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

내용 없음

Description

테그네튬-99m의 양이온 착물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (12)

  1. 하기식을 갖는 리간드
    Y2QZQY2
    상기식에서 Q는 인 또는 비소이며, Y는 서로 동일하거나, 상이하며, 각각은 3개까지의 에테르 산소원자를 함유하는 C1-C8 포화 탄화수소 또는 포화 플루오르 탄화수소, 또는 H이며, Z는 3개까지의 에테르 산소원자를 함유하는 적어도 하나의 C1-C8 포화 탄화수소 또는 포화 플루오르탄화수소에 의해 치환된 -CC-, -CCC- 또는 -COC-에테르 결합이 상기 리간드에 포함됨을 조건으로 한다.
  2. 제1항에 있어서, Y 기는 동일하거나 상이하며, 그 각각은 H 또는 C1-C4알콕시에 의해 치환된 C1-C4 알킬이며, Z는 C1-C4알콕시 또는 알콕시알킬 또는 스피로시클릭 에테르에 의해 치환된 -CC-, -CCC- 또는 -COC-사슬인 리간드.
  3. 제1항에 있어서, 각각의 Q는 인이며, Z는 -CC- 또는 -CCC- 사슬이며, 각각의 Y는 H 또는 메틸이며, 하나 또는 그 이상의 메톡시 치환체가 하나 또는 그 이상의 Y에 결합하거나, 하나 또는 그 이상의 메톡시메틸 또는 -COC-스피로시클릭 에테르 기가 Z의 탄소원자에 결합하는 리간드.
  4. 제1항에 있어서, 하기식을 갖는 리간드.
  5. 제1항에 있어서, 하기식을 갖는 리간드.
  6. 제1항에 있어서, 하기식을 갖는 리간드.
  7. 제1항에 있어서, 하기식을 갖는 리간드.
  8. 제1항 내지 제7항중 어느 한항에 따른 리간드와 테크네튬-99m 과의 양이온 착물.
  9. 제8항에 있어서, [Tc(NO)n×mL2]+A-및 [TcL3]+A-로 구성되는 그룹으로부터 선택되는 양이온 착물.
    상기식에서, X는 Tc에 대한 한가지 리간드이며, A 는 음이온이며, n은 1 또는 2이며, m은 1 또는 0이며, L은 제1항 내지 제7항 중 어느 한항에 따른 리간드이다.
  10. 제9항에 있어서, [Tc(NO)XL2]+A-의 구조식을 갖는 양이온 착물.
    상기식에서
  11. 제9항에 있어서, [TcL3]+A-의 구조식을 갖는 양이온 착물.
    상기식에서,
  12. 제8항 내지 제11항중 어느 한 항에 있어서, 심장 형상화제로서 사용된느 양이온 착물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890701012A 1987-10-06 1988-10-04 테크네튬-99m의 양이온성 착물 KR970011165B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB8123438 1987-10-06
GB8723438 1987-10-06
GB878723438A GB8723438D0 (en) 1987-10-06 1987-10-06 Cationic complexes of technetium-99m
PCT/GB1988/000817 WO1989003388A1 (en) 1987-10-06 1988-10-04 Cationic complexes of technetium-99m

Publications (2)

Publication Number Publication Date
KR890701601A true KR890701601A (ko) 1989-12-21
KR970011165B1 KR970011165B1 (ko) 1997-07-08

Family

ID=10624861

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019890701012A KR970011165B1 (ko) 1987-10-06 1988-10-04 테크네튬-99m의 양이온성 착물

Country Status (12)

Country Link
US (1) US4916214A (ko)
EP (1) EP0311352B1 (ko)
JP (1) JPH0737472B2 (ko)
KR (1) KR970011165B1 (ko)
AT (1) ATE63559T1 (ko)
CA (1) CA1336438C (ko)
DE (1) DE3862843D1 (ko)
DK (1) DK171487B1 (ko)
ES (1) ES2037234T3 (ko)
GB (1) GB8723438D0 (ko)
IL (1) IL87944A (ko)
WO (1) WO1989003388A1 (ko)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8808414D0 (en) * 1988-04-11 1988-05-11 Amersham Int Plc Ligands & cationic complexes thereof with technetium-99m
GB8902362D0 (en) * 1989-02-03 1989-03-22 Amersham Int Plc Cationic complexes of technetium-99m
US4917879A (en) * 1989-05-19 1990-04-17 University Of Cincinnati 99MTC(III) myocardial imaging agents that are effective in humans
US6001979A (en) 1989-08-29 1999-12-14 Nycomed Amersham Plc Cores for technetium radiopharmaceuticals
DD291327A5 (de) * 1989-12-29 1991-06-27 �������@����@�K@��@��k�� Myokardgaengige technetium-komplexverbindungen und verfahren zu deren herstellung
GB2242189A (en) * 1990-03-23 1991-09-25 Shell Int Research Bidentate ligands and their precursors
US5541289A (en) * 1994-03-30 1996-07-30 Washington University Phosphine containing amino acids and peptides and methods of preparing and using same
US5834456A (en) * 1996-02-23 1998-11-10 The Dow Chemical Company Polyazamacrocyclofluoromonoalkylphosphonic acids, and their complexes, for use as contrast agents
IT1286879B1 (it) * 1996-11-21 1998-07-17 Consiglio Nazionale Ricerche Leganti 1,3-difosfinopropanici e complessi da essi formati con metalli di transizione,loro preparazione e uso
KR100554563B1 (ko) * 1996-12-18 2006-03-03 니혼 메디피직스 가부시키가이샤 방사성 전이 금속 질화물 헤테로-착물
US6733767B2 (en) * 1998-03-19 2004-05-11 Merck & Co., Inc. Liquid polymeric compositions for controlled release of bioactive substances
US6794553B2 (en) 2001-11-09 2004-09-21 Shell Oil Company Process for the telomerization of a conjugated diene, catalyst and bidentate ligand useful therein
EP2899195A1 (en) 2014-01-28 2015-07-29 ROTOP Pharmaka AG Stabilized form of Tetrofosmin and its use

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1917884A1 (de) * 1968-04-08 1969-10-16 Toa Gosei Chem Ind Verfahren zur Herstellung von 1-Buten-2,3,4-tricarbonsaeureestern
US4387087A (en) * 1980-04-18 1983-06-07 Research Corporation Cationic lipophilic complexes of 99m Tc and their use for myocardial and hepatobiliary imaging
US4489054A (en) * 1980-04-18 1984-12-18 Research Corporation Cationic lipophilic complexes of 99m Tc and their use for myocardial and hepatobiliary imaging
US4451450A (en) * 1981-10-15 1984-05-29 New England Nuclear Corporation Cationic compounds useful for making radiodiagnostic agents
US4374821A (en) * 1982-06-28 1983-02-22 E. R. Squibb & Sons, Inc. Myocardial imaging agent and method
US4481184A (en) * 1983-02-14 1984-11-06 E. R. Squibb & Sons, Inc. Cationic technetium (I) complexes
US4526776A (en) * 1983-04-15 1985-07-02 E. I. Du Pont De Nemours & Company Cationic cyanato and thiocyanato complexes useful as radiodiagnostic agents
US4795626A (en) * 1985-05-10 1989-01-03 University Of Cincinnati 99m Tc.sup.(III) myocardial imaging agents which are non-reducable in vivo
US4765971A (en) * 1985-05-31 1988-08-23 Mallinckrodt, Inc. Technetium (Tc-99m)-arene complexes useful in myocardial imaging
GB8531296D0 (en) * 1985-12-19 1986-01-29 Amersham Int Plc Cationic complexes of technetium

Also Published As

Publication number Publication date
EP0311352B1 (en) 1991-05-15
JPH01128990A (ja) 1989-05-22
US4916214A (en) 1990-04-10
DK266689D0 (da) 1989-06-01
WO1989003388A1 (en) 1989-04-20
GB8723438D0 (en) 1987-11-11
CA1336438C (en) 1995-07-25
ES2037234T3 (es) 1993-06-16
EP0311352A1 (en) 1989-04-12
KR970011165B1 (ko) 1997-07-08
DK171487B1 (da) 1996-11-25
JPH0737472B2 (ja) 1995-04-26
DE3862843D1 (de) 1991-06-20
DK266689A (da) 1989-06-01
IL87944A0 (en) 1989-03-31
ATE63559T1 (de) 1991-06-15
IL87944A (en) 1994-07-31

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