KR890017255A - 화합물의 제조방법 - Google Patents

화합물의 제조방법 Download PDF

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Publication number
KR890017255A
KR890017255A KR1019890005922A KR890005922A KR890017255A KR 890017255 A KR890017255 A KR 890017255A KR 1019890005922 A KR1019890005922 A KR 1019890005922A KR 890005922 A KR890005922 A KR 890005922A KR 890017255 A KR890017255 A KR 890017255A
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KR
South Korea
Prior art keywords
compound
formula
cef
oxime
reaction
Prior art date
Application number
KR1019890005922A
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English (en)
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KR970001530B1 (ko
Inventor
조오지 그레이 마이클
Original Assignee
원본미기재
글락소 그룹 리미티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 원본미기재, 글락소 그룹 리미티드 filed Critical 원본미기재
Publication of KR890017255A publication Critical patent/KR890017255A/ko
Application granted granted Critical
Publication of KR970001530B1 publication Critical patent/KR970001530B1/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

내용 없음

Description

화합물의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (6)

  1. 다음 일반식(Ⅱ)의 화합물을 0-메틸 옥심화제와 반응시킨 다음, 최초에 생성된 일반식(Ⅰ)의 화합물을 필요에 따라 (ⅰ) Z가 -S0-인 화합물을 환원시켜 Z가 S인 화합물을 얻는 반응, (ⅱ) 2-이성질체를 3-이성질체로 전환시키는 반응, (ⅲ) 카르바모일 치환체의 제거반응중의 1이상의 반응에 의하여 일반식(Ⅰ)의 다른 화합물을 얻는 것이 특징인 다음 일반식(Ⅰ)의 화합물의 제조방법.
    (위 각 식에 있어서, R은 수소원자 또는 카르바모일 보호기이고, Z은 S 또는 -SO-이며, 점선은 이들 화합물이 세프-2-엠 또는 세프-3-엠 화합물임을 나타냄)
  2. 제 1 항에 있어서, 옥심화 반응이 -20℃ 내지 100℃범위의 온도에서 효과적인 방법.
  3. 제 1 항 내지 제 2 항에 있어서, 옥심화제가 메톡실아민 또는 그의 염인 방법.
  4. 제1 내지 3항중 어느 하나의 항에 있어서, 일반식(Ⅱ)의 화합물(여기서, R은 수소원자 또는 카르바모일 보호기, Z는 S이고, 점선은 이 화합물이 세프-3-엠임을 나타냄)을 상기 0-메틸-옥심화제와 반응시키는 방법.
  5. 상기 전극중 어느 하나의 항에 의한 방법으로 제조되는 상기 제 1 항 기재의 일반식(Ⅰ)의 화합물.
  6. 제 4 항의 방법으로 제조된 세푸록심 악세틸.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890005922A 1988-05-03 1989-05-02 화합물의 제조 방법 KR970001530B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB888810393A GB8810393D0 (en) 1988-05-03 1988-05-03 Chemical process
GB8810393.2 1988-05-03

Publications (2)

Publication Number Publication Date
KR890017255A true KR890017255A (ko) 1989-12-15
KR970001530B1 KR970001530B1 (ko) 1997-02-11

Family

ID=10636246

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019890005922A KR970001530B1 (ko) 1988-05-03 1989-05-02 화합물의 제조 방법

Country Status (8)

Country Link
JP (1) JPH0256489A (ko)
KR (1) KR970001530B1 (ko)
CH (1) CH678624A5 (ko)
DE (1) DE3914672A1 (ko)
FR (1) FR2631032A1 (ko)
GB (2) GB8810393D0 (ko)
IT (1) IT1232829B (ko)
NL (1) NL8901110A (ko)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1208015A (en) * 1967-03-23 1970-10-07 Glaxo Lab Ltd Cephalosporins
GB1208014A (en) * 1967-03-23 1970-10-07 Glaxo Lab Ltd Cephalosporins
CA1094545A (en) * 1976-02-16 1981-01-27 Michael Gregson Cephalosporin antibiotics
GB8400024D0 (en) * 1984-01-03 1984-02-08 Glaxo Group Ltd Cephalosporin antibiotics

Also Published As

Publication number Publication date
NL8901110A (nl) 1989-12-01
FR2631032A1 (fr) 1989-11-10
JPH0256489A (ja) 1990-02-26
KR970001530B1 (ko) 1997-02-11
GB8909986D0 (en) 1989-06-21
IT1232829B (it) 1992-03-05
GB2218092A (en) 1989-11-08
GB8810393D0 (en) 1988-06-08
DE3914672A1 (de) 1989-11-16
IT8947903A0 (it) 1989-05-02
CH678624A5 (ko) 1991-10-15

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