KR890016171A - N-말단 프롤린으로 출발하는 단백질의 제조방법 - Google Patents
N-말단 프롤린으로 출발하는 단백질의 제조방법 Download PDFInfo
- Publication number
- KR890016171A KR890016171A KR1019890004645A KR890004645A KR890016171A KR 890016171 A KR890016171 A KR 890016171A KR 1019890004645 A KR1019890004645 A KR 1019890004645A KR 890004645 A KR890004645 A KR 890004645A KR 890016171 A KR890016171 A KR 890016171A
- Authority
- KR
- South Korea
- Prior art keywords
- proline
- terminal extension
- extension sequence
- starting
- macrophage colony
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
- C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제 1 도는 pS203의 절단부위를 도시한 것이다. 제 2 도는 pS500의 절단부위를 도시한 것이다.
Claims (9)
- 유전자 조작에 의해 수득된, 짧은 N-말단 연장 서열을 갖는 전구체를 아미노펩티다제 P로 효소 절단 시킴을 특징으로하여, N-말단 프롤린으로 출발하는 단백질을 제조하는 방법.
- 제 1 항에 있어서, 짧은 N-말단 연장 서열이 메티오난 잔기를 함유하는 방법.
- 제 1 항에 있어서, 사용된 출발물질이, 일부만이 N 말단에 메티오닌 잔기를 갖는 단백질의 혼합물인 방법.
- 제 2 항에 있어서, 사용된 출발물질이, 일부만이 N 말단에 메티오닌 잔기를 갖는 단백질의 혼합물인 방법.
- 제 1 항에 있어서, 프롤린으로 출발하고 N-말단 연장 서열을 갖는 인간 과립구 대식세포 콜로니-자극인자 유도체를 사용한 방법.
- 제 2 항에 있어서, 프롤린으로 출발하고 N-말단 연장 서열을 갖는 인간과립구 대식세포 콜로니- 자극인자 유도체를 사용한 방법.
- 제 3 항에 있어서, 프롤린으로 출발하고 N-말단 연장 서열을 갖는 인간 과립구 대식세포 콜로니-자극인자 유도체를 사용한 방법.
- 제 4 항에 있어서, 플롤린으로 출발하고 N-말단 연장 서열을 갖는 인간 과립구 대식세포 콜로니-자극인자 유도체를 사용한 방법.
- 제 5 항에 있어서, 프롤린으로 출발하고 N-말단 연장 서열을 갖는 인간 과립구 대식세포 콜로니-자극인자 유도체를 사용한 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DEP3811921.8 | 1988-04-09 | ||
DE3811921A DE3811921A1 (de) | 1988-04-09 | 1988-04-09 | Verfahren zur herstellung von proteinen, die n-terminal mit prolin beginnen |
Publications (1)
Publication Number | Publication Date |
---|---|
KR890016171A true KR890016171A (ko) | 1989-11-28 |
Family
ID=6351689
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019890004645A KR890016171A (ko) | 1988-04-09 | 1989-04-08 | N-말단 프롤린으로 출발하는 단백질의 제조방법 |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP0337264A3 (ko) |
JP (1) | JPH01304895A (ko) |
KR (1) | KR890016171A (ko) |
AU (1) | AU3253689A (ko) |
DE (1) | DE3811921A1 (ko) |
DK (1) | DK169889A (ko) |
FI (1) | FI891652A (ko) |
HU (1) | HUT51676A (ko) |
IL (1) | IL89877A0 (ko) |
NO (1) | NO891451L (ko) |
PT (1) | PT90225A (ko) |
ZA (1) | ZA892551B (ko) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3822045A1 (de) * | 1988-06-30 | 1990-01-11 | Hoechst Ag | Verfahren zur herstellung von proteinen |
GB9017008D0 (en) * | 1990-08-02 | 1990-09-19 | Erba Carlo Spa | Process for the enzymatic preparation of basic fibroblast growth factor |
US7504372B2 (en) | 2004-09-08 | 2009-03-17 | Clariant Produkte (Deutschland) Gmbh | Mixtures of bleaching agents |
DE102004043360A1 (de) | 2004-09-08 | 2006-03-09 | Clariant Gmbh | Bleichaktivator-Mischungen |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL60184A (en) * | 1979-05-31 | 1984-05-31 | Schering Ag | Process for the specific cleavage of protein sequences from proteins |
JPS60500043A (ja) * | 1982-12-10 | 1985-01-17 | ノルデイスク・インスリンラボラトリウム | 原核細胞又は真核細胞中で合成される融合蛋白質から成熟蛋白質を作る方法 |
DE3586773T2 (de) * | 1984-08-16 | 1993-03-18 | Bio Technology General Corp | Verfahren zur beseitigung von n-endaminosaeureresten aus eukaryotpolypeptidanlagen und so erzeugte polypeptide. |
WO1986007380A1 (en) * | 1985-06-04 | 1986-12-18 | Takeda Chemical Industries, Ltd. | Process for preparing polypeptide |
US4865974A (en) * | 1985-09-20 | 1989-09-12 | Cetus Corporation | Bacterial methionine N-terminal peptidase |
DE3822045A1 (de) * | 1988-06-30 | 1990-01-11 | Hoechst Ag | Verfahren zur herstellung von proteinen |
-
1988
- 1988-04-09 DE DE3811921A patent/DE3811921A1/de not_active Withdrawn
-
1989
- 1989-04-05 EP EP89105927A patent/EP0337264A3/de not_active Withdrawn
- 1989-04-06 FI FI891652A patent/FI891652A/fi not_active Application Discontinuation
- 1989-04-06 HU HU891661A patent/HUT51676A/hu unknown
- 1989-04-07 IL IL89877A patent/IL89877A0/xx unknown
- 1989-04-07 PT PT90225A patent/PT90225A/pt not_active Application Discontinuation
- 1989-04-07 DK DK169889A patent/DK169889A/da not_active IP Right Cessation
- 1989-04-07 AU AU32536/89A patent/AU3253689A/en not_active Abandoned
- 1989-04-07 ZA ZA892551A patent/ZA892551B/xx unknown
- 1989-04-07 JP JP1089576A patent/JPH01304895A/ja active Pending
- 1989-04-07 NO NO89891451A patent/NO891451L/no unknown
- 1989-04-08 KR KR1019890004645A patent/KR890016171A/ko not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
FI891652A (fi) | 1989-10-10 |
FI891652A0 (fi) | 1989-04-06 |
HUT51676A (en) | 1990-05-28 |
EP0337264A3 (de) | 1990-08-01 |
DE3811921A1 (de) | 1989-10-19 |
AU3253689A (en) | 1989-10-12 |
DK169889A (da) | 1989-10-10 |
EP0337264A2 (de) | 1989-10-18 |
NO891451L (no) | 1989-10-10 |
JPH01304895A (ja) | 1989-12-08 |
IL89877A0 (en) | 1989-12-15 |
PT90225A (pt) | 1989-11-10 |
DK169889D0 (da) | 1989-04-07 |
NO891451D0 (no) | 1989-04-07 |
ZA892551B (en) | 1989-12-27 |
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Legal Events
Date | Code | Title | Description |
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WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |