KR890014092A - 경피성의 약 방출시의 감작 또는 자극 저감방법 및 그 수단 - Google Patents

경피성의 약 방출시의 감작 또는 자극 저감방법 및 그 수단 Download PDF

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KR890014092A
KR890014092A KR1019890002562A KR890002562A KR890014092A KR 890014092 A KR890014092 A KR 890014092A KR 1019890002562 A KR1019890002562 A KR 1019890002562A KR 890002562 A KR890002562 A KR 890002562A KR 890014092 A KR890014092 A KR 890014092A
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composition
drug
metabolic
phenyl
modulator
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KR1019890002562A
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English (en)
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제이.엔.코트미에르 미첼
윌리엄 리져 필립
엠크러트 알프레드
폴 마르티 진
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에드워드 엘.맨델
알자 코포레이숀
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Publication of KR890014092A publication Critical patent/KR890014092A/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/005—Enzyme inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

내용 없음.

Description

경피성의 약 방출시의 감작 또는 자극 저감방법 및 그 수단
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 연쇄길이에 대하여 방향족 알코올에 의한 프로프라놀올 신진대사억제를 나타낸 그래프.
제2도는 속도조절막과 평행접촉성 접착제가 있는 본 발명에 의한 경피성의 치료제의 한가지 실시태양의 단면도.
제3도는 접착성 표피물이 있는 본 발명의 다른 실시 태양의 단면도.

Claims (10)

  1. 피부 또는 점막에서 신진대사되기 쉬운 약물과 이 약물의 신진대사를 변화시키는 대사조절제를 함유하고 경피투여된 약물에 의해 나타나는 피부 또는 점막에서의 불필요한 부작용을 예방하며 약물과 대사 조절제를 담체내에 분산시켜서 된 조성물.
  2. 제 1항에 있어서, 미리 설정된 시간동안 대사를 변화시키는 속도로 투여할 수 있는 충분한 양으로 대사조절제를 함유시키고 미리 설정된 시간동안 치료 효과가 있는 속도로 투여할 수 있는 충분한 양으로 약물을 함유시켜서 되는 조성물.
  3. 제 2항에 있어서, 조절제를 조성물에 대해 약 0.1-20wt.% 함유시킨 조성물.
  4. 제 1항에 있어서, 불필요한 부작용이 자극에 의해 나타나는데 쓰이는 조성물.
  5. 제 1항에 있어서, 불필요한 부작용이 감작에 의해 나타나는데 쓰이는 조성물.
  6. 제 1항에 있어서, 모노아민 산화효소의 활성에 의해 약물을 신진대사시키는 조성물.
  7. 제 6항에 있어서, 대사조절제가 모노아민 산화효소 억제제인 조성물.
  8. 제 7항에 있어서, 대사조절제의 구조식이 (C6H5)-ROH인 조성물(위의 식에서 R은 (CH2)nCH(n=2)과 CH=CHCH2중에서 선택됨).
  9. 제 8항에 있어서, 약물은 프로프라놀올이고 조절제가 2-페닐-1-에탄올인 조성물.
  10. 제 8항에 있어서, 약물은 테트라카인이고 조절제는 2-페닐-1-에탄올 또는 3-페닐-1-프로판올인 조성물.
    ※ 참고사항:최초출원 내용에 의하여 공개하는 것임.
KR1019890002562A 1988-03-01 1989-03-02 경피성의 약 방출시의 감작 또는 자극 저감방법 및 그 수단 KR890014092A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US162777 1988-03-01
US07/162,777 US4885154A (en) 1988-03-01 1988-03-01 Method for reducing sensitization or irritation in transdermal drug delivery and means therefor

Publications (1)

Publication Number Publication Date
KR890014092A true KR890014092A (ko) 1989-10-21

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KR1019890002562A KR890014092A (ko) 1988-03-01 1989-03-02 경피성의 약 방출시의 감작 또는 자극 저감방법 및 그 수단

Country Status (12)

Country Link
US (2) US4885154A (ko)
EP (1) EP0331391A1 (ko)
JP (1) JPH0296514A (ko)
KR (1) KR890014092A (ko)
AU (1) AU618073B2 (ko)
BR (1) BR8900943A (ko)
DK (1) DK96189A (ko)
FI (1) FI890960A (ko)
NO (1) NO890766L (ko)
NZ (1) NZ227925A (ko)
PT (1) PT89878A (ko)
ZA (1) ZA891494B (ko)

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US5304379A (en) 1994-04-19
AU2999489A (en) 1989-09-07
US4885154A (en) 1989-12-05
NO890766D0 (no) 1989-02-23
DK96189A (da) 1989-09-02
EP0331391A1 (en) 1989-09-06
AU618073B2 (en) 1991-12-12
NZ227925A (en) 1990-10-26
ZA891494B (en) 1990-10-31
FI890960A0 (fi) 1989-02-28
PT89878A (pt) 1989-11-10
DK96189D0 (da) 1989-02-28
NO890766L (no) 1989-09-04
BR8900943A (pt) 1989-10-24
FI890960A (fi) 1989-09-02
JPH0296514A (ja) 1990-04-09

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