KR890013014A - 2-치환 카르보닐이미다조[4,5-c]퀴놀린 - Google Patents

2-치환 카르보닐이미다조[4,5-c]퀴놀린 Download PDF

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KR890013014A
KR890013014A KR1019890001792A KR890001792A KR890013014A KR 890013014 A KR890013014 A KR 890013014A KR 1019890001792 A KR1019890001792 A KR 1019890001792A KR 890001792 A KR890001792 A KR 890001792A KR 890013014 A KR890013014 A KR 890013014A
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South Korea
Prior art keywords
alkyl
optionally substituted
halogen
compound
quinoline
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KR1019890001792A
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KR970005301B1 (ko
Inventor
스스무 다까다
도시오 후지시따
다까시 사사따니
아끼라 마쯔시따
마사미 에이교
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요시또시 가즈오
시오노기세이야꾸 가부시끼가이샤
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Publication of KR890013014A publication Critical patent/KR890013014A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Luminescent Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

내용 없음.

Description

2-치환 카르보닐이미다조[4,5-c)퀴놀린
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (5)

  1. 하기 일반식(Ⅰ)의 화합물 또는 그의 약학적으로 허용 가능한 산부 가염.
    [상기식중, R은 (1) 수소; (2) 히드록시; (3) 할로겐, C1∼C5알킬티오, C1∼C5알킬옥시카르보닐 또는 페닐에 의해 임의 치환된 C1∼C10알킬; (4) C1∼C5알킬에 의해 임의 치환된 C3∼C5시클로알킬; (5) C1∼C5알킬 또는 디-C1∼C5알킬에 의해 임의 치환된 C2∼C5알케닐; (6) C1∼C5알콕시; (7) 펜옥시; (8) C1∼C5알킬 또는 디-C1∼C5알킬에 의해 임의 치환된 아미노; (9) 할로겐, 트리플루오로메틸, C1∼C5알콕시 및 C1∼C5알킬티오로 구성된 군으로부터 각각 선택된 하나 또는 두개에 의해 임의 치환된 페닐; 또는 (10) 할로겐, C1∼C5알킬 및 페닐로 구성된 군으로부터 각각 선택된 하나 또는 두개의 의해 임의 치환된 5- 또는 6-원 헤테로사이클기이고; Q는 수소, C1∼C5알킬, 벤질, 벤즈히드릴, 트리틸, C1∼C13아실, C1∼C5알킬술포닐, 또는 C6∼C12아릴술포닐로서 단, Q는 1-, 3- 또는 5-위치의 질소 원자에 존재하며; R1및 R2각각은 수소, C1∼C5알킬, C1∼C5알콕시 또한 할로겐이고; 점선은 2(3), 3a(9b), 4(5); 1(9b), 2(3), 3a(4); 또는 1(2), 3a(9b), 4(5)의 위치에 존재하는 세개의 이중 결합을 나타낸다]
  2. 제1항에 있어서, 2-시클로프로필카르보닐-7-플루오로-1H-이미다조[4,5-c]퀴놀린인 화합물.
  3. 제1항에 있어서, 2-시클로프로필카르보닐-7-메톡시-1H-이미다조[4,5-c]퀴놀린인 화합물.
  4. 약학적으로 유효량인 제1항의 화합물을 담체, 희석제 및/또는 부형제와 함께 함유함을 특징으로 하는 울병, 경련, 불안, 건망증, 지능 및 행동 장해 또는 뇌 장해 치료용 약학 조성물.
  5. 제4항의 약학 조성물을 환자에게 투여함을 특징으로 하는 울병, 경련, 불안, 건망증, 지능 및 행동 장해 또는 뇌 장해로 고생하는 환자의 치료 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890001792A 1988-02-16 1989-02-16 2-치환 카르보닐이미다조[4,5-c]퀴놀린 KR970005301B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP3327088 1988-02-16
JP63-33270 1988-02-16
JP033270/1988 1988-02-16

Publications (2)

Publication Number Publication Date
KR890013014A true KR890013014A (ko) 1989-09-20
KR970005301B1 KR970005301B1 (ko) 1997-04-15

Family

ID=12381834

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019890001792A KR970005301B1 (ko) 1988-02-16 1989-02-16 2-치환 카르보닐이미다조[4,5-c]퀴놀린

Country Status (11)

Country Link
US (1) US4940714A (ko)
EP (1) EP0329073B1 (ko)
JP (1) JPH07116186B2 (ko)
KR (1) KR970005301B1 (ko)
AT (1) ATE116319T1 (ko)
AU (1) AU615260B2 (ko)
CA (1) CA1335996C (ko)
DE (1) DE68920168T2 (ko)
DK (1) DK69889A (ko)
ES (1) ES2068841T3 (ko)
GR (1) GR3014985T3 (ko)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0361489A3 (en) * 1988-09-30 1991-06-12 Chugai Seiyaku Kabushiki Kaisha Novel 3,4-diaminoquinoline and pyridine compounds
CA3056030A1 (en) * 2017-03-10 2018-09-13 Pfizer Inc. Novel imidazo[4,5-c]quinoline derivatives as lrrk2 inhibitors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4563463A (en) * 1983-03-18 1986-01-07 Usv Pharmaceutical Corp. 2-Oxo-1,3-oxazolo[4,5-h] quinolines useful as anti-allergy agents
IL73534A (en) * 1983-11-18 1990-12-23 Riker Laboratories Inc 1h-imidazo(4,5-c)quinoline-4-amines,their preparation and pharmaceutical compositions containing certain such compounds
ZA848968B (en) * 1983-11-18 1986-06-25 Riker Laboratories Inc 1h-imidazo(4,5-c)quinolines and 1h-imidazo(4,5-c)quinolin-4-amines
CA1271477A (en) * 1983-11-18 1990-07-10 John F. Gerster 1h-imidazo[4,5-c]quinolin-4-amines
CA1263378A (en) * 1985-01-08 1989-11-28 Robert James Alaimo Imidazo¬4,5-f|quinolines useful as immunomodulating agents
CA1306260C (en) * 1985-10-18 1992-08-11 Shionogi & Co., Ltd. Condensed imidazopyridine derivatives

Also Published As

Publication number Publication date
GR3014985T3 (en) 1995-05-31
KR970005301B1 (ko) 1997-04-15
DK69889D0 (da) 1989-02-15
CA1335996C (en) 1995-06-20
EP0329073A2 (en) 1989-08-23
AU2993489A (en) 1989-08-17
AU615260B2 (en) 1991-09-26
EP0329073A3 (en) 1991-03-13
EP0329073B1 (en) 1994-12-28
ES2068841T3 (es) 1995-05-01
JPH01308280A (ja) 1989-12-12
DE68920168T2 (de) 1995-07-06
JPH07116186B2 (ja) 1995-12-13
DE68920168D1 (de) 1995-02-09
ATE116319T1 (de) 1995-01-15
US4940714A (en) 1990-07-10
DK69889A (da) 1989-08-17

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