KR890009908A - N-(2-클로로벤질)-2-(2-티에닐)에틸아민의 제조방법 - Google Patents

N-(2-클로로벤질)-2-(2-티에닐)에틸아민의 제조방법 Download PDF

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Publication number
KR890009908A
KR890009908A KR1019880016378A KR880016378A KR890009908A KR 890009908 A KR890009908 A KR 890009908A KR 1019880016378 A KR1019880016378 A KR 1019880016378A KR 880016378 A KR880016378 A KR 880016378A KR 890009908 A KR890009908 A KR 890009908A
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KR
South Korea
Prior art keywords
chlorobenzyl
ethylamine
thienyl
molar ratio
catalyst
Prior art date
Application number
KR1019880016378A
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English (en)
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KR960014798B1 (en
Inventor
라디쏭 조엘
Original Assignee
원본미기재
사노피 소시에떼 아노님
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 원본미기재, 사노피 소시에떼 아노님 filed Critical 원본미기재
Publication of KR890009908A publication Critical patent/KR890009908A/ko
Application granted granted Critical
Publication of KR960014798B1 publication Critical patent/KR960014798B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

내용 없음

Description

N-(2-클로로벤질)-2-(2-티에닐)에틸아민의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (9)

  1. 수소화 촉매의 존재하에서 2-티오펜 아세토니트릴을 2-클로로 벤질아민 및 수소와 반응시키는 것을 특징으로 하는 N-(2-클로로벤질)-2-(2-티에닐)에틸아민의 제조방법.
  2. 제1항에 있어서, 반응조의 수소 압력이 1-10MPa인 것을 특징으로 하는 방법.
  3. 제2항에 있어서, 수소 압력이 2.5-7MPa인 것을 특징으로 하는 방법.
  4. 제1항에 있어서, 반응이 80℃ 미만에서 이루어지는 것을 특징으로 하는 방법.
  5. 제4항에 있어서, 온도가 40-60℃인 것을 특징으로 하는 방법.
  6. 제1항에 있어서, 알콜을 용매로하여 반응이 이루어지는 것을 특징으로 하는 방법.
  7. 제1항에 있어서, 2-클로로 벤질아민과 2-티오펜 아세토리트릴의 몰비가 1-5인 것을 특징으로 하는 방법.
  8. 제7항에 있어서, 촉매가 라니 니켈이고 상기 몰비가 2-4인 것을 특징으로 하는 방법.
  9. 제7항에 있어서, 촉매가 팔라듐이고 상기 몰비가 1-2인 것을 특징으로 하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR88016378A 1987-12-18 1988-12-08 Process for the preparation of n-(2-chloro-benzyl)(2-thienyl)-2-ethylamine KR960014798B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8717755 1987-12-18
FR8717755A FR2624860B1 (fr) 1987-12-18 1987-12-18 Procede de preparation de la n-(chloro-2 benzyl) (thienyl-2)-2 ethylamine

Publications (2)

Publication Number Publication Date
KR890009908A true KR890009908A (ko) 1989-08-04
KR960014798B1 KR960014798B1 (en) 1996-10-19

Family

ID=9358062

Family Applications (1)

Application Number Title Priority Date Filing Date
KR88016378A KR960014798B1 (en) 1987-12-18 1988-12-08 Process for the preparation of n-(2-chloro-benzyl)(2-thienyl)-2-ethylamine

Country Status (10)

Country Link
US (1) US4873343A (ko)
EP (1) EP0321349B1 (ko)
JP (1) JP2664450B2 (ko)
KR (1) KR960014798B1 (ko)
AT (1) ATE74918T1 (ko)
CA (1) CA1329212C (ko)
DE (1) DE3870183D1 (ko)
ES (1) ES2032218T3 (ko)
FR (1) FR2624860B1 (ko)
PT (1) PT89228B (ko)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2664596B1 (fr) * 1990-07-10 1994-06-10 Sanofi Sa Procede de preparation d'un derive n-phenylacetique de tetrahydrothieno [3,2-c] pyridine et son intermediaire de synthese.
US6043368A (en) * 1996-09-04 2000-03-28 Poli Industria Chimica, S.P.A. Method of making thieno-pyridine derivatives
FR2760456B1 (fr) * 1997-03-05 2000-05-12 Sanofi Sa Procede de preparation de derives de 2-thienyl-ethylamine

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2300090A1 (fr) * 1975-02-07 1976-09-03 Parcor Procede de preparation de derives de la thienopyridine
FR2508455A1 (fr) * 1981-06-30 1982-12-31 Sanofi Sa Procede de preparation de derives des (thienyl-2)- et (thienyl-3)-2 ethylamines
FR2608607B1 (fr) * 1986-12-23 1989-04-28 Sanofi Sa Procede de preparation de thienylethylamines et dithienylethylamines ainsi obtenues

Also Published As

Publication number Publication date
DE3870183D1 (de) 1992-05-21
KR960014798B1 (en) 1996-10-19
PT89228A (pt) 1989-12-29
JP2664450B2 (ja) 1997-10-15
PT89228B (pt) 1993-07-30
JPH01197478A (ja) 1989-08-09
US4873343A (en) 1989-10-10
ES2032218T3 (es) 1993-01-16
ATE74918T1 (de) 1992-05-15
CA1329212C (en) 1994-05-03
EP0321349A1 (fr) 1989-06-21
FR2624860A1 (fr) 1989-06-23
EP0321349B1 (fr) 1992-04-15
FR2624860B1 (fr) 1990-06-01

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