KR890007754A - 항체류의 안정화 - Google Patents

항체류의 안정화 Download PDF

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Publication number
KR890007754A
KR890007754A KR1019880015552A KR880015552A KR890007754A KR 890007754 A KR890007754 A KR 890007754A KR 1019880015552 A KR1019880015552 A KR 1019880015552A KR 880015552 A KR880015552 A KR 880015552A KR 890007754 A KR890007754 A KR 890007754A
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KR
South Korea
Prior art keywords
aqueous solution
polyoxyethylene
polyoxypropylene
protective polymer
phospholipid
Prior art date
Application number
KR1019880015552A
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English (en)
Inventor
얀센 테오도루스
요하네스 마리아 얀센 엔젤베르투스
코르넬리우스 라메르트
Original Assignee
에이.지.제이 베르메렌·에프.지.엠 헤르만스
악조 엔.브이
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 에이.지.제이 베르메렌·에프.지.엠 헤르만스, 악조 엔.브이 filed Critical 에이.지.제이 베르메렌·에프.지.엠 헤르만스
Publication of KR890007754A publication Critical patent/KR890007754A/ko

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

내용 없음

Description

항체류의 안정화
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (8)

  1. 폴리옥시프로필렌-폴리옥시에틸렌 보호 중합체와 포스포리피드의 혼합물을 포함하는 것을 특징으로 하는 안정한 항체 수용액.
  2. 제 1항에 있어서, 폴리옥시프로필렌-폴리옥시에틸렌 보호 중합체가 950 내지 4,000달톤의 분자량을 가짐을 특징으로 하는 수용액.
  3. 제 1항 또는 제2항에 있어서, 폴리옥시에틸렌 함량이 최소한 80%인 폴리옥시프로필렌-폴리옥시에틸렌 보호 중합체를 포함하는 것을 특징으로 하는 수용액.
  4. 제 3항에 있어서, 폴리옥시에틸렌 함량이 최소한 50%인 폴리옥시프로필렌-폴리옥시에틸렌 보호 중합체를 포함하는 것을 특징으로 하는 수용액.
  5. 제 1항 내지 제 4 항중 어느한항에 있어서, 포스포리피드로서 레시턴을 포함하는 것을 특징으로 하는 수용액.
  6. 제 1항 내지 제 5 항중 어느한항에 있어서, 0.01-5%의 폴리옥시프로필렌-폴리옥시에틸렌 보호 중합체를 포함하는 것을 특징으로 하는 수용액.
  7. 제 1항 내지 제 6 항중 어느한항에 있어서, 0.0001-1%의 포스포리피드를 포함하는 것을 특징으로 하는 수용액.
  8. 제 1항 내지 제 7 항중 어느한항에 있어서, 0.0001-1mg의 항체/ml를 포함하는 것을 특징으로 하는 수용액.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019880015552A 1987-11-27 1988-11-25 항체류의 안정화 KR890007754A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL8702848 1987-11-27
NL8702848 1987-11-27

Publications (1)

Publication Number Publication Date
KR890007754A true KR890007754A (ko) 1989-07-05

Family

ID=19850988

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019880015552A KR890007754A (ko) 1987-11-27 1988-11-25 항체류의 안정화

Country Status (15)

Country Link
US (1) US4902500A (ko)
EP (1) EP0318081B1 (ko)
JP (1) JPH01168624A (ko)
KR (1) KR890007754A (ko)
AT (1) ATE65410T1 (ko)
AU (1) AU612430B2 (ko)
CA (1) CA1317899C (ko)
DE (1) DE3863908D1 (ko)
DK (1) DK648088A (ko)
ES (1) ES2051830T3 (ko)
GR (1) GR3002971T3 (ko)
IE (1) IE60719B1 (ko)
MX (1) MX165991B (ko)
NZ (1) NZ227088A (ko)
ZA (1) ZA888577B (ko)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0417821A1 (en) * 1989-09-13 1991-03-20 Duphar International Research B.V Method of stabilising colostrum for immunochemical examination
DE4100470A1 (de) * 1991-01-09 1992-07-16 Byk Gulden Lomberg Chem Fab Echokontrastmittel
US6933286B2 (en) * 1991-03-19 2005-08-23 R. Martin Emanuele Therapeutic delivery compositions and methods of use thereof
US20020123476A1 (en) * 1991-03-19 2002-09-05 Emanuele R. Martin Therapeutic delivery compositions and methods of use thereof
JP3388894B2 (ja) * 1994-07-27 2003-03-24 富士写真フイルム株式会社 固体微粒子分散物とその製造方法
US5981296A (en) * 1997-02-18 1999-11-09 Dade Behring Inc. Stabilization of particle reagents
WO1998044948A2 (en) * 1997-04-07 1998-10-15 Cangene Corporation Intravenous immune globulin formulation containing a non-ionic surface active agent with improved pharmacokinetic properties
US6066602A (en) * 1997-08-07 2000-05-23 Becton Dickinson And Company Waterborne non-silicone lubricant comprising phospholipid and polyether
ATE220558T1 (de) 1997-11-22 2002-08-15 Roche Diagnostics Gmbh Verbessertes verfahren zur stabilisierung von proteinen
US20030166525A1 (en) 1998-07-23 2003-09-04 Hoffmann James Arthur FSH Formulation
US6447806B1 (en) 1999-02-25 2002-09-10 Novartis Ag Pharmaceutical compositions comprised of stabilized peptide particles
US9700866B2 (en) * 2000-12-22 2017-07-11 Baxter International Inc. Surfactant systems for delivery of organic compounds
EP1421170A2 (en) * 2001-07-31 2004-05-26 CytRx Corporation Therapeutic delivery compositions and methods of use thereof
KR101235507B1 (ko) * 2003-02-28 2013-02-20 추가이 세이야쿠 가부시키가이샤 단백질을 함유하는 안정화 제제
PL1610822T5 (pl) * 2003-04-02 2019-05-31 Ares Trading Sa Płynne formulacje farmaceutyczne FSH i LH z niejonowym surfaktantem
DK1638595T3 (da) 2003-06-20 2013-04-08 Ares Trading Sa Frysetørrede FSH-/LH-formuleringer
KR101808872B1 (ko) 2009-10-30 2017-12-13 교와 메덱스 가부시키가이샤 검체 중의 측정 대상 성분의 측정 방법 및 측정용 키트
ES2722201T3 (es) 2010-03-22 2019-08-08 Hoffmann La Roche Composiciones y procedimientos útiles para estabilizar formulaciones que contienen proteínas
CA3020477A1 (en) * 2016-09-01 2018-03-08 Romeo BEBEACHIBULI Food factor-based formulation, products produced using said formulation and methods for producing same

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3271181D1 (en) * 1982-02-08 1986-06-19 Schweiz Serum & Impfinst Intravenously administrable human immunoglobuline and process for its preparation
JPS58206513A (ja) * 1982-05-28 1983-12-01 Eisai Co Ltd セクレチン吸着防止組成物および方法
US4397870A (en) * 1982-07-27 1983-08-09 The University Of Pennsylvania Process for prolonging retention of emulsion particles in the bloodstream
US4606918A (en) * 1983-08-22 1986-08-19 Syntex (U.S.A.) Inc. Polyoxypropylene-polyoxyethylene block polymer based adjuvants
US4707441A (en) * 1984-08-06 1987-11-17 Technicon Instruments Corp. Binding assays in automated apparatus with liposome compatible surfactants
DK166762B1 (da) * 1986-01-14 1993-07-12 Nederlanden Staat Fremgangsmaade til fremstilling af immunogenkomplekser og farmaceutisk sammensaetning indeholdende saadanne komplekser

Also Published As

Publication number Publication date
EP0318081B1 (en) 1991-07-24
EP0318081A1 (en) 1989-05-31
US4902500A (en) 1990-02-20
GR3002971T3 (en) 1993-01-25
JPH01168624A (ja) 1989-07-04
AU612430B2 (en) 1991-07-11
IE60719B1 (en) 1994-08-10
IE883445L (en) 1989-05-27
DE3863908D1 (de) 1991-08-29
AU2579188A (en) 1989-06-01
ZA888577B (en) 1989-08-30
MX165991B (es) 1992-12-14
ES2051830T3 (es) 1994-07-01
DK648088A (da) 1989-05-28
CA1317899C (en) 1993-05-18
ATE65410T1 (de) 1991-08-15
DK648088D0 (da) 1988-11-18
NZ227088A (en) 1990-07-26

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