KR890007754A - 항체류의 안정화 - Google Patents
항체류의 안정화 Download PDFInfo
- Publication number
- KR890007754A KR890007754A KR1019880015552A KR880015552A KR890007754A KR 890007754 A KR890007754 A KR 890007754A KR 1019880015552 A KR1019880015552 A KR 1019880015552A KR 880015552 A KR880015552 A KR 880015552A KR 890007754 A KR890007754 A KR 890007754A
- Authority
- KR
- South Korea
- Prior art keywords
- aqueous solution
- polyoxyethylene
- polyoxypropylene
- protective polymer
- phospholipid
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39591—Stabilisation, fragmentation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Endocrinology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (8)
- 폴리옥시프로필렌-폴리옥시에틸렌 보호 중합체와 포스포리피드의 혼합물을 포함하는 것을 특징으로 하는 안정한 항체 수용액.
- 제 1항에 있어서, 폴리옥시프로필렌-폴리옥시에틸렌 보호 중합체가 950 내지 4,000달톤의 분자량을 가짐을 특징으로 하는 수용액.
- 제 1항 또는 제2항에 있어서, 폴리옥시에틸렌 함량이 최소한 80%인 폴리옥시프로필렌-폴리옥시에틸렌 보호 중합체를 포함하는 것을 특징으로 하는 수용액.
- 제 3항에 있어서, 폴리옥시에틸렌 함량이 최소한 50%인 폴리옥시프로필렌-폴리옥시에틸렌 보호 중합체를 포함하는 것을 특징으로 하는 수용액.
- 제 1항 내지 제 4 항중 어느한항에 있어서, 포스포리피드로서 레시턴을 포함하는 것을 특징으로 하는 수용액.
- 제 1항 내지 제 5 항중 어느한항에 있어서, 0.01-5%의 폴리옥시프로필렌-폴리옥시에틸렌 보호 중합체를 포함하는 것을 특징으로 하는 수용액.
- 제 1항 내지 제 6 항중 어느한항에 있어서, 0.0001-1%의 포스포리피드를 포함하는 것을 특징으로 하는 수용액.
- 제 1항 내지 제 7 항중 어느한항에 있어서, 0.0001-1mg의 항체/ml를 포함하는 것을 특징으로 하는 수용액.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NL8702848 | 1987-11-27 | ||
NL8702848 | 1987-11-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
KR890007754A true KR890007754A (ko) | 1989-07-05 |
Family
ID=19850988
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019880015552A KR890007754A (ko) | 1987-11-27 | 1988-11-25 | 항체류의 안정화 |
Country Status (15)
Country | Link |
---|---|
US (1) | US4902500A (ko) |
EP (1) | EP0318081B1 (ko) |
JP (1) | JPH01168624A (ko) |
KR (1) | KR890007754A (ko) |
AT (1) | ATE65410T1 (ko) |
AU (1) | AU612430B2 (ko) |
CA (1) | CA1317899C (ko) |
DE (1) | DE3863908D1 (ko) |
DK (1) | DK648088A (ko) |
ES (1) | ES2051830T3 (ko) |
GR (1) | GR3002971T3 (ko) |
IE (1) | IE60719B1 (ko) |
MX (1) | MX165991B (ko) |
NZ (1) | NZ227088A (ko) |
ZA (1) | ZA888577B (ko) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0417821A1 (en) * | 1989-09-13 | 1991-03-20 | Duphar International Research B.V | Method of stabilising colostrum for immunochemical examination |
DE4100470A1 (de) * | 1991-01-09 | 1992-07-16 | Byk Gulden Lomberg Chem Fab | Echokontrastmittel |
US6933286B2 (en) * | 1991-03-19 | 2005-08-23 | R. Martin Emanuele | Therapeutic delivery compositions and methods of use thereof |
US20020123476A1 (en) * | 1991-03-19 | 2002-09-05 | Emanuele R. Martin | Therapeutic delivery compositions and methods of use thereof |
JP3388894B2 (ja) * | 1994-07-27 | 2003-03-24 | 富士写真フイルム株式会社 | 固体微粒子分散物とその製造方法 |
US5981296A (en) * | 1997-02-18 | 1999-11-09 | Dade Behring Inc. | Stabilization of particle reagents |
WO1998044948A2 (en) * | 1997-04-07 | 1998-10-15 | Cangene Corporation | Intravenous immune globulin formulation containing a non-ionic surface active agent with improved pharmacokinetic properties |
US6066602A (en) * | 1997-08-07 | 2000-05-23 | Becton Dickinson And Company | Waterborne non-silicone lubricant comprising phospholipid and polyether |
ATE220558T1 (de) | 1997-11-22 | 2002-08-15 | Roche Diagnostics Gmbh | Verbessertes verfahren zur stabilisierung von proteinen |
US20030166525A1 (en) | 1998-07-23 | 2003-09-04 | Hoffmann James Arthur | FSH Formulation |
US6447806B1 (en) | 1999-02-25 | 2002-09-10 | Novartis Ag | Pharmaceutical compositions comprised of stabilized peptide particles |
US9700866B2 (en) * | 2000-12-22 | 2017-07-11 | Baxter International Inc. | Surfactant systems for delivery of organic compounds |
EP1421170A2 (en) * | 2001-07-31 | 2004-05-26 | CytRx Corporation | Therapeutic delivery compositions and methods of use thereof |
KR101235507B1 (ko) * | 2003-02-28 | 2013-02-20 | 추가이 세이야쿠 가부시키가이샤 | 단백질을 함유하는 안정화 제제 |
PL1610822T5 (pl) * | 2003-04-02 | 2019-05-31 | Ares Trading Sa | Płynne formulacje farmaceutyczne FSH i LH z niejonowym surfaktantem |
DK1638595T3 (da) | 2003-06-20 | 2013-04-08 | Ares Trading Sa | Frysetørrede FSH-/LH-formuleringer |
KR101808872B1 (ko) | 2009-10-30 | 2017-12-13 | 교와 메덱스 가부시키가이샤 | 검체 중의 측정 대상 성분의 측정 방법 및 측정용 키트 |
ES2722201T3 (es) | 2010-03-22 | 2019-08-08 | Hoffmann La Roche | Composiciones y procedimientos útiles para estabilizar formulaciones que contienen proteínas |
CA3020477A1 (en) * | 2016-09-01 | 2018-03-08 | Romeo BEBEACHIBULI | Food factor-based formulation, products produced using said formulation and methods for producing same |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3271181D1 (en) * | 1982-02-08 | 1986-06-19 | Schweiz Serum & Impfinst | Intravenously administrable human immunoglobuline and process for its preparation |
JPS58206513A (ja) * | 1982-05-28 | 1983-12-01 | Eisai Co Ltd | セクレチン吸着防止組成物および方法 |
US4397870A (en) * | 1982-07-27 | 1983-08-09 | The University Of Pennsylvania | Process for prolonging retention of emulsion particles in the bloodstream |
US4606918A (en) * | 1983-08-22 | 1986-08-19 | Syntex (U.S.A.) Inc. | Polyoxypropylene-polyoxyethylene block polymer based adjuvants |
US4707441A (en) * | 1984-08-06 | 1987-11-17 | Technicon Instruments Corp. | Binding assays in automated apparatus with liposome compatible surfactants |
DK166762B1 (da) * | 1986-01-14 | 1993-07-12 | Nederlanden Staat | Fremgangsmaade til fremstilling af immunogenkomplekser og farmaceutisk sammensaetning indeholdende saadanne komplekser |
-
1988
- 1988-11-16 AT AT88202555T patent/ATE65410T1/de not_active IP Right Cessation
- 1988-11-16 ZA ZA888577A patent/ZA888577B/xx unknown
- 1988-11-16 ES ES88202555T patent/ES2051830T3/es not_active Expired - Lifetime
- 1988-11-16 EP EP88202555A patent/EP0318081B1/en not_active Expired - Lifetime
- 1988-11-16 DE DE8888202555T patent/DE3863908D1/de not_active Expired - Fee Related
- 1988-11-17 IE IE344588A patent/IE60719B1/en not_active IP Right Cessation
- 1988-11-18 DK DK648088A patent/DK648088A/da not_active Application Discontinuation
- 1988-11-22 AU AU25791/88A patent/AU612430B2/en not_active Ceased
- 1988-11-22 MX MX013884A patent/MX165991B/es unknown
- 1988-11-23 US US07/275,250 patent/US4902500A/en not_active Expired - Fee Related
- 1988-11-24 CA CA000583975A patent/CA1317899C/en not_active Expired - Fee Related
- 1988-11-25 NZ NZ227088A patent/NZ227088A/xx unknown
- 1988-11-25 JP JP63298007A patent/JPH01168624A/ja active Pending
- 1988-11-25 KR KR1019880015552A patent/KR890007754A/ko not_active Application Discontinuation
-
1991
- 1991-10-23 GR GR91401599T patent/GR3002971T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
EP0318081B1 (en) | 1991-07-24 |
EP0318081A1 (en) | 1989-05-31 |
US4902500A (en) | 1990-02-20 |
GR3002971T3 (en) | 1993-01-25 |
JPH01168624A (ja) | 1989-07-04 |
AU612430B2 (en) | 1991-07-11 |
IE60719B1 (en) | 1994-08-10 |
IE883445L (en) | 1989-05-27 |
DE3863908D1 (de) | 1991-08-29 |
AU2579188A (en) | 1989-06-01 |
ZA888577B (en) | 1989-08-30 |
MX165991B (es) | 1992-12-14 |
ES2051830T3 (es) | 1994-07-01 |
DK648088A (da) | 1989-05-28 |
CA1317899C (en) | 1993-05-18 |
ATE65410T1 (de) | 1991-08-15 |
DK648088D0 (da) | 1988-11-18 |
NZ227088A (en) | 1990-07-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
A201 | Request for examination | ||
E902 | Notification of reason for refusal | ||
E601 | Decision to refuse application |