KR890004703A - 살부타몰 함유 외용 첩부제 및 그의 제조방법 - Google Patents
살부타몰 함유 외용 첩부제 및 그의 제조방법 Download PDFInfo
- Publication number
- KR890004703A KR890004703A KR1019880011542A KR880011542A KR890004703A KR 890004703 A KR890004703 A KR 890004703A KR 1019880011542 A KR1019880011542 A KR 1019880011542A KR 880011542 A KR880011542 A KR 880011542A KR 890004703 A KR890004703 A KR 890004703A
- Authority
- KR
- South Korea
- Prior art keywords
- salbutamol
- external patch
- polymer material
- adhesive base
- contained
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/45—Non condensed piperidines, e.g. piperocaine having oxo groups directly attached to the heterocyclic ring, e.g. cycloheximide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7076—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising ingredients of undetermined constitution or reaction products thereof, e.g. rosin or other plant resins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Botany (AREA)
- Neurosurgery (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 첩부제의 첩부시간과 약제의 경피투과량의 관계를 표시한 도.
제2도는 첩부제의 첩부시간과 히스타민 기관지 수축작용의 억제율과의 관계를 표시한 도.
제3도는 금속 봉쇄제의 약제 안정효과를 표시한 실험도이다.
Claims (10)
- 고분자 물질 및 금속이온 봉쇄제를 함유한 점착성기제 중에서 살부타몰 또는 의약품으로서 허용되는 그의 염이 유효량 배합된 약물 보유층이 지지체상에 설치된 것을 특징으로 하는 살부타몰 외용 첩부제.
- 제1항에 있어서, 고분자 물질이 천연 고무, 폴리이소프렌, 폴리부타디엔, 스티렌-이소프렌-스티렌 블럭 공중합체, 폴리아크릴산 에스테르, 폴리메타크릴산에스테르, 아클릴산에스테르-메타크릴산에스테르 공중합체, 아크릴산-아크릴산에스테르-아세트산비닐 공중합체, 석유계 수지의 군에서 선택되는 적어도 1종의 고분자 물질인 것을 특징으로 하는 살부타몰 외용 첩부제.
- 제1항에 있어서, 점착성 기제중에 점착력 부여 수지가 함유되어 있는 것을 특징으로 하는 살부타몰 외용 첩부제.
- 제1항에 있어서, 점착성 기제중에 연화제가 함유되어 있는 것을 특지으로 하는 살부타몰 외용 첨부제.
- 제1항에 있어서, 고분자 물질이 2중 결합을 가지는 경우에, 점착성 기제중에 산화방지제가 함유되어 있는 것을 특징으로 하는 살부타몰 외용 첩부제.
- 제1항에 있어서, 약물 보유층 중의 살부타몰 및 금속이온 봉쇄제의 배합량이 살부타몰: 1 내지 6%(중량%, 이하 같음) 금속이온 봉쇄제: 0.01 내지 2%인 것을 특징으로 하는 살부타몰 외용 첩부제.
- 제2항에 있어서, 고분자 물질이 아크릴산:10% 이하 아크릴산에스테르:60 내지 100% 아세트산비닐:20%이하의 공중합체인 것을 특징으로 하는 살부타몰 외용 첩부제.
- 제2항에 있어서, 고분자 물질이 천연고무인 경우에 있어서, 점착성 기제중의 배합량이 천연고무:30 내지 70% 점착력부여 수지:30 내지 60% 연환제:20% 이하 산화방지제: 0.01 내지 2% 금속이온 봉쇄제: 0.01 내지 2%인 것을 특징으로 하는 살부타몰 외용 첩부제.
- 제4항에 있어서, 고분자 물질이 스티렌-이소프렌-스티렌 블럭 공중합체이며, 연화제가 액상 고무인 경우에 있어서 점착 기제중에 있어서 이들의 배합량이 스티렌-이소프렌-스티렌블럭 공중합체: 20 내지 40% 액상고무:5 내지 20%인 것을 특징으로 하는 살부타몰 외용 첩부제.
- 고분자 물질 및 금속이온 봉쇄제를 필수적으로 함유하는 점착성 물질에 살부타몰을 함유시켜서 지지체상에 전연하는 것을 특징으로 하는 살부타몰 함유 외용 첩부제의 제조방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP62-224487 | 1987-09-08 | ||
JP62224487A JPS6468316A (en) | 1987-09-08 | 1987-09-08 | External plaster containing salbutamol |
Publications (1)
Publication Number | Publication Date |
---|---|
KR890004703A true KR890004703A (ko) | 1989-05-09 |
Family
ID=16814566
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019880011542A KR890004703A (ko) | 1987-09-08 | 1988-09-07 | 살부타몰 함유 외용 첩부제 및 그의 제조방법 |
Country Status (11)
Country | Link |
---|---|
US (1) | US5068103A (ko) |
EP (1) | EP0306926A3 (ko) |
JP (1) | JPS6468316A (ko) |
KR (1) | KR890004703A (ko) |
AU (1) | AU616902B2 (ko) |
DK (1) | DK498688A (ko) |
FI (1) | FI884110A (ko) |
NO (1) | NO883976L (ko) |
NZ (1) | NZ226072A (ko) |
PT (1) | PT88440B (ko) |
ZA (1) | ZA886558B (ko) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100369779B1 (ko) * | 1999-07-12 | 2003-01-29 | 주식회사 엘지생명과학 | 교감신경 흥분성 기관지확장 약물의 경피흡수 투여용 조성물및 이를 포함하는 경피흡수 투여용 제형 |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0725669B2 (ja) * | 1988-12-23 | 1995-03-22 | 日東電工株式会社 | 経皮投与用医薬製剤 |
IE903782A1 (en) * | 1989-10-23 | 1991-04-24 | Searle & Co | Novel multiple layer transdermal drug administration system |
DE4002281A1 (de) * | 1990-01-26 | 1991-08-01 | Lohmann Therapie Syst Lts | Transdermales therapeutisches system mit dem wirkstoff tulobuterol |
DE4033524A1 (de) * | 1990-10-22 | 1992-04-23 | Sanol Arznei Schwarz Gmbh | Pharmazeutische verwendung von 1-(tert-butylamino)-3-((6-chloro-m-tolyl)oxy)-2-propanol in einer transdermalen applikationsform |
BR9509524A (pt) | 1994-10-28 | 1997-09-16 | Kimberly Clark Co | Artigo absorvente dispositivo catamenial e absorvente higiênico |
NZ309980A (en) * | 1995-06-07 | 2001-06-29 | Noven Pharma | Transdermal composition containing a blend of one or more polymers, one or more drugs that has a low molecular weight and is liquid at room temperature |
US6822033B2 (en) | 2001-11-19 | 2004-11-23 | United States Gypsum Company | Compositions and methods for treating set gypsum |
GB0625270D0 (en) * | 2006-12-19 | 2007-01-31 | Univ Leicester | Angiogenesis |
US8070895B2 (en) | 2007-02-12 | 2011-12-06 | United States Gypsum Company | Water resistant cementitious article and method for preparing same |
US8329308B2 (en) | 2009-03-31 | 2012-12-11 | United States Gypsum Company | Cementitious article and method for preparing the same |
CN113143848A (zh) * | 2021-03-31 | 2021-07-23 | 广东工业大学 | 用于治疗银屑病的外用乳膏剂及其制备方法 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS54138124A (en) * | 1978-04-19 | 1979-10-26 | Hisamitsu Pharmaceut Co Inc | Novel plaster and its preparation |
JPS6034922B2 (ja) * | 1978-09-01 | 1985-08-12 | 久光製薬株式会社 | 新規貼付薬 |
GB2045618B (en) * | 1979-04-03 | 1983-05-11 | Hisamitsu Pharmaceutical Co | Adhesive plaster |
JPS5620515A (en) * | 1979-07-30 | 1981-02-26 | Suzuki Nihondou:Kk | Preparation of plaster |
JPS56133381A (en) * | 1980-03-25 | 1981-10-19 | Nippon Kayaku Co Ltd | Pressure-sensitive adhesive tape or sheet containing nitroglycerin |
JPS57209217A (en) * | 1981-06-17 | 1982-12-22 | Nitto Electric Ind Co Ltd | Medicament preparation |
HU184575B (en) * | 1982-07-16 | 1984-09-28 | Otto Mallasz | Method for producing preparations fixable on skin generating locally electrolytic and bio currents |
JPS5925320A (ja) * | 1982-08-02 | 1984-02-09 | Watanabe Yakuhin Kogyo Kk | 薬物投与用貼付剤 |
CA1248450A (en) * | 1984-04-05 | 1989-01-10 | Kazuo Kigasawa | Soft patch |
US4568343A (en) * | 1984-10-09 | 1986-02-04 | Alza Corporation | Skin permeation enhancer compositions |
GB8515522D0 (en) * | 1985-06-19 | 1985-07-24 | Beecham Group Plc | Compounds |
JPS6310716A (ja) * | 1986-07-02 | 1988-01-18 | Teijin Ltd | β−刺激薬外用剤 |
US4938759A (en) * | 1986-09-02 | 1990-07-03 | Alza Corporation | Transdermal delivery device having a rate controlling adhesive |
AU607172B2 (en) * | 1986-12-22 | 1991-02-28 | Cygnus, Inc. | Diffusion matrix for transdermal drug administration |
-
1987
- 1987-09-08 JP JP62224487A patent/JPS6468316A/ja active Pending
-
1988
- 1988-09-02 ZA ZA886558A patent/ZA886558B/xx unknown
- 1988-09-07 EP EP88114626A patent/EP0306926A3/en not_active Withdrawn
- 1988-09-07 NO NO88883976A patent/NO883976L/no unknown
- 1988-09-07 FI FI884110A patent/FI884110A/fi not_active IP Right Cessation
- 1988-09-07 KR KR1019880011542A patent/KR890004703A/ko not_active Application Discontinuation
- 1988-09-07 PT PT88440A patent/PT88440B/pt not_active IP Right Cessation
- 1988-09-07 DK DK498688A patent/DK498688A/da not_active Application Discontinuation
- 1988-09-07 NZ NZ226072A patent/NZ226072A/en unknown
- 1988-09-08 US US07/241,458 patent/US5068103A/en not_active Expired - Fee Related
- 1988-09-08 AU AU22004/88A patent/AU616902B2/en not_active Ceased
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100369779B1 (ko) * | 1999-07-12 | 2003-01-29 | 주식회사 엘지생명과학 | 교감신경 흥분성 기관지확장 약물의 경피흡수 투여용 조성물및 이를 포함하는 경피흡수 투여용 제형 |
Also Published As
Publication number | Publication date |
---|---|
DK498688D0 (da) | 1988-09-07 |
EP0306926A2 (en) | 1989-03-15 |
EP0306926A3 (en) | 1989-07-05 |
DK498688A (da) | 1989-03-09 |
NO883976D0 (no) | 1988-09-07 |
AU2200488A (en) | 1989-03-23 |
NZ226072A (en) | 1991-01-29 |
NO883976L (no) | 1989-03-09 |
JPS6468316A (en) | 1989-03-14 |
ZA886558B (en) | 1989-04-26 |
US5068103A (en) | 1991-11-26 |
PT88440B (pt) | 1991-05-22 |
FI884110A (fi) | 1989-03-09 |
FI884110A0 (fi) | 1988-09-07 |
AU616902B2 (en) | 1991-11-14 |
PT88440A (pt) | 1990-02-08 |
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Legal Events
Date | Code | Title | Description |
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WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |