KR890003781A - 신규화합물들 - Google Patents
신규화합물들 Download PDFInfo
- Publication number
- KR890003781A KR890003781A KR1019880010621A KR880010621A KR890003781A KR 890003781 A KR890003781 A KR 890003781A KR 1019880010621 A KR1019880010621 A KR 1019880010621A KR 880010621 A KR880010621 A KR 880010621A KR 890003781 A KR890003781 A KR 890003781A
- Authority
- KR
- South Korea
- Prior art keywords
- group
- pharmaceutically acceptable
- iii
- carboxylate anion
- formula
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title claims 7
- -1 carboxylate anion Chemical group 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- 150000002148 esters Chemical class 0.000 claims 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 3
- 238000001727 in vivo Methods 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 208000035143 Bacterial infection Diseases 0.000 claims 1
- 229940123930 Lactamase inhibitor Drugs 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 claims 1
- 230000010933 acylation Effects 0.000 claims 1
- 238000005917 acylation reaction Methods 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 208000022362 bacterial infectious disease Diseases 0.000 claims 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000006239 protecting group Chemical group 0.000 claims 1
- JUJWROOIHBZHMG-UHFFFAOYSA-O pyridinium Chemical compound C1=CC=[NH+]C=C1 JUJWROOIHBZHMG-UHFFFAOYSA-O 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/57—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with a further substituent in position 7, e.g. cephamycines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (9)
- 하기 일반구조식(Ⅰ)의 화합물 또는 이들의 염.(Ⅰ)상기식에서 CO2R은 카르복시 또는 카르복실레이트 음이온이거나 기 R은 즉시제거될 수 있는 카르복시보호기이다.
- 하기 일반구조식(Ⅰa)의 화합물 또는 이들의 제약학적으로 허용가능한 염 또는 제약학적으로 허용가능한 생체내 가수분해성 에스테르:(Ⅰa)상기식에서 CO2R1은 카르복시 또는 카르복실레이트 음이온이다.
- 7-[D-2-(3,4-디히드록시페닐)-2-[(4-에틸-2,3-디옥소피페라진-1-일)카르보닐아미노]아세트아미도]-7-포름아미도-3-(피리디늄)메틸-세포-3-엠-4-카르복실레이트.
- 제약학적으로 허용가능한 담체 또는 부형제와 함께 항균적으로 효과적인 양의 제 2 항 또는 제 3 항에서 청구된 화합물을 포함하는 제약학적 조성물.
- 제 4 항에 있어서,-락탐아제 억제제가 포함되는 제약학적 조성물.
- 하기 일반구조식(Ⅳ)의 화합물 또는 이들의 염:(Ⅳ)(상기식에서 CO2R은 카르복시 또는 카르복실레이트 음이온이거나 R은 즉시제거될 수 있는 카르복시보호기이며, 아미노기는 아실화가 일어날 수 있도록 하는 기로 임의 치환됨)를 하기 일반구조식(Ⅴ)산의 N-아실화 유도체:(Ⅴ)(상기식에서 임의의 반응성 기는 보호될 수 있다)로 처리한 다음 필요하거나 원한다면 하기(ⅰ)-(ⅲ)단계 중 한가지 이상을 수행하는 것을 포함하는 제 1 항에 청구된 일반구조식(Ⅰ)화합물의 제조방법; (ⅰ) 임의의 보호기를 제거하는 단계 ; (ⅱ) 기 -CO2R을 다른 기 -CO2R로 전환시키는 단계; (ⅲ) 생성물을 염으로 전환시키는 단계.
- 제 6 항에 있어서, 기 CO2R가 카르복실레이트 음이온인 방법.
- 제 2 항에 있어서, 치료하는데 사용하기 위한 일반구조식(Ⅰa) 화합물 또는 이들의 제약학적으로 허용가능한 염 또는 제약학적으로 허용가능한 생채내 가수 분해성 에스테르.
- 인간 및 동물에게 있어서 세균감염을 치료하는 약제를 제조하기 위하여 제 2 항에서 청구된 일반구조식(Ⅰa) 화합물 또는 이들의 제약학적으로 허용가능한 염 또는 제약학적으로 허용가능한 생체내 가수분해성 에스테르의 사용.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8719875 | 1987-08-22 | ||
| GB878719875A GB8719875D0 (en) | 1987-08-22 | 1987-08-22 | Compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR890003781A true KR890003781A (ko) | 1989-04-18 |
Family
ID=10622671
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019880010621A KR890003781A (ko) | 1987-08-22 | 1988-08-20 | 신규화합물들 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5028427A (ko) |
| EP (1) | EP0305111A3 (ko) |
| JP (1) | JPS6468379A (ko) |
| KR (1) | KR890003781A (ko) |
| AU (1) | AU2112588A (ko) |
| DK (1) | DK468788A (ko) |
| GB (1) | GB8719875D0 (ko) |
| NZ (1) | NZ225875A (ko) |
| PT (1) | PT88308A (ko) |
| ZA (1) | ZA886160B (ko) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2341053B1 (en) | 2008-10-31 | 2016-01-13 | Shionogi&Co., Ltd. | Cephalosporin having catechol group |
| US9145425B2 (en) | 2010-04-05 | 2015-09-29 | Shionogi & Co., Ltd. | Cephem compound having catechol group |
| CN102918047A (zh) | 2010-04-05 | 2013-02-06 | 盐野义制药株式会社 | 具有假儿茶酚基团的头孢烯类化合物 |
| JP5852562B2 (ja) | 2010-04-28 | 2016-02-03 | 塩野義製薬株式会社 | 新規なセフェム誘導体 |
| WO2012147773A1 (ja) | 2011-04-28 | 2012-11-01 | 塩野義製薬株式会社 | カテコールまたは擬似カテコール構造を有する新規セフェム化合物 |
| WO2013002215A1 (ja) | 2011-06-27 | 2013-01-03 | 塩野義製薬株式会社 | ピリジニウム基を有するセフェム化合物 |
| US10441115B2 (en) * | 2016-02-11 | 2019-10-15 | Gojo Industries, Inc. | High quality non-aerosol hand sanitizing foam |
| US10912426B2 (en) | 2016-04-06 | 2021-02-09 | Gojo Industries, Inc. | Sequentially activated multi-diaphragm foam pumps, refill units and dispenser systems |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3278878D1 (en) * | 1981-07-25 | 1988-09-15 | Beecham Group Plc | Beta-lactam antibacterial agents |
| GB8520155D0 (en) | 1985-08-10 | 1985-09-18 | Beecham Group Plc | Compounds |
| EP0211656A3 (en) * | 1985-08-10 | 1988-03-09 | Beecham Group Plc | Cephalosporin derivatives, process for their preparation and pharmaceutical compositions containing them |
-
1987
- 1987-08-22 GB GB878719875A patent/GB8719875D0/en active Pending
-
1988
- 1988-08-18 EP EP19880307659 patent/EP0305111A3/en not_active Withdrawn
- 1988-08-19 DK DK468788A patent/DK468788A/da not_active Application Discontinuation
- 1988-08-19 NZ NZ225875A patent/NZ225875A/en unknown
- 1988-08-19 ZA ZA886160A patent/ZA886160B/xx unknown
- 1988-08-19 AU AU21125/88A patent/AU2112588A/en not_active Abandoned
- 1988-08-19 PT PT88308A patent/PT88308A/pt unknown
- 1988-08-20 KR KR1019880010621A patent/KR890003781A/ko not_active Application Discontinuation
- 1988-08-22 JP JP63207966A patent/JPS6468379A/ja active Pending
- 1988-08-22 US US07/235,388 patent/US5028427A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| GB8719875D0 (en) | 1987-09-30 |
| DK468788A (da) | 1989-02-23 |
| US5028427A (en) | 1991-07-02 |
| EP0305111A2 (en) | 1989-03-01 |
| EP0305111A3 (en) | 1991-04-03 |
| DK468788D0 (da) | 1988-08-19 |
| NZ225875A (en) | 1990-12-21 |
| JPS6468379A (en) | 1989-03-14 |
| AU2112588A (en) | 1989-02-23 |
| PT88308A (pt) | 1989-06-30 |
| ZA886160B (en) | 1989-09-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |