KR890001940A - 소염제/항알레르기제로서의 나프탈렌프로피온산 유도체 화합물 - Google Patents

소염제/항알레르기제로서의 나프탈렌프로피온산 유도체 화합물 Download PDF

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KR890001940A
KR890001940A KR1019880009599A KR880009599A KR890001940A KR 890001940 A KR890001940 A KR 890001940A KR 1019880009599 A KR1019880009599 A KR 1019880009599A KR 880009599 A KR880009599 A KR 880009599A KR 890001940 A KR890001940 A KR 890001940A
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methyl
compound according
naphthaleneacetic acid
inflammatory
propionic acid
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KR1019880009599A
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프랑크 크레프트 3세 안토니
헨리 머써 존
제이콥 빅슬러 제임스
윌리엄 기버슨 존
마틴 커브랙 데니스
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버어나드 카나반
아메리칸 홈 프로덕츠 코포레이션
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Publication of KR890001940A publication Critical patent/KR890001940A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/34—Esters of acyclic saturated polycarboxylic acids having an esterified carboxyl group bound to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D215/14—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/24—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Quinoline Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Furan Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

내용없음

Description

소염제/항알레르기제로서의 나프탈레프로피온산 유도체 화합물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (16)

  1. 하기 일반식(I)의 화합물 및 약제학적으로 허용되는 염.
    상기식에서, A는 탄소수 3 내지 19의 알킬, 디-저급알킬비닐, 디할로비닐, 디폐닐비닐, 저급알키닐, 또는또는[여기에서, X는 N 또는 CR이고 ; Z는 ; R은 수소 또는 저급알킬이고, R¹은 수소, 저급알킬 또는 페닐이고; R²는 수소 또는 저급알킬이거나 ; R¹ 및 R²는 함께 벤젠환을 형성한다]이다.
  2. 제 1 항에 있어서, α-메틸-6-(2-퀴놀리닐메톡시)-2-나프탈렌아세트산인 화합물.
  3. 제 1 항에 있어서,α-메틸-6-(페닐메톡시)-2-나프탈렌아세트산인 화합물.
  4. 제 1 항에 있어서, α-메틸-6-[(1-메틸-IH-벤즈이미다졸-2-일)메톡시]-2-나프탈렌아세트산인 화합물.
  5. 제 1 항에 있어서,α-메틸-6-(2-피리디니리메톡시)-2-나프탈렌아세트산인 화합물.
  6. 제 1 항에 있어서, α-메틸-6-(2-벤조티아졸릴메톡시)-2-나프탈렌아세트산인 화합물.
  7. 제 1 항에 있어서, α-메틸-6-(2-나프탈레닐메톡시)-2-나프탈렌아세트산인 화합물.
  8. 제 1 항에 있어서, S-(+)-α-메틸-6-(2-퀴놀리닐메톡시)-2-나프탈렌아세트산인 화합물.
  9. 제 1 항에 있어서, R-(-)-α-메틸-6-(2-퀴놀리닐메톡시)-2-나프탈렌아세트산인 화합물.
  10. 제 1 항에 있어서, α-메틸-6-[(2-페닐-4-티아졸릴)메톡시]-2-나프탈렌아세트산인 화합물.
  11. 제1항에 있어서, α-메틸-6-(헥실옥시)-2-나프탈렌아세트산인 화합물.
  12. 제 1 항에 있어서, α-메틸-6-(부틸옥시)-2-나프탈렌아세트산인 화합물.
  13. 제 1 항에 있어서, α-메틸-6-(펜틸옥시)-2-나프탈렌아세트산인 화합물.
  14. 제 1 항에 있어서, α-메틸-6-(도데실옥시)-2-나프탈렌아세트산인 화합물.
  15. 제 1 항에 있어서, α-메틸-6-(3-메틸-2-부텐옥시)-2-나프탈렌아세트산인 화합물.
  16. 제 1항에 있어서, α-메틸-6-(3,3-디클로로알릴옥시)-2-나프탈렌아세트산인 화합물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019880009599A 1987-07-31 1988-07-29 소염제/항알레르기제로서의 나프탈렌프로피온산 유도체 화합물 KR890001940A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US8012287A 1987-07-31 1987-07-31
US080,122 1987-07-31
US20297588A 1988-06-10 1988-06-10
US202,975 1988-06-10

Publications (1)

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KR890001940A true KR890001940A (ko) 1989-04-06

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KR1019880009599A KR890001940A (ko) 1987-07-31 1988-07-29 소염제/항알레르기제로서의 나프탈렌프로피온산 유도체 화합물

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EP (1) EP0301813B1 (ko)
JP (1) JPH01100144A (ko)
KR (1) KR890001940A (ko)
AU (1) AU611699B2 (ko)
DE (1) DE3860439D1 (ko)
DK (1) DK426288A (ko)
ES (1) ES2032018T3 (ko)
GB (1) GB2207428B (ko)
GR (1) GR3000719T3 (ko)
IE (1) IE60240B1 (ko)
PT (1) PT88116B (ko)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4960892A (en) * 1988-06-10 1990-10-02 American Home Products Corporation Naphthalenepropionic acid derivatives as anti-inflammatory/anti-allergic agents
US5084575A (en) * 1987-07-31 1992-01-28 American Home Products Corporation Quinoline substituted naphthalenepropionic acid derivatives as anti-inflammatory/antiallergic agents
US4937373A (en) * 1988-12-08 1990-06-26 Hoffmann-La Roche Inc. Substituted naphthalene carboxylic acids
PT95692A (pt) * 1989-10-27 1991-09-13 American Home Prod Processo para a preparacao de derivados de acidos indole-,indeno-,piranoindole- e tetra-hidrocarbazole-alcanoicos, ou quais sao uteis como inibidores de pla2 e da lipoxigenase
ES2150848B1 (es) * 1998-04-15 2001-07-01 Menarini Lab Heterociclos metiloxinaftil sustituidos con accion antagonista de los leucotrienos.
KR100370597B1 (ko) * 2000-06-22 2003-02-05 박정일 산형매립초로부터 분리한 신규한 나프탈렌계 화합물 및이를 유효성분으로 하는 약학적 조성물
CN1675154A (zh) * 2002-06-07 2005-09-28 科蒂科股份有限公司 抑制巨噬细胞移动抑制因子(mif)的细胞因子或生物活性的萘衍生物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4001301A (en) * 1971-11-04 1977-01-04 Syntex Corporation 6-substituted 2-naphthyl acetic acid derivatives
IT1208109B (it) * 1983-11-23 1989-06-06 Alfa Chem Ital Procedimento per la risoluzione ottica di acidi arilpropionici
IT1196334B (it) * 1984-11-22 1988-11-16 Alfa Chem Ital Processo per la risoluzione ottica di miscugli racemi di acidi alfanaftil-propionici

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AU611699B2 (en) 1991-06-20
IE60240B1 (en) 1994-06-15
IE882304L (en) 1989-01-31
GR3000719T3 (en) 1991-10-10
JPH01100144A (ja) 1989-04-18
GB2207428A (en) 1989-02-01
GB2207428B (en) 1991-10-30
ES2032018T3 (es) 1993-01-01
EP0301813B1 (en) 1990-08-08
DK426288A (da) 1989-02-01
PT88116A (pt) 1989-06-30
GB8817831D0 (en) 1988-09-01
EP0301813A1 (en) 1989-02-01
DE3860439D1 (de) 1990-09-13
PT88116B (pt) 1995-03-01
AU1920988A (en) 1989-02-02
DK426288D0 (da) 1988-07-29

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