KR890000762B1 - 1-β-D-아라비노프라노실-(E)-5-(2-할로게노비닐)우라실-5'-인산의 제조방법 - Google Patents

1-β-D-아라비노프라노실-(E)-5-(2-할로게노비닐)우라실-5'-인산의 제조방법 Download PDF

Info

Publication number
KR890000762B1
KR890000762B1 KR8203969A KR820003969A KR890000762B1 KR 890000762 B1 KR890000762 B1 KR 890000762B1 KR 8203969 A KR8203969 A KR 8203969A KR 820003969 A KR820003969 A KR 820003969A KR 890000762 B1 KR890000762 B1 KR 890000762B1
Authority
KR
South Korea
Prior art keywords
uracil
halogenovinyl
phosphate
halogenovinylara
arabinofuranosyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
KR8203969A
Other languages
English (en)
Korean (ko)
Other versions
KR840001589A (ko
Inventor
신지 사까다
하루히꼬 마찌다
Original Assignee
하마구찌 기헤에
야마사 쇼오유 가부시기가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=15306105&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR890000762(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 하마구찌 기헤에, 야마사 쇼오유 가부시기가이샤 filed Critical 하마구찌 기헤에
Publication of KR840001589A publication Critical patent/KR840001589A/ko
Application granted granted Critical
Publication of KR890000762B1 publication Critical patent/KR890000762B1/ko
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Curing Cements, Concrete, And Artificial Stone (AREA)
KR8203969A 1981-09-09 1982-09-03 1-β-D-아라비노프라노실-(E)-5-(2-할로게노비닐)우라실-5'-인산의 제조방법 Expired KR890000762B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP81-142045 1981-09-09
JP56142045A JPS5843993A (ja) 1981-09-09 1981-09-09 １−β−Ｄ−アラビノフラノシル−（Ｅ）−５−（２−ハロゲノビニル）ウラシル−５′−りん酸およびその製造法

Publications (2)

Publication Number Publication Date
KR840001589A KR840001589A (ko) 1984-05-07
KR890000762B1 true KR890000762B1 (ko) 1989-04-05

Family

ID=15306105

Family Applications (1)

Application Number Title Priority Date Filing Date
KR8203969A Expired KR890000762B1 (ko) 1981-09-09 1982-09-03 1-β-D-아라비노프라노실-(E)-5-(2-할로게노비닐)우라실-5'-인산의 제조방법

Country Status (12)

Country Link
US (1) US4542210A (https=)
EP (1) EP0074101B1 (https=)
JP (1) JPS5843993A (https=)
KR (1) KR890000762B1 (https=)
AT (1) ATE12503T1 (https=)
AU (1) AU552353B2 (https=)
CA (1) CA1204107A (https=)
DE (1) DE3262887D1 (https=)
ES (1) ES8308570A1 (https=)
GB (1) GB2108964B (https=)
MY (1) MY8700826A (https=)
SG (1) SG81787G (https=)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5843993A (ja) * 1981-09-09 1983-03-14 Yamasa Shoyu Co Ltd １−β−Ｄ−アラビノフラノシル−（Ｅ）−５−（２−ハロゲノビニル）ウラシル−５′−りん酸およびその製造法
JPS58225097A (ja) * 1982-06-23 1983-12-27 Yamasa Shoyu Co Ltd ヌクレオシド５′−アルキルもしくはアルケニルりん酸
EP0104066B1 (en) * 1982-09-17 1988-08-10 Glaxo Group Limited 5-halovinyl-2'-deoxyuridine derivatives
US4658044A (en) * 1983-09-16 1987-04-14 Glaxo Group Limited Intermediates for uracil derivatives
ATE43348T1 (de) * 1985-01-24 1989-06-15 Neopharmed Spa Acylierte cytidin-diphosphat-choline, verfahren zu ihrer herstellung und ihre therapeutische verwendung.
GB8912972D0 (en) * 1989-06-06 1989-07-26 Wellcome Found Therapeutic nucleosides
CA2085994A1 (en) * 1991-04-24 1992-10-25 Shinji Sakata 1-beta-d-arabinofuranosyl-(e)-5- (2-halogenovinyl) uracil derivatives
US5446031A (en) * 1991-04-24 1995-08-29 Yamasa Shuyu Kabushiki Kaisha 1-β-D-arabinofuranosyl-(E)-5-(2-halogenovinyl)uracil derivatives
ATE413881T1 (de) * 1997-08-08 2008-11-15 Celmed Oncology Usa Inc Verfahren und zubereitungen um resistenz gegen biologische oder chemische therapien zu überwinden
CA2317505C (en) 1998-01-23 2011-01-04 Newbiotics, Inc. Enzyme catalyzed therapeutic agents
US7462605B2 (en) * 1998-01-23 2008-12-09 Celmed Oncology (Usa), Inc. Phosphoramidate compounds and methods of use
US6653318B1 (en) * 1999-07-21 2003-11-25 Yale University 5-(E)-Bromovinyl uracil analogues and related pyrimidine nucleosides as anti-viral agents and methods of use
AU774492B2 (en) 1999-07-22 2004-07-01 Celmed Oncology (Usa) Inc. Methods for treating therapy-resistant tumors
US6683061B1 (en) * 1999-07-22 2004-01-27 Newbiotics, Inc. Enzyme catalyzed therapeutic activation
EP1359921A4 (en) * 2001-01-19 2006-09-06 Newbiotics Inc METHODS RELATING TO THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISEASES
AU2002360697B2 (en) * 2001-12-20 2009-04-23 Beth Israel Deaconess Medical Center Treatment of EBV and KHSV infection and associated abnormal cellular proliferation
JP4964473B2 (ja) * 2006-02-10 2012-06-27 アリジェン製薬株式会社 ピリミジンヌクレオシド誘導体及びその塩
WO2008099492A1 (ja) * 2007-02-15 2008-08-21 Arigen Pharmaceuticals, Inc. ピリミジンヌクレオシド誘導体及びその塩

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1157275A (en) * 1965-07-27 1969-07-02 Takeda Chemical Industries Ltd A Method for the Production of 5'-Ribonucleotide
US3382232A (en) * 1965-08-26 1968-05-07 Takeda Chemical Industries Ltd Method for the production of 5'-ribonucleotide
FR5616M (https=) * 1966-07-29 1968-01-15
EP0015584A3 (de) * 1979-03-12 1980-12-10 Kailash Kumar Dr. Prof. Gauri Neue Nukleotide, Verfahren zu ihrer Herstellung und Arzneimittel
US4247544A (en) * 1979-07-02 1981-01-27 The Regents Of The University Of California C-5 Substituted uracil nucleosides
US4267171A (en) * 1979-07-02 1981-05-12 The Regents Of The University Of California C-5 Substituted cytosine nucleosides
GB2060604B (en) * 1979-10-03 1983-11-23 Univ Birmingham And Stichting E15-(2-halogenovinyl)-2'-deoxycytidines
JPS5687599A (en) * 1979-12-19 1981-07-16 Yamasa Shoyu Co Ltd E 55 22halogenovinyl arabinofuranosyluracil and its preparation
JPS5714598A (en) * 1980-06-30 1982-01-25 Yamasa Shoyu Co Ltd 5-substituted-1-beta-d-arabinofuranosyluracil derivative and its preparation
US4383990A (en) * 1980-10-01 1983-05-17 Beecham Group Limited Antiviral agents, their preparation and use
JPS5843993A (ja) * 1981-09-09 1983-03-14 Yamasa Shoyu Co Ltd １−β−Ｄ−アラビノフラノシル−（Ｅ）−５−（２−ハロゲノビニル）ウラシル−５′−りん酸およびその製造法

Also Published As

Publication number Publication date
ES515573A0 (es) 1983-09-16
ES8308570A1 (es) 1983-09-16
KR840001589A (ko) 1984-05-07
CA1204107A (en) 1986-05-06
SG81787G (en) 1988-04-15
MY8700826A (en) 1987-12-31
JPS5843993A (ja) 1983-03-14
GB2108964B (en) 1985-04-11
DE3262887D1 (en) 1985-05-09
EP0074101A1 (en) 1983-03-16
AU8799682A (en) 1983-03-17
EP0074101B1 (en) 1985-04-03
GB2108964A (en) 1983-05-25
ATE12503T1 (de) 1985-04-15
JPS637559B2 (https=) 1988-02-17
US4542210A (en) 1985-09-17
AU552353B2 (en) 1986-05-29

Similar Documents

Publication Publication Date Title
KR890000762B1 (ko) 1-β-D-아라비노프라노실-(E)-5-(2-할로게노비닐)우라실-5'-인산의 제조방법
CA2155673C (en) N-alkyl-2-substituted atp analogues
US3798209A (en) 1,2,4-triazole nucleosides
USRE29835E (en) 1,2,4-Triazole nucleosides
CA1336820C (en) Fluorinated nucleosides and process for treating retrovirus infections therewith
US4093714A (en) 9β-D-Arabinofuranosylpurine nucleotides and method of use
FI61315B (fi) Foerfarande foer framstaellning av antivirala 9-(beta-d-arabinofuranosyl)purin-5'-fosfater
US4210638A (en) Antiviral composition and method of treating virus diseases
EP0579643A1 (en) Atp analogues
EP0031128B1 (en) (e)-5-(2-halogenovinyl)-arabinofuranosyluracil, process for preparation thereof, and uses thereof
Meier et al. Chemistry and anti-herpes simplex virus type 1 evaluation of cyclo Sal-nucleotides of acyclic nucleoside analogues
WO1984000759A1 (fr) Derives de desoxyuridine, leurs procedes de preparation et leur utilisation comme produits pharmaceutiques
IL25712A (en) 5',5'-dinucleoside phosphate
US5153180A (en) Fluorinated nucleosides and process for treating retrovirus infections therewith
Chu et al. Nucleosides. 107. Synthesis of 5-(. beta.-D-arabinofuranosyl) isocytosine and related C-nucleosides
EP0331080A2 (en) Imidazole derivatives, process for production thereof, and use thereof
US3812098A (en) O2,2'-anhydro-1-(beta-d-arabinofuranosyl)-cytosine derivatives and methods of making and related procedures
EP0445258B1 (en) 5'-alkylphosphonylnucleosides as antivirals
EP0351795A2 (en) Novel deoxyadenosine compounds and methods of making and using the same
US4104461A (en) 2,2'-Anhydro-β-D-arabinofuranosyl-5-fluorocytosine
IL44537A (en) 9-beta-d-arabinofuranosyl purine nucleotides and their preparation
US5374626A (en) 5'-alkylphosphonylnucleosides as antivirals
Revankar et al. Synthesis and anti-DNA virus activity of the 5'-monophosphate and the cyclic 3', 5'-monophosphate of 9-(. beta.-D-xylofuranosyl) guanine
KR800001478B1 (ko) 1, 2, 4-트리아졸 뉴크리오사이드의 제법
Sanghvi et al. In Vivo Antiviral Activity of 5-Amino-1-Methyl-3-β-D-Ribofuranosyl-Pyrazolo [4, 3-d] Pyrimidin-7 (6 H)-One and related guanosine analogues prepared from formycin

Legal Events

Date Code Title Description
PA0109 Patent application

St.27 status event code: A-0-1-A10-A12-nap-PA0109

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PG1605 Publication of application before grant of patent

St.27 status event code: A-2-2-Q10-Q13-nap-PG1605

PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U11-oth-PR1002

Fee payment year number: 1

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 4

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 5

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 6

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 7

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 8

PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 19970406

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 19970406