KR890000185B1 - 7-옥사비시클로헵탄 및 7-옥사비시클로헵텐 화합물 - Google Patents

7-옥사비시클로헵탄 및 7-옥사비시클로헵텐 화합물 Download PDF

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Publication number
KR890000185B1
KR890000185B1 KR8205040A KR820005040A KR890000185B1 KR 890000185 B1 KR890000185 B1 KR 890000185B1 KR 8205040 A KR8205040 A KR 8205040A KR 820005040 A KR820005040 A KR 820005040A KR 890000185 B1 KR890000185 B1 KR 890000185B1
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South Korea
Prior art keywords
compound
hept
oxabicyclo
hydroxy
solution
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Expired
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KR8205040A
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English (en)
Korean (ko)
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KR840002400A (ko
Inventor
루위스 스니트맨 데이비드
프레데릭크 하슬래인저 마아틴
위트니 스프래거 피터
Original Assignee
조오지 제이.코에서
이이 아아트 스퀴부 앤드 산즈 인코포레이팃드
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Publication of KR840002400A publication Critical patent/KR840002400A/ko
Priority to KR1019880015036A priority Critical patent/KR890000186B1/ko
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Publication of KR890000185B1 publication Critical patent/KR890000185B1/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C35/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C35/22—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system
    • C07C35/23—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings
    • C07C35/36—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings the condensed ring system being a (4.4.0) system, e.g. naphols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4018—Esters of cycloaliphatic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4056—Esters of arylalkanephosphonic acids
    • C07F9/4059—Compounds containing the structure (RY)2P(=X)-(CH2)n-C(=O)-(CH2)m-Ar, (X, Y = O, S, Se; n>=1, m>=0)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR8205040A 1981-11-09 1982-11-08 7-옥사비시클로헵탄 및 7-옥사비시클로헵텐 화합물 Expired KR890000185B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019880015036A KR890000186B1 (ko) 1981-11-09 1988-11-15 7-옥사비시클로헵탄 및 7-옥사비시클로헵텐을 함유하는 제약 조성물

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US31951181A 1981-11-09 1981-11-09
US319511 1981-11-09
US06/378,547 US4537981A (en) 1981-11-09 1982-05-17 7-Oxabicycloheptane and 7-oxabicycloheptene compounds
US378547 1982-05-17

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1019880015036A Division KR890000186B1 (ko) 1981-11-09 1988-11-15 7-옥사비시클로헵탄 및 7-옥사비시클로헵텐을 함유하는 제약 조성물

Publications (2)

Publication Number Publication Date
KR840002400A KR840002400A (ko) 1984-07-02
KR890000185B1 true KR890000185B1 (ko) 1989-03-09

Family

ID=26982040

Family Applications (1)

Application Number Title Priority Date Filing Date
KR8205040A Expired KR890000185B1 (ko) 1981-11-09 1982-11-08 7-옥사비시클로헵탄 및 7-옥사비시클로헵텐 화합물

Country Status (13)

Country Link
US (1) US4537981A (enExample)
EP (1) EP0079694B1 (enExample)
KR (1) KR890000185B1 (enExample)
AU (1) AU569464B2 (enExample)
CA (1) CA1215063A (enExample)
DE (1) DE3276317D1 (enExample)
DK (1) DK497682A (enExample)
GR (1) GR76780B (enExample)
IE (1) IE54086B1 (enExample)
IL (1) IL66989A0 (enExample)
NZ (1) NZ202138A (enExample)
PH (1) PH22106A (enExample)
PT (1) PT75811B (enExample)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4837234A (en) * 1981-12-23 1989-06-06 National Research Development Corporation Prostaglandins
US4628061A (en) * 1981-12-23 1986-12-09 National Research Development Corporation Prostaglandins
US4614825A (en) * 1982-05-17 1986-09-30 E. R. Squibb & Sons, Inc. 7-oxabicycloheptane and 7-oxabicycloheptene compounds
US4474972A (en) * 1983-03-14 1984-10-02 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane prostaglandin intermediates and method for preparing same
US4536514A (en) * 1984-04-06 1985-08-20 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane substituted prostaglandin analogs useful in the treatment of thrombolytic disease
US4661506A (en) * 1984-11-30 1987-04-28 E. R. Squibb & Sons, Inc. 7-oxabicycloheptane substituted ox prostaglandin analogs
US4588743A (en) * 1985-01-22 1986-05-13 E. R. Squibb & Sons, Inc. 7-oxabicycloheptane-substituted oxa prostaglandin analogs and their use in the treatment of thrombolytic disease
US4591603A (en) * 1985-02-25 1986-05-27 E. R. Squibb & Sons, Inc. 7-oxabicycloheptane substituted prostaglandin analogs useful in the treatment of thrombotic disease
US4611007A (en) * 1985-04-22 1986-09-09 E. R. Squibb & Sons, Inc. 7-oxabicycloheptane substituted prostaglandin analogs useful in the treatment of thrombotic disease
US4654366A (en) * 1986-02-14 1987-03-31 E. R. Squibb & Sons, Inc. Hydroxamic acids of 7-oxabicyclo[2.2.1]heptane substituted ethers useful as anti-thrombotic agents
US4931460A (en) * 1987-09-17 1990-06-05 E. R. Squibb & Sons, Inc. Post-ischemic myocardial dysfunction using thromboxane A2 antagonists
US4900723A (en) * 1988-04-29 1990-02-13 E. R. Squibb & Sons, Inc. Method of preventing or reducing venous thrombosis using a thromboxane A2 receptor antagonist in conjunction with heparin and combination
US4925873A (en) * 1988-09-01 1990-05-15 E. R. Squibb & Sons, Inc. Method of treating skin injuries using thromboxane A2 receptor antagonists
US4839384A (en) * 1988-10-07 1989-06-13 E. R. Squibb & Sons, Inc. Method of inhibiting onset of or treating migraine headache using a thromboxane A2 receptor antagonist
CA2006086A1 (en) * 1989-01-17 1990-07-17 A. K. Gunnar Aberg Method of preventing or treating atherosclerosis using a thromboxane a receptor antagonist
CA2007896A1 (en) * 1989-02-06 1990-08-06 A.K. Gunnar Aberg Method of treating hypertension using a thromboxane a2 receptor antagonist and new combinations
CA2012852A1 (en) * 1989-05-01 1990-11-01 Miguel A. Ondetti Method of inhibiting vasospasm and platelet aggregation resulting from angioplasty using thromboxane a receptor antagonists
US5093329A (en) * 1990-03-12 1992-03-03 Allergan, Inc. Intraocular pressure reducing prostaglandin-like 7-oxabicyclo derivatives
ZA911453B (en) * 1990-03-19 1991-11-27 Squibb & Sons Inc Method of protecting against and/or treating ulcerative gastrointestinal conditions using a thromoboxane,a2 receptor antagonist and combination useful in preventing and/or treating ulcers and/or inflammation
JP4202250B2 (ja) 2001-07-25 2008-12-24 バイオマリン ファーマシューティカル インコーポレイテッド 血液脳関門輸送を調節するための組成物および方法
EP3827747A1 (en) 2005-04-28 2021-06-02 Otsuka Pharmaceutical Co., Ltd. Pharma-informatics system
CN101594878A (zh) 2006-09-18 2009-12-02 雷普特药品公司 通过给予受体相关蛋白（rap）-缀合物对肝病症的治疗
DK3395372T3 (da) 2009-02-20 2022-04-19 Enhanx Biopharm Inc System til afgivelse af glutathion-baseret medikament
CN110075069A (zh) 2009-05-06 2019-08-02 实验室护肤股份有限公司 包含活性剂-磷酸钙颗粒复合物的皮肤递送组合物及其应用
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
JP6273072B2 (ja) 2014-05-16 2018-01-31 カンバーランド ファーマシューティカルズ，インコーポレーテッド イフェトロバンにより心臓線維症を治療する組成物及び方法
JP7033454B2 (ja) 2015-06-30 2022-03-10 カンバーランド ファーマシューティカルズ，インコーポレーテッド Ａｅｒｄ／喘息におけるトロンボキサン受容体拮抗薬
WO2017197107A1 (en) 2016-05-11 2017-11-16 Cumberland Pharmaceuticals, Inc. Compositions and methods of treating muscular dystrophy with thromboxane-a2 receptor antagonists

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4088779A (en) * 1973-05-18 1978-05-09 Ciba-Geigy Corporation 9-Oxaprostaglandins
DE2357953A1 (de) * 1973-11-21 1975-05-28 Hoechst Ag Neue, natuerlich nicht vorkommende analoga von prostansaeuren und verfahren zu ihrer herstellung
US4220594A (en) * 1977-11-04 1980-09-02 E. R. Squibb & Sons, Inc. Hexa- and octahydro-4,7-epoxyisobenzofuran-1-ol and hexa- and octahydro-5,8-epoxy-1H-2-benzopyran-3-ol
US4187236A (en) * 1977-11-04 1980-02-05 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane compounds
US4143054A (en) * 1977-11-04 1979-03-06 E. R. Squibb & Sons, Inc. 7-oxabicycloheptane- and 7-oxabicycloheptene compounds
US4254044A (en) * 1977-11-04 1981-03-03 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane- and 7-oxabicycloheptene compounds
US4228180A (en) * 1979-11-01 1980-10-14 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane and 7-oxabicycloheptene prostaglandin analogs
US4436934A (en) * 1981-02-05 1984-03-13 Iowa State University Research Foundation, Inc. Bicyclic prostaglandin analogs and method of synthesis
US4416896A (en) * 1982-05-17 1983-11-22 E. R. Squibb & Sons, Inc. 7-Oxabicyclopheptane substituted amino prostaglandin analogs useful in the treatment of thrombolytic disease
US4456615A (en) * 1982-10-25 1984-06-26 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane substituted amino prostaglandin analogs and their use in inhibiting platelet aggregation and bronchoconstriction
US4456616A (en) * 1982-12-27 1984-06-26 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane substituted amino prostaglandin analogs and their use in inhibiting platelet aggregation and bronchoconstriction

Also Published As

Publication number Publication date
PT75811A (en) 1982-12-01
IE822648L (en) 1983-05-09
PT75811B (en) 1985-07-26
NZ202138A (en) 1986-03-14
IE54086B1 (en) 1989-06-07
DK497682A (da) 1983-05-10
PH22106A (en) 1988-06-01
AU8935982A (en) 1983-05-19
EP0079694B1 (en) 1987-05-13
AU569464B2 (en) 1988-02-04
DE3276317D1 (en) 1987-06-19
KR840002400A (ko) 1984-07-02
GR76780B (enExample) 1984-09-04
US4537981A (en) 1985-08-27
IL66989A0 (en) 1983-02-23
EP0079694A1 (en) 1983-05-25
CA1215063A (en) 1986-12-09

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