KR880003624A - 신규의 시네르지스트 약제학적 조성물과 이의 용도 및 제조방법 - Google Patents

신규의 시네르지스트 약제학적 조성물과 이의 용도 및 제조방법 Download PDF

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Publication number
KR880003624A
KR880003624A KR870010125A KR870010125A KR880003624A KR 880003624 A KR880003624 A KR 880003624A KR 870010125 A KR870010125 A KR 870010125A KR 870010125 A KR870010125 A KR 870010125A KR 880003624 A KR880003624 A KR 880003624A
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KR
South Korea
Prior art keywords
thromboxane
pharmaceutical composition
antagonist
pharmaceutical compositions
sinerzist
Prior art date
Application number
KR870010125A
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English (en)
Inventor
하르만 발테르
니클 요셉
Original Assignee
디에테르 라우디엔, 게르하드 휴버
닥터 칼 토매 게엠바하
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 디에테르 라우디엔, 게르하드 휴버, 닥터 칼 토매 게엠바하 filed Critical 디에테르 라우디엔, 게르하드 휴버
Publication of KR880003624A publication Critical patent/KR880003624A/ko

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Abstract

내용 없음

Description

신규의 시네르지스트 약제학적 조성물과 이의 용도 및 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (7)

  1. 포스포디에스테라제 억제제 및 트롬복산 A2길항제를 한개 이상의 불활성 담체와 함께 함유하는 시네르지스트 약제학적 조성물.
  2. 제1항에 있어서, 피리미노[5,4-d]피리미딘 계열, 이소퀴놀린 계열. 피리노[3,2-d] 피리미딘 계열, 인돌린 및 카르보스티릴 계열과 벤족사진-2-온계열로부터 선택된 PDE 억제제와, 벤젤설폰 아미도에틸 계열 및 헵테노산 계열로부터 선택된 트롬복산 A2길항제를 함유하는 약제학적 조성물.
  3. 제1항 또는 제2항에 있어서, 디피리다몰 및 4-[2-(벤젠설폰아미도)-에틸]-페녹시-아세트산 또는 3-[4-(2-(P-톨루엔설폰아미도)-에틸)-벤조일]-프로피온산을 함유하는 약제학적 조성물.
  4. 제1항 내지 3항중의 어느 한 항에 있어서, 1내지 500mg의 PDE 억제제 및 10내지 300mg의 트롬복산 A2길항제를 함유함을 특징으로 하는 약제학적 조성물.
  5. 정맥 및 동맥 혈전중의 치료 및 예방을 위한 제1항 내지 4항중의 어느 한 항에서 청구된 약제학적 조성물의 용도.
  6. 정맥 및 동맥 혈전중의 치료 및 예방에 적합한 약제학적 조성물의 제조를 위한 PDE 억제제 및 트롬 복산 A2길항제로 구성된 조성물의 용도.
  7. PDE억제제 및 트롬복산 A2길항제를 비화학적 방법에 의해 통상의 불활성 담체중에 혼입시킴을 특징으로 하는 제1항 내지 4항중의 어느 한 한에서 청구된 약제학적 조성물의 제조방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR870010125A 1986-09-13 1987-09-12 신규의 시네르지스트 약제학적 조성물과 이의 용도 및 제조방법 KR880003624A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19863631294 DE3631294A1 (de) 1986-09-13 1986-09-13 Neue synergistische kombination bestehend aus einem phosphodiesterase-hemmer und einem thromboxan-a(pfeil abwaerts)2(pfeil abwaerts)-antagonisten und deren verwendung bzw. herstellung
DEP3631294.0 1986-09-13

Publications (1)

Publication Number Publication Date
KR880003624A true KR880003624A (ko) 1988-05-28

Family

ID=6309586

Family Applications (1)

Application Number Title Priority Date Filing Date
KR870010125A KR880003624A (ko) 1986-09-13 1987-09-12 신규의 시네르지스트 약제학적 조성물과 이의 용도 및 제조방법

Country Status (12)

Country Link
EP (1) EP0260527B1 (ko)
JP (1) JPS6379838A (ko)
KR (1) KR880003624A (ko)
AU (1) AU597718B2 (ko)
DE (2) DE3631294A1 (ko)
DK (1) DK472487A (ko)
ES (1) ES2033755T3 (ko)
GR (1) GR3004969T3 (ko)
IL (1) IL83872A0 (ko)
NZ (1) NZ221779A (ko)
PH (1) PH23553A (ko)
ZA (1) ZA876806B (ko)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0306846A3 (de) * 1987-09-11 1990-05-02 Dr. Karl Thomae GmbH Neue synergistische Kombination bestehend aus einem Phosphodiesterase-Hemmer und einem Thromboxan-A2-Antagonisten und deren Verwendung bzw. Herstellung
US5858694A (en) * 1997-05-30 1999-01-12 Cell Pathways, Inc. Method for identifying compounds for inhibition of cancerous lesions
EP1216037A2 (en) 1999-09-21 2002-06-26 Emory University Methods and compositions for treating platelet-related disorders using mpl pathway inhibitory agents

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4291368A (en) * 1979-03-30 1981-09-22 Borg-Warner Corporation Pulse-width modulated inverter system and method
DE3166627D1 (en) * 1980-12-12 1984-11-15 Thomae Gmbh Dr K Pyrimidones, their preparation and medicines containing them
DE3049207A1 (de) * 1980-12-27 1982-07-29 Dr. Karl Thomae Gmbh, 7950 Biberach Neue trisubstituierte pyrimido (5,4-d) pyrimidine, ihre herstellung und ihre verwendung als arzneimittel
US4568676A (en) * 1983-11-25 1986-02-04 Thomas Jefferson University Method of inhibiting aggregation using thromboxane synthetase inhibitor in combination with a cyclic AMP phosphodiesterase inhibitor

Also Published As

Publication number Publication date
EP0260527A3 (en) 1989-08-09
ES2033755T3 (es) 1993-04-01
DE3777926D1 (de) 1992-05-07
GR3004969T3 (ko) 1993-04-28
ZA876806B (en) 1989-05-30
IL83872A0 (en) 1988-02-29
EP0260527B1 (de) 1992-04-01
PH23553A (en) 1989-08-25
DE3631294A1 (de) 1988-03-24
AU597718B2 (en) 1990-06-07
EP0260527A2 (de) 1988-03-23
NZ221779A (en) 1990-03-27
JPS6379838A (ja) 1988-04-09
DK472487A (da) 1988-03-14
DK472487D0 (da) 1987-09-10
AU7829687A (en) 1988-03-17

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