KR880001354B1 - Ml-236b 유도체의 제조방법 - Google Patents

Ml-236b 유도체의 제조방법 Download PDF

Info

Publication number
KR880001354B1
KR880001354B1 KR8203252A KR820003252A KR880001354B1 KR 880001354 B1 KR880001354 B1 KR 880001354B1 KR 8203252 A KR8203252 A KR 8203252A KR 820003252 A KR820003252 A KR 820003252A KR 880001354 B1 KR880001354 B1 KR 880001354B1
Authority
KR
South Korea
Prior art keywords
compound
ifo
microorganism
group
apsidia
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
KR8203252A
Other languages
English (en)
Korean (ko)
Other versions
KR840000519A (ko
Inventor
아끼라 데라하라
미노루 다나까
Original Assignee
가와무라 요시부미
상꾜 가부시끼가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 가와무라 요시부미, 상꾜 가부시끼가이샤 filed Critical 가와무라 요시부미
Publication of KR840000519A publication Critical patent/KR840000519A/ko
Application granted granted Critical
Publication of KR880001354B1 publication Critical patent/KR880001354B1/ko
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/145—Fungi isolates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Seasonings (AREA)
  • Steering-Linkage Mechanisms And Four-Wheel Steering (AREA)
KR8203252A 1981-07-21 1982-07-21 Ml-236b 유도체의 제조방법 Expired KR880001354B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP56114038A JPS5815968A (ja) 1981-07-21 1981-07-21 Ｍｌ−２３６ｂ誘導体およびその製法
JP114038/81 1981-07-21

Publications (2)

Publication Number Publication Date
KR840000519A KR840000519A (ko) 1984-02-25
KR880001354B1 true KR880001354B1 (ko) 1988-07-28

Family

ID=14627469

Family Applications (1)

Application Number Title Priority Date Filing Date
KR8203252A Expired KR880001354B1 (ko) 1981-07-21 1982-07-21 Ml-236b 유도체의 제조방법

Country Status (12)

Country Link
US (1) US4447626A (enExample)
EP (1) EP0070649B1 (enExample)
JP (1) JPS5815968A (enExample)
KR (1) KR880001354B1 (enExample)
AT (1) ATE39487T1 (enExample)
AU (1) AU547968B2 (enExample)
CA (1) CA1185199A (enExample)
DE (1) DE3279304D1 (enExample)
DK (1) DK159397C (enExample)
ES (1) ES8308358A1 (enExample)
FI (1) FI75186C (enExample)
IE (1) IE54747B1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE33033E (en) * 1985-07-05 1989-08-22 Merck & Co., Inc. Process for the preparation of HMG-CoA reductase inhibitors intermediates
US4611081A (en) * 1985-07-05 1986-09-09 Merck & Co., Inc. Process for the preparation of HMG-CoA reductase inhibitors intermediates
US4841074A (en) * 1987-12-11 1989-06-20 Merck & Co., Inc. Intermediates and processes for 6-carboxy HMG-CoA reductase inhibitors
JP2792600B2 (ja) * 1989-04-14 1998-09-03 旭電化工業株式会社 メバロン酸生産菌
ATE135352T1 (de) * 1989-06-09 1996-03-15 Merck & Co Inc 3-keto-hmg-coa reduktase-inhibitoren
KR100186758B1 (ko) 1996-08-09 1999-04-01 영진약품공업 주식회사 프라바스타틴(pravastatin)전구체의제조방법
IN191580B (enExample) 1999-12-17 2003-12-06 Ranbaxy Lab Ltd

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5612114B2 (enExample) * 1974-06-07 1981-03-18
DK149080C (da) * 1980-06-06 1986-07-28 Sankyo Co Fremgangsmaade til fremstilling af derivater af ml-236b-carboxylsyre

Also Published As

Publication number Publication date
FI75186C (fi) 1988-05-09
FI75186B (fi) 1988-01-29
IE821738L (en) 1983-01-21
DK325782A (da) 1983-01-22
IE54747B1 (en) 1990-01-31
AU8592682A (en) 1983-01-27
JPS6355502B2 (enExample) 1988-11-02
DE3279304D1 (en) 1989-02-02
KR840000519A (ko) 1984-02-25
AU547968B2 (en) 1985-11-14
FI822567L (fi) 1983-01-22
ES514185A0 (es) 1983-08-16
EP0070649A3 (en) 1984-04-04
EP0070649B1 (en) 1988-12-28
FI822567A0 (fi) 1982-07-20
US4447626A (en) 1984-05-08
DK159397C (da) 1991-03-25
JPS5815968A (ja) 1983-01-29
EP0070649A2 (en) 1983-01-26
ES8308358A1 (es) 1983-08-16
CA1185199A (en) 1985-04-09
DK159397B (da) 1990-10-08
ATE39487T1 (de) 1989-01-15

Similar Documents

Publication Publication Date Title
US4342767A (en) Hypocholesteremic fermentation products
EP0074222B1 (en) Mb-530b derivatives, their preparation and pharmaceutical compositions containing them
US4319039A (en) Preparation of ammonium salt of hypocholesteremic fermentation product
US4294926A (en) Hypocholesteremic fermentation products and process of preparation
US4231938A (en) Hypocholesteremic fermentation products and process of preparation
US4448979A (en) ML-236B Derivatives
EP0022478B1 (en) Polyhydro-3,7-dimethyl-8-(2-(tetrahydro-4-hydroxy-6-oxo-2h-pyran-2-yl)-ethyl)-1-naphthylenyl-2-methylbutanoates, corresponding hydroxy acids, process for preparing and pharmaceutical compositions containing the same
US4294846A (en) Hypocholesteremic fermentation products and products of preparation
US4695587A (en) M-4 and IsoM-4 derivatives, their preparation and compositions containing them
US4420491A (en) Hypocholesteremic fermentation products and process of preparation
KR880001354B1 (ko) Ml-236b 유도체의 제조방법
US4343814A (en) Hypocholesterolemic fermentation products
US4432996A (en) Hypocholesterolemic fermentation products and process of preparation
US4578383A (en) CL 1565 antibiotic compounds
US4387242A (en) Hypocholesterolemic fermentation products and process of preparation
EP0087021A2 (en) CL 1565 Antibiotic compounds and their production
US4771070A (en) CL-1957A antibiotic compound
EP0065843B1 (en) New m-4 and iso m-4 derivatives, their preparation and compositions containing them
US4696948A (en) Indanyl derivatives and process for their preparation
US5102793A (en) Stereospecific keto reduction of bicyclooctandione-carboxylic acid esters by microorganisms
US4036876A (en) 18- AND 19-Hydroxylated prostaglandins
EP0381478A1 (en) Process for the preparation of 6-alpha-hydroxymethyl lovastatin derivatives
US4918100A (en) CL-1957B antibiotic compound and its production
JPH0355471B2 (enExample)
US4696912A (en) Stabilized compositions

Legal Events

Date Code Title Description
PA0109 Patent application

Patent event code: PA01091R01D

Comment text: Patent Application

Patent event date: 19820721

PG1501 Laying open of application
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 19870228

Comment text: Request for Examination of Application

Patent event code: PA02011R01I

Patent event date: 19820721

Comment text: Patent Application

PG1605 Publication of application before grant of patent

Comment text: Decision on Publication of Application

Patent event code: PG16051S01I

Patent event date: 19880629

PE0701 Decision of registration

Patent event code: PE07011S01D

Comment text: Decision to Grant Registration

Patent event date: 19881011

PR0701 Registration of establishment

Comment text: Registration of Establishment

Patent event date: 19881103

Patent event code: PR07011E01D

PR1002 Payment of registration fee

Payment date: 19881103

End annual number: 3

Start annual number: 1

PR1001 Payment of annual fee

Payment date: 19910702

Start annual number: 4

End annual number: 4

PR1001 Payment of annual fee

Payment date: 19920710

Start annual number: 5

End annual number: 5

PR1001 Payment of annual fee

Payment date: 19930716

Start annual number: 6

End annual number: 6

PR1001 Payment of annual fee

Payment date: 19940624

Start annual number: 7

End annual number: 7

PR1001 Payment of annual fee

Payment date: 19950603

Start annual number: 8

End annual number: 8

PR1001 Payment of annual fee

Payment date: 19960624

Start annual number: 9

End annual number: 9

PR1001 Payment of annual fee

Payment date: 19970710

Start annual number: 10

End annual number: 10

PR1001 Payment of annual fee

Payment date: 19971226

Start annual number: 11

End annual number: 11

PR1001 Payment of annual fee

Payment date: 19990714

Start annual number: 12

End annual number: 12

PR1001 Payment of annual fee

Payment date: 20000714

Start annual number: 13

End annual number: 13

PR1001 Payment of annual fee

Payment date: 20010719

Start annual number: 14

End annual number: 14

PC1801 Expiration of term