KR860007264A - 새로운 1-옥사-1-데티아 세팔로스포린 화합물의 제조방법 - Google Patents

새로운 1-옥사-1-데티아 세팔로스포린 화합물의 제조방법 Download PDF

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Publication number
KR860007264A
KR860007264A KR1019860001452A KR860001452A KR860007264A KR 860007264 A KR860007264 A KR 860007264A KR 1019860001452 A KR1019860001452 A KR 1019860001452A KR 860001452 A KR860001452 A KR 860001452A KR 860007264 A KR860007264 A KR 860007264A
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South Korea
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group
sup
general formula
formula
hydrogen atom
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KR1019860001452A
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KR900003500B1 (ko
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세이지 사바하라
쓰네오 오코노기
야스시 무라이
순조 후카쓰
슌조 후카쓰
타로 니이다
타다시 와카자와
지.크리스 텐센 버론
지. 크리스텐센 버톤
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메이지제과 주식회사
나카가와 타케시
메르크 앤드캄파니 인코포레이티드
원본미기재
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Publication of KR860007264A publication Critical patent/KR860007264A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D505/00—Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D505/02—Preparation
    • C07D505/06—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D505/00—Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D505/00—Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D505/10—Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D505/12—Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 substituted in position 7

Abstract

내용 없음

Description

새로운 1-옥사-1데티아 세팔로스포린 화합물의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (2)

  1. 다음 일반식(Ⅴ)화합물에 대하여 다음 일반식(Ⅶ)의 N-알킬피리도-4-티온유도체를 반응시켜 일반식(Ⅶ)의 화합물을 생성하는 공정과, 다음 일반식(Ⅶ)의 화합물 중에 잔류하는 보호기를 이탈시키는 공정으로 구성시킴을 특징으로 하는 다음 일반식(Ⅰ)의 1-옥사-1-데티아-세팔로스 포린화합물의 제조방법.
    위 식에서,
    R1은 다음식으로 나타낸 기,
    (R5는 메틸기, 에틸기, 카르복시메틸기 또는 2-카르복시이소프로필기임)
    또는 다음 식으로 나타낸 기이며,
    (위 식에서 R6은 수소원자, 4-에틸-2,3-디옥소피페라딘-1-일기, 3-4-디히드록시페닐기 또는 링(ring)내에 유일한 헤테로치환체로서 2원자의 질소를 가지며 또 다음식의 링질소에 인접한 탄소상에 적어도 하나의 헤테로기를 가진 5-또는 5-멤버 헤테로사이클기이며,
    (*가 붙은 탄소원자의 부위의 입체배치는 (R)형 또는 (S)형, 또는 이들의 혼합물임)
    R2및 R3는 각각 수소원자 또는 R2와 R3의 어느 것이나 한쪽이 수소원자이며 다른쪽이 메틸기이고,
    R4는 수소원자, 메틸기, 카르복실기, 트리플루오로 메틸기, 또는 모노플루오로메틸기이며,
    R7는 카르복실 보호기이고,
    X는 클로린, 브로민 또는 요오드 원자이다.
  2. 제 1 항에 있어서,
    카르복실보호기는 t-부틸기, 디클로로에틸기, 트리클로로에틸기등의 알킬기, 벤질기, p-니트로 벤질기, p-메톡시벤질기, 페나실메틸기, 디페닐 메틸기등의 아랄킬기임을 특징으로 한 상기방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019860001452A 1985-03-01 1986-02-28 새로운 1-옥사-1-데티아 세팔로스포린 화합물의 제조방법 KR900003500B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/705,799 US4645769A (en) 1985-03-01 1985-03-01 1-oxa-1-dethia-cephalosporin compounds and antibacterial agent comprising the same
US705799 1985-03-01

Publications (2)

Publication Number Publication Date
KR860007264A true KR860007264A (ko) 1986-10-10
KR900003500B1 KR900003500B1 (ko) 1990-05-21

Family

ID=24835001

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019860001452A KR900003500B1 (ko) 1985-03-01 1986-02-28 새로운 1-옥사-1-데티아 세팔로스포린 화합물의 제조방법

Country Status (9)

Country Link
US (1) US4645769A (ko)
EP (1) EP0193858B1 (ko)
JP (1) JPH0633280B2 (ko)
KR (1) KR900003500B1 (ko)
AT (1) ATE69819T1 (ko)
CA (1) CA1268177A (ko)
DE (1) DE3682599D1 (ko)
DK (1) DK92486A (ko)
ES (2) ES8705450A1 (ko)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK123488A (da) * 1987-03-09 1988-09-10 Otsuka Pharma Co Ltd 2-oxa-isocephemforbindelser, praeparater indeholdende dem, og fremgangsmaader til fremstilling af dem
DK582788A (da) * 1987-10-22 1989-04-23 Otsuka Pharma Co Ltd 2-oxa-isocephemforbindelser, midler der indeholder dem og fremgangsmaader til fremstilling af dem
US5525599A (en) * 1993-07-21 1996-06-11 Eli Lilly And Company 7-substituted-amino-3-substituted-3-cephem-4-carboxylic acids
JP6377570B2 (ja) * 2014-04-28 2018-08-22 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ ２−置換セフェム化合物を含有する医薬組成物

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4226866A (en) * 1972-11-06 1980-10-07 Merck & Co., Inc. Novel antibiotic analogues of cephalosporins
JPS5331690A (en) * 1976-09-01 1978-03-25 Shionogi & Co Ltd Oxadithiacephalosporins
GB1557552A (en) * 1977-02-15 1979-12-12 Shionogi & Co 1 oxadethiacepham compounds
DE2714880A1 (de) * 1977-04-02 1978-10-26 Hoechst Ag Cephemderivate und verfahren zu ihrer herstellung
ES486026A1 (es) * 1978-11-17 1980-09-01 Glaxo Group Ltd Un procedimiento para la preparacion de antibioticos de ce- falosporina
ES8102135A1 (es) * 1979-05-23 1980-12-16 Rhone Poulenc Ind Procedimiento para la obtencion de tiovinil-3 cefalosporinas
FR2474504A1 (fr) * 1979-05-23 1981-07-31 Rhone Poulenc Ind Nouvelles thiovinyl-3 cephalosporines, leur preparation et les medicaments qui les contiennent
DE3137038A1 (de) * 1981-09-17 1983-03-24 Bayer Ag, 5090 Leverkusen Ss-lactam antibiotika, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
JPS5849382A (ja) * 1981-09-18 1983-03-23 Kyowa Hakko Kogyo Co Ltd β−ラクタム化合物
JPS5874680A (ja) * 1981-10-01 1983-05-06 Kyowa Hakko Kogyo Co Ltd β−ラクタム化合物
FR2516515A1 (fr) * 1981-11-16 1983-05-20 Sanofi Sa Nouveaux derives de pyridinium thiomethyl cephalosporines, procede pour leur preparation et compositions pharmaceutiques les contenant
US4534898A (en) * 1982-07-23 1985-08-13 Merck & Co., Inc. 1-Oxa-1-dethia-cephalosporin derivatives

Also Published As

Publication number Publication date
DE3682599D1 (de) 1992-01-09
ATE69819T1 (de) 1991-12-15
KR900003500B1 (ko) 1990-05-21
JPH0633280B2 (ja) 1994-05-02
EP0193858B1 (en) 1991-11-27
JPS61251685A (ja) 1986-11-08
ES557155A0 (es) 1987-08-16
ES552486A0 (es) 1987-05-01
ES8707726A1 (es) 1987-08-16
CA1268177A (en) 1990-04-24
EP0193858A1 (en) 1986-09-10
DK92486D0 (da) 1986-02-28
ES8705450A1 (es) 1987-05-01
DK92486A (da) 1986-09-02
US4645769A (en) 1987-02-24

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