ES2001516A6 - Un procedimiento para preparar derivados de 7-oxo-4-tia-1-azabiciclo(3,2,o)hept-2-eno - Google Patents

Un procedimiento para preparar derivados de 7-oxo-4-tia-1-azabiciclo(3,2,o)hept-2-eno

Info

Publication number
ES2001516A6
ES2001516A6 ES8601112A ES8601112A ES2001516A6 ES 2001516 A6 ES2001516 A6 ES 2001516A6 ES 8601112 A ES8601112 A ES 8601112A ES 8601112 A ES8601112 A ES 8601112A ES 2001516 A6 ES2001516 A6 ES 2001516A6
Authority
ES
Spain
Prior art keywords
group
groups
phenyl
carbon atoms
different
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8601112A
Other languages
English (en)
Inventor
Michael David Cooke
Stephen Connolly
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis UK Holdings Ltd
Original Assignee
Hoechst UK Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst UK Ltd filed Critical Hoechst UK Ltd
Publication of ES2001516A6 publication Critical patent/ES2001516A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

EL PROCEDIMIENTO DESCRITO PREPARA COMPUESTOS DE FORMULA DONDE R REPRESENTA HIDROGENO O UN GRUPO ESTERIFICADOR DE ACIDO CARBOXILICO, R1 REPRESENTA CIANO, NITRO O UN RADICAL ORGANICO, R2 REPRESENTA HIDROGENO, HALOGENO, CIANO, NITRO O UN RADICAL ORGANICO Y R3 REPRESENTA HIDROGENO O UN GRUPO PROTECTOR DE HIDROXI, HACIENDO REACCIONAR UN COMPUESTO DE FORMULA DONDE R3 ES COMO ANTES, R4 ES UN GRUPO PROTECTOR DE CARBOXI, R5 ES UN GRUPO R1 O UN GRUPO CONVERTIBLE EN R1, R6 ES UN GRUPO R2 O UN GRUPO CONVERTIBLE EN R2, R7 ES FENILO O ALQUILO Y R8 ES BROMO O CLORO, CON UNA BASE TAL COMO AMONIACO, CARBONATO, BICARBONATO O HIDROXIDO DE METAL ALCALINO Y OTROS COMPUESTOS BASICOS. LOS COMPUESTOS OBTENIDOS SE PUEDEN INCORPORAR EN FORMULACIONES FARMACEUTICAS DEBIDO A SU ACTIVIDAD ANTIBACTERIANA.
ES8601112A 1985-08-16 1986-08-14 Un procedimiento para preparar derivados de 7-oxo-4-tia-1-azabiciclo(3,2,o)hept-2-eno Expired ES2001516A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB858520631A GB8520631D0 (en) 1985-08-16 1985-08-16 Derivatives

Publications (1)

Publication Number Publication Date
ES2001516A6 true ES2001516A6 (es) 1988-06-01

Family

ID=10583916

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8601112A Expired ES2001516A6 (es) 1985-08-16 1986-08-14 Un procedimiento para preparar derivados de 7-oxo-4-tia-1-azabiciclo(3,2,o)hept-2-eno

Country Status (15)

Country Link
EP (1) EP0212404A1 (es)
JP (1) JPS6245589A (es)
KR (1) KR870002147A (es)
AU (1) AU593829B2 (es)
DK (1) DK388986A (es)
ES (1) ES2001516A6 (es)
FI (1) FI863300A (es)
GB (1) GB8520631D0 (es)
GR (1) GR862138B (es)
IL (1) IL79716A0 (es)
NO (1) NO863304L (es)
NZ (1) NZ217202A (es)
PH (1) PH24057A (es)
PT (1) PT83197A (es)
ZA (1) ZA866161B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0597401A3 (en) * 1992-11-11 1995-07-26 Takeda Chemical Industries Ltd Preparation of penemes.
US6395894B2 (en) 1998-04-16 2002-05-28 Philip J. Pye Process for the synthesis of carbapenem intermidiates, and compounds produced
JP2002518402A (ja) 1998-06-17 2002-06-25 メルク エンド カムパニー インコーポレーテッド カルバペネム中間体の合成方法、及び製造された化合物
US6194568B1 (en) 1998-07-13 2001-02-27 Merck & Co., Inc. Process for synthesizing carbapenem intermediates
AU2003227220A1 (en) 2002-03-26 2003-10-08 Daiichi Suntory Pharma Co., Ltd Process for producing cyclic compound

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4168314A (en) * 1977-11-17 1979-09-18 Merck & Co., Inc. 6-(1'-Hydroxyethyl)-2-aminoethylthio-pen-2-em-3-carboxylic acid
JPS5625110A (en) * 1978-12-18 1981-03-10 Bristol Myers Co Antibacterial
EP0180252B1 (en) * 1981-07-15 1989-04-26 Sumitomo Pharmaceuticals Company, Limited Process of preparing azetidinone compounds
GB2164334B (en) * 1984-09-10 1988-08-03 Hoechst Uk Ltd Antibacterial 7-oxo-4-thia-1-azabicyclo 3,2,0 hept-2-ene derivativess

Also Published As

Publication number Publication date
PH24057A (en) 1990-03-05
ZA866161B (en) 1987-04-29
DK388986A (da) 1987-02-17
PT83197A (en) 1986-09-01
DK388986D0 (da) 1986-08-15
KR870002147A (ko) 1987-03-30
FI863300A0 (fi) 1986-08-14
NO863304D0 (no) 1986-08-15
NZ217202A (en) 1989-08-29
JPS6245589A (ja) 1987-02-27
AU593829B2 (en) 1990-02-22
FI863300A (fi) 1987-02-17
GB8520631D0 (en) 1985-09-25
GR862138B (en) 1986-12-30
AU6151086A (en) 1987-02-19
EP0212404A1 (en) 1987-03-04
IL79716A0 (en) 1986-11-30
NO863304L (no) 1987-02-17

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19980401