KR860007246A - 헤테로 사이클릭 디설파이드의 제조방법 - Google Patents

헤테로 사이클릭 디설파이드의 제조방법 Download PDF

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KR860007246A
KR860007246A KR1019860001768A KR860001768A KR860007246A KR 860007246 A KR860007246 A KR 860007246A KR 1019860001768 A KR1019860001768 A KR 1019860001768A KR 860001768 A KR860001768 A KR 860001768A KR 860007246 A KR860007246 A KR 860007246A
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het
formula
compound
nitrogen atoms
reacted
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KR1019860001768A
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KR940001773B1 (ko
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플라이 쉬만 클라우스
뒤르크 하이머 발터
뒤르크하이머 발터
블룸 바흐 유르겐
블룸바흐 유르겐
림베르트 미카엘
쇼를 렘머 한스-울리히
쇼를렘머 한스-울리히
디크나이테 게르하르트
알트 세드라섹 한스-하르
세드라섹 한스-하르알트
Original Assignee
베링베르케 아크티엔게젤샤프트
하인리히 벡커, 베른하르트 벡크
훽스트 아크티엔게젤샤프트
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Publication of KR860007246A publication Critical patent/KR860007246A/ko
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Publication of KR940001773B1 publication Critical patent/KR940001773B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/28—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/56—One oxygen atom and one sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/36—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

내용 없음

Description

헤테로 사이클릭 디설파이드의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (1)

  1. 일반식(Ⅱ)의 화합물을 산화제와 반응시켜 일반식(Ⅰ') 화합물로 전환시키거나 :
    일반식(Ⅲ)의 화합물을 일반식 Me2S2(여기에서, Me는 이하에서 정의하는 바와 같다)의 화합물과 반응시키거나 :
    일반식(Ⅳ) 화합물을 수성 매질중에서 요오드와 반응시키고 :
    경우에 따라, 상기 반응에서 수득된 일반식(Ⅰ')의 화합물에서, 헤테로사이클 Het'의 치환체를 Het'의 다른 치환체로 전환시킴을 특징으로 하여, 일반식(Ⅰ')의 디설파이드를 제조하는 방법.
    Het'-S-S-Het' (Ⅰ')
    Het'-SH (Ⅱ)
    Het'-X (Ⅲ)
    Het'-S-S02Me (Ⅳ)
    상기식에서,
    Het'는 1개의 황원자와 1개 또는 2개의 질소원자를 함유하거나 1개 내지 3개의 질소원자를 함유하며, 또한 벤조-융함될 수도 있는 임의로 치환된 5-원 헤테로 사이클을 나타내거나, 1개 내지 3개의 질소원자를 함유하며 또한 완전히 또는 부분적으로 수소화될 수도 있는 임의로 치환된 6-원 헤테로 사이클을 나타내고,
    X는 용이하게 제거될 수 있는 반응성 그룹을 나타내며, Me는 알카리 금속을 나타낸다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019860001768A 1985-03-12 1986-03-12 헤테로 사이클릭 디설파이드의 제조방법 KR940001773B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19853508666 DE3508666A1 (de) 1985-03-12 1985-03-12 Heterocyclische disulfide und ihre anwendung als immunmodulatoren
DEP3508666.1 1985-03-12

Publications (2)

Publication Number Publication Date
KR860007246A true KR860007246A (ko) 1986-10-10
KR940001773B1 KR940001773B1 (ko) 1994-03-05

Family

ID=6264871

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019860001768A KR940001773B1 (ko) 1985-03-12 1986-03-12 헤테로 사이클릭 디설파이드의 제조방법

Country Status (19)

Country Link
EP (1) EP0194571B1 (ko)
JP (1) JPH0751572B2 (ko)
KR (1) KR940001773B1 (ko)
AR (1) AR245113A1 (ko)
AT (1) ATE58293T1 (ko)
AU (1) AU594943B2 (ko)
DE (2) DE3508666A1 (ko)
DK (1) DK165181C (ko)
ES (3) ES8801506A1 (ko)
FI (1) FI860980A (ko)
GR (1) GR860649B (ko)
HU (1) HU201742B (ko)
IE (1) IE58729B1 (ko)
IL (1) IL78091A (ko)
NO (1) NO168357C (ko)
NZ (1) NZ215424A (ko)
PH (1) PH22275A (ko)
PT (1) PT82166B (ko)
ZA (1) ZA861780B (ko)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3915094A1 (de) 1989-05-09 1991-01-10 Hoechst Ag Verfahren zur herstellung von 2-mercapto-4-methyl-1,3-thiazol-5-yl-essigsaeure und deren ester
TW252112B (ko) * 1993-08-19 1995-07-21 Pfizer
DE10055219A1 (de) * 2000-11-08 2002-05-29 Bayer Ag Verfahren zur Herstellung von Dithiazolyldisulfiden
EP1383499B1 (en) 2001-01-10 2013-03-06 The GRASSETTI Family Trust Method of immunomodulation using thione-forming disulfides
DE102005004472A1 (de) * 2005-01-31 2006-08-10 Rhein Chemie Rheinau Gmbh Verfahren zur Herstellung von Bis-DMTD

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR5680M (ko) * 1966-08-19 1968-01-08
IL36587A (en) * 1970-05-05 1977-10-31 Grassetti D Compositions containing pyridine derivatives and their use in a method of modifying cellular surface reactions
US4378364A (en) * 1970-05-05 1983-03-29 Grassetti Davide R Postoperative treatment of carcinoma patients
GB1365943A (en) * 1970-09-16 1974-09-04 Gaf Corp Metalworking additive and composition and process for making the same
GB1327467A (en) * 1970-10-12 1973-08-22 Merck & Co Inc Pharmaceutical compositions for inhibiting indoleamine- n-methyl transferase
FR2403798A1 (fr) * 1977-09-22 1979-04-20 Rorer Inc William H Compositions synergiques a base de disulfure de bis(2-pyridyl-1-oxyde et leur utilisation pour leur activite anti-inflammatoire
US4152439A (en) * 1978-01-12 1979-05-01 Davide R. Grassetti Stimulant and antidepressant agents
DE2944225A1 (de) * 1979-11-02 1981-05-07 Akzo Gmbh, 5600 Wuppertal Verfahren zur herstellung von dithiazoldisulfiden
US4451471A (en) * 1981-03-18 1984-05-29 Ciba-Geigy Corporation Certain 2,4,5-tri-substituted thiazoles, pharmaceutical compositions containing same and methods of using same
DE3118128A1 (de) * 1981-05-07 1982-12-02 Bayer Ag, 5090 Leverkusen Verwendung von disulfiden als lipoxygenasehemmer und diese enthaltende arzneimittel
EP0077630B1 (en) * 1981-10-21 1985-04-17 Beecham Group Plc Topical antimicrobial compositions
HU193951B (en) * 1985-03-11 1987-12-28 Richter Gedeon Vegyeszet Process for producing new sulfur-containing 5-substituted benzimidazol derivatives and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
DE3675561D1 (de) 1990-12-20
DK165181B (da) 1992-10-19
IL78091A (en) 1990-04-29
IL78091A0 (en) 1986-07-31
ES557614A0 (es) 1988-02-16
PT82166B (pt) 1988-07-29
NO168357C (no) 1992-02-12
ZA861780B (en) 1986-10-29
NZ215424A (en) 1989-04-26
GR860649B (en) 1986-07-11
JPH0751572B2 (ja) 1995-06-05
DE3508666A1 (de) 1986-09-18
ES8801624A1 (es) 1988-02-16
FI860980A (fi) 1986-09-13
ES8801506A1 (es) 1988-01-16
IE58729B1 (en) 1993-11-03
DK108786A (da) 1986-09-13
ES552840A0 (es) 1988-01-16
NO860908L (no) 1986-09-15
AU594943B2 (en) 1990-03-22
PT82166A (de) 1986-04-01
DK108786D0 (da) 1986-03-10
AR245113A1 (es) 1993-12-30
DK165181C (da) 1993-03-01
AU5460586A (en) 1986-10-16
JPS61207331A (ja) 1986-09-13
ES557615A0 (es) 1988-02-16
EP0194571A1 (de) 1986-09-17
FI860980A0 (fi) 1986-03-10
HU201742B (en) 1990-12-28
PH22275A (en) 1988-07-14
ES8801625A1 (es) 1988-02-16
NO168357B (no) 1991-11-04
IE860630L (en) 1986-09-12
EP0194571B1 (de) 1990-11-14
ATE58293T1 (de) 1990-11-15
KR940001773B1 (ko) 1994-03-05

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