KR850008671A - Method for producing acid addition salt of 2-[(2-aminoethyl) -thiomethyl] -5 to dimethylaminomethyl furan - Google Patents

Method for producing acid addition salt of 2-[(2-aminoethyl) -thiomethyl] -5 to dimethylaminomethyl furan Download PDF

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Publication number
KR850008671A
KR850008671A KR1019850002962A KR850002962A KR850008671A KR 850008671 A KR850008671 A KR 850008671A KR 1019850002962 A KR1019850002962 A KR 1019850002962A KR 850002962 A KR850002962 A KR 850002962A KR 850008671 A KR850008671 A KR 850008671A
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KR
South Korea
Prior art keywords
general formula
dimethylaminomethyl
acid addition
addition salt
iii
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KR1019850002962A
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Korean (ko)
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KR920005828B1 (en
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카스쯔레이네르(외 14) 엔드레
Original Assignee
괴르지 페케테, 괸지베르 패렌치
리크터 게데온 베게스재티 기아르 알티
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Publication of KR850008671A publication Critical patent/KR850008671A/en
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Publication of KR920005828B1 publication Critical patent/KR920005828B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Furan Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

내용없음No content

Description

2-〔(2-아미노에틸)-티오메틸〕-5~디메틸아미노메틸 푸란의 산부가염의 제조방법Method for producing acid addition salt of 2-[(2-aminoethyl) -thiomethyl] -5 to dimethylaminomethylfuran

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

Claims (7)

하기 일반식(Ⅲ)의 양성이온성(5-디메틸아미노메틸)-2-푸릴메틸)히드로겐 술페이트와 시스테아민 또는 이의 산부가염과 반응시키거나(a), 하기 일반식(Ⅳ)의 5-디메틸아미노메틸-2-푸르푸릴 알코올과 삼산화황 또는 용매중에서 삼산화황을 적절히 도입할 수 있는 시료로 처리한 후, 분리하여 얻은 하기 일반식(Ⅲ)의 (5-디메틸아미노메틸-2-푸릴메틸)히드로겐 술페이트와 시스테아민 또는 이의 산부가염 반응시키고(b), 바람직하기로는, 제법 a/또는 b/로 얻은 하기 일반식(Ⅰ)의 염기의 산부가염의 분리 및 /또는, 바람직하기로는, 하기 일반식(Ⅰ)염기의 유리, 정제 및/또는, 일반식(Ⅰ)의 염기의 다른 산부가염으로 변형시킴을 특징으로 하는 하기일반식(Ⅰ)의 2-〔(2-아미노에틸)-티오메틸)〕-5-디메틸아미노메틸푸란의 산부가염의 제조방법 및, 바람직하기로는 얻어진 신규의 염을 일반식(Ⅰ)의 공지의 염기로 변형시키는 방법.Reacting the zwitterionic (5-dimethylaminomethyl) -2-furylmethyl) hydrogen sulfate of the general formula (III) with cysteamine or an acid addition salt thereof (a), or the following general formula (IV) Treatment with 5-dimethylaminomethyl-2-furfuryl alcohol and sulfur trioxide or a sample capable of introducing sulfur trioxide in a solvent, followed by separation of (5-dimethylaminomethyl-2-furylmethyl of general formula (III) (B) separating the acid addition salts of the base of the general formula (I) obtained by the production process a / or b /, and / or, preferably, Is 2-[(2-aminoethyl) of the following general formula (I), characterized in that it is transformed into another acid addition salt of the base of the general formula (I), free, purified and / or of the following general formula (I). ) -Thiomethyl)] method for preparing acid addition salt of -5-dimethylaminomethylfuran, and preferably How to transform the novel salts obtained with a known base of general formula (Ⅰ). 제1항에 있어서, 용매의 부재하에서 일반식(Ⅲ)의 양성이온성(5-디메틸아미노메틸-2-푸릴메틸)히드로겐 술체이트와 또는 이의 산부가염과 반응시킴을 특징으로하는 방법.A process according to claim 1, characterized in that it is reacted with a zwitterionic (5-dimethylaminomethyl-2-furylmethyl) hydrogen sulphate of formula (III) in the absence of solvent or with acid addition salts thereof. 제 1또는 2항에 있어서, 반응을 60내지 90℃에서 수행시킴을 특징으로 하는 방법.The process according to claim 1 or 2, characterized in that the reaction is carried out at 60 to 90 ° C. 제 1내지 3항중에서 어느 한항에 있어서, 시스테아민의 산부가염으로 시스테아민 히드로클로라이드를 사용함을 특징으로 하는 방법.The process according to any one of claims 1 to 3, characterized in that cysteamine hydrochloride is used as the acid addition salt of cysteamine. 제 1항에 있어서, 방법 b/에서 삼산화황과 삼산화황 도입에 적절한 시료로서 디메틸포름아미드로 형성된 복합물을 사용함을 특징으로 하는 방법.2. A process according to claim 1, characterized in that the method b / uses a complex formed of dimethylformamide as a sample suitable for introducing sulfur trioxide and sulfur trioxide. 제1 또는 5항에 있어서, 일반식(Ⅲ)의 양이온성 화함물 제조용 용매로 디메틸포름아미드, 아세토니트릴 또는 사염화탄소를 사용함을 특징으로 하는 방법.The method according to claim 1 or 5, wherein dimethylformamide, acetonitrile or carbon tetrachloride is used as a solvent for preparing the cationic compound of general formula (III). 용매의 존재하에서 5-디메틸아미노메틸-2-푸르푸릴 알코올과 삼산화항 또는 삼산화황 도입에 적절한 시료와 반응시킴을 특징으로 하는 일반식(Ⅲ)의 양성이온성(5-디메틸아미노메틸-2-푸릴메틸)히드로겐 술페이트의 제조방법.Zwitterionic (5-dimethylaminomethyl-2-furyl) of formula (III), characterized by reacting 5-dimethylaminomethyl-2-furfuryl alcohol with a sample suitable for introducing trioxide or sulfur trioxide in the presence of a solvent Method for preparing methyl) hydrogen sulfate. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019850002962A 1984-05-02 1985-05-01 Process for preparing salt of 2-(2-aminomethyl)-thiomethyl-5-dimethyl amino methylfuran KR920005828B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
HU841690A HU198196B (en) 1984-05-02 1984-05-02 Process for production of basic tioether and its salts
HU1690 1984-05-02
HU1690/84 1984-05-02

Publications (2)

Publication Number Publication Date
KR850008671A true KR850008671A (en) 1985-12-21
KR920005828B1 KR920005828B1 (en) 1992-07-20

Family

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KR1019850002962A KR920005828B1 (en) 1984-05-02 1985-05-01 Process for preparing salt of 2-(2-aminomethyl)-thiomethyl-5-dimethyl amino methylfuran

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KR (1) KR920005828B1 (en)
AR (1) AR240455A1 (en)
AT (1) AT387573B (en)
CA (1) CA1268474A (en)
CS (1) CS259878B2 (en)
DK (1) DK196785A (en)
ES (1) ES8609292A1 (en)
FI (1) FI88501C (en)
GR (1) GR851062B (en)
HU (1) HU198196B (en)
IT (1) IT1200464B (en)
MX (1) MX161373A (en)
NO (1) NO168942C (en)
PT (1) PT80382B (en)
SU (1) SU1375133A3 (en)
YU (1) YU45714B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9009437D0 (en) * 1990-04-26 1990-06-20 Glaxo Group Ltd Chemical compounds

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1565966A (en) * 1976-08-04 1980-04-23 Allen & Hanburys Ltd Aminoalkyl furan derivatives
CH640846A5 (en) * 1977-07-29 1984-01-31 Allen & Hanburys Ltd Aminoalkylfuran derivative
ES497514A0 (en) * 1980-12-05 1981-10-16 Liade Sa Lab PROCEDURE FOR OBTAINING A HETEROCICLICAL PRIMARY AMINE DERIVATIVE
ES8300732A1 (en) * 1981-06-10 1982-11-01 Lafarquim Procedure for the obtaining of derivados de furil mettil mercaptano and its salts of pharmacological interest (Machine-translation by Google Translate, not legally binding)
ES506422A0 (en) * 1981-10-21 1982-08-16 Liade Sa Lab PROCEDURE FOR OBTAINING A HETERO-CYCLE DERIVATIVE OF DIMETHYLAMINE AND ITS PHYSIOLOGICALLY ACCEPTABLE SALTS.
ES507360A0 (en) * 1981-11-20 1982-11-16 Especialidades Latinas Medic U PROCEDURE FOR OBTAINING N- (2-5-DIMETHYLAMINE, METHYL-2-FURANIL-METHYL-THIO-ETHYL-N'-METHYL-S-NITRO-ETHANE-DIAMINE.

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Publication number Publication date
FI851742A0 (en) 1985-05-02
NO168942B (en) 1992-01-13
AR240455A1 (en) 1990-04-30
MX161373A (en) 1990-09-18
NO168942C (en) 1992-04-22
AT387573B (en) 1989-02-10
ATA129585A (en) 1988-07-15
HU198196B (en) 1989-08-28
IT8520558A0 (en) 1985-05-02
PT80382A (en) 1985-06-01
ES8609292A1 (en) 1986-08-16
ES542782A0 (en) 1986-08-16
CS316085A2 (en) 1988-03-15
NO851727L (en) 1985-11-04
YU73385A (en) 1987-12-31
YU45714B (en) 1992-07-20
CA1268474A (en) 1990-05-01
FI851742L (en) 1985-11-03
FI88501C (en) 1993-05-25
DK196785D0 (en) 1985-05-02
FI88501B (en) 1993-02-15
HUT37774A (en) 1986-02-28
SU1375133A3 (en) 1988-02-15
KR920005828B1 (en) 1992-07-20
PT80382B (en) 1987-08-19
DK196785A (en) 1985-11-03
IT1200464B (en) 1989-01-18
CS259878B2 (en) 1988-11-15
GR851062B (en) 1985-11-25

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