KR850008163A - 2,4-디아미노-6-할로게노-5-알킬티오-피리미딘의 제조방법 - Google Patents

2,4-디아미노-6-할로게노-5-알킬티오-피리미딘의 제조방법 Download PDF

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Publication number
KR850008163A
KR850008163A KR1019850003159A KR850003159A KR850008163A KR 850008163 A KR850008163 A KR 850008163A KR 1019850003159 A KR1019850003159 A KR 1019850003159A KR 850003159 A KR850003159 A KR 850003159A KR 850008163 A KR850008163 A KR 850008163A
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South Korea
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alkyl
general formula
carbon atoms
pyrimidine
hydrogen
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KR1019850003159A
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English (en)
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슈밤보른 미카엘 (외 6)
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요아힘 그렘, 하인쯔-게르트 뮐러
바이엘 아크티엔 게젤샤프트
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Publication of KR850008163A publication Critical patent/KR850008163A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/54—1,3-Diazines; Hydrogenated 1,3-diazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/38—One sulfur atom

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Plant Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Agronomy & Crop Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Pest Control & Pesticides (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음

Description

2,4-디아미노-6-할로게노-5-알킬티오-피리미딘의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (4)

  1. 다음 일반식(Ⅱ)의 트리할로게노피리미딘을 (A) 우선 산-결합제 존재하, 필요한 경우 희석제 존재하에서 다음 일반식(Ⅲ)의 알콕시알킬아민과 반응시켜(제1단계) 일반식(Ⅳa) 및 (Ⅳb)의 이성체 피리미딘 유도체 혼합물을 수득하고, 두 이성체를 분리한 후 일반식(Ⅳa)의 피리미딘 유도체를 산-결합체 존재하, 필요한 경우 희석제 존재하에서 다음 일반식(Ⅴ)의 아민과 반응시켜(제2단계) 일반식(Ⅰ)의 피리미딘 유도체를 수득하거나, (B) 우선 방법(A)와 동일한 반응조건하에서 일반식(Ⅴ)의 아민과 반응시켜 일반식(Ⅵa) 및 (Ⅵb)의 이성체 피리미딘 유도체혼합물을 수득하고 두 이성체를 분리시킨 후 일반식(Ⅵb)의 피리미딘 유도체를 다시 (A)와 동일한 반응조건하에서 일반식(Ⅲ)의 알콕시알킬아민과 반응시켜 일반식(Ⅰ) 및 (Ⅰa)의 이성체 피리미딘 유도체 혼합물을 수득하고, 최종적으로 일반식(Ⅰ)의 목적하는 이성체를 분리함을 특징으로 하여 다음 일반식(Ⅰ)의 2,4-디아미노-6-할로게노-5-알킬티오-피리미딘을 제조하는 방법.
    상기식에서, X는 할로겐이고, R1은 할로겐으로 임의 치환된 알킬이고, R2는 수소 또는 알킬이고, R3는 수소, 알킬 또는 알콕시알킬이고, R4는 수소 또는 알킬이고, Z는 직쇄 또는 측쇄알킬렌그룹이고, R5는 알킬이다.
  2. 제1항에 있어서, X가 염소 또는 불소이고, R1은 염소 및/또는 불소로 임의 치환된 탄소수 1 내지 6의 알킬이며 R2, R3및 R4는 각 경우에 있어서 서로 독립적으로 수소 또는 탄소수 1 내지 6의 알킬이며, 또한 R3는 (C1-C6)-알콕시-(C1-C6)-알킬이고, Z는 탄소수 2 내지 10의 측쇄 또는 직쇄알킬렌그룹이고 R5는 탄소수 1 내지 6의 알킬인 일반식(Ⅰ)의 피리미딘 유도체를 제조하는 방법.
  3. 제1항에 있어서, X는 염소 또는 불소이고 R1은 불소로 임의 치환된 탄소수 1 내지 4의 알킬이고 R2, R3및 R4는 각 경우에 있어서 서로 독립적으로 수소 또는 탄소수 1 내지 4의 알킬이며, 또한 R3는 (C1-C4)-알콕시-(C1-C4)-알킬이고 Z는 탄소수 2 내지 7의 측쇄 또는 직쇄알킬렌그룹이고 R5는 탄소수 1 내지 4의 알킬인 일반식(Ⅰ)의 피리미딘 유도체를 제조하는 방법.
  4. 제1항에 있어서, 다음 구조식의 4-아미노-2-(3-이소프로폭시프로필아미노)-6-클로로-5-메틸티오-피리미딘을 제조하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019850003159A 1984-05-10 1985-05-09 2,4-디아미노-6-할로게노-5-알킬티오-피리미딘의 제조방법 KR850008163A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19843417264 DE3417264A1 (de) 1984-05-10 1984-05-10 Neue 2,4-diamino-6-halogen-5-alkylthio-pyrimidine
DEP3417264.5 1984-05-10

Publications (1)

Publication Number Publication Date
KR850008163A true KR850008163A (ko) 1985-12-13

Family

ID=6235427

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019850003159A KR850008163A (ko) 1984-05-10 1985-05-09 2,4-디아미노-6-할로게노-5-알킬티오-피리미딘의 제조방법

Country Status (11)

Country Link
US (2) US4614532A (ko)
EP (1) EP0160908A3 (ko)
JP (1) JPS60239471A (ko)
KR (1) KR850008163A (ko)
AU (1) AU4200785A (ko)
BR (1) BR8502197A (ko)
DE (1) DE3417264A1 (ko)
DK (1) DK207085A (ko)
HU (1) HUT39432A (ko)
IL (1) IL75109A0 (ko)
ZA (1) ZA853510B (ko)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3445293A1 (de) * 1984-12-12 1986-06-12 Bayer Ag, 5090 Leverkusen Neue 2,4-diaminopyrimidine
IE913974A1 (en) * 1990-11-14 1992-05-20 Protos Corp Specific inhibition of dihydrofolate reductase and compounds¹therefor
US6093421A (en) * 1999-08-31 2000-07-25 Biotics Research Corporation Maca and antler for augmenting testosterone levels

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2119234A5 (en) * 1970-12-24 1972-08-04 Ugine Kuhlmann 5-alkylthio amino halopyrimidines - fungicides herbicides insecticides and bactericides
FR2173746B1 (ko) * 1972-03-01 1975-04-25 Ugine Kuhlmann
FR2244520B1 (ko) * 1973-07-06 1977-02-04 Ugine Kuhlmann
US4166852A (en) * 1974-08-09 1979-09-04 Produits Chimiques Ugine Kuhlmann Piperazino-pyrimidines and their use as spasmolytic agents
FR2311776A1 (fr) * 1975-05-23 1976-12-17 Sogeras Diamino-2,4 bromo-5 chloro-6 pyrimidines et procede pour leur preparation
FR2417507A2 (fr) * 1977-07-28 1979-09-14 Ugine Kuhlmann Diamino-2,4 (ou -4,6) methylthio-5 pyrimidines herbicides

Also Published As

Publication number Publication date
EP0160908A3 (de) 1986-11-20
ZA853510B (en) 1985-12-24
EP0160908A2 (de) 1985-11-13
US4640923A (en) 1987-02-03
BR8502197A (pt) 1986-01-07
HUT39432A (en) 1986-09-29
AU4200785A (en) 1985-11-14
DK207085D0 (da) 1985-05-09
US4614532A (en) 1986-09-30
JPS60239471A (ja) 1985-11-28
DE3417264A1 (de) 1985-11-14
IL75109A0 (en) 1985-09-29
DK207085A (da) 1985-11-11

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