KR850002100A - 치환된 피리도(1,2-c) 이미다조(1,2-a) 벤즈이미다졸의 제조방법 - Google Patents
치환된 피리도(1,2-c) 이미다조(1,2-a) 벤즈이미다졸의 제조방법 Download PDFInfo
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- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/53—Nitrogen atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
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- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Animal Behavior & Ethology (AREA)
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- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Steroid Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (2)
- R이 수소인 일반식(Ⅰ)의 화합물을 제조하기 위해서, 일반식(Ⅱ)의 화합물을 폐환시키거나 일반식(Ⅲa)의 화합물을 폐환시키거나; R이 설페닐인 일반식(Ⅰ)의 화합물을 제조하기 위해서, 일반식(Ⅲ)의 2-벤즈이미다졸 2'-피리딜 설폭사이드를 산으로 처리하거나(이때 R1≠R2이면 위치 이성체 화합물의 혼합물이 형성될 수 있다), R1내지 R5가 하기한 바와 같고 R이 수소인 일반식(Ⅰ)의 화합물을 황원소 또는 유기용매중의 S2Cl2와 반응시키거나; R이 수소 또는 설페닐인 일반식(Ⅰ)의 화합물을 제조하기 위해서, R'내지 R5가 하기한 바와 같고, R이 설페닐인 일반식(Ⅰ)의 화합물을 R6가 수소인 일반식(Ⅰ)의 화합물로 환원시키고, 필요시 생성된 화합물을 일반식 R6X(여기에서 R6는 자유-라디칼 전자 및 수소를 제외하고는 하기한 바와 같고, X는 이탈그룹이다)의 화합물과 반응시키고; 필요시 상기 수득된 화합물을 이들의 생리적으로 허용되는 염들로 전환시킴을 특징으로 하는, 일반식(Ⅰ)의 화합물 및 이의 생리적으로 허용되는 염의 제조방법.상기 식에서, R1및 R2는 같거나 다르며, 수소, (C1내지 C3)-알킬, 트리플루오로메틸, 할로겐, 메톡시카보닐, 에톡시카보닐, (C1내지 C5), 알콕시 또는 (C1내지 C4)-알카노일이고, R3, R4및 R5는 같거나 다르며, 수소, 메틸, 메톡시, 에톡시, 메톡시에톡시 또는 에톡시에톡시이고 R은 수소 또는 그룹 SR6이고, 여기에서 R6는 12-설페닐라디칼의 고립된 짝안지은 전자; 수소; (C1내지 C4)-알콕시로 치환되거나 (C6내지 C10)-아릴로 일- 또는 다-치환될 수 있는 (C1내지 C6)-알킬;(C|2내지 C6)-알케닐; (C2내지 C6)-알커닐; (C1내지 C7)알카노일; (C5내지 C7)-시클로알카노일; (C1내지 C7)-알킬, (C1내지 C5)-알콕시, (C1내지 C4)-알콕시카보닐, 시아노, 트리플루오로메틸 및/또는 할로겐으로 일- 또는 다-치환될 수 있는 벤조일; 푸로일; 펜아실; 페녹시아세틸; 또는 페닐아세틸이고, 이들중 뒤의 세 그룹은 상기 벤조일항에서 정의한 그룹 또는 다른 통상적 티올-보호그룹으로 치환될 수 있고, Y1+Y2는 하나의 결합을 나타내고 Z가 이탈그룹을 나타내거나, Y1은 수소이고 Y2+Z가 옥소그룹을 나타낸다.
- Y1+Y2가 하나의 결합을 나타내고 Z가 이탈그룹인 일반식(Ⅱ)의 화합물을 제조하기 위해서, 일반식(Ⅳ)의 화합물을 일반식(Ⅴ)의 화합물과 반응시키거나, Y1이 수소이고 Y2+Z가 옥소인 일반식(Ⅱ)의 화합물을 제조하기 위해서 일반식(Ⅵ)의 화합물을 카본산 유도체와 반응시킴을 특징으로 하는 일반식(Ⅲ)의 화합물의 제조방법.상기 식에서, R1및 R2는 같거나 다르며, 수소, (C2내지 C6)-알킬, 트리플루오로메틸, 할로겐, 메톡시카보닐, 에톡시카보닐, (C1내지 C5), 알콕시 또는 (C1내지 C4)-알카노일이고, R3, R4및 R5는 같거나 다르며, 수소, 메틸, 메톡시, 에톡시, 메톡시에톡시 또는 에톡시에톡시이고, Y1+Y2는 하나의 결합을 나타내고 Z가 이탈그룹을 나타내거나, Y1은 수소이고 Y2+Z가 옥소그룹을 나타낸다.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DEP3333314,9 | 1983-09-15 | ||
DE19833333314 DE3333314A1 (de) | 1983-09-15 | 1983-09-15 | Substituierte pyrido(1,2-c)imidazo(1,2-a)benzimidazole, verfahren zu ihrer herstellung, ihre verwendung sowie pharmazeutische praeparate auf basis dieser verbindungen |
Publications (1)
Publication Number | Publication Date |
---|---|
KR850002100A true KR850002100A (ko) | 1985-05-06 |
Family
ID=6209147
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019840005595A KR850002100A (ko) | 1983-09-15 | 1984-09-14 | 치환된 피리도(1,2-c) 이미다조(1,2-a) 벤즈이미다졸의 제조방법 |
Country Status (14)
Country | Link |
---|---|
US (1) | US4585775A (ko) |
EP (1) | EP0138034B1 (ko) |
JP (1) | JPS6084289A (ko) |
KR (1) | KR850002100A (ko) |
AT (1) | ATE41775T1 (ko) |
AU (1) | AU3306884A (ko) |
CA (1) | CA1247621A (ko) |
DE (2) | DE3333314A1 (ko) |
DK (1) | DK440084A (ko) |
ES (2) | ES8505678A1 (ko) |
GR (1) | GR80358B (ko) |
HU (1) | HU194234B (ko) |
PT (1) | PT79200B (ko) |
ZA (1) | ZA847261B (ko) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR243167A1 (es) | 1985-08-24 | 1993-07-30 | Hoechst Ag | Procedimiento para la preparacion de toluidinas sustituidas. |
DE3639926A1 (de) * | 1986-11-22 | 1988-06-01 | Hoechst Ag | Substituierte thienoimidazoltoluidin-derivate, verfahren zu ihrer herstellung, sie enthaltende pharmazeutische zubereitungen und ihre verwendung als magensaeuresekretionshemmer |
US5008282A (en) * | 1988-12-28 | 1991-04-16 | Kotobuki Seiyaku Co. Ltd. | Cyclic guanidine derivatives, anti-ulceratives and methods of manufacturing the same |
SE9500051D0 (sv) * | 1995-01-09 | 1995-01-09 | Frode Rise | Antioxidants, tissue- and/or neuroprotectants |
RU2645917C1 (ru) * | 2017-04-12 | 2018-03-01 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Ярославский государственный университет им. П.Г. Демидова" | Способ синтеза пиридо[1,2-а]имидазо[4,5-f]бензимидазола и его производных |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS4821274Y1 (ko) * | 1969-05-31 | 1973-06-20 | ||
JPS5124517B1 (ko) * | 1971-03-15 | 1976-07-24 | ||
US3880866A (en) * | 1972-05-01 | 1975-04-29 | American Home Prod | 7-Azaindole fused heterocyclic compounds |
US3911130A (en) * | 1973-04-18 | 1975-10-07 | American Home Prod | Novel 7-azaindole fused heterocyclic compounds for producing analgesia |
US3880870A (en) * | 1973-04-18 | 1975-04-29 | American Home Prod | 7-Azaindole fused heterocyclic compounds |
SE416649B (sv) * | 1974-05-16 | 1981-01-26 | Haessle Ab | Forfarande for framstellning av foreningar som paverkar magsyrasekretionen |
SE7804231L (sv) * | 1978-04-14 | 1979-10-15 | Haessle Ab | Magsyrasekretionsmedel |
GB2028317B (en) * | 1978-08-15 | 1982-11-10 | Pfizer Ltd | 2-(imidazol-1-ylmethyl)-pyridine and -quinoline thromboxane synthetase inhibitors |
US4255573A (en) * | 1979-03-29 | 1981-03-10 | Adhikary Parimal K | Imidazoindole derivatives and pharmaceutical compositions comprising imidazoindole derivatives |
JPS56116980A (en) * | 1980-02-15 | 1981-09-14 | Nippon Bulge Ind | Bend for pipings |
US4254127A (en) * | 1980-04-03 | 1981-03-03 | Janssen Pharmaceutica, N.V. | 1,3-Dihydro-1-[(1-piperidinyl)alkyl]-2H-benzimidazol-2-one derivatives |
US4472409A (en) * | 1981-11-05 | 1984-09-18 | Byk Gulden Lomberg Chemische Fabrik Gesellschaft Mit Beschrankter Haftung | 2-Pyridylmethyl thio(sulfinyl)benzimidazoles with gastric acid secretion inhibiting effects |
-
1983
- 1983-09-15 DE DE19833333314 patent/DE3333314A1/de not_active Withdrawn
-
1984
- 1984-09-06 DE DE8484110589T patent/DE3477490D1/de not_active Expired
- 1984-09-06 EP EP84110589A patent/EP0138034B1/de not_active Expired
- 1984-09-06 AT AT84110589T patent/ATE41775T1/de not_active IP Right Cessation
- 1984-09-10 HU HU843413A patent/HU194234B/hu not_active IP Right Cessation
- 1984-09-13 GR GR80358A patent/GR80358B/el unknown
- 1984-09-13 CA CA000463077A patent/CA1247621A/en not_active Expired
- 1984-09-13 US US06/650,106 patent/US4585775A/en not_active Expired - Fee Related
- 1984-09-13 ES ES535875A patent/ES8505678A1/es not_active Expired
- 1984-09-14 KR KR1019840005595A patent/KR850002100A/ko not_active Application Discontinuation
- 1984-09-14 AU AU33068/84A patent/AU3306884A/en not_active Abandoned
- 1984-09-14 JP JP59191867A patent/JPS6084289A/ja active Pending
- 1984-09-14 PT PT79200A patent/PT79200B/pt unknown
- 1984-09-14 ZA ZA847261A patent/ZA847261B/xx unknown
- 1984-09-14 DK DK440084A patent/DK440084A/da not_active Application Discontinuation
-
1985
- 1985-02-19 ES ES540511A patent/ES540511A0/es active Granted
Also Published As
Publication number | Publication date |
---|---|
HU194234B (en) | 1988-01-28 |
PT79200B (de) | 1986-09-10 |
ES535875A0 (es) | 1985-06-01 |
EP0138034B1 (de) | 1989-03-29 |
DK440084D0 (da) | 1984-09-14 |
DE3477490D1 (en) | 1989-05-03 |
CA1247621A (en) | 1988-12-28 |
ES8602790A1 (es) | 1985-12-01 |
ATE41775T1 (de) | 1989-04-15 |
ZA847261B (en) | 1985-05-29 |
HUT36120A (en) | 1985-08-28 |
ES8505678A1 (es) | 1985-06-01 |
DK440084A (da) | 1985-03-16 |
PT79200A (de) | 1984-10-01 |
DE3333314A1 (de) | 1985-03-28 |
US4585775A (en) | 1986-04-29 |
AU3306884A (en) | 1985-03-21 |
ES540511A0 (es) | 1985-12-01 |
EP0138034A1 (de) | 1985-04-24 |
GR80358B (en) | 1985-01-11 |
JPS6084289A (ja) | 1985-05-13 |
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