KR850001666B1 - 마크로라이드 항생물질의 제조방법 - Google Patents

마크로라이드 항생물질의 제조방법 Download PDF

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Publication number
KR850001666B1
KR850001666B1 KR1019810004342A KR810004342A KR850001666B1 KR 850001666 B1 KR850001666 B1 KR 850001666B1 KR 1019810004342 A KR1019810004342 A KR 1019810004342A KR 810004342 A KR810004342 A KR 810004342A KR 850001666 B1 KR850001666 B1 KR 850001666B1
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South Korea
Prior art keywords
omt
acid
dmt
medium
strong
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Expired
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KR1019810004342A
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English (en)
Korean (ko)
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KR830007833A (ko
Inventor
헨리 발쯔 리차드
앤드류 키스트 허버트
무리엘 윌드 제느
토마스 세노 유젠
Original Assignee
일라이 릴리 앤드 캄파니
아더 알. 웨일
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Publication of KR830007833A publication Critical patent/KR830007833A/ko
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces
    • C12R2001/54—Streptomyces fradiae
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/886—Streptomyces
    • Y10S435/896—Streptomyces fradiae

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
KR1019810004342A 1980-11-10 1981-11-10 마크로라이드 항생물질의 제조방법 Expired KR850001666B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US205539 1980-11-10
US06/205,539 US4304856A (en) 1980-11-10 1980-11-10 Process for producing 20-dihydro-20-deoxy-23-demycinosyltylosin
US205,539 1980-11-10

Publications (2)

Publication Number Publication Date
KR830007833A KR830007833A (ko) 1983-11-07
KR850001666B1 true KR850001666B1 (ko) 1985-11-13

Family

ID=22762621

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019810004342A Expired KR850001666B1 (ko) 1980-11-10 1981-11-10 마크로라이드 항생물질의 제조방법

Country Status (22)

Country Link
US (1) US4304856A (https=)
EP (1) EP0052005B1 (https=)
JP (1) JPS57108097A (https=)
KR (1) KR850001666B1 (https=)
AR (1) AR227563A1 (https=)
AU (1) AU7731381A (https=)
BG (1) BG36939A3 (https=)
CA (1) CA1169374A (https=)
CS (1) CS236663B2 (https=)
DD (1) DD202032A5 (https=)
DE (1) DE3168693D1 (https=)
DK (1) DK494381A (https=)
FI (1) FI813527A7 (https=)
GB (1) GB2086902B (https=)
GR (1) GR75386B (https=)
HU (1) HU190360B (https=)
IE (1) IE51826B1 (https=)
IL (1) IL64240A (https=)
PH (1) PH17375A (https=)
PL (1) PL233747A1 (https=)
PT (1) PT73947B (https=)
ZA (1) ZA817718B (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4419508A (en) * 1980-11-10 1983-12-06 Eli Lilly And Company 20-Dihydro-20-deoxy-23-demycinosyltylosin and process for its production
AU551142B2 (en) * 1981-07-09 1986-04-17 Zaidan Hojin Biseibutsu Kagaku Kenkyukai Tylosin derivatives
US4423148A (en) * 1982-07-02 1983-12-27 Eli Lilly And Company Process for producing 20-dihydro-20-deoxy-23-de(mycinosyloxy)tylosin
US4528369A (en) * 1982-07-02 1985-07-09 Eli Lilly And Company 20-Dihydro-20-deoxy-23-de(mycinosyloxy)tylosin
US4452784A (en) * 1982-07-19 1984-06-05 Eli Lilly And Company C-23-Modified derivatives of DMT
US4443436A (en) * 1982-09-13 1984-04-17 Eli Lilly And Company C-20-Modified macrolide derivatives of the macrolide antibiotics tylosin, desmycosin, macrocin, and lactenocin
IL71032A0 (en) * 1983-02-28 1984-05-31 Lilly Co Eli C-20 and c-23-modified macrolide derivatives
US4629786A (en) * 1983-02-28 1986-12-16 Eli Lilly And Company C-20- and C-23 modified macrolide derivatives
US4468511A (en) * 1983-02-28 1984-08-28 Eli Lilly And Company C-20- And C-23-Modified macrolide derivatives
US5716939A (en) * 1993-07-15 1998-02-10 Pfizer Inc. Amide derivatives of 16-membered ring antibiotic macrolides
US6362009B1 (en) 1997-11-21 2002-03-26 Merck & Co., Inc. Solid phase synthesis of heterocycles

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3178341A (en) * 1960-06-27 1965-04-13 Lilly Co Eli Antibiotics tylosin and desmycosin and derivatives thereof
US3326759A (en) * 1962-07-19 1967-06-20 Lilly Co Eli Antibiotics macrocin and lactenocin
US3344024A (en) * 1963-04-17 1967-09-26 American Cyanamid Co Antibiotic am-684 and method of production
BE667952A (https=) * 1964-08-05
US4161523A (en) * 1972-11-15 1979-07-17 Schering Corporation Rosamicin esters, acid addition salts and methods for production thereof
US4056616A (en) * 1976-03-05 1977-11-01 Schering Corporation Rosamicin derivatives and method of using same
GB1587685A (en) * 1977-03-09 1981-04-08 Microbial Chem Res Found Macrolactone derivatives and their production
US4252898A (en) * 1979-05-23 1981-02-24 Eli Lilly And Company Antibiotics A6888C and A6888X
NL8004922A (nl) * 1979-09-19 1981-03-23 Toyo Jozo Kk Deformyltylosinederivaten.

Also Published As

Publication number Publication date
IE812616L (en) 1982-05-10
HU190360B (en) 1986-08-28
PL233747A1 (https=) 1982-11-22
IE51826B1 (en) 1987-04-01
ZA817718B (en) 1982-10-27
GB2086902A (en) 1982-05-19
BG36939A3 (bg) 1985-02-15
GR75386B (https=) 1984-07-13
AU7731381A (en) 1982-05-20
FI813527L (fi) 1982-05-11
EP0052005B1 (en) 1985-01-30
PH17375A (en) 1984-08-06
US4304856A (en) 1981-12-08
DK494381A (da) 1982-05-11
AR227563A1 (es) 1982-11-15
IL64240A (en) 1985-08-30
GB2086902B (en) 1985-06-26
CS236663B2 (en) 1985-05-15
PT73947B (en) 1983-11-30
IL64240A0 (en) 1982-02-28
JPS57108097A (en) 1982-07-05
EP0052005A1 (en) 1982-05-19
KR830007833A (ko) 1983-11-07
FI813527A7 (fi) 1982-05-11
DD202032A5 (de) 1983-08-24
PT73947A (en) 1981-12-01
CA1169374A (en) 1984-06-19
DE3168693D1 (en) 1985-03-14

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